BR112022019713A2 - Composições que compreendem um polipeptídeo variante cas12i2 e usos das mesmas - Google Patents
Composições que compreendem um polipeptídeo variante cas12i2 e usos das mesmasInfo
- Publication number
- BR112022019713A2 BR112022019713A2 BR112022019713A BR112022019713A BR112022019713A2 BR 112022019713 A2 BR112022019713 A2 BR 112022019713A2 BR 112022019713 A BR112022019713 A BR 112022019713A BR 112022019713 A BR112022019713 A BR 112022019713A BR 112022019713 A2 BR112022019713 A2 BR 112022019713A2
- Authority
- BR
- Brazil
- Prior art keywords
- cas12i2
- variant
- polypeptides
- compositions
- complexes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003090P | 2020-03-31 | 2020-03-31 | |
| US202063002999P | 2020-03-31 | 2020-03-31 | |
| US202063003064P | 2020-03-31 | 2020-03-31 | |
| US202063012007P | 2020-04-17 | 2020-04-17 | |
| US202063026277P | 2020-05-18 | 2020-05-18 | |
| US202063026562P | 2020-05-18 | 2020-05-18 | |
| US202063026606P | 2020-05-18 | 2020-05-18 | |
| US202063026523P | 2020-05-18 | 2020-05-18 | |
| US202063063831P | 2020-08-10 | 2020-08-10 | |
| US202063063879P | 2020-08-10 | 2020-08-10 | |
| US202063063819P | 2020-08-10 | 2020-08-10 | |
| US202063063859P | 2020-08-10 | 2020-08-10 | |
| US202063085862P | 2020-09-30 | 2020-09-30 | |
| US202063085752P | 2020-09-30 | 2020-09-30 | |
| US202063085792P | 2020-09-30 | 2020-09-30 | |
| US202063085895P | 2020-09-30 | 2020-09-30 | |
| US202163147850P | 2021-02-10 | 2021-02-10 | |
| US202163147968P | 2021-02-10 | 2021-02-10 | |
| PCT/US2021/025257 WO2021202800A1 (en) | 2020-03-31 | 2021-03-31 | Compositions comprising a cas12i2 variant polypeptide and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022019713A2 true BR112022019713A2 (pt) | 2022-12-20 |
Family
ID=75640000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022019713A BR112022019713A2 (pt) | 2020-03-31 | 2021-03-31 | Composições que compreendem um polipeptídeo variante cas12i2 e usos das mesmas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230332119A1 (https=) |
| EP (1) | EP4127154A1 (https=) |
| JP (1) | JP2023520504A (https=) |
| KR (1) | KR20230009379A (https=) |
| CN (2) | CN121380024A (https=) |
| AU (1) | AU2021249119A1 (https=) |
| BR (1) | BR112022019713A2 (https=) |
| CA (1) | CA3177749A1 (https=) |
| CO (1) | CO2022015170A2 (https=) |
| IL (1) | IL296791A (https=) |
| MX (1) | MX2022012189A (https=) |
| WO (1) | WO2021202800A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2021243267A2 (en) * | 2020-05-29 | 2021-12-02 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i2 polypeptide and uses thereof |
| US20230407343A1 (en) * | 2020-10-30 | 2023-12-21 | Arbor Biotechnologies, Inc. | Compositions comprising an rna guide targeting pdcd1 and uses thereof |
| IL308806A (en) * | 2021-06-01 | 2024-01-01 | Arbor Biotechnologies Inc | Gene editing systems including nuclease crisper and their uses |
| CA3222159A1 (en) | 2021-06-04 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting hydroxyacid oxidase 1 (hao1) and uses thereof |
| US20240261435A1 (en) | 2021-06-04 | 2024-08-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting transthyretin (ttr) and uses thereof |
| WO2022256655A2 (en) | 2021-06-04 | 2022-12-08 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting lactate dehydrogenase a (ldha) and uses thereof |
| KR20240052763A (ko) | 2021-08-11 | 2024-04-23 | 아버 바이오테크놀로지스, 인크. | 스타스민 2 (stmn2)를 표적화하는 rna 가이드를 포함하는 유전자 편집 시스템 및 이의 용도 |
| WO2023018856A1 (en) | 2021-08-11 | 2023-02-16 | Arbor Biotechnologies, Inc. | Gene editing systems comprising an rna guide targeting polypyrimidine tract binding protein 1 (ptbp1) and uses thereof |
| WO2023034475A1 (en) | 2021-09-01 | 2023-03-09 | Arbor Biotechnologies, Inc. | Cells modified by a cas12i polypeptide |
| US20230287456A1 (en) * | 2021-09-10 | 2023-09-14 | Arbor Biotechnologies, Inc. | Compositions comprising a cas12i polypeptide and uses thereof |
| KR20240111314A (ko) * | 2021-11-02 | 2024-07-16 | 후이다진 테라퓨틱스 (싱가포르) 피티이. 엘티디. | 신규 crispr-cas12i 시스템 및 그의 용도 |
