BR9713849A - Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna. - Google Patents
Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna.Info
- Publication number
- BR9713849A BR9713849A BR9713849-5A BR9713849A BR9713849A BR 9713849 A BR9713849 A BR 9713849A BR 9713849 A BR9713849 A BR 9713849A BR 9713849 A BR9713849 A BR 9713849A
- Authority
- BR
- Brazil
- Prior art keywords
- calpain
- gene
- ncl
- sequence
- ncl3
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
"GENE DE CALPAìNA nCL-3, CONSTRUçãO DE GENE, SEQUêNCIA DE AMINOáCIDOS, PROCESSOS PARA IDENTIFICAR INIBIDORES DE CALPAìNA E PARA PREPARAR A ENZIMA nCL3, E, USOS DE UM INIBIDOR DE CALPAìNA, DA CALPAìNA nCL-3, DE UMA SEQUêNCIA DE GENES mRNA ANTI-SENTIDO E DE UM GENE DE CALPAìNA. A invenção diz respeito a novas calpaínas e sua produção. A invenção ainda diz respeito a um processo de triagem para novos inibidores de calpaína e o seu uso.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1996150142 DE19650142A1 (de) | 1996-12-04 | 1996-12-04 | Neue Calpaine, ihre Herstellung und Verwendung |
DE1997118248 DE19718248A1 (de) | 1997-04-30 | 1997-04-30 | Neue Calpaine, ihre Herstellung und Verwendung |
PCT/EP1997/006644 WO1998024916A1 (de) | 1996-12-04 | 1997-11-28 | Neue calpaine, ihre herstellung und verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9713849A true BR9713849A (pt) | 2000-02-29 |
Family
ID=26031846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9713849-5A BR9713849A (pt) | 1996-12-04 | 1997-11-28 | Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6569665B1 (pt) |
EP (1) | EP0942995A1 (pt) |
JP (1) | JP2001506846A (pt) |
KR (1) | KR20000057365A (pt) |
CN (1) | CN1245536A (pt) |
AU (1) | AU737504B2 (pt) |
BR (1) | BR9713849A (pt) |
CA (1) | CA2274304A1 (pt) |
CZ (1) | CZ9902005A3 (pt) |
HU (1) | HUP0000498A3 (pt) |
IL (1) | IL129909A0 (pt) |
NO (1) | NO992690L (pt) |
WO (1) | WO1998024916A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ656500A0 (en) * | 2000-03-28 | 2000-04-20 | Autogen Pty Ltd | A method of treatment and agents for same |
WO2005082860A1 (en) * | 2004-02-27 | 2005-09-09 | National Research Council Of Canada | Tetracyclines and their use as calpain inhibitors |
CA2631071A1 (en) * | 2008-05-09 | 2009-11-09 | Tong-Jun Lin | Inhibition of calpain reduces allergic inflammation |
CN104458709A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选钙激活中性蛋白酶-1抑制剂高通量筛选方法 |
CN105334329B (zh) * | 2015-12-10 | 2017-07-28 | 中国农业科学院农产品加工研究所 | 钙蛋白酶磷酸化水平的测定方法 |
WO2018071216A1 (en) * | 2016-10-11 | 2018-04-19 | University Of Iowa Research Foundation | Methods and compositions for treating genetic eye diseases |
WO2021072196A1 (en) * | 2019-10-11 | 2021-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for measuring and inhibiting calpain-5 activity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69533135T2 (de) * | 1994-07-15 | 2005-06-16 | Cephalon, Inc. | In baculovirus exprimiertes aktives calpain |
EP0717110A1 (en) * | 1994-11-22 | 1996-06-19 | Association Francaise Contre Les Myopathies | LGMD gene |
-
1997
- 1997-11-28 CA CA002274304A patent/CA2274304A1/en not_active Abandoned
- 1997-11-28 WO PCT/EP1997/006644 patent/WO1998024916A1/de not_active Application Discontinuation
- 1997-11-28 CN CN97181646A patent/CN1245536A/zh active Pending
- 1997-11-28 IL IL12990997A patent/IL129909A0/xx unknown
- 1997-11-28 BR BR9713849-5A patent/BR9713849A/pt not_active IP Right Cessation
- 1997-11-28 AU AU55576/98A patent/AU737504B2/en not_active Ceased
- 1997-11-28 CZ CZ992005A patent/CZ9902005A3/cs unknown
- 1997-11-28 EP EP97952002A patent/EP0942995A1/de not_active Withdrawn
- 1997-11-28 HU HU0000498A patent/HUP0000498A3/hu unknown
- 1997-11-28 JP JP52516098A patent/JP2001506846A/ja active Pending
- 1997-11-28 KR KR1019990704896A patent/KR20000057365A/ko not_active Application Discontinuation
- 1997-11-28 US US09/308,345 patent/US6569665B1/en not_active Expired - Fee Related
-
1999
- 1999-06-03 NO NO992690A patent/NO992690L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ9902005A3 (cs) | 1999-09-15 |
WO1998024916A1 (de) | 1998-06-11 |
HUP0000498A3 (en) | 2003-08-28 |
HUP0000498A2 (hu) | 2000-06-28 |
AU737504B2 (en) | 2001-08-23 |
IL129909A0 (en) | 2000-02-29 |
JP2001506846A (ja) | 2001-05-29 |
AU5557698A (en) | 1998-06-29 |
KR20000057365A (ko) | 2000-09-15 |
CN1245536A (zh) | 2000-02-23 |
EP0942995A1 (de) | 1999-09-22 |
NO992690L (no) | 1999-08-03 |
CA2274304A1 (en) | 1998-06-11 |
US6569665B1 (en) | 2003-05-27 |
NO992690D0 (no) | 1999-06-03 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1905 DE 10/07/2007. |