BR8507219A - PROGRAMMABLE ASSEMBLY AND CONTROL SYSTEM FOR TRANSDERMAL DRUG APPLICATOR - Google Patents

PROGRAMMABLE ASSEMBLY AND CONTROL SYSTEM FOR TRANSDERMAL DRUG APPLICATOR

Info

Publication number
BR8507219A
BR8507219A BR8507219A BR8507219A BR8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A BR 8507219 A BR8507219 A BR 8507219A
Authority
BR
Brazil
Prior art keywords
applicator
drug
skin
mounting structure
power supply
Prior art date
Application number
BR8507219A
Other languages
Portuguese (pt)
Inventor
Dan Sibalis
Sanford Rosen
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Publication of BR8507219A publication Critical patent/BR8507219A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444Membrane

Abstract

A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin, with the applicator (100) removably connected to the mounting structure (138,140). A power supply for the applicator (100) and a circuit transmitting electrical power from the power supply to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin. The device includes a computer with the mounting structure(138,140) for receiving programmed instructions relative to the drug, and transmitting signals relative to the drug and the programmed instructions to the power supply for regulating the generation of power and delievery of drug through the skin. <IMAGE>
BR8507219A 1985-06-10 1985-06-10 PROGRAMMABLE ASSEMBLY AND CONTROL SYSTEM FOR TRANSDERMAL DRUG APPLICATOR BR8507219A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1985/001075 WO1986007269A1 (en) 1985-06-10 1985-06-10 Programmable control and mounting system for transdermal drug applicator

Publications (1)

Publication Number Publication Date
BR8507219A true BR8507219A (en) 1987-08-04

Family

ID=22188715

Family Applications (1)

Application Number Title Priority Date Filing Date
BR8507219A BR8507219A (en) 1985-06-10 1985-06-10 PROGRAMMABLE ASSEMBLY AND CONTROL SYSTEM FOR TRANSDERMAL DRUG APPLICATOR

Country Status (9)

