BR8507219A - Sistema de montagem e controle programavel para aplicador de droga transdermico - Google Patents

Sistema de montagem e controle programavel para aplicador de droga transdermico

Info

Publication number
BR8507219A
BR8507219A BR8507219A BR8507219A BR8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A
Authority
BR
Brazil
Prior art keywords
applicator
drug
skin
mounting structure
power supply
Prior art date
Application number
BR8507219A
Other languages
English (en)
Inventor
Dan Sibalis
Sanford Rosen
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Publication of BR8507219A publication Critical patent/BR8507219A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Massaging Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Stabilization Of Oscillater, Synchronisation, Frequency Synthesizers (AREA)
  • Stored Programmes (AREA)
BR8507219A 1985-06-10 1985-06-10 Sistema de montagem e controle programavel para aplicador de droga transdermico BR8507219A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1985/001075 WO1986007269A1 (en) 1985-06-10 1985-06-10 Programmable control and mounting system for transdermal drug applicator

Publications (1)

Publication Number Publication Date
BR8507219A true BR8507219A (pt) 1987-08-04

Family

ID=22188715

Family Applications (1)

Application Number Title Priority Date Filing Date
BR8507219A BR8507219A (pt) 1985-06-10 1985-06-10 Sistema de montagem e controle programavel para aplicador de droga transdermico

Country Status (9)

