BR9307584A - Molécula de ácido nucleico, polipeptìdio isolado, processo para produzir a sintetase ii de fosfato de carbamoìla de "plasmodium falciparum" ou uma porção do mesmo, ribozima, oligonucleotìdeo antisenso, e formação de polinucleotìdeo - Google Patents

Molécula de ácido nucleico, polipeptìdio isolado, processo para produzir a sintetase ii de fosfato de carbamoìla de "plasmodium falciparum" ou uma porção do mesmo, ribozima, oligonucleotìdeo antisenso, e formação de polinucleotìdeo

Info

Publication number
BR9307584A
BR9307584A BR9307584-7A BR9307584A BR9307584A BR 9307584 A BR9307584 A BR 9307584A BR 9307584 A BR9307584 A BR 9307584A BR 9307584 A BR9307584 A BR 9307584A
Authority
BR
Brazil
Prior art keywords
ribozyme
phosphate synthetase
carbamoyl phosphate
nucleic acid
acid molecule
Prior art date
Application number
BR9307584-7A
Other languages
English (en)
Inventor
Thomas Stanley Stewart
Maria Vega Flores
William James O'sullivan
Original Assignee
Unisearch Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unisearch Ltd filed Critical Unisearch Ltd
Publication of BR9307584A publication Critical patent/BR9307584A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05005—Carbamoyl-phosphate synthase (glutamine-hydrolysing) (6.3.5.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

<B>Patente de Invenção de "MOLéCULA DE áCIDO NUCLEICO, POLIPEPTìDEO ISOLADO, PROCESSO PARA PRODUZIR A SINTEASE II DE FOSFATO DE CARBAMOìLA DE "Plasmidium falciparum" OU UMA PORçãO DO MESMO, RIBOZIMA OLIGONUCLEOTìDEO ANTISENSO, E FORMAçãO DE POLINUCLEOTìDEO"<D>. A presente invenção proporciona uma seq³ência de nucleotídeo codificando sintetase II de fosfato de carbamoíla de Plasmodium falciparum. Sintetase II de fosfato de carbomoíla catalisa a primeira etapa de limitação de taxa e empenhada na via biosintética de pirimidina. P. falciparum baseia-se exclusivamente em síntese de pirimidina de novo devido a sua inabilidade de salvar pirimidinas. Células vermelhas de sangue humano maduras, contudo, não apresentam exigência reconhecida para um nucleotídeo de pirimidina. Por conseguinte, esta enzima representa um local quimioterapêutico principal. A presente invenção refere-se ao uso da seq³ência codificando sintetase II de fosfato de carbamoíla na produção recombinante de sintetase II de fosfato de carbomoíla e para moléculas antisenso, rebozimas e outros agentes de inativação de gens concebidos a partir desta seq³ência.
BR9307584-7A 1992-12-03 1993-12-02 Molécula de ácido nucleico, polipeptìdio isolado, processo para produzir a sintetase ii de fosfato de carbamoìla de "plasmodium falciparum" ou uma porção do mesmo, ribozima, oligonucleotìdeo antisenso, e formação de polinucleotìdeo BR9307584A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPL620692 1992-12-03
AUPL638092 1992-12-16
PCT/AU1993/000617 WO1994012643A1 (en) 1992-12-03 1993-12-02 Nucleotide sequence encoding carbamoyl phosphate synthetase ii

Publications (1)

Publication Number Publication Date
BR9307584A true BR9307584A (pt) 1999-08-31

Family

ID=25644386

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9307584-7A BR9307584A (pt) 1992-12-03 1993-12-02 Molécula de ácido nucleico, polipeptìdio isolado, processo para produzir a sintetase ii de fosfato de carbamoìla de "plasmodium falciparum" ou uma porção do mesmo, ribozima, oligonucleotìdeo antisenso, e formação de polinucleotìdeo

Country Status (17)

Country Link
US (1) US5849573A (pt)
EP (1) EP0675958A4 (pt)
JP (1) JPH08503607A (pt)
KR (1) KR950704495A (pt)
CN (1) CN1041535C (pt)
AP (1) AP429A (pt)
BR (1) BR9307584A (pt)
CA (1) CA2150572A1 (pt)
FI (1) FI952697A (pt)
HU (2) HUT71930A (pt)
IL (1) IL107845A0 (pt)
MX (1) MX9307662A (pt)
MY (1) MY109022A (pt)
NO (1) NO952175D0 (pt)
OA (1) OA10163A (pt)
PL (1) PL309261A1 (pt)
WO (1) WO1994012643A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6468765B1 (en) * 1995-04-21 2002-10-22 Human Genome Sciences, Inc. Selected Haemophilus influenzae Rd polynucleotides and polypeptides
AU3984497A (en) * 1996-08-16 1998-03-06 Innovir Laboratories, Inc. Phenotypic conversion of cells mediated by external guide sequences
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
CA2329146A1 (en) * 1998-06-01 1999-12-09 Incyte Pharmaceuticals, Inc. Carbamoyl phosphate synthase homolog
CN100510080C (zh) * 2001-04-04 2009-07-08 中国医学科学院基础医学研究所 恶性疟原虫新的抗原候选基因PfMAg
CN100510079C (zh) * 2001-04-04 2009-07-08 中国医学科学院基础医学研究所 恶性疟原虫蛋白基因
CN1316015C (zh) * 2001-08-03 2007-05-16 味之素株式会社 新突变型氨甲酰磷酸合成酶以及生产由氨甲酰磷酸衍生的化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA

Also Published As

Publication number Publication date
FI952697A0 (fi) 1995-06-02
AP429A (en) 1995-11-09
CN1041535C (zh) 1999-01-06
MY109022A (en) 1996-11-30
FI952697A (fi) 1995-07-14
AP9400607A0 (en) 1994-01-31
HU9501583D0 (en) 1995-08-28
IL107845A0 (en) 1994-04-12
CN1090327A (zh) 1994-08-03
HUT71930A (en) 1996-02-28
MX9307662A (es) 1994-06-30
WO1994012643A1 (en) 1994-06-09
EP0675958A4 (en) 1997-10-22
US5849573A (en) 1998-12-15
PL309261A1 (en) 1995-10-02
KR950704495A (ko) 1995-11-20
EP0675958A1 (en) 1995-10-11
HU211526A9 (en) 1995-11-28
NO952175L (no) 1995-06-01
NO952175D0 (no) 1995-06-01
OA10163A (en) 1996-12-18
JPH08503607A (ja) 1996-04-23
CA2150572A1 (en) 1994-06-09

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal