BR9811709A - Polipeptìdeos modificados com alta atividade e reduzida alergenicidade - Google Patents
Polipeptìdeos modificados com alta atividade e reduzida alergenicidadeInfo
- Publication number
- BR9811709A BR9811709A BR9811709-2A BR9811709A BR9811709A BR 9811709 A BR9811709 A BR 9811709A BR 9811709 A BR9811709 A BR 9811709A BR 9811709 A BR9811709 A BR 9811709A
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- twinned
- reduced allergenicity
- modified
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"POLIPEPTìDEOS MODIFICADOS COM ALTA ATIVIDADE E REDUZIDA ALERGENICIDADE". A presente invenção refere-se a um polipeptídeo modificado que tem um nível de atividade enzimática maior do que cerca de 70% do polipeptídeo original e um nível de resposta alergênica menor do que cerca de 33% do polipeptídeo original. As modalidades da presente invenção referem-se a polipeptídeos modificados com reduzida alergenecidade e alta atividade enzimática, que compreendem a fórmula: A-B~ n~, onde A é uma enzima, e suas misturas; B é um grupamento polimérico geminado que tem um peso molecular entre cerca de 0,5 quilodaltons (kd) e cerca de 40 kd, tendo a fórmula (1), conjugado à enzima, onde R~ 1~ e R~ 2~ são polímeros com cadeia essencialmente linear, tendo um peso molecular na faixa entre cerca de 0,25 kd e cerca de 20 kd; onde a relação entre os pesos moleculares de R~ 1~ e R~ 2~ é entre cerca de 1:10 e cerca de 10:1; onde X é um grupamento ligante que liga o grupamento geminado a um único sítio da enzima, e n é o número de grupamentos poliméricos geminados conjugados à enzima, e representa um número inteiro entre cerca de 1 e cerca de 15.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/903,298 US6284246B1 (en) | 1997-07-30 | 1997-07-30 | Modified polypeptides with high activity and reduced allergenicity |
PCT/US1998/015282 WO1999006071A1 (en) | 1997-07-30 | 1998-07-23 | Modified polypeptides with high activity and reduced allergenicity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811709A true BR9811709A (pt) | 2000-07-25 |
Family
ID=25417259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811709-2A BR9811709A (pt) | 1997-07-30 | 1998-07-23 | Polipeptìdeos modificados com alta atividade e reduzida alergenicidade |
Country Status (12)
Country | Link |
---|---|
US (1) | US6284246B1 (pt) |
EP (1) | EP1005373A1 (pt) |
JP (1) | JP2001511461A (pt) |
KR (1) | KR20010022419A (pt) |
CN (1) | CN1268062A (pt) |
AR (1) | AR016561A1 (pt) |
AU (1) | AU8583498A (pt) |
BR (1) | BR9811709A (pt) |
CA (1) | CA2297437A1 (pt) |
CO (1) | CO4810246A1 (pt) |
WO (1) | WO1999006071A1 (pt) |
ZA (1) | ZA986756B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6495136B1 (en) * | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
TW586945B (en) | 2001-01-12 | 2004-05-11 | Novartis Ag | Lens care product containing dexpanthenol |
US20040007251A1 (en) * | 2002-07-10 | 2004-01-15 | Kimberly-Clark Worldwide, Inc. | Cleaners for the control and removal of allergens |
WO2004014973A2 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
US20070134335A1 (en) * | 2005-06-08 | 2007-06-14 | Lledo Ernest G | Polypeptides with the capacity to entrap drugs and release them in a controlled way |
CA2624667C (en) | 2005-10-05 | 2018-01-09 | Commonwealth Scientific And Industrial Research Organisation | Silk proteins containing coiled coil region |
US8674077B2 (en) | 2009-08-26 | 2014-03-18 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing silk dope |
JP6317258B2 (ja) | 2011-11-16 | 2018-04-25 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション | コラーゲン様絹遺伝子 |
EP2850191A4 (en) | 2012-03-26 | 2016-03-23 | Commw Scient Ind Res Org | SILK POLYPEPTIDES |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
DE2631656C2 (de) | 1976-07-14 | 1983-02-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung eines Hydroxysuccinimidoester-Derivats zur Bindung von biologisch aktiven Proteinen aneinander und/oder an flüssige oder feste Trägerstoffe |
US4556554A (en) | 1981-06-01 | 1985-12-03 | Germaine Monteil Cosmetiques Corp. | Immobilized enzymes |
US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
US5185258A (en) | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
DE3750916T2 (de) | 1986-04-30 | 1995-06-01 | Genencor Int | Mutante einer nicht menschlichen Carbonyl-Hydrolase, für diese kodierende DNS-Sequenzen und Vektoren und durch diese Vektoren transformierte Wirte. |
JP2546807B2 (ja) * | 1988-09-30 | 1996-10-23 | 鐘紡株式会社 | 化粧料 |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
US5030378A (en) | 1990-01-02 | 1991-07-09 | The Procter & Gamble Company | Liquid detergents containing anionic surfactant, builder and proteolytic enzyme |
US5230891A (en) * | 1990-08-20 | 1993-07-27 | Kanebo Limited | Modified protease, method of producing the same and cosmetic products containing the modified protease |
US5133968A (en) | 1990-08-20 | 1992-07-28 | Kanebo, Ltd. | Modified protease, method of producing the same and cosmetic products containing the modified protease |
DE69130113T2 (de) | 1990-12-05 | 1999-05-12 | Novo Nordisk As | Proteine mit geänderten epitopen und verfahren zur deren herstellung |
