BR9812498A - Nucleosìdeo ligante, sua preparação e seu uso - Google Patents
Nucleosìdeo ligante, sua preparação e seu usoInfo
- Publication number
- BR9812498A BR9812498A BR9812498-6A BR9812498A BR9812498A BR 9812498 A BR9812498 A BR 9812498A BR 9812498 A BR9812498 A BR 9812498A BR 9812498 A BR9812498 A BR 9812498A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- binding nucleoside
- nucleoside
- binding
- oligonucleotides
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
- H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
- H10K85/761—Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Materials Engineering (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Patente de Invenção: <B>"NUCLEOSìDEO LIGANTE, SUA PREPARAçãO E SEU USO"<D>. A presente invenção refere-se a um nucleosídeo ligante, à sua preparação e ao seu uso para a ligação covalente de biomoléculas em oligonucleotídeos, em particular oligonucleotídeos p-RNA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19741738A DE19741738A1 (de) | 1997-09-22 | 1997-09-22 | Linker-Nucleosid, seine Herstellung und Verwendung |
PCT/EP1998/006000 WO1999015542A2 (de) | 1997-09-22 | 1998-09-21 | Linker-nucleosid, seine herstellung und verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9812498A true BR9812498A (pt) | 2000-09-19 |
Family
ID=7843199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9812498-6A BR9812498A (pt) | 1997-09-22 | 1998-09-21 | Nucleosìdeo ligante, sua preparação e seu uso |
Country Status (10)
Country | Link |
---|---|
US (2) | US6699978B1 (pt) |
EP (1) | EP1034180B1 (pt) |
JP (1) | JP4460153B2 (pt) |
KR (1) | KR20010024210A (pt) |
AT (1) | ATE321768T1 (pt) |
AU (1) | AU758101B2 (pt) |
BR (1) | BR9812498A (pt) |
CA (1) | CA2303527A1 (pt) |
DE (2) | DE19741738A1 (pt) |
WO (1) | WO1999015542A2 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19741739B4 (de) * | 1997-09-22 | 2006-04-27 | Nanogen Recognomics Gmbh | Supramolekulares Paarungssystem, dessen Herstellung und Verwendung |
DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
DE19837387A1 (de) | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
DE10010118A1 (de) * | 2000-03-03 | 2001-09-20 | Henkel Kgaa | Beschichtungssystem auf der Basis von Pyranosyl-Nukleinsäuren |
US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
KR101010640B1 (ko) * | 2003-07-02 | 2011-01-24 | 주식회사 포스코 | 소결강 선별 스크린 장입 슈트에서의 균일 분산 장치 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3752804A (en) * | 1969-06-14 | 1973-08-14 | Takeda Chemical Industries Ltd | 2-allyloxyinosine-5'-phosphate and physiologically acceptable salts thereof |
US4352795A (en) * | 1981-01-29 | 1982-10-05 | Warner-Lambert Company | 7-β-D-Arabinofuranosyl-7H-pyrrolo[2,3-d]pyrimidine compounds and methods for their production |
DE3434039A1 (de) * | 1984-09-17 | 1986-03-27 | Behringwerke Ag, 3550 Marburg | Glycopeptide, verfahren zu ihrer herstellung und ihre verwendung |
JP3012244B2 (ja) | 1987-09-21 | 2000-02-21 | ジェン―プローブ インコーポレイテッド | ヌクレオチドプローブ用非ヌクレオチド連結試薬 |
US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
US5849482A (en) * | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
US5391723A (en) | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
US5681941A (en) * | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
GB9207086D0 (en) * | 1992-03-31 | 1992-05-13 | Sharp Kk | Improvements relating to information technology |
US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
DE69533856T2 (de) * | 1994-10-24 | 2005-12-08 | Genencor International, Inc., Palo Alto | L-pyranosyl-nukleoside |
US5718915A (en) | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
AU4279996A (en) | 1994-11-01 | 1996-05-23 | Ariad Gene Therapeutics, Inc. | New method for identifying and evaluating biologically active molecules |
ES2165446T3 (es) * | 1995-03-13 | 2002-03-16 | Aventis Pharma Gmbh | Fosfonomonoester-acidos nucleicos, procedimiento para su preparacion y su utilizacion. |
WO1996039414A1 (en) * | 1995-06-01 | 1996-12-12 | Hybridon, Inc. | Novel base protecting groups for oligonucleotide synthesis |
KR19990028344A (ko) * | 1995-06-23 | 1999-04-15 | 로버터 에이.커리 | 치료 화합물 |
AU6514096A (en) | 1995-07-27 | 1997-02-26 | Carsten Behrens | A new achiral linker reagent for the incorporation of multiple amino groups into oligonucleotides |
US5912340A (en) | 1995-10-04 | 1999-06-15 | Epoch Pharmaceuticals, Inc. | Selective binding complementary oligonucleotides |
GB9602028D0 (en) | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
DE19741715A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
DE19815901A1 (de) * | 1998-04-08 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden |
-
1997
- 1997-09-22 DE DE19741738A patent/DE19741738A1/de not_active Withdrawn
-
1998
- 1998-09-21 BR BR9812498-6A patent/BR9812498A/pt not_active IP Right Cessation
- 1998-09-21 KR KR1020007003013A patent/KR20010024210A/ko not_active Application Discontinuation
- 1998-09-21 JP JP2000512847A patent/JP4460153B2/ja not_active Expired - Fee Related
- 1998-09-21 AU AU10247/99A patent/AU758101B2/en not_active Ceased
- 1998-09-21 US US09/509,011 patent/US6699978B1/en not_active Expired - Lifetime
- 1998-09-21 AT AT98952612T patent/ATE321768T1/de not_active IP Right Cessation
- 1998-09-21 DE DE59813469T patent/DE59813469D1/de not_active Expired - Lifetime
- 1998-09-21 WO PCT/EP1998/006000 patent/WO1999015542A2/de active IP Right Grant
- 1998-09-21 CA CA002303527A patent/CA2303527A1/en not_active Abandoned
- 1998-09-21 EP EP98952612A patent/EP1034180B1/de not_active Expired - Lifetime
-
2004
- 2004-03-02 US US10/792,289 patent/US20050004356A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1999015542A3 (de) | 1999-08-05 |
CA2303527A1 (en) | 1999-04-01 |
JP4460153B2 (ja) | 2010-05-12 |
US20050004356A1 (en) | 2005-01-06 |
EP1034180A2 (de) | 2000-09-13 |
JP2001517677A (ja) | 2001-10-09 |
AU1024799A (en) | 1999-04-12 |
KR20010024210A (ko) | 2001-03-26 |
WO1999015542A2 (de) | 1999-04-01 |
DE19741738A1 (de) | 1999-03-25 |
DE59813469D1 (de) | 2006-05-18 |
EP1034180B1 (de) | 2006-03-29 |
US6699978B1 (en) | 2004-03-02 |
ATE321768T1 (de) | 2006-04-15 |
AU758101B2 (en) | 2003-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Free format text: NANOGEN RECOGNOMICS GMBH (DE) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |