BR9713849A - Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna. - Google Patents

Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna.

Info

Publication number
BR9713849A
BR9713849A BR9713849-5A BR9713849A BR9713849A BR 9713849 A BR9713849 A BR 9713849A BR 9713849 A BR9713849 A BR 9713849A BR 9713849 A BR9713849 A BR 9713849A
Authority
BR
Brazil
Prior art keywords
calpain
gene
ncl
sequence
ncl3
Prior art date
Application number
BR9713849-5A
Other languages
English (en)
Inventor
Thomas Boehm
Neil T Dear Australiano
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996150142 external-priority patent/DE19650142A1/de
Priority claimed from DE1997118248 external-priority patent/DE19718248A1/de
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9713849A publication Critical patent/BR9713849A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"GENE DE CALPAìNA nCL-3, CONSTRUçãO DE GENE, SEQUêNCIA DE AMINOáCIDOS, PROCESSOS PARA IDENTIFICAR INIBIDORES DE CALPAìNA E PARA PREPARAR A ENZIMA nCL3, E, USOS DE UM INIBIDOR DE CALPAìNA, DA CALPAìNA nCL-3, DE UMA SEQUêNCIA DE GENES mRNA ANTI-SENTIDO E DE UM GENE DE CALPAìNA. A invenção diz respeito a novas calpaínas e sua produção. A invenção ainda diz respeito a um processo de triagem para novos inibidores de calpaína e o seu uso.
BR9713849-5A 1996-12-04 1997-11-28 Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna. BR9713849A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1996150142 DE19650142A1 (de) 1996-12-04 1996-12-04 Neue Calpaine, ihre Herstellung und Verwendung
DE1997118248 DE19718248A1 (de) 1997-04-30 1997-04-30 Neue Calpaine, ihre Herstellung und Verwendung
PCT/EP1997/006644 WO1998024916A1 (de) 1996-12-04 1997-11-28 Neue calpaine, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
BR9713849A true BR9713849A (pt) 2000-02-29

Family

ID=26031846

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713849-5A BR9713849A (pt) 1996-12-04 1997-11-28 Gene de calpaìna ncl-3, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzina ncl3, e usos de um inibidor de calpaìna, da calpaìna ncl-3, de uma sequência de genes, do mrna anti-sentido e de um gene de calpaìna.

Country Status (13)

Country Link
US (1) US6569665B1 (pt)
EP (1) EP0942995A1 (pt)
JP (1) JP2001506846A (pt)
KR (1) KR20000057365A (pt)
CN (1) CN1245536A (pt)
AU (1) AU737504B2 (pt)
BR (1) BR9713849A (pt)
CA (1) CA2274304A1 (pt)
CZ (1) CZ9902005A3 (pt)
HU (1) HUP0000498A3 (pt)
IL (1) IL129909A0 (pt)
NO (1) NO992690L (pt)
WO (1) WO1998024916A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ656500A0 (en) * 2000-03-28 2000-04-20 Autogen Pty Ltd A method of treatment and agents for same
WO2005082860A1 (en) * 2004-02-27 2005-09-09 National Research Council Of Canada Tetracyclines and their use as calpain inhibitors
CA2631071A1 (en) * 2008-05-09 2009-11-09 Tong-Jun Lin Inhibition of calpain reduces allergic inflammation
CN104458709A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选钙激活中性蛋白酶-1抑制剂高通量筛选方法
CN105334329B (zh) * 2015-12-10 2017-07-28 中国农业科学院农产品加工研究所 钙蛋白酶磷酸化水平的测定方法
WO2018071216A1 (en) * 2016-10-11 2018-04-19 University Of Iowa Research Foundation Methods and compositions for treating genetic eye diseases
WO2021072196A1 (en) * 2019-10-11 2021-04-15 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for measuring and inhibiting calpain-5 activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69533135T2 (de) * 1994-07-15 2005-06-16 Cephalon, Inc. In baculovirus exprimiertes aktives calpain
EP0717110A1 (en) * 1994-11-22 1996-06-19 Association Francaise Contre Les Myopathies LGMD gene

Also Published As

Publication number Publication date
CZ9902005A3 (cs) 1999-09-15
WO1998024916A1 (de) 1998-06-11
HUP0000498A3 (en) 2003-08-28
HUP0000498A2 (hu) 2000-06-28
AU737504B2 (en) 2001-08-23
IL129909A0 (en) 2000-02-29
JP2001506846A (ja) 2001-05-29
AU5557698A (en) 1998-06-29
KR20000057365A (ko) 2000-09-15
CN1245536A (zh) 2000-02-23
EP0942995A1 (de) 1999-09-22
NO992690L (no) 1999-08-03
CA2274304A1 (en) 1998-06-11
US6569665B1 (en) 2003-05-27
NO992690D0 (no) 1999-06-03

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1905 DE 10/07/2007.