BR9808858A - Terapias antitumores compreendendo uma combinação de um extrato de cartilagem e um agente antineoplástico provendo uma alta eficácia e baixos efeitos colaterais tóxicos - Google Patents
Terapias antitumores compreendendo uma combinação de um extrato de cartilagem e um agente antineoplástico provendo uma alta eficácia e baixos efeitos colaterais tóxicosInfo
- Publication number
- BR9808858A BR9808858A BR9808858A BR9808858A BR9808858A BR 9808858 A BR9808858 A BR 9808858A BR 9808858 A BR9808858 A BR 9808858A BR 9808858 A BR9808858 A BR 9808858A BR 9808858 A BR9808858 A BR 9808858A
- Authority
- BR
- Brazil
- Prior art keywords
- cartilage extract
- combination
- side effects
- toxic side
- providing high
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Patente de Invenção: <B>"TERAPIAS ANTITUMORES COMPREENDENDO UMA COMBINAçãO DE UM EXTRATO DE CARTILAGEM E UM AGENTE ANTINEOPLáSTICO PROVENDO UMA ALTA EFICáCIA E BAIXOS EFEITOS COLATERAIS TóXICOS"<D>. A presente invenção descreve um novo uso para extrato de cartilagem, isto é um extrato de cartilagem de tubarão, em uma terapia antitumor combinada. O extrato de cartilagem é usado em combinação com um antineoplástico. A terapia combinada proporciona um eficácia antitumor mais alta sem nenhum aumento concomitante, ainda melhor com uma redução de efeitos colaterais tóxicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2199694 | 1997-03-11 | ||
PCT/CA1998/000202 WO1998040088A1 (en) | 1997-03-11 | 1998-03-11 | Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808858A true BR9808858A (pt) | 2000-08-01 |
Family
ID=4160148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808858A BR9808858A (pt) | 1997-03-11 | 1998-03-11 | Terapias antitumores compreendendo uma combinação de um extrato de cartilagem e um agente antineoplástico provendo uma alta eficácia e baixos efeitos colaterais tóxicos |
Country Status (19)
Country | Link |
---|---|
US (2) | US6383522B1 (pt) |
EP (1) | EP0967987B1 (pt) |
JP (1) | JP2001500899A (pt) |
KR (1) | KR100417612B1 (pt) |
CN (2) | CN1824317A (pt) |
AT (1) | ATE241993T1 (pt) |
AU (1) | AU745769B2 (pt) |
BR (1) | BR9808858A (pt) |
CA (1) | CA2281570C (pt) |
DE (1) | DE69815310T2 (pt) |
DK (1) | DK0967987T3 (pt) |
ES (1) | ES2200316T3 (pt) |
HK (1) | HK1026364A1 (pt) |
IL (1) | IL131701A (pt) |
NO (1) | NO322847B1 (pt) |
NZ (1) | NZ337376A (pt) |
PT (1) | PT967987E (pt) |
RU (1) | RU2195946C2 (pt) |
WO (1) | WO1998040088A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
CN100441176C (zh) * | 2001-09-24 | 2008-12-10 | 杰西·L·S·奥 | 测定联合疗法中使用的苏拉明的化学敏感化剂量的方法和组合物 |
PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
US8309603B2 (en) | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
JPWO2004083257A1 (ja) * | 2003-03-20 | 2006-06-22 | ホソカワミクロン株式会社 | 軟骨魚類から単離されたプロテオグリカンおよびその製造方法 |
US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
WO2006059236A2 (en) * | 2004-11-16 | 2006-06-08 | Aeterna Zentaris Inc. | Method of using cartilage extract for increasing blood parameters |
CN105012953B (zh) | 2005-07-25 | 2018-06-22 | 阿普泰沃研发有限责任公司 | 用cd37-特异性和cd20-特异性结合分子减少b-细胞 |
US7951782B2 (en) | 2005-09-29 | 2011-05-31 | Maruha Nichiro Seafoods, Inc | Composition effective to prevent or treat adult disease |
CA2654317A1 (en) | 2006-06-12 | 2007-12-21 | Trubion Pharmaceuticals, Inc. | Single-chain multivalent binding proteins with effector function |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
EP2167130A2 (en) * | 2007-07-06 | 2010-03-31 | Trubion Pharmaceuticals, Inc. | Binding peptides having a c-terminally disposed specific binding domain |
US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