Country Link
EP (2) EP0225872B1 (en)
JP (1) JPH0716518B2 (en)
KR (1) KR880002524B1 (en)
AT (1) ATE80048T1 (en)
BR (1) BR8507219A (en)
CA (1) CA1279542C (en)
DE (1) DE3586595T2 (en)
MX (1) MX169673B (en)
WO (1) WO1986007269A1 (en)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731926A (en) * 1985-02-19 1988-03-22 Drug Delivery Systems Inc. Method of manufacturing disposable and/or replenishable transdermal drug applicators
AU597890B2 (en) * 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5961482A (en) * 1986-07-25 1999-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
EP0313638A4 (en) * 1987-05-15 1989-06-14 Martin H Newman Iontophoresis drug delivery system.
US4865582A (en) * 1987-06-05 1989-09-12 Drug Delivery Systems Inc. Disposable transdermal drug applicators
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
JP2907342B2 (en) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ion infiltration non-invasive sampling or delivery device
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
IL86076A (en) * 1988-04-14 1992-12-01 Inventor S Funding Corp Ltd Transdermal drug delivery device
CA1319174C (en) * 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
ES2012944A6 (en) * 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon A device for the administration of medication by iontopheresis for local - regional treatment.
US5205819A (en) * 1989-05-11 1993-04-27 Bespak Plc Pump apparatus for biomedical use
IT1244030B (en) * 1989-12-21 1994-06-28 Elan Corp Plc TWO-PART DEVICE FOR THE CONTROLLED ADMINISTRATION OF AN INGREDIENT
DE4028125A1 (en) * 1990-01-17 1991-07-18 Klimke Markus Application plaster for regulated dosing of various pharmacons - uses electrical correct for percutaneous transport for local and systematic therapy
WO1991015261A1 (en) * 1990-03-30 1991-10-17 Medtronic, Inc. Activity controlled electrotransport drug delivery device
US5213568A (en) * 1990-03-30 1993-05-25 Medtronic Inc. Activity controlled electrotransport drug delivery device
US5383848A (en) * 1990-04-12 1995-01-24 Gensia, Inc. Iontophoretic administration of drugs
GR1000433B (en) * 1990-04-24 1992-07-30 Alza Corp Device and method for a medicine iontophbore release
US5160316A (en) * 1990-09-10 1992-11-03 Henley Julian L Iontophoretic drug delivery apparatus
CN1025720C (en) * 1991-03-05 1994-08-24 金同(广州)保健用品有限公司 Composite therapeutic apparatus
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
JPH07501238A (en) * 1991-08-26 1995-02-09 ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー Ionization therapy device and method
EP0676973B1 (en) * 1992-12-31 1998-01-28 Alza Corporation Electrotransport system having flexible means
EP0616818A3 (en) * 1993-03-26 1995-04-05 Tech Res Ass Med & Welfare App Electrical, drug introducing apparatus.
US5458569A (en) * 1993-06-08 1995-10-17 Becton Dickinson And Company Wearable iontophoresis system
AU682515B2 (en) * 1993-06-08 1997-10-09 Hisamitsu Pharmaceutical Co., Inc. Iontophoresis system
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
FR2709670B1 (en) * 1993-09-10 1995-10-20 Asulab Sa Device in three modules for transdermal administration of drugs by electrophoresis or iontophoresis.
US7027859B1 (en) 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
WO1996010441A1 (en) * 1994-09-30 1996-04-11 Becton Dickinson And Company Iontophoretic drug delivery system, including disposable patch and reusable, removable controller
US5795321A (en) * 1994-09-30 1998-08-18 Becton Dickinson And Company Iontophoretic drug delivery system, including removable controller
DE69513672T3 (en) * 1994-09-30 2007-09-06 Vyteris, Inc. (n.d.Ges.d. Staates Delaware) IMPROVED DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICAMENTS
US5876368A (en) * 1994-09-30 1999-03-02 Becton Dickinson And Company Iontophoretic drug delivery device having improved controller
DE69509782T2 (en) * 1994-09-30 1999-11-11 Becton Dickinson Co DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICINES WITH IMPROVED CONTROL DEVICE AND PILLOW ELECTRODE
FR2726770B1 (en) * 1994-11-16 1997-01-31 Lhd Lab Hygiene Dietetique TRANSDERMAL DRUG DELIVERY DEVICE FOR THE TREATMENT OF MALE ERECTILE IMPOTENCE
US5843014A (en) * 1995-03-24 1998-12-01 Alza Corporation Display for an electrotransport delivery device
US5978701A (en) * 1995-06-02 1999-11-02 Alza Corporation Electrotransport device with separable controller and drug unit and method of setting controller output
US5688232A (en) * 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
AU720742B2 (en) * 1995-09-28 2000-06-08 Vyteris, Inc. Iontophoretic drug delivery system, including disposable patch
WO1997014473A1 (en) * 1995-10-18 1997-04-24 Novartis Ag Thermopile powered transdermal drug delivery device
US6175763B1 (en) * 1996-03-29 2001-01-16 Alza Corporation Electrotransport drug delivery device having tactile signaling means
FR2747313B1 (en) * 1996-04-16 1998-06-05 Lhd Lab Hygiene Dietetique TRANSDERMAL MEDICINE DELIVERY DEVICE BY IONOPHORESIS
US6086572A (en) * 1996-05-31 2000-07-11 Alza Corporation Electrotransport device and method of setting output
NO308095B1 (en) * 1997-06-30 2000-07-24 Consensus As Method for transporting liquid in textiles
EP1047475B1 (en) * 1997-12-17 2007-02-21 ALZA Corporation Iontophoresis with programmed adjustment of electric current
EP0970719A3 (en) * 1998-07-08 2000-08-23 Nitto Denko Corporation Electrode structure
JP2002541934A (en) * 1999-04-16 2002-12-10 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド Drug delivery device with dual chamber reservoir
US6385488B1 (en) 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
DE10015928B4 (en) * 2000-03-30 2004-12-09 Hafner, Dieter, Dr. Carrier for a medicament and method for checking the integrity of this carrier
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
KR20020070705A (en) * 2001-03-02 2002-09-11 파워뱅크 주식회사 Insulin patch device
US6823202B2 (en) 2002-04-01 2004-11-23 Iomed, Inc. Iontophoretic power supply
TR200200942A2 (en) * 2002-04-08 2004-02-23 Tuncer De��M �. Urea meter / urea clock: detection of urea in human blood by reverse iontophoresis, without taking blood or biological samples.
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
WO2006127905A2 (en) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Portable drug delivery device
JPWO2007026671A1 (en) * 2005-08-29 2009-03-05 Tti・エルビュー株式会社 An iontophoresis device that selects a drug to be administered based on information from a sensor
WO2007037476A1 (en) * 2005-09-30 2007-04-05 Tti Ellebeau, Inc. Iontophoresis apparatus capable of controlling dose and timing of administration of sleep inducer and analeptic agent
MX2008011714A (en) 2006-03-14 2008-11-12 Univ Southern California Mems device for delivery of therapeutic agents.
JP5241714B2 (en) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス, インコーポレイテッド Smart parenteral delivery system
KR100837083B1 (en) * 2007-02-28 2008-06-11 김종택 Device for improving penetration through skin
EP2211974A4 (en) 2007-10-25 2013-02-27 Proteus Digital Health Inc Fluid transfer port information system
WO2009073686A1 (en) * 2007-12-03 2009-06-11 Trans Dermal Patents Company, Llc Agent delivery system and uses of the same
CA2708497A1 (en) * 2007-12-10 2009-06-18 Isis Biopolymer Llc Iontophoretic drug delivery device and software application
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
EP2323716B1 (en) 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
WO2009137780A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Implantable pumps and cannulas therefor
US9199035B2 (en) 2008-05-08 2015-12-01 Minipumps, Llc. Drug-delivery pumps with dynamic, adaptive control
US8109912B2 (en) * 2008-09-12 2012-02-07 Calibra Medical, Inc. Wearable infusion assembly
KR20120114368A (en) 2010-02-01 2012-10-16 프로테우스 디지털 헬스, 인코포레이티드 Two-wrist data gathering system
SG182825A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Data gathering system
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
CN103768707A (en) * 2013-12-28 2014-05-07 陈宁飞 Leading-in device with permeation sensing function
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
EP3565617A1 (en) 2017-01-06 2019-11-13 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
WO2023108207A1 (en) * 2021-12-17 2023-06-22 Cosmoaesthetics Pty Ltd A wearable transdermal drug applicator

