BR112023023559A2 - Moduladores de receptores acoplados à proteína g - Google Patents
Moduladores de receptores acoplados à proteína gInfo
- Publication number
- BR112023023559A2 BR112023023559A2 BR112023023559A BR112023023559A BR112023023559A2 BR 112023023559 A2 BR112023023559 A2 BR 112023023559A2 BR 112023023559 A BR112023023559 A BR 112023023559A BR 112023023559 A BR112023023559 A BR 112023023559A BR 112023023559 A2 BR112023023559 A2 BR 112023023559A2
- Authority
- BR
- Brazil
- Prior art keywords
- chemical entities
- glp
- disorder
- disease
- coupled receptor
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 101150020692 Gipr gene Proteins 0.000 abstract 2
- 230000008484 agonism Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000011664 signaling Effects 0.000 abstract 2
- 102100039997 Gastric inhibitory polypeptide receptor Human genes 0.000 abstract 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 abstract 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 102000000072 beta-Arrestins Human genes 0.000 abstract 1
- 108010080367 beta-Arrestins Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 108010036598 gastric inhibitory polypeptide receptor Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Holo Graphy (AREA)
- Gyroscopes (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163188342P | 2021-05-13 | 2021-05-13 | |
| PCT/US2022/029305 WO2022241287A2 (en) | 2021-05-13 | 2022-05-13 | Modulators of g-protein coupled receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023023559A2 true BR112023023559A2 (pt) | 2024-02-06 |
Family
ID=82019613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023023559A BR112023023559A2 (pt) | 2021-05-13 | 2022-05-13 | Moduladores de receptores acoplados à proteína g |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US12281149B2 (https=) |
| EP (1) | EP4337682A2 (https=) |
| JP (1) | JP2024517942A (https=) |
| KR (1) | KR20240007251A (https=) |
| CN (1) | CN117980325A (https=) |
| AU (1) | AU2022272251A1 (https=) |
| BR (1) | BR112023023559A2 (https=) |
| CA (1) | CA3220005A1 (https=) |
| CL (1) | CL2023003369A1 (https=) |
| CO (1) | CO2023015805A2 (https=) |
| CR (1) | CR20230530A (https=) |
| DO (1) | DOP2023000247A (https=) |
| EC (1) | ECSP23093673A (https=) |
| GE (1) | GEAP202416419A (https=) |
| IL (1) | IL308392A (https=) |
| JO (1) | JOP20230291A1 (https=) |
| MX (1) | MX2023013492A (https=) |
| PE (1) | PE20240890A1 (https=) |
| TW (1) | TW202313666A (https=) |
| WO (1) | WO2022241287A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
| US12281149B2 (en) * | 2021-05-13 | 2025-04-22 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| JP2025530024A (ja) * | 2023-01-18 | 2025-09-10 | シャンハイ ミンウェイ バイオテクノロジー カンパニー，リミテッド | 三重活性を有する融合タンパク質およびその応用 |
| TW202500575A (zh) * | 2023-05-21 | 2025-01-01 | 美商卡默療法股份有限公司 | 具有或不具有體重相關合併症之過重或肥胖成人之治療 |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| US20260116848A1 (en) | 2024-07-31 | 2026-04-30 | Carmot Therapeutics Inc. | Synthesis of an Intermediate and Its Use for the Preparation of GLP-1R/GIPR Agonists |
| WO2026027650A1 (en) | 2024-08-02 | 2026-02-05 | F. Hoffmann-La Roche Ag | Process for the preparation of 2-(3-cyano-5-fluorophenyl)-2-methyl-propionic acid |
| WO2026073030A1 (en) | 2024-09-27 | 2026-04-02 | Carmot Therapeutics Inc. | Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists |
| CN119930843B (zh) * | 2025-01-22 | 2025-12-30 | 北京康乐卫士生物技术股份有限公司 | 具有glp和gip双重活性的融合蛋白及其应用 |
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| KR20220092442A (ko) | 2020-12-24 | 2022-07-01 | 한미약품 주식회사 | 신규한 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중활성체 및 이의 용도 |
| US12281149B2 (en) * | 2021-05-13 | 2025-04-22 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
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-
2022
- 2022-05-13 US US17/744,540 patent/US12281149B2/en active Active
- 2022-05-13 EP EP22729907.0A patent/EP4337682A2/en active Pending
- 2022-05-13 CA CA3220005A patent/CA3220005A1/en active Pending
- 2022-05-13 GE GEAP202416419A patent/GEAP202416419A/en unknown
- 2022-05-13 PE PE2023003051A patent/PE20240890A1/es unknown
- 2022-05-13 MX MX2023013492A patent/MX2023013492A/es unknown
- 2022-05-13 CR CR20230530A patent/CR20230530A/es unknown
- 2022-05-13 WO PCT/US2022/029305 patent/WO2022241287A2/en not_active Ceased
- 2022-05-13 JP JP2023569936A patent/JP2024517942A/ja active Pending
- 2022-05-13 IL IL308392A patent/IL308392A/en unknown
- 2022-05-13 KR KR1020237042878A patent/KR20240007251A/ko active Pending
- 2022-05-13 AU AU2022272251A patent/AU2022272251A1/en active Pending
- 2022-05-13 BR BR112023023559A patent/BR112023023559A2/pt unknown
- 2022-05-13 CN CN202280048710.4A patent/CN117980325A/zh active Pending
- 2022-05-13 TW TW111118138A patent/TW202313666A/zh unknown
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2023
- 2023-11-09 DO DO2023000247A patent/DOP2023000247A/es unknown
- 2023-11-10 CL CL2023003369A patent/CL2023003369A1/es unknown
- 2023-11-13 JO JOJO/P/2023/0291A patent/JOP20230291A1/ar unknown
- 2023-11-21 CO CONC2023/0015805A patent/CO2023015805A2/es unknown
- 2023-12-13 EC ECSENADI202393673A patent/ECSP23093673A/es unknown
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2024
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Also Published As
| Publication number | Publication date |
|---|---|
| US12281149B2 (en) | 2025-04-22 |
| WO2022241287A2 (en) | 2022-11-17 |
| CL2023003369A1 (es) | 2024-05-17 |
| US20230151074A1 (en) | 2023-05-18 |
| ECSP23093673A (es) | 2024-01-31 |
| CO2023015805A2 (es) | 2023-12-11 |
| JOP20230291A1 (ar) | 2023-11-13 |
| DOP2023000247A (es) | 2024-03-28 |
| EP4337682A2 (en) | 2024-03-20 |
| TW202313666A (zh) | 2023-04-01 |
| CA3220005A1 (en) | 2022-11-17 |
| CN117980325A (zh) | 2024-05-03 |
| MX2023013492A (es) | 2024-02-29 |
| IL308392A (en) | 2024-01-01 |
| JP2024517942A (ja) | 2024-04-23 |
| PE20240890A1 (es) | 2024-04-24 |
| WO2022241287A3 (en) | 2022-12-29 |
| AU2022272251A1 (en) | 2023-11-16 |
| GEAP202416419A (en) | 2024-03-25 |
| CR20230530A (es) | 2024-02-19 |
| US20240383960A1 (en) | 2024-11-21 |
| KR20240007251A (ko) | 2024-01-16 |
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