Country Link
EP (2) EP0225872B1 (pt)
JP (1) JPH0716518B2 (pt)
KR (1) KR880002524B1 (pt)
AT (1) ATE80048T1 (pt)
BR (1) BR8507219A (pt)
CA (1) CA1279542C (pt)
DE (1) DE3586595T2 (pt)
MX (1) MX169673B (pt)
WO (1) WO1986007269A1 (pt)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5961482A (en) * 1986-07-25 1999-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
WO1988008729A1 (en) * 1987-05-15 1988-11-17 Newman Martin H Iontophoresis drug delivery system
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
WO1989006989A1 (en) * 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
CA1319174C (en) * 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
ES2012944A6 (es) * 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
US5205819A (en) * 1989-05-11 1993-04-27 Bespak Plc Pump apparatus for biomedical use
IT1244030B (it) * 1989-12-21 1994-06-28 Elan Corp Plc Dispostitivo in due parti per la somministrazione controllata di un ingrediente
DE4028125A1 (de) * 1990-01-17 1991-07-18 Klimke Markus Applikationsvorrichtung fuer die geregelte dosierung verschiedener pharmakons mittels elektrischem strom zum perkutanen transport zur lokalen und systemischen therapie
WO1991015261A1 (en) * 1990-03-30 1991-10-17 Medtronic, Inc. Activity controlled electrotransport drug delivery device
US5213568A (en) * 1990-03-30 1993-05-25 Medtronic Inc. Activity controlled electrotransport drug delivery device
US5383848A (en) * 1990-04-12 1995-01-24 Gensia, Inc. Iontophoretic administration of drugs
GR1000433B (el) * 1990-04-24 1992-07-30 Alza Corp Συσκευη και μεθοδος ιοντοφορητικης απελευθερωσης φαρμακου.
US5160316A (en) * 1990-09-10 1992-11-03 Henley Julian L Iontophoretic drug delivery apparatus
CN1025720C (zh) * 1991-03-05 1994-08-24 金同(广州)保健用品有限公司 复合治疗仪
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
JPH07501238A (ja) * 1991-08-26 1995-02-09 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 電離療法装置及び方法
DE69328042T2 (de) * 1992-12-31 2000-11-16 Alza Corp., Palo Alto Elektrotransporteinrichtung
EP0616818A3 (en) * 1993-03-26 1995-04-05 Tech Res Ass Med & Welfare App Iontophoresis device.
US5458569A (en) * 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
TW358741B (en) * 1993-06-08 1999-05-21 Hisamitsu Pharmaceutical Co Iontophoresis system
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
FR2709670B1 (fr) * 1993-09-10 1995-10-20 Asulab Sa Dispositif en trois modules pour l'administration transdermique de médicaments par électrophorèse ou iontophorèse.
US7027859B1 (en) 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
WO1996010441A1 (en) * 1994-09-30 1996-04-11 Becton Dickinson And Company Iontophoretic drug delivery system, including disposable patch and reusable, removable controller
CA2201380C (en) * 1994-09-30 2007-05-08 Ronald J. Flower Improved iontophoretic drug delivery device
DE69509782T2 (de) * 1994-09-30 1999-11-11 Becton Dickinson And Co., Franklin Lakes Vorrichtung zur iontophoretischen verabreichung von medikamenten mit verbesserter steuereinrichtung und kissenelektrode
US5795321A (en) * 1994-09-30 1998-08-18 Becton Dickinson And Company Iontophoretic drug delivery system, including removable controller
US5876368A (en) * 1994-09-30 1999-03-02 Becton Dickinson And Company Iontophoretic drug delivery device having improved controller
FR2726770B1 (fr) * 1994-11-16 1997-01-31 Lhd Lab Hygiene Dietetique Dispositif d'administration transdermique de medicaments pour le traitement de l'impuissance erectile masculine
US5843014A (en) * 1995-03-24 1998-12-01 Alza Corporation Display for an electrotransport delivery device
US5978701A (en) * 1995-06-02 1999-11-02 Alza Corporation Electrotransport device with separable controller and drug unit and method of setting controller output
AU720742B2 (en) * 1995-09-28 2000-06-08 Vyteris, Inc. Iontophoretic drug delivery system, including disposable patch
US5688232A (en) * 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
AU7286996A (en) * 1995-10-18 1997-05-07 Ciba-Geigy Ag Thermopile powered transdermal drug delivery device
US6175763B1 (en) * 1996-03-29 2001-01-16 Alza Corporation Electrotransport drug delivery device having tactile signaling means
FR2747313B1 (fr) * 1996-04-16 1998-06-05 Lhd Lab Hygiene Dietetique Dispositif d'administration transdermique de medicaments par ionophorese
US6086572A (en) * 1996-05-31 2000-07-11 Alza Corporation Electrotransport device and method of setting output
NO308095B1 (no) * 1997-06-30 2000-07-24 Consensus As Fremgangsmate for transport av vaeske i tekstiler
EP1047475B1 (en) * 1997-12-17 2007-02-21 ALZA Corporation Iontophoresis with programmed adjustment of electric current
EP0970719A3 (en) * 1998-07-08 2000-08-23 Nitto Denko Corporation Electrode structure
AU4238900A (en) * 1999-04-16 2000-11-02 Johnson & Johnson Consumer Companies, Inc. Drug delivery device comprising a dual chamber reservoir
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
DE10015928B4 (de) * 2000-03-30 2004-12-09 Hafner, Dieter, Dr. Träger für ein Arzneimittel und Verfahren zur Überprüfung der Unversehrtheit dieses Trägers
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
KR20020070705A (ko) * 2001-03-02 2002-09-11 파워뱅크 주식회사 인슐린 패치 착용장치
US6823202B2 (en) * 2002-04-01 2004-11-23 Iomed, Inc. Iontophoretic power supply
TR200200942A2 (tr) * 2002-04-08 2004-02-23 Tuncer De��M �. Üre ölçer/üre saati:insan kanındaki ürenin ters iyontoforez ile, kan veya biyolojik örnek alınmadan tespiti.
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
WO2006031856A2 (en) 2004-09-13 2006-03-23 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
WO2006127905A2 (en) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Portable drug delivery device
WO2007026671A1 (ja) * 2005-08-29 2007-03-08 Transcu Ltd. センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
EP1944057A4 (en) * 2005-09-30 2009-02-18 Tti Ellebeau Inc IONTOPHORESIS DEVICE FOR MONITORING THE DOSE AND TIME OF ADMINISTRATION OF A SLEEP-INDUCING AND ANALYTICAL AGENT
CA2647362C (en) 2006-03-14 2014-10-14 University Of Southern California Mems device and method for delivery of therapeutic agents
WO2008008281A2 (en) 2006-07-07 2008-01-17 Proteus Biomedical, Inc. Smart parenteral administration system
KR100837083B1 (ko) * 2007-02-28 2008-06-11 김종택 피부 흡수 향상 장치
JP5243548B2 (ja) 2007-10-25 2013-07-24 プロテウス デジタル ヘルス， インコーポレイテッド 情報システムのための流体伝達ポート
WO2009073686A1 (en) * 2007-12-03 2009-06-11 Trans Dermal Patents Company, Llc Agent delivery system and uses of the same
EP2242537A1 (en) * 2007-12-10 2010-10-27 Isis Biopolymer LLC Iontophoretic drug delivery device and software application
MX364408B (es) 2007-12-20 2019-04-25 Univ Southern California Aparatos y metodos para suministrar agentes terapeuticos.
MX2010012213A (es) 2008-05-08 2011-05-03 Minipumps Llc Bombas implantables y cánulas para las mismas.
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US8109912B2 (en) * 2008-09-12 2012-02-07 Calibra Medical, Inc. Wearable infusion assembly
CA2771584A1 (en) 2009-08-18 2011-02-24 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
AU2011210648B2 (en) 2010-02-01 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Data gathering system
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
CN103768707A (zh) * 2013-12-28 2014-05-07 陈宁飞 一种具有渗透感测导入的装置
EP3250258A4 (en) 2015-01-28 2018-09-05 Chrono Therapeutics, Inc. Drug delivery methods and systems
WO2016145373A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
AU2018205529B2 (en) 2017-01-06 2023-08-10 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
AU2022412026A1 (en) * 2021-12-17 2024-07-25 Cosmoaesthetics Pty Ltd A wearable transdermal drug applicator

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2263792A1 (en) * 1974-03-12 1975-10-10 Bondivenne Jean Ionotherapy current generator - comprises thin flexible bag giving percutaneous medicament penetration
GB1555062A (en) * 1977-02-11 1979-11-07 Orr T Heartbeat rate monitors
US4259963A (en) * 1979-07-03 1981-04-07 Albert Huch Multi-purpose transducer for transcutaneous blood measurements
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
DE3266982D1 (en) * 1981-03-05 1985-11-28 Medtronic Inc Iontophoretic device
US4419092A (en) * 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4494950A (en) * 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament

Also Published As

Publication number Publication date
KR870700374A (ko) 1987-12-28
EP0225872A4 (en) 1987-10-05
JPH0716518B2 (ja) 1995-03-01
ATE80048T1 (de) 1992-09-15
DE3586595T2 (de) 1993-04-08
MX169673B (es) 1993-07-19
EP0461680A2 (en) 1991-12-18
EP0225872A1 (en) 1987-06-24
CA1279542C (en) 1991-01-29
WO1986007269A1 (en) 1986-12-18
DE3586595D1 (de) 1992-10-08
EP0461680A3 (en) 1992-02-26
JPS63500009A (ja) 1988-01-07
KR880002524B1 (ko) 1988-11-28
EP0225872B1 (en) 1992-09-02

Similar Documents

Publication Publication Date Title
BR8507219A (pt) Sistema de montagem e controle programavel para aplicador de droga transdermico
EP0337642A3 (en) Transdermal drug delivery device
FR2582221B1 (fr) Dispositif implantable d'injection chronique d'une substance, notamment therapeutique
ATE263598T1 (de) Vorrichtung für elektrotherapie
ES555288A0 (es) Procedimiento de obtencion de un sistema de suministro de ingredientes activos
DE3665127D1 (en) Stylet for an implantable electrode
ATE127028T1 (de) Einpflanzbares iontophoretisches abgabesystem.
AU5426890A (en) Improved transcutaneous electrical nerve stimulation (tens) device
AU6022286A (en) Transdermal drug applicator and electrodes therefor
EP0598459A3 (en) Electrode for stimulating and/or detecting the muscle activity of muscles or muscle groups of a patient, which are accessible through a body orifice.
CA2393104A1 (en) Percutaneous electrical therapy system and electrode
HUT43919A (en) Herbicides comprising 3-/substituted thio/-2-benzoyl-cyclohex-2-enone derivatives as active substance
EP0228833A3 (en) Immunostimulant agents
DE3769707D1 (de) Therapeutisches system mit geregelter wirkstoffabgabe.
EP0228448A4 (en) Use of biologically active copolymers for the manufacture of a medicament for stimulating the growth of animals.
IT8621547A0 (it) Apparecchio generatore di impulsi elettrici per applicazione terapeutica.
HUT44396A (en) Herbicides comprising substituted 3-amino-2-benzoyl-cyclohex-2-en-1-one derivatives as active substance
HUT43918A (en) Herbicides comprising derivatives of 3-/substituted-oxy/-2-benzoyl-cyclohex-2-enone as active substance
IL80984A0 (en) Medical device for infusing antimicrobials into the body
GB2181053B (en) Pharmaceutical formulations with controlled release of the active substance
GB2178135B (en) A controlling device for an intravenous feeding or medicating device
DE69228745D1 (de) Elektrisches System mit mehreren Signalen zur transdermalen Medikamentenverabreichung
GR3001277T3 (en) Chlorpheniramine therapy
FR2624748B1 (fr) Dispositif generateur d'impulsions electriques pour usage therapeutique
AU6137586A (en) Control member for coulters of agricultural drills

Legal Events

Date Code Title Description
FF Decision: intention to grant
FG Letter patent granted
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 10/06/2000