BR9809313A - Compostos, promedicamento, medicamento, processo para a sua preparação e utilização dos mesmos - Google Patents
Compostos, promedicamento, medicamento, processo para a sua preparação e utilização dos mesmosInfo
- Publication number
- BR9809313A BR9809313A BR9809313-4A BR9809313A BR9809313A BR 9809313 A BR9809313 A BR 9809313A BR 9809313 A BR9809313 A BR 9809313A BR 9809313 A BR9809313 A BR 9809313A
- Authority
- BR
- Brazil
- Prior art keywords
- bond
- double bond
- preparation
- analogs
- medication
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 201000002980 Hyperparathyroidism Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Electroplating Methods And Accessories (AREA)
- Electroplating And Plating Baths Therefor (AREA)
Abstract
<B><MU>COMPOSTOS, PROMEDICAMENTO, MEDICAMENTO, PROCESSO PARA A SUA PREPARAçãO E UTILIZAçãO DOS MESMOS<MV><D> Esta invenção proporciona análogos de Vitamina D~ 3~ da fórmula (I) em que: X é H~ 2~ ou CH~ 2~: Y é hidrogênio, hidróxi ou flúor; Z é hidróxi; R~ 1~ e R~ 2~ são uma alquila ou fluoroalquila (C~ 1~-C~ 4~), ou R~ 1~ e R~ 2~ em conjunto com C~ 25~ formam uma cicloalquila ou ciclofluoroalquila (C~ 3~-C~ 6~); R~ 3~ e R~ 4~ são uma alquila ou fluoroalquila (C~ 1~-C~ 4~), ou R~ 3~ e R~ 4~ em conjunto com C~ 25~ formam uma cicloalquila ou ciclofluoroalquila (C~ 3~-C~ 6~); A é uma ligação única ou uma ligação dupla; B~ 1~, é uma ligação única, uma ligação E dupla, uma ligação Z dupla ou uma ligação tripla; e B~ 2~ é uma ligação única, uma ligação E dupla, uma ligação Z dupla ou uma ligação tripla; e as suas pró-drogas: intermediários e processos para a preparação destes análogos, composições farmacêuticas que contêm tais análogos e processos de tratamento de osteoporose, doenças de hiperparatiroidismo, de auto-imunização e para tratamento e prevenção de doenças neoplásticas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4466197P | 1997-04-28 | 1997-04-28 | |
| US7214098P | 1998-01-22 | 1998-01-22 | |
| PCT/EP1998/002390 WO1998049138A2 (en) | 1997-04-28 | 1998-04-22 | Vitamin d3 analogs with bis c-20 side chains |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9809313A true BR9809313A (pt) | 2000-07-04 |
| BR9809313B1 BR9809313B1 (pt) | 2010-11-16 |
Family
ID=26721826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9809313-4A BR9809313B1 (pt) | 1997-04-28 | 1998-04-22 | compostos análogos de vitamina d3, processo para a sua preparação e utilização dos mesmos para a preparação de medicamentos para o tratamento de hiperparatiroidismo primário e secundário, osteodistrofia renal, doenças de auto imunização, esclerose múltipla ou lúpus, e doenças neoplásticas. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0980354B1 (pt) |
| JP (1) | JP3479310B2 (pt) |
| KR (1) | KR100351490B1 (pt) |
| CN (1) | CN1189465C (pt) |
| AT (1) | ATE219483T1 (pt) |
| AU (1) | AU732331B2 (pt) |
| BR (1) | BR9809313B1 (pt) |
| CA (1) | CA2287881C (pt) |
| DE (1) | DE69806152T2 (pt) |
| DK (1) | DK0980354T3 (pt) |
| ES (1) | ES2178217T3 (pt) |
| HK (1) | HK1026705A1 (pt) |
| MA (1) | MA26485A1 (pt) |
| PT (1) | PT980354E (pt) |
| TR (1) | TR199902639T2 (pt) |
| WO (1) | WO1998049138A2 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479474B2 (en) | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| JP2006525367A (ja) * | 2003-04-30 | 2006-11-09 | ビオクセル エッセ ピ ア | ジェミニビタミンｄ３化合物及びその使用方法 |
| SG110107A1 (en) | 2003-09-24 | 2005-04-28 | Bioxell Spa | Compound and use in treatment |
| JP4795023B2 (ja) * | 2004-02-03 | 2011-10-19 | 中外製薬株式会社 | ビタミンｄ化合物及びそれらの合成中間体の合成方法 |
| AU2005216651A1 (en) | 2004-03-01 | 2005-09-09 | Bioxell Spa | Treatment of interstitial cystitis with vitamin D compounds |
| US20090099140A1 (en) * | 2005-03-23 | 2009-04-16 | Bioxell S.P.A. | 20-Alkyl, Gemini Vitamin D3 Compounds and Methods of Use Thereof |
| CN114276284A (zh) * | 2021-12-30 | 2022-04-05 | 正大制药（青岛）有限公司 | 一种氟骨化醇的制备方法 |
| CN114957068A (zh) * | 2022-04-19 | 2022-08-30 | 正大制药（青岛）有限公司 | 一种氟骨化醇20s异构体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145846A (en) * | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
-
1998
- 1998-04-22 BR BRPI9809313-4A patent/BR9809313B1/pt not_active IP Right Cessation
- 1998-04-22 PT PT98924177T patent/PT980354E/pt unknown
- 1998-04-22 AT AT98924177T patent/ATE219483T1/de not_active IP Right Cessation
- 1998-04-22 ES ES98924177T patent/ES2178217T3/es not_active Expired - Lifetime
- 1998-04-22 TR TR1999/02639T patent/TR199902639T2/xx unknown
- 1998-04-22 DK DK98924177T patent/DK0980354T3/da active
- 1998-04-22 CN CNB988045818A patent/CN1189465C/zh not_active Expired - Fee Related
- 1998-04-22 CA CA002287881A patent/CA2287881C/en not_active Expired - Fee Related
- 1998-04-22 EP EP98924177A patent/EP0980354B1/en not_active Expired - Lifetime
- 1998-04-22 JP JP54657298A patent/JP3479310B2/ja not_active Expired - Fee Related
