BR112022022341A2 - Compostos heterocíclicos como receptor desencadeador expresso em agonistas de células mieloides 2 e métodos de uso - Google Patents
Compostos heterocíclicos como receptor desencadeador expresso em agonistas de células mieloides 2 e métodos de usoInfo
- Publication number
- BR112022022341A2 BR112022022341A2 BR112022022341A BR112022022341A BR112022022341A2 BR 112022022341 A2 BR112022022341 A2 BR 112022022341A2 BR 112022022341 A BR112022022341 A BR 112022022341A BR 112022022341 A BR112022022341 A BR 112022022341A BR 112022022341 A2 BR112022022341 A2 BR 112022022341A2
- Authority
- BR
- Brazil
- Prior art keywords
- myeloid
- compounds
- methods
- heterocyclic compounds
- receptor trigger
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
Abstract
COMPOSTOS HETEROCÍCLICOS COMO RECEPTOR DESENCADEADOR EXPRESSO EM AGONISTAS DE CÉLULAS MIELOIDES 2 E MÉTODOS DE USO. A presente invenção refere-se a compostos da Fórmula I, úteis para a ativação de Receptor Desencadeador Expresso em Células Mieloides 2 (TREM2). A presente invenção também se refere a composições farmacêuticas que compreendem os compostos, usos dos compostos e composições para tratamento de, por exemplo, um distúrbio neurodegenerativo. Além disso, a presente invenção refere-se a intermediários úteis na síntese de compostos da Fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063019772P | 2020-05-04 | 2020-05-04 | |
PCT/US2021/070507 WO2021226629A1 (en) | 2020-05-04 | 2021-05-04 | Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022022341A2 true BR112022022341A2 (pt) | 2023-01-10 |
Family
ID=78468522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022022341A BR112022022341A2 (pt) | 2020-05-04 | 2021-05-04 | Compostos heterocíclicos como receptor desencadeador expresso em agonistas de células mieloides 2 e métodos de uso |
Country Status (19)
Country | Link |
---|---|
US (3) | US11608344B2 (pt) |
EP (1) | EP4146222A1 (pt) |
JP (1) | JP2023525035A (pt) |
KR (1) | KR20230019822A (pt) |
CN (1) | CN115867284A (pt) |
AR (1) | AR122010A1 (pt) |
AU (1) | AU2021266805A1 (pt) |
BR (1) | BR112022022341A2 (pt) |
CA (1) | CA3182105A1 (pt) |
CL (1) | CL2022003047A1 (pt) |
CO (1) | CO2022015930A2 (pt) |
CR (1) | CR20220560A (pt) |
CU (1) | CU20220064A7 (pt) |
EC (1) | ECSP22089527A (pt) |
IL (1) | IL297833A (pt) |
MX (1) | MX2022013842A (pt) |
PE (1) | PE20230846A1 (pt) |
TW (1) | TW202208355A (pt) |
WO (1) | WO2021226629A1 (pt) |
Families Citing this family (5)
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TW202208355A (zh) | 2020-05-04 | 2022-03-01 | 美商安進公司 | 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法 |
CN116322696A (zh) | 2020-05-04 | 2023-06-23 | 安进公司 | 作为髓样细胞上表达的触发受体2激动剂的杂环化合物和使用方法 |
WO2022120390A1 (en) * | 2020-12-04 | 2022-06-09 | Vigil Neuroscience, Inc. | Treatment of diseases related to atp-binding cassette transporter 1 dysfunction using trem2 agonists |
IL308167A (en) * | 2021-05-04 | 2023-12-01 | Vigil Neuroscience Inc | Heterocyclic compounds as agonists for an excitatory receptor expressed on myeloid cells 2 and methods of use |
WO2023192288A1 (en) * | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Monovalent anti-trem2 binding molecules and methods of use thereof |
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2021
- 2021-05-03 TW TW110115924A patent/TW202208355A/zh unknown
- 2021-05-04 BR BR112022022341A patent/BR112022022341A2/pt unknown
- 2021-05-04 US US17/302,502 patent/US11608344B2/en active Active
- 2021-05-04 AU AU2021266805A patent/AU2021266805A1/en active Pending
- 2021-05-04 JP JP2022567487A patent/JP2023525035A/ja active Pending
- 2021-05-04 EP EP21800538.7A patent/EP4146222A1/en active Pending
- 2021-05-04 CU CU2022000064A patent/CU20220064A7/es unknown
- 2021-05-04 IL IL297833A patent/IL297833A/en unknown
- 2021-05-04 CN CN202180047705.7A patent/CN115867284A/zh active Pending
- 2021-05-04 KR KR1020227038841A patent/KR20230019822A/ko unknown
- 2021-05-04 MX MX2022013842A patent/MX2022013842A/es unknown
- 2021-05-04 CA CA3182105A patent/CA3182105A1/en active Pending
- 2021-05-04 PE PE2022002567A patent/PE20230846A1/es unknown
- 2021-05-04 WO PCT/US2021/070507 patent/WO2021226629A1/en active Application Filing
- 2021-05-04 AR ARP210101218A patent/AR122010A1/es unknown
- 2021-05-04 CR CR20220560A patent/CR20220560A/es unknown
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2022
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- 2022-11-04 CO CONC2022/0015930A patent/CO2022015930A2/es unknown
- 2022-11-21 EC ECSENADI202289527A patent/ECSP22089527A/es unknown
- 2022-11-30 US US18/072,501 patent/US11884675B2/en active Active
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Also Published As
Publication number | Publication date |
---|---|
US11608344B2 (en) | 2023-03-21 |
PE20230846A1 (es) | 2023-05-23 |
US20230295170A1 (en) | 2023-09-21 |
US20230002390A1 (en) | 2023-01-05 |
US20230295169A1 (en) | 2023-09-21 |
CL2022003047A1 (es) | 2023-07-14 |
JP2023525035A (ja) | 2023-06-14 |
CU20220064A7 (es) | 2023-06-13 |
ECSP22089527A (es) | 2023-02-28 |
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