EP2365003A1 (en) * | 2008-04-11 | 2011-09-14 | Emergent Product Development Seattle, LLC | CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
EA201890613A1 (ru) | 2015-09-21 | 2018-10-31 | Аптево Рисёрч Энд Девелопмент Ллс | Полипептиды, связывающие cd3 |
WO2017201200A1 (en) * | 2016-05-19 | 2017-11-23 | Orphagen Pharmaceuticals, Inc. | Therapeutic compositions containing rar-alpha antagonists |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
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USRE28093E (en) | 1962-02-28 | 1974-07-30 | Wound-healing cartilage powder | |
US3478146A (en) | 1965-02-26 | 1969-11-11 | Leslie L Balassa | Wound-healing cartilage powder extracting process |
US3966908A (en) | 1973-11-29 | 1976-06-29 | Lescarden Ltd. | Method of treating degenerative joint afflictions |
US4042457A (en) | 1975-11-10 | 1977-08-16 | Rush-Presbyterian-St. Luke's Medical Center | Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor |
US4822607A (en) | 1976-10-29 | 1989-04-18 | Lescarden Ltd. | Anti-tumor agent and method |
US4212857A (en) | 1976-10-29 | 1980-07-15 | Lescarden Ltd. | Method for stimulating the production of immunoglobulin and total complement |
US4243582A (en) | 1979-04-26 | 1981-01-06 | Monsanto Company | Novel glycoproteins from bovine cartilage |
US4350682A (en) | 1979-05-11 | 1982-09-21 | Lescarden Ltd. | Cartilage extraction processes and products |
US4356261A (en) | 1980-04-22 | 1982-10-26 | Rush-Presbyterian-St. Luke's Medical Center | Anti-invasion factor containing cultures |
US4456589A (en) | 1982-07-08 | 1984-06-26 | Genetic Laboratories, Inc. | Preparation of animal tissues for surgical implantation in human recipients |
US4473551A (en) | 1982-08-23 | 1984-09-25 | Faxon Pharmaceuticals, Inc. | Anti-inflammatory composition |
JPS5939828A (ja) | 1982-08-28 | 1984-03-05 | Ajinomoto Co Inc | 抗腫瘍活性物質の製造方法 |
US4444752A (en) | 1982-09-13 | 1984-04-24 | Lescarden Ltd. | Method for treating progressive systemic sclerosis |
US4469676A (en) | 1983-06-21 | 1984-09-04 | Michel Hecmati | Method for eliminating wrinkles occurring in the human skin |
JPS60178820A (ja) | 1984-02-22 | 1985-09-12 | Ajinomoto Co Inc | 抗腫瘍活性物質の製造方法 |
US4656137A (en) | 1985-09-12 | 1987-04-07 | Lescarden Inc | Method of processing animal cartilage |
US4749522A (en) | 1985-10-31 | 1988-06-07 | Angio-Medical Corporation | Supercritical fluid extraction of animal derived materials |
US4746729A (en) | 1986-07-30 | 1988-05-24 | Kuettner Klaus E | Cartilage-derived leukocyte elastase-inhibitor |
US5135919A (en) | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
US5096892A (en) | 1988-05-27 | 1992-03-17 | The Children's Medical Center Corporation | Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin |
US5075112A (en) | 1990-02-12 | 1991-12-24 | Cartilage Technologies Inc. | Method of and dosage unit for inhibiting angiogenesis or vascularization in an animal using shark cartilage |
EP0571597A4 (en) | 1991-11-15 | 1994-06-01 | Arthro Res & Dev Corp | Method for treatment of acute and chronic painful arthropathic conditions in human and other mammals |
WO1994012510A1 (en) | 1992-11-30 | 1994-06-09 | Lane I William | Processing shark cartilage |
DK0797988T3 (da) | 1993-07-19 | 2009-05-11 | Univ British Columbia | Anti-angiogene præparater og fremgangsmåder til anvendelse deraf |
US5618925A (en) | 1994-04-28 | 1997-04-08 | Les Laboratories Aeterna Inc. | Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof |
US6025334A (en) * | 1994-04-28 | 2000-02-15 | Les Laboratoires Aeterna Inc. | Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof |
US6028118A (en) | 1996-08-08 | 2000-02-22 | Les Laboratoires Aeterna Inc. | Methods of using extracts of shark cartilage |
