BR9807840A - Derivados de 4-aminoalcóxi-1,3-dihidrobenzoimidazol-2-tionas, sua preparação e seu uso como agonistas de auto-receptor de dopamina (d2) - Google Patents

Derivados de 4-aminoalcóxi-1,3-dihidrobenzoimidazol-2-tionas, sua preparação e seu uso como agonistas de auto-receptor de dopamina (d2)

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Publication number
BR9807840A
BR9807840A BR9807840-2A BR9807840A BR9807840A BR 9807840 A BR9807840 A BR 9807840A BR 9807840 A BR9807840 A BR 9807840A BR 9807840 A BR9807840 A BR 9807840A
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Brazil
Prior art keywords
alkyl
derivatives
preparation
receptor agonists
hydrogen
Prior art date
Application number
BR9807840-2A
Other languages
English (en)
Inventor
James Albert Nelson
Richard Eric Mewshaw
Uresh Shantilal Shah
Original Assignee
American Home Prod
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Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9807840A publication Critical patent/BR9807840A/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • H—ELECTRICITY
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    • H04N19/102—Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the element, parameter or selection affected or controlled by the adaptive coding
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    • H04N19/134—Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the element, parameter or criterion affecting or controlling the adaptive coding
    • H04N19/146—Data rate or code amount at the encoder output
    • H04N19/149—Data rate or code amount at the encoder output by estimating the code amount by means of a model, e.g. mathematical model or statistical model
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    • H04N19/134—Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the element, parameter or criterion affecting or controlling the adaptive coding
    • H04N19/146—Data rate or code amount at the encoder output
    • H04N19/15—Data rate or code amount at the encoder output by monitoring actual compressed data size at the memory before deciding storage at the transmission buffer
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    • H04N19/10—Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding
    • H04N19/134—Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the element, parameter or criterion affecting or controlling the adaptive coding
    • H04N19/146—Data rate or code amount at the encoder output
    • H04N19/152—Data rate or code amount at the encoder output by measuring the fullness of the transmission buffer
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Signal Processing (AREA)
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  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção:<B>"DERIVADOS DE 4-AMINOALCóXI-1,3-DIHIDRO-BENZOIMIDAZOL-2-TIONAS, SUA PREPARAçãO E SEU USO COMO AGONISTAS DE AUTO-RECEPTOR DE DOPAMINA (D2)"<D>. Esta invenção refere-se a uma nova série de compostos tendo potência no receptor de dopamina D~ 2~ que são ilustrados pela fórmula (I) onde R^ 1^ é hidrogênio ou C~ 1~-C~ 6~ alquila; R^ 2^ é hidrogênio ou C~ 1~-C~ 6~ alquila; R^ 3^ é selecionado a partir de hidrogênio, grupo alquila de cadeia reta ou ramificada tendo até 10 átomos de carbono, ciclohexilmetila ou - (CH~ 2~)~ m~Ar onde Ar é fenila, naftila, tienila, furanila ou piridinila, cada uma opcionalmente substituída por um ou dois substituintes independentemente selecionados de C~ 1~- C~ 6~ alquila, halogênio, C~ 1~-C~ 6~ alcóxido e trifluormetila; ou NR^ 2^R^ 3^ é 1,2,3,4-tetrahidroquinolin-1-ila ou 1,2,3,4-tetrahidroisoquinolin-2-ila; m é 1-5; n é 1 ou 2; Y é halogênio, C~ 1~-C~ 6~ alquila, e C~ 1~-C~ 6~ alcóxi; ou um seu sal farmaceuticamente aceitável.
BR9807840-2A 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-dihidrobenzoimidazol-2-tionas, sua preparação e seu uso como agonistas de auto-receptor de dopamina (d2) BR9807840A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80265197A 1997-02-18 1997-02-18
PCT/US1998/000612 WO1998035947A1 (en) 1997-02-18 1998-01-13 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-thiones derivatives, their preparation and their use as dopamine autoreceptor (d2) agonists

Publications (1)

Publication Number Publication Date
BR9807840A true BR9807840A (pt) 2000-09-19

Family

ID=25184324

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807840-2A BR9807840A (pt) 1997-02-18 1998-01-13 Derivados de 4-aminoalcóxi-1,3-dihidrobenzoimidazol-2-tionas, sua preparação e seu uso como agonistas de auto-receptor de dopamina (d2)

Country Status (12)

Country Link
EP (1) EP0964854A1 (pt)
JP (1) JP2001511803A (pt)
KR (1) KR20000071124A (pt)
CN (1) CN1252061A (pt)
AR (1) AR011139A1 (pt)
AU (1) AU5915298A (pt)
BR (1) BR9807840A (pt)
CA (1) CA2278718A1 (pt)
HU (1) HUP0001942A2 (pt)
IL (1) IL131157A0 (pt)
WO (1) WO1998035947A1 (pt)
ZA (1) ZA981308B (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189473B1 (de) * 1984-08-15 1992-05-27 Schering Aktiengesellschaft Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists

Also Published As

Publication number Publication date
WO1998035947A1 (en) 1998-08-20
IL131157A0 (en) 2001-01-28
KR20000071124A (ko) 2000-11-25
HUP0001942A2 (hu) 2000-11-28
CN1252061A (zh) 2000-05-03
AU5915298A (en) 1998-09-08
EP0964854A1 (en) 1999-12-22
CA2278718A1 (en) 1998-08-20
ZA981308B (en) 1999-08-17
JP2001511803A (ja) 2001-08-14
AR011139A1 (es) 2000-08-02

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