BR9806875A - Processo para a preparação de um composto. - Google Patents
Processo para a preparação de um composto.Info
- Publication number
- BR9806875A BR9806875A BR9806875-0A BR9806875A BR9806875A BR 9806875 A BR9806875 A BR 9806875A BR 9806875 A BR9806875 A BR 9806875A BR 9806875 A BR9806875 A BR 9806875A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- compound
- synthesis
- formula
- effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Length Measuring Devices By Optical Means (AREA)
- Steroid Compounds (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Esta invenção refere-se a um processo para a preparação de um intermediário-chave na síntese de um antagonista de endotelina, possuindo a fórmula (I) por meio do uso de um aditivo quiral para efetuar uma adição conjugada assimétrica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3546297P | 1997-01-14 | 1997-01-14 | |
GBGB9705858.0A GB9705858D0 (en) | 1997-03-21 | 1997-03-21 | Asymmetric conjugate addition reaction using a chiral additive |
PCT/US1998/000263 WO1998030543A1 (en) | 1997-01-14 | 1998-01-09 | Endothelin intermediates by asymmetric conjugate addition reaction using a chiral additive |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9806875A true BR9806875A (pt) | 2000-04-18 |
Family
ID=26311228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9806875-0A BR9806875A (pt) | 1997-01-14 | 1998-01-09 | Processo para a preparação de um composto. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0973742A1 (pt) |
JP (1) | JP2000507969A (pt) |
KR (1) | KR20000070085A (pt) |
CN (1) | CN1243509A (pt) |
AU (1) | AU728441B2 (pt) |
BR (1) | BR9806875A (pt) |
CA (1) | CA2277161A1 (pt) |
EA (1) | EA002056B1 (pt) |
HR (1) | HRP980001A2 (pt) |
NZ (1) | NZ336220A (pt) |
PL (1) | PL334318A1 (pt) |
SK (1) | SK93499A3 (pt) |
TW (1) | TW432028B (pt) |
WO (1) | WO1998030543A1 (pt) |
YU (1) | YU30499A (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
US6465664B1 (en) | 1999-09-15 | 2002-10-15 | Massachusetts Institute Of Technology | Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems |
GB2355724A (en) | 1999-10-28 | 2001-05-02 | Merck & Co Inc | Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid) |
GB2355988A (en) | 1999-10-28 | 2001-05-09 | Merck & Co Inc | Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate |
EP2417097A2 (en) | 2009-04-09 | 2012-02-15 | Lonza Ltd. | Autocatalytic process for the synthesis of chiral propargylic alcohols |
US8115032B2 (en) | 2009-04-09 | 2012-02-14 | Lonza Ltd. | Process for the synthesis of a propargylic alcohol |
EP2447247A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of chiral propargylic alcohols |
EP2447255A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
ES2164054T3 (es) * | 1991-11-05 | 2002-02-16 | Smithkline Beecham Corp | Antagonistas de receptores de endotelina. |
-
1998
- 1998-01-05 TW TW087100082A patent/TW432028B/zh not_active IP Right Cessation
- 1998-01-05 HR HR9705858.0A patent/HRP980001A2/hr not_active Application Discontinuation
- 1998-01-09 CN CN98801833A patent/CN1243509A/zh active Pending
- 1998-01-09 CA CA002277161A patent/CA2277161A1/en not_active Abandoned
- 1998-01-09 WO PCT/US1998/000263 patent/WO1998030543A1/en not_active Application Discontinuation
- 1998-01-09 KR KR1019997006306A patent/KR20000070085A/ko not_active Application Discontinuation
- 1998-01-09 SK SK934-99A patent/SK93499A3/sk unknown
- 1998-01-09 BR BR9806875-0A patent/BR9806875A/pt not_active IP Right Cessation
- 1998-01-09 EA EA199900661A patent/EA002056B1/ru not_active IP Right Cessation
- 1998-01-09 PL PL98334318A patent/PL334318A1/xx unknown
- 1998-01-09 YU YU30499A patent/YU30499A/sh unknown
- 1998-01-09 EP EP98902416A patent/EP0973742A1/en not_active Withdrawn
- 1998-01-09 JP JP10531063A patent/JP2000507969A/ja active Pending
- 1998-01-09 AU AU59089/98A patent/AU728441B2/en not_active Ceased
- 1998-01-09 NZ NZ336220A patent/NZ336220A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998030543A1 (en) | 1998-07-16 |
SK93499A3 (en) | 2000-05-16 |
YU30499A (sh) | 2002-06-19 |
EP0973742A1 (en) | 2000-01-26 |
CA2277161A1 (en) | 1998-07-16 |
PL334318A1 (en) | 2000-02-14 |
EA002056B1 (ru) | 2001-12-24 |
JP2000507969A (ja) | 2000-06-27 |
EA199900661A1 (ru) | 2000-02-28 |
AU5908998A (en) | 1998-08-03 |
TW432028B (en) | 2001-05-01 |
NZ336220A (en) | 2000-12-22 |
HRP980001A2 (en) | 1998-10-31 |
AU728441B2 (en) | 2001-01-11 |
CN1243509A (zh) | 2000-02-02 |
KR20000070085A (ko) | 2000-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A, 6A,7A,8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1887 DE 06/03/2007. |