TW432028B - Asymmetric conjugate addition reaction using a chiral additive - Google Patents
Asymmetric conjugate addition reaction using a chiral additive Download PDFInfo
- Publication number
- TW432028B TW432028B TW087100082A TW87100082A TW432028B TW 432028 B TW432028 B TW 432028B TW 087100082 A TW087100082 A TW 087100082A TW 87100082 A TW87100082 A TW 87100082A TW 432028 B TW432028 B TW 432028B
- Authority
- TW
- Taiwan
- Prior art keywords
- alkyl
- cycloalkyl
- alkynyl
- alkenyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Length Measuring Devices By Optical Means (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3546297P | 1997-01-14 | 1997-01-14 | |
| GBGB9705858.0A GB9705858D0 (en) | 1997-03-21 | 1997-03-21 | Asymmetric conjugate addition reaction using a chiral additive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW432028B true TW432028B (en) | 2001-05-01 |
Family
ID=26311228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087100082A TW432028B (en) | 1997-01-14 | 1998-01-05 | Asymmetric conjugate addition reaction using a chiral additive |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0973742A1 (pt) |
| JP (1) | JP2000507969A (pt) |
| KR (1) | KR20000070085A (pt) |
| CN (1) | CN1243509A (pt) |
| AU (1) | AU728441B2 (pt) |
| BR (1) | BR9806875A (pt) |
| CA (1) | CA2277161A1 (pt) |
| EA (1) | EA002056B1 (pt) |
| HR (1) | HRP980001A2 (pt) |
| NZ (1) | NZ336220A (pt) |
| PL (1) | PL334318A1 (pt) |
| SK (1) | SK93499A3 (pt) |
| TW (1) | TW432028B (pt) |
| WO (1) | WO1998030543A1 (pt) |
| YU (1) | YU30499A (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
| WO2001019761A2 (en) | 1999-09-15 | 2001-03-22 | Massachusetts Institute Of Technology | Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems |
| GB2355988A (en) | 1999-10-28 | 2001-05-09 | Merck & Co Inc | Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate |
| GB2355724A (en) | 1999-10-28 | 2001-05-02 | Merck & Co Inc | Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid) |
| WO2010115639A1 (en) | 2009-04-09 | 2010-10-14 | Lonza Ltd | Process for the synthesis of a propargylic alcohol |
| WO2010115638A2 (en) | 2009-04-09 | 2010-10-14 | Lonza Ltd. | Autocatalytic process for the synthesis of chiral propargylic alcohols |
| EP2447255A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
| EP2447247A1 (en) | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of chiral propargylic alcohols |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| RU2125980C1 (ru) * | 1991-11-05 | 1999-02-10 | Смитклайн Бичам Корпорейшн | Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов |
-
1998
- 1998-01-05 TW TW087100082A patent/TW432028B/zh not_active IP Right Cessation
- 1998-01-05 HR HR9705858.0A patent/HRP980001A2/hr not_active Application Discontinuation
- 1998-01-09 EP EP98902416A patent/EP0973742A1/en not_active Withdrawn
- 1998-01-09 KR KR1019997006306A patent/KR20000070085A/ko not_active Application Discontinuation
- 1998-01-09 NZ NZ336220A patent/NZ336220A/xx unknown
- 1998-01-09 WO PCT/US1998/000263 patent/WO1998030543A1/en not_active Application Discontinuation
- 1998-01-09 AU AU59089/98A patent/AU728441B2/en not_active Ceased
- 1998-01-09 BR BR9806875-0A patent/BR9806875A/pt not_active IP Right Cessation
- 1998-01-09 CA CA002277161A patent/CA2277161A1/en not_active Abandoned
- 1998-01-09 PL PL98334318A patent/PL334318A1/xx unknown
- 1998-01-09 CN CN98801833A patent/CN1243509A/zh active Pending
- 1998-01-09 JP JP10531063A patent/JP2000507969A/ja active Pending
- 1998-01-09 YU YU30499A patent/YU30499A/sh unknown
- 1998-01-09 EA EA199900661A patent/EA002056B1/ru not_active IP Right Cessation
- 1998-01-09 SK SK934-99A patent/SK93499A3/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2277161A1 (en) | 1998-07-16 |
| EA199900661A1 (ru) | 2000-02-28 |
| KR20000070085A (ko) | 2000-11-25 |
| HRP980001A2 (en) | 1998-10-31 |
| NZ336220A (en) | 2000-12-22 |
| YU30499A (sh) | 2002-06-19 |
| AU5908998A (en) | 1998-08-03 |
| EA002056B1 (ru) | 2001-12-24 |
| CN1243509A (zh) | 2000-02-02 |
| EP0973742A1 (en) | 2000-01-26 |
| BR9806875A (pt) | 2000-04-18 |
| JP2000507969A (ja) | 2000-06-27 |
| AU728441B2 (en) | 2001-01-11 |
| SK93499A3 (en) | 2000-05-16 |
| PL334318A1 (en) | 2000-02-14 |
| WO1998030543A1 (en) | 1998-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |