BR9706804A - Preparações de cápsula macia contendo ciclosporina. - Google Patents
Preparações de cápsula macia contendo ciclosporina.Info
- Publication number
- BR9706804A BR9706804A BR9706804-7A BR9706804A BR9706804A BR 9706804 A BR9706804 A BR 9706804A BR 9706804 A BR9706804 A BR 9706804A BR 9706804 A BR9706804 A BR 9706804A
- Authority
- BR
- Brazil
- Prior art keywords
- soft capsule
- fatty acid
- hydrophilic
- preparations containing
- capsule preparations
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 229960001265 ciclosporin Drugs 0.000 title abstract 4
- 229930182912 cyclosporin Natural products 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000007901 soft capsule Substances 0.000 title abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- -1 fatty acid compound Chemical class 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 150000004667 medium chain fatty acids Chemical class 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
- 150000003138 primary alcohols Chemical class 0.000 abstract 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"PREPARAçõES DE CáPSULA MACIA CONTENDO CICLOSPORINA<D>". A presente invenção refere-se a uma preparação de cápsula macia contendo ciclosporina que compreende uma composição contendo ciclosporina como um ingrediente ativo; um componente hidrofílico polietileno glicol ou um componente não-hidrofílico carbonato de propileno ou sua mistura, uma mistura de um composto esterificado de ácido graxo e álcool primário, triglicerídeo de ácido graxo de cadeia média e monoglicerídeo de ácido graxo como um componente óleo; e um tensoativo tendo um valor HLB(balanço lipofílico hidrofílico) de 8 a 17, em uma concha de gelatina contendo polietileno glicol e propileno glicol como um plastificante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019960022417A KR0183449B1 (ko) | 1996-06-19 | 1996-06-19 | 사이클로스포린-함유 연질캅셀제 |
| KR1019970008750A KR19980073479A (ko) | 1997-03-14 | 1997-03-14 | 사이클로스포린-함유 연질캅셀제 |
| PCT/EP1997/003213 WO1997048410A1 (en) | 1996-06-19 | 1997-06-19 | Cyclosporin-containing soft capsule preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9706804A true BR9706804A (pt) | 1999-11-03 |
Family
ID=26631929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9706804-7A BR9706804A (pt) | 1996-06-19 | 1997-06-19 | Preparações de cápsula macia contendo ciclosporina. |
| BR9713811-8A BR9713811A (pt) | 1996-06-19 | 1997-06-19 | Preparações de cápsula macia contendo ciclosporina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713811-8A BR9713811A (pt) | 1996-06-19 | 1997-06-19 | Preparações de cápsula macia contendo ciclosporina |
Country Status (28)
| Country | Link |
|---|---|
| EP (2) | EP1413297B1 (pt) |
| JP (2) | JP3519414B2 (pt) |
| KR (2) | KR20000016761A (pt) |
| CN (2) | CN1494920A (pt) |
| AT (2) | ATE392891T1 (pt) |
| AU (1) | AU719251B2 (pt) |
| BR (2) | BR9706804A (pt) |
| CA (2) | CA2226091C (pt) |
| CY (1) | CY2549B1 (pt) |
| CZ (2) | CZ291641B6 (pt) |
| DE (2) | DE69731072T2 (pt) |
| DK (1) | DK0869810T3 (pt) |
| ES (2) | ES2305396T3 (pt) |
| HK (1) | HK1010492A1 (pt) |
| HU (1) | HUP9801109A3 (pt) |
| IL (5) | IL123840A (pt) |
| MX (2) | MX9804414A (pt) |
| MY (1) | MY117765A (pt) |
| NO (2) | NO321921B1 (pt) |
| NZ (1) | NZ330062A (pt) |
| PL (1) | PL188500B1 (pt) |
| PT (2) | PT1413297E (pt) |
| RU (2) | RU2181055C2 (pt) |
| SG (1) | SG88752A1 (pt) |
| SI (2) | SI9720010B (pt) |
| SK (2) | SK283361B6 (pt) |
| TR (2) | TR199800525T2 (pt) |
| WO (1) | WO1997048410A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU722285B2 (en) * | 1996-06-19 | 2000-07-27 | Novartis Ag | Cyclosporin-containing soft capsule preparations |
| SK283361B6 (sk) * | 1996-06-19 | 2003-06-03 | Novartis Ag | Prípravok vo forme mäkkej kapsuly obsahujúci cyklosporín |
| KR19980073479A (ko) * | 1997-03-14 | 1998-11-05 | 한스루돌프하우스, 니콜케르커 | 사이클로스포린-함유 연질캅셀제 |
| US6187747B1 (en) | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
| US6346511B1 (en) | 1997-09-08 | 2002-02-12 | Panacea Biotec Limited | Pharmaceutical composition comprising cyclosporin |
| NZ329929A (en) * | 1998-03-09 | 1999-10-28 | Bernard Charles Sherman | Pharmaceutical emulsion preconcentrate containing cyclosporin in a solvent system containing glycerides, propylene or polyethylene glycol, a surfactant and a co-surfactant |
| CA2422580C (en) | 2000-09-18 | 2011-05-17 | Rpg Life Sciences Limited | Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities |
| IL158765A0 (en) | 2001-06-21 | 2004-05-12 | Pfizer Prod Inc | Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors |
| FR2838349B1 (fr) * | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
| KR100533460B1 (ko) * | 2002-07-20 | 2005-12-08 | 대화제약 주식회사 | 난용성 약물의 가용화용 점막흡착성 조성물, 이를 이용한난용성 약물의 가용화용 제형 및 이들의 제조 방법 |