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2263792A1 (en) * 1974-03-12 1975-10-10 Bondivenne Jean Ionotherapy current generator - comprises thin flexible bag giving percutaneous medicament penetration
GB1555062A (en) * 1977-02-11 1979-11-07 Orr T Heartbeat rate monitors
US4259963A (en) * 1979-07-03 1981-04-07 Albert Huch Multi-purpose transducer for transcutaneous blood measurements
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
US4416274A (en) * 1981-02-23 1983-11-22 Motion Control, Inc. Ion mobility limiting iontophoretic bioelectrode
EP0060452B1 (en) * 1981-03-05 1985-10-23 Medtronic, Inc. Iontophoretic device
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
US4419092A (en) * 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4494950A (en) * 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament

Also Published As

Publication number Publication date
EP0461680A2 (en) 1991-12-18
KR880002524B1 (en) 1988-11-28
EP0225872B1 (en) 1992-09-02
MX169673B (en) 1993-07-19
EP0225872A4 (en) 1987-10-05
EP0225872A1 (en) 1987-06-24
WO1986007269A1 (en) 1986-12-18
ATE80048T1 (en) 1992-09-15
EP0461680A3 (en) 1992-02-26
KR870700374A (en) 1987-12-28
DE3586595D1 (en) 1992-10-08
DE3586595T2 (en) 1993-04-08
CA1279542C (en) 1991-01-29
JPS63500009A (en) 1988-01-07
JPH0716518B2 (en) 1995-03-01

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Legal Events

Date Code Title Description
FF Decision: intention to grant
FG Letter patent granted
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 10/06/2000