US5583153A (en) | 1994-10-06 | 1996-12-10 | Regents Of The University Of California | Use of taxol in the treatment of rheumatoid arthritis |
JPH11502514A (ja) * | 1995-02-03 | 1999-03-02 | レ ラボラトワール エテルナ インコーポレイティド | サメ軟骨の抽出物、その製造法および使用 |
US5843920A (en) | 1996-09-16 | 1998-12-01 | Biocell Technology, Llc | Anionic saccharides for extraction of anti-angiogenic protein from cartilage |
US6168807B1 (en) | 1998-07-23 | 2001-01-02 | Les Laboratoires Aeterna Inc. | Low molecular weight components of shark cartilage, processes for their preparation and therapeutic uses thereof |
-
1998
- 1998-03-11 PT PT98907789T patent/PT967987E/pt unknown
- 1998-03-11 WO PCT/CA1998/000202 patent/WO1998040088A1/en active IP Right Grant
- 1998-03-11 ES ES98907789T patent/ES2200316T3/es not_active Expired - Lifetime
- 1998-03-11 EP EP19980907789 patent/EP0967987B1/en not_active Expired - Lifetime
- 1998-03-11 CN CNA200510138143XA patent/CN1824317A/zh active Pending
- 1998-03-11 CA CA 2281570 patent/CA2281570C/en not_active Expired - Fee Related
- 1998-03-11 DK DK98907789T patent/DK0967987T3/da active
- 1998-03-11 BR BR9808858A patent/BR9808858A/pt not_active IP Right Cessation
- 1998-03-11 IL IL13170198A patent/IL131701A/xx active IP Right Grant
- 1998-03-11 NZ NZ337376A patent/NZ337376A/en unknown
- 1998-03-11 DE DE1998615310 patent/DE69815310T2/de not_active Expired - Fee Related
- 1998-03-11 AU AU66055/98A patent/AU745769B2/en not_active Ceased
- 1998-03-11 KR KR10-1999-7008010A patent/KR100417612B1/ko not_active IP Right Cessation
- 1998-03-11 CN CNB988032678A patent/CN1245993C/zh not_active Expired - Fee Related
- 1998-03-11 JP JP53900398A patent/JP2001500899A/ja active Pending
- 1998-03-11 AT AT98907789T patent/ATE241993T1/de not_active IP Right Cessation
- 1998-03-11 RU RU99121332A patent/RU2195946C2/ru not_active IP Right Cessation
-
1999
- 1999-09-02 NO NO19994274A patent/NO322847B1/no unknown
- 1999-09-09 US US09/393,037 patent/US6383522B1/en not_active Expired - Fee Related
-
2000
- 2000-09-05 HK HK00105559A patent/HK1026364A1/xx not_active IP Right Cessation
-
2002
- 2002-02-28 US US10/087,041 patent/US6855338B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6855338B2 (en) | 2005-02-15 |
AU745769B2 (en) | 2002-03-28 |
CN1824317A (zh) | 2006-08-30 |
NO322847B1 (no) | 2006-12-11 |
WO1998040088A1 (en) | 1998-09-17 |
CA2281570C (en) | 2003-09-23 |
DE69815310T2 (de) | 2004-04-22 |
HK1026364A1 (en) | 2000-12-15 |
KR20000075929A (ko) | 2000-12-26 |
DK0967987T3 (da) | 2003-09-22 |
ATE241993T1 (de) | 2003-06-15 |
IL131701A (en) | 2005-03-20 |
EP0967987A1 (en) | 2000-01-05 |
AU6605598A (en) | 1998-09-29 |
CN1250375A (zh) | 2000-04-12 |
US20020146462A1 (en) | 2002-10-10 |
ES2200316T3 (es) | 2004-03-01 |
PT967987E (pt) | 2003-10-31 |
IL131701A0 (en) | 2001-03-19 |
EP0967987B1 (en) | 2003-06-04 |
NZ337376A (en) | 2002-02-01 |
CN1245993C (zh) | 2006-03-22 |
NO994274L (no) | 1999-11-09 |
CA2281570A1 (en) | 1998-09-17 |
RU2195946C2 (ru) | 2003-01-10 |
KR100417612B1 (ko) | 2004-02-05 |
NO994274D0 (no) | 1999-09-02 |
DE69815310D1 (de) | 2003-07-10 |
US6383522B1 (en) | 2002-05-07 |
JP2001500899A (ja) | 2001-01-23 |
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Legal Events
Date | Code | Title | Description |
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B25G | Requested change of headquarter approved | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADES. |
|
B25D | Requested change of name of applicant approved |
Owner name: AETERNA ZENTARIS INC. (CA) Free format text: ALTERADO DE: LES LABORATOIRES AETERNA INC. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A E 11A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009. |