| US20070092559A1 (en) * | 2005-10-24 | 2007-04-26 | Jinghua Yuan | Liquid dosage forms having enteric properties of delayed and then sustained release |
| FR3029792B1 (fr) * | 2014-12-15 | 2018-01-26 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Liberation maitrisee de substances actives. |
| KR20170001569U (ko) | 2015-10-27 | 2017-05-10 | 이제홍 | 쑥뜸장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0522006A1 (en) * | 1990-03-30 | 1993-01-13 | Alza Corporation | Compositions comprising cytotoxic agent and permeation enhancers |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| KR0167613B1 (ko) * | 1994-12-28 | 1999-01-15 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 조성물 |
| NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
| SK283361B6 (sk) * | 1996-06-19 | 2003-06-03 | Novartis Ag | Prípravok vo forme mäkkej kapsuly obsahujúci cyklosporín |
-
1997
- 1997-06-19 SK SK372-98A patent/SK283361B6/sk not_active IP Right Cessation
- 1997-06-19 CZ CZ1998834A patent/CZ291641B6/cs not_active IP Right Cessation
- 1997-06-19 CA CA002226091A patent/CA2226091C/en not_active Expired - Fee Related
- 1997-06-19 AT AT03029109T patent/ATE392891T1/de not_active IP Right Cessation
- 1997-06-19 MY MYPI97002776A patent/MY117765A/en unknown
- 1997-06-19 NZ NZ330062A patent/NZ330062A/xx unknown
- 1997-06-19 IL IL12384097A patent/IL123840A/en not_active IP Right Cessation
- 1997-06-19 RU RU98105629/14A patent/RU2181055C2/ru not_active IP Right Cessation
- 1997-06-19 KR KR1019980710368A patent/KR20000016761A/ko not_active IP Right Cessation
- 1997-06-19 SK SK371-98A patent/SK283216B6/sk not_active IP Right Cessation
- 1997-06-19 IL IL12367697A patent/IL123676A/en not_active IP Right Cessation
- 1997-06-19 DE DE69731072T patent/DE69731072T2/de not_active Expired - Fee Related
- 1997-06-19 BR BR9706804-7A patent/BR9706804A/pt not_active IP Right Cessation
- 1997-06-19 KR KR10-2003-7000108A patent/KR20040000379A/ko not_active Application Discontinuation
- 1997-06-19 TR TR1998/00525T patent/TR199800525T2/xx unknown
- 1997-06-19 EP EP03029109A patent/EP1413297B1/en not_active Expired - Lifetime
- 1997-06-19 ES ES03029109T patent/ES2305396T3/es not_active Expired - Lifetime
- 1997-06-19 ES ES97929227T patent/ES2227700T3/es not_active Expired - Lifetime
- 1997-06-19 IL IL14736997A patent/IL147369A/en not_active IP Right Cessation
- 1997-06-19 CN CNA2003101142054A patent/CN1494920A/zh active Pending
- 1997-06-19 CA CA002240705A patent/CA2240705C/en not_active Expired - Fee Related
- 1997-06-19 BR BR9713811-8A patent/BR9713811A/pt not_active Application Discontinuation
- 1997-06-19 AT AT97929227T patent/ATE278412T1/de not_active IP Right Cessation
- 1997-06-19 SI SI9720010A patent/SI9720010B/sl not_active IP Right Cessation
- 1997-06-19 JP JP50229798A patent/JP3519414B2/ja not_active Expired - Fee Related
- 1997-06-19 AU AU33411/97A patent/AU719251B2/en not_active Ceased
- 1997-06-19 HU HU9801109A patent/HUP9801109A3/hu unknown
- 1997-06-19 CN CN97191060A patent/CN1127350C/zh not_active Expired - Fee Related
- 1997-06-19 DK DK97929227T patent/DK0869810T3/da active
- 1997-06-19 SG SG9901629A patent/SG88752A1/en unknown
- 1997-06-19 EP EP97929227A patent/EP0869810B1/en not_active Expired - Lifetime
- 1997-06-19 RU RU98106393/14A patent/RU2185187C2/ru not_active IP Right Cessation
- 1997-06-19 WO PCT/EP1997/003213 patent/WO1997048410A1/en active IP Right Grant
- 1997-06-19 SI SI9720011A patent/SI9720011A/sl not_active IP Right Cessation
- 1997-06-19 PT PT03029109T patent/PT1413297E/pt unknown
- 1997-06-19 PL PL97325832A patent/PL188500B1/pl not_active IP Right Cessation
- 1997-06-19 PT PT97929227T patent/PT869810E/pt unknown
- 1997-06-19 DE DE69738656T patent/DE69738656T2/de not_active Expired - Fee Related
- 1997-06-19 CZ CZ1998835A patent/CZ292378B6/cs not_active IP Right Cessation
- 1997-06-19 TR TR1998/00526T patent/TR199800526T2/xx unknown
-
1998
- 1998-03-17 NO NO19981200A patent/NO321921B1/no not_active IP Right Cessation
- 1998-03-26 IL IL12384098A patent/IL123840A0/xx unknown
- 1998-05-26 NO NO19982382A patent/NO323816B1/no not_active IP Right Cessation
- 1998-06-03 MX MX9804414A patent/MX9804414A/es not_active IP Right Cessation
- 1998-06-04 MX MX9804442A patent/MX9804442A/es not_active IP Right Cessation
- 1998-11-04 HK HK98111747A patent/HK1010492A1/xx not_active IP Right Cessation
-
2001
- 2001-12-27 IL IL14736901A patent/IL147369A0/xx unknown
-
2003
- 2003-11-06 JP JP2003376460A patent/JP2004043511A/ja not_active Withdrawn
-
2006
- 2006-02-13 CY CY0600003A patent/CY2549B1/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
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| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO DE PATENTE COM BASE NO ARTIGO 25 DA LPI 9.279/96. |
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 13A ANUI DADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |