BR112023015715A2 - Inibidor de cdk - Google Patents
Inibidor de cdkInfo
- Publication number
- BR112023015715A2 BR112023015715A2 BR112023015715A BR112023015715A BR112023015715A2 BR 112023015715 A2 BR112023015715 A2 BR 112023015715A2 BR 112023015715 A BR112023015715 A BR 112023015715A BR 112023015715 A BR112023015715 A BR 112023015715A BR 112023015715 A2 BR112023015715 A2 BR 112023015715A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- cdk inhibitor
- preparing
- pharmaceutical
- cancer
- Prior art date
Links
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title abstract 3
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
inibidor de cdk. um composto que serve como um inibidor seletivo de cdk, uma composição farmacêutica contendo o mesmo, um intermediário útil para preparar o composto e um uso do composto para preparar um fármaco para o tratamento de doenças proliferativas celulares, tal como o câncer. o composto tem a estrutura mostrada na fórmula (i-a).
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110161786 | 2021-02-05 | ||
CN202110483256 | 2021-04-30 | ||
CN202111062178 | 2021-09-10 | ||
CN202111398260 | 2021-11-19 | ||
CN202210048365 | 2022-01-17 | ||
PCT/CN2022/074491 WO2022166793A1 (zh) | 2021-02-05 | 2022-01-28 | Cdk抑制剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023015715A2 true BR112023015715A2 (pt) | 2023-11-07 |
Family
ID=82741960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023015715A BR112023015715A2 (pt) | 2021-02-05 | 2022-01-28 | Inibidor de cdk |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4289835A1 (pt) |
JP (1) | JP2024506039A (pt) |
KR (1) | KR20230142504A (pt) |
CN (1) | CN116472270A (pt) |
AU (1) | AU2022215725A1 (pt) |
BR (1) | BR112023015715A2 (pt) |
CA (1) | CA3207392A1 (pt) |
TW (1) | TW202231633A (pt) |
WO (1) | WO2022166793A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023226920A1 (en) * | 2022-05-27 | 2023-11-30 | Anrui Biomedical Technology (Guangzhou) Co.,Ltd. | Aminoheteroaryl kinase inhibitors |
WO2024027825A1 (zh) * | 2022-08-05 | 2024-02-08 | 齐鲁制药有限公司 | 一种cdk抑制剂及其磷酸盐的多晶型 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101044121A (zh) * | 2003-02-10 | 2007-09-26 | 霍夫曼-拉罗奇有限公司 | 4-氨基嘧啶-5-酮 |
US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
US7423051B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 2,6-diaminopyridine derivatives |
CN101490041A (zh) * | 2006-05-26 | 2009-07-22 | 阿斯利康(瑞典)有限公司 | 作为细胞增殖抑制剂的2-杂环氨基-4-咪唑基嘧啶 |
TW200815417A (en) * | 2006-06-27 | 2008-04-01 | Astrazeneca Ab | New compounds II |
TW202100520A (zh) * | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
JP2023509260A (ja) * | 2019-08-14 | 2023-03-08 | インサイト・コーポレイション | Cdk2阻害剤としてのイミダゾリルピリミジニルアミン化合物 |
CN115551856A (zh) * | 2020-02-28 | 2022-12-30 | 重庆复尚源创医药技术有限公司 | 作为cdk2/4/6抑制剂的化合物 |
-
2022
- 2022-01-28 WO PCT/CN2022/074491 patent/WO2022166793A1/zh active Application Filing
- 2022-01-28 KR KR1020237027652A patent/KR20230142504A/ko unknown
- 2022-01-28 BR BR112023015715A patent/BR112023015715A2/pt unknown
- 2022-01-28 CA CA3207392A patent/CA3207392A1/en active Pending
- 2022-01-28 AU AU2022215725A patent/AU2022215725A1/en active Pending
- 2022-01-28 EP EP22749072.9A patent/EP4289835A1/en active Pending
- 2022-01-28 CN CN202280007638.0A patent/CN116472270A/zh active Pending
- 2022-01-28 JP JP2023547678A patent/JP2024506039A/ja active Pending
- 2022-01-28 TW TW111104024A patent/TW202231633A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA3207392A1 (en) | 2022-08-11 |
EP4289835A1 (en) | 2023-12-13 |
TW202231633A (zh) | 2022-08-16 |
CN116472270A (zh) | 2023-07-21 |
JP2024506039A (ja) | 2024-02-08 |
KR20230142504A (ko) | 2023-10-11 |
WO2022166793A1 (zh) | 2022-08-11 |
AU2022215725A1 (en) | 2023-09-14 |
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