BR9713735A - Vacina para imunocastração reversìvel de mamìferos - Google Patents
Vacina para imunocastração reversìvel de mamìferosInfo
- Publication number
- BR9713735A BR9713735A BR9713735-9A BR9713735A BR9713735A BR 9713735 A BR9713735 A BR 9713735A BR 9713735 A BR9713735 A BR 9713735A BR 9713735 A BR9713735 A BR 9713735A
- Authority
- BR
- Brazil
- Prior art keywords
- gnrh
- mammals
- hormone
- reversible
- pro
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 4
- 230000002130 immunocastration Effects 0.000 title abstract 2
- 230000002441 reversible effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 4
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 3
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"VACINA PARA IMUNOCASTRAçãO REVERSìVEL DE MAMìFEROS"<D>. A presente invenção está relacionada com o campo da Engenharia e da Biotecnia e em particular com o uso de um peptídeo derivado da GnRH para a imunocastração de mamíferos. Em mamíferos, testou-se a vacinação como o hormónio liberador de gonadotropina (GnRH, em inglês), com o fim de provocar uma resposta imunológica que neutralize a atividade do dito hormónio. A presente invenção refere-se ao uso de uma variante da GnRH de mamíferos que apresenta uma mudança de um resíduo glicina por um resíduo prolina na posição 6: Glu-His-Trp-Ser-Tyr-Pro-Leu-Arg-Pro-Gly. Esta mudança mostrou induzir uma resposta imunológica superior a da GnRH natural, quando ambas estão acopladas a uma mesma proteína portadora, em experimentos realizados em porcos. Este mesmo resultado é de se esperar em qualquer outro mamífero já que este hormónio é conservado em todas as espécies.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU1996120A CU22627A1 (es) | 1996-12-17 | 1996-12-17 | Preparado vacunal para la inmuno-castración reversible de mamíferos |
| PCT/CU1997/000008 WO1998027111A1 (es) | 1996-12-17 | 1997-12-17 | Vacuna para la inmuno-castración reversible de mamíferos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9713735A true BR9713735A (pt) | 2000-03-28 |
Family
ID=5459402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713735-9A BR9713735A (pt) | 1996-12-17 | 1997-12-17 | Vacina para imunocastração reversìvel de mamìferos |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0959079A1 (pt) |
| KR (1) | KR100461732B1 (pt) |
| AR (1) | AR009840A1 (pt) |
| AU (1) | AU736538B2 (pt) |
| BR (1) | BR9713735A (pt) |
| CA (1) | CA2275440A1 (pt) |
| CU (1) | CU22627A1 (pt) |
| UY (1) | UY24815A1 (pt) |
| WO (1) | WO1998027111A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23204A1 (es) * | 2002-12-27 | 2007-05-18 | Ct Ingenieria Genetica Biotech | Combinaciones de factores reguladores del crecimiento y hormonas para el tratamiento de neoplasias |
| CU23739A1 (es) * | 2008-09-30 | 2011-12-28 | Ct Ingenieria Genetica Biotech | Composición farmacéutica utilizando combinaciones de variantes de la hormona liberadora de las gonadotropinas (gnrh) como inmunógeno |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ220932A (en) * | 1986-07-03 | 1990-05-28 | Victoria State | Composition comprising an antigenic substance, such as lhrh, conjugated to at least two different carriers and method of immunological castration and spaying |
| AU602187B2 (en) * | 1987-01-14 | 1990-10-04 | Commonwealth Scientific And Industrial Research Organisation | Anti-reproductive hormone |
| JP3177246B2 (ja) * | 1991-03-01 | 2001-06-18 | メリアル | 未去勢のオスの家畜に対する抗ｌｈｒｈ免疫方法と、そのためのペプチド |
| AU634379B2 (en) * | 1991-04-29 | 1993-02-18 | Csl Limited | Recombinant immunocastration vaccine |
-
1996
- 1996-12-17 CU CU1996120A patent/CU22627A1/es unknown
-
1997
- 1997-12-17 WO PCT/CU1997/000008 patent/WO1998027111A1/es active IP Right Grant
- 1997-12-17 BR BR9713735-9A patent/BR9713735A/pt not_active IP Right Cessation
- 1997-12-17 AU AU53975/98A patent/AU736538B2/en not_active Ceased
- 1997-12-17 EP EP97947684A patent/EP0959079A1/en not_active Withdrawn
- 1997-12-17 CA CA002275440A patent/CA2275440A1/en not_active Abandoned
- 1997-12-17 UY UY24815A patent/UY24815A1/es not_active IP Right Cessation
- 1997-12-17 AR ARP970105935A patent/AR009840A1/es unknown
- 1997-12-17 KR KR10-1999-7005452A patent/KR100461732B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100461732B1 (ko) | 2004-12-14 |
| KR20000057647A (ko) | 2000-09-25 |
| AU5397598A (en) | 1998-07-15 |
| WO1998027111A1 (es) | 1998-06-25 |
| AU736538B2 (en) | 2001-08-02 |
| EP0959079A1 (en) | 1999-11-24 |
| CU22627A1 (es) | 2000-12-22 |
| AR009840A1 (es) | 2000-05-03 |
| UY24815A1 (es) | 2001-03-16 |
| CA2275440A1 (en) | 1998-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1908 DE 31/07/2007. |