EP0516200B1 (en) | 1991-05-01 | 1996-07-24 | Unilever N.V. | Detergent compositions containing stabilized enzymes |
IT1260468B (it) | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
GB9207280D0 (en) | 1992-04-02 | 1992-05-13 | Unilever Plc | Skin care method and composition |
GB9207288D0 (en) | 1992-04-02 | 1992-05-13 | Unilever Plc | Cosmetic composition |
US5470733A (en) | 1993-06-01 | 1995-11-28 | University Of Maryland | Calcium free subtilisin mutants |
US6436690B1 (en) | 1993-09-15 | 2002-08-20 | The Procter & Gamble Company | BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
MA23346A1 (fr) | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
ZA952220B (en) | 1994-05-02 | 1995-12-14 | Procter & Gamble | Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
US6599730B1 (en) | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
WO1996017929A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
DE69631329T2 (de) | 1995-03-10 | 2004-11-18 | Sumitomo Pharmaceuticals Co., Ltd. | Menschlicher wachstumsfaktor (hgf), verändert durch polyethylenglykol |
AU5893696A (en) | 1995-06-07 | 1996-12-30 | Novo Nordisk A/S | Modification of polypeptides |
JPH11502256A (ja) * | 1995-12-29 | 1999-02-23 | ザ、プロクター、エンド、ギャンブル、カンパニー | 固定化酵素を含有する洗剤組成物 |
US6159688A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
-
1997
- 1997-07-30 US US08/903,298 patent/US6284246B1/en not_active Expired - Fee Related
-
1998
- 1998-07-23 EP EP98937034A patent/EP1005373A1/en not_active Withdrawn
- 1998-07-23 CA CA002297437A patent/CA2297437A1/en not_active Abandoned
- 1998-07-23 WO PCT/US1998/015282 patent/WO1999006071A1/en not_active Application Discontinuation
- 1998-07-23 BR BR9811709-2A patent/BR9811709A/pt not_active IP Right Cessation
- 1998-07-23 KR KR1020007001000A patent/KR20010022419A/ko not_active Application Discontinuation
- 1998-07-23 JP JP2000504882A patent/JP2001511461A/ja active Pending
- 1998-07-23 AU AU85834/98A patent/AU8583498A/en not_active Abandoned
- 1998-07-23 CN CN98808492A patent/CN1268062A/zh active Pending
- 1998-07-28 CO CO98042894A patent/CO4810246A1/es unknown
- 1998-07-29 ZA ZA986756A patent/ZA986756B/xx unknown
- 1998-07-30 AR ARP980103756A patent/AR016561A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2297437A1 (en) | 1999-02-11 |
CN1268062A (zh) | 2000-09-27 |
AR016561A1 (es) | 2001-07-25 |
CO4810246A1 (es) | 1999-06-30 |
WO1999006071A1 (en) | 1999-02-11 |
JP2001511461A (ja) | 2001-08-14 |
ZA986756B (en) | 1999-02-10 |
US6284246B1 (en) | 2001-09-04 |
AU8583498A (en) | 1999-02-22 |
EP1005373A1 (en) | 2000-06-07 |
KR20010022419A (ko) | 2001-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9811709A (pt) | Polipeptìdeos modificados com alta atividade e reduzida alergenicidade | |
DE69027950D1 (de) | Auf Polyurethan basierende Polymermaterialien und diese verwendende biomedizinische Artikel und pharmazeutische Zusammensetzungen | |
BR0113608A (pt) | Composição cosmética clara em emulsão antiperspirante e/ou desodorante | |
DE69914928D1 (de) | Polymerkomplexe von glukuronoglukanen | |
DE69613481T2 (de) | Hydrogele auf basis von dreiblockcopolymerisate, ihre herstellung und ihre verwendung | |
BR9712969A (pt) | Gel sensìvel à temperatura para distribuição sustentada de drogas de proteìnas | |
BR0307893A (pt) | Formulação oftálmica com sistema de goma | |
DE68919061D1 (de) | Verbindungen. | |
MXPA04006091A (es) | Composiciones polimericas fotocromicas y articulos de las mismas. | |
EP0997482A4 (en) | MODIFIED CYCLOOLEFIN ADDITION POLYMER AND CURABLE RESIN COMPOSITION BASED ON SAID POLYMER | |
ES2159769T3 (es) | Polimero en bloque lineal que comprende grupos urea y uretano, procedimiento para producirlo y su utilizacion en forma de implantes. | |
DK98285A (da) | Gummi/gelatine-blanding | |
BR0300522A (pt) | Composições, contendo elastÈmeros e polietilenos com alto peso molecular com forma de partìculas irregular,processos para a sua preparação e sua aplicação | |
BR9814764A (pt) | Composição aquosa, uso da mesma, e, substrato. | |
BR9814760A (pt) | Proteìna anticongelamento, sequência de ácido nucléico, e, produto alimentìcio. | |
DE69811061D1 (de) | Kosmetische zusammensetzungen enthaltend ein kationisches polymer mit niedrigem molekulargewicht und einem silikon sowie deren verwendungen | |
ATE358161T1 (de) | Thermoplaste mit verbesserter flexibilität und transparenz | |
FI893681A0 (fi) | N-2,3-butadienyltri- och tetra-aminoalkanderivat. | |
DE58903499D1 (de) | Fuellstoffe. | |
ES2037858T3 (es) | Composicion polimera de elevada resistencia al choque. | |
DE69931261D1 (de) | Polymerträger mit polyoxalkylenen | |
TR199903203A3 (tr) | Yüksek oranda seffaf polimerik bilesim. | |
BR9810210A (pt) | Melhoramentos em ou referentes a composiçõespoliméricas | |
BR9714937A (pt) | Material de textura macia e processo para aumentar a capacidade de respiração de um material de textura | |
DE68914700D1 (de) | Polymere Zusammensetzungen und ihre Herstellung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: C11D 3/386 (2006.01), A61K 8/02 (2006.0 |