| TW202334421A (zh) * | 2021-11-05 | 2023-09-01 | 美商阿伯生物技術公司 | 包含靶向ciita之rna引導之組合物及其用途 |
| WO2023122433A1 (en) | 2021-12-22 | 2023-06-29 | Arbor Biotechnologies, Inc. | Gene editing systems targeting hydroxyacid oxidase 1 (hao1) and lactate dehydrogenase a (ldha) |
| US20250101394A1 (en) * | 2022-01-24 | 2025-03-27 | Huidagene Therapeutics (Singapore) Pte. Ltd. | Novel crispr-cas12i systems and uses thereof |
| EP4514954A4 (en) * | 2022-04-25 | 2026-03-25 | Huidagene Therapeutics Singapore Pte Ltd | NEW CRISPR-CAS12I SYSTEMS AND THEIR USES |
| EP4627083A1 (en) | 2022-11-30 | 2025-10-08 | Arbor Biotechnologies, Inc. | Reverse transcriptase-mediated genetic editing of transthyretin (ttr) and uses thereof |
| WO2024173645A1 (en) | 2023-02-15 | 2024-08-22 | Arbor Biotechnologies, Inc. | Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript |
| AU2024369584A1 (en) | 2023-10-30 | 2026-04-09 | Allogene Therapeutics, Inc. | Cells expressing anti-cd19 chimeric antigen receptors and methods of use thereof |
| CN117431235A (zh) * | 2023-11-06 | 2024-01-23 | 微光基因(苏州)有限公司 | CRISPR-Cas系统及其应用 |
| WO2025147604A1 (en) | 2024-01-05 | 2025-07-10 | Arbor Biotechnologies, Inc. | Methods for treating primary hyperoxaluria via genetic editing of hydroxyacid oxidase 1 |
| WO2025171210A1 (en) | 2024-02-09 | 2025-08-14 | Arbor Biotechnologies, Inc. | Compositions and methods for gene editing via homology-mediated end joining |
| WO2026015829A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| WO2026015832A2 (en) | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| CN120424908B (zh) * | 2025-07-10 | 2025-09-12 | 南京农业大学 | 一种基于LAMP与CRISPR/Cas的检测方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2931897T3 (en) | 2012-12-12 | 2018-02-05 | Broad Inst Inc | CONSTRUCTION, MODIFICATION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION AND THERAPEUTICAL APPLICATIONS |
| EP3011030B1 (en) * | 2013-06-17 | 2023-11-08 | The Broad Institute, Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| AU2014346559B2 (en) | 2013-11-07 | 2020-07-09 | Editas Medicine,Inc. | CRISPR-related methods and compositions with governing gRNAs |
| PL3765615T3 (pl) * | 2018-03-14 | 2023-11-13 | Arbor Biotechnologies, Inc. | Nowe enzymy i układy crispr ukierunkowane na dna |
| KR20210139265A (ko) * | 2019-02-13 | 2021-11-22 | 빔 테라퓨틱스, 인크. | 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법 |
| WO2024178144A1 (en) * | 2023-02-22 | 2024-08-29 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
-
2021
- 2021-03-31 KR KR1020227037945A patent/KR20230009379A/ko active Pending
- 2021-03-31 MX MX2022012189A patent/MX2022012189A/es unknown
- 2021-03-31 CN CN202511379190.7A patent/CN121380024A/zh active Pending
- 2021-03-31 CA CA3177749A patent/CA3177749A1/en active Pending
- 2021-03-31 AU AU2021249119A patent/AU2021249119A1/en active Pending
- 2021-03-31 IL IL296791A patent/IL296791A/en unknown
- 2021-03-31 US US17/916,270 patent/US20230332119A1/en active Pending
- 2021-03-31 CN CN202180038904.1A patent/CN115698278B/zh active Active
- 2021-03-31 EP EP21720912.1A patent/EP4127154A1/en active Pending
- 2021-03-31 BR BR112022019713A patent/BR112022019713A2/pt unknown
- 2021-03-31 JP JP2022560154A patent/JP2023520504A/ja active Pending
- 2021-03-31 WO PCT/US2021/025257 patent/WO2021202800A1/en not_active Ceased
-
2022
- 2022-10-25 CO CONC2022/0015170A patent/CO2022015170A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN121380024A (zh) | 2026-01-23 |
| KR20230009379A (ko) | 2023-01-17 |
| CO2022015170A2 (es) | 2022-11-08 |
| CN115698278B (zh) | 2025-10-17 |
| MX2022012189A (es) | 2023-01-05 |
| IL296791A (en) | 2022-11-01 |
| WO2021202800A1 (en) | 2021-10-07 |
| CN115698278A (zh) | 2023-02-03 |
| EP4127154A1 (en) | 2023-02-08 |
| CA3177749A1 (en) | 2021-10-07 |
| JP2023520504A (ja) | 2023-05-17 |
| AU2021249119A1 (en) | 2022-10-20 |
| US20230332119A1 (en) | 2023-10-19 |
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