- 1998-04-22 DE DE69806152T patent/DE69806152T2/de not_active Expired - Lifetime
- 1998-04-22 AU AU76468/98A patent/AU732331B2/en not_active Ceased
- 1998-04-22 KR KR1019997009961A patent/KR100351490B1/ko not_active IP Right Cessation
- 1998-04-22 WO PCT/EP1998/002390 patent/WO1998049138A2/en active IP Right Grant
- 1998-04-24 MA MA25045A patent/MA26485A1/fr unknown
-
2000
- 2000-09-22 HK HK00105986A patent/HK1026705A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT980354E (pt) | 2002-10-31 |
| AU7646898A (en) | 1998-11-24 |
| DE69806152T2 (de) | 2003-02-06 |
| JP3479310B2 (ja) | 2003-12-15 |
| EP0980354A2 (en) | 2000-02-23 |
| JP2000510875A (ja) | 2000-08-22 |
| DE69806152D1 (de) | 2002-07-25 |
| AU732331B2 (en) | 2001-04-12 |
| CA2287881A1 (en) | 1998-11-05 |
| KR100351490B1 (ko) | 2002-09-05 |
| ATE219483T1 (de) | 2002-07-15 |
| CN1189465C (zh) | 2005-02-16 |
| EP0980354B1 (en) | 2002-06-19 |
| DK0980354T3 (da) | 2002-10-14 |
| CN1253557A (zh) | 2000-05-17 |
| ES2178217T3 (es) | 2002-12-16 |
| MA26485A1 (fr) | 2004-12-20 |
| WO1998049138A3 (en) | 1999-01-28 |
| HK1026705A1 (en) | 2000-12-22 |
| KR20010020343A (ko) | 2001-03-15 |
| WO1998049138A2 (en) | 1998-11-05 |
| CA2287881C (en) | 2008-09-09 |
| BR9809313B1 (pt) | 2010-11-16 |
| TR199902639T2 (xx) | 2000-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE9302080D0 (sv) | New compounds | |
| HUP0402225A2 (hu) | Makrolid-vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| BR9907300A (pt) | Inibidores do fator xa oxoaza-heterociclila substituìdos | |
| IL133623A0 (en) | Antithrombotic agents | |
| IL133627A0 (en) | Antithrombotic agents | |
| HUP0105437A2 (hu) | Új malonsavszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| IL120266A (en) | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions | |
| ZA9610418B (en) | Phenylimidazolidines containing in particular a nitrooxy or carbonyloxy radical, preparation process and intermediates, use as medicaments, new uses and pharmaceutical compositions. | |
| BR0210285A (pt) | Utilização de um composto, composto e composição farmacêutica | |
| IL132690A0 (en) | Prostaglandin pharmaceutical compositions | |
| AU1400801A (en) | Aralkyl-1,2-diamines having calcimimetic activity and preparation mode | |
| HK1054373A1 (en) | Vitamin d derivatives possessing a 22-oxa or 22-thia atom, a c17-side chain substituted by an acid, ester or amide group and a 16(17)-double bond | |
| BR9809313A (pt) | Compostos, promedicamento, medicamento, processo para a sua preparação e utilização dos mesmos | |
| ES2032752T3 (es) | Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina. | |
| DK0690850T3 (da) | 2-Substituerede morpholin- og thiomorpholinderivater som GABAB-antagonister | |
| AU6454196A (en) | Use of sulfamic acid derivatives, acyl sulfonamides or sulfonyl carbamates for the manufacture of a medicament for lowering lipoprotein levels | |
| MX9600816A (es) | Nuevos derivados triciclicos, su preparacion, su aplicacion a la preparacion de la colquicina y de la tiocolquicina, opticamente activas o racemicas, y de compuestos analogos o derivados e intermedios. | |
| HUP0202647A2 (hu) | Új arilalkanoilszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények | |
| FI872997A0 (fi) | Amidderivat. | |
| SE9202218D0 (sv) | Pharmacologically active alfa-(tertiary-aminomethyl)-benzenemethanol derivatives, pharmaceutical composition containing them, therapeutical use thereof and processes for their preparation | |
| SE9401965D0 (sv) | New compounds | |
| JO1757B1 (en) | New vehicles | |
| EA200100156A2 (ru) | Новые производные 6-сульфамоил-3-хинолилфосфоновой кислоты, способ их получения и содержащие их фармацевтические композиции | |
| PT1235850E (pt) | 14,15-ciclopropano-androstanos insaturados, processo para a sua preparacao e composicoes farmaceuticas contendo estes compostos | |
| UY26972A1 (es) | Nuevos antagonistas de neuroquinina, procedimiento para su preparación y composiciones farmacéuticas que contienen estos compuestos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: C07C 401/00, C07F 7/18, C07F 9/28, C07F 9/53, A61K 31/59, A61K 31/593, A61K 31/695, A61P 5/18, A61P 9/10, A61P 35/00, A61P 37/06 Ipc: C07C 401/00 (2007.01), C07F 7/18 (2007.01), C07F 9 |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/11/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B24H | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi) | ||
| B24F | Patent annual fee: publication cancelled |
Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2257 DE 08/04/2014 POR TER SIDO INDEVIDA. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE AS 14A, 15A, 16A, 17A, 18A, 19A, 20A, 21A E 22A ANUIDADES. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2606 DE 15-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |