BR112022015116A2 - Moduladores de monoacilglicerol lipase - Google Patents
Moduladores de monoacilglicerol lipaseInfo
- Publication number
- BR112022015116A2 BR112022015116A2 BR112022015116A BR112022015116A BR112022015116A2 BR 112022015116 A2 BR112022015116 A2 BR 112022015116A2 BR 112022015116 A BR112022015116 A BR 112022015116A BR 112022015116 A BR112022015116 A BR 112022015116A BR 112022015116 A2 BR112022015116 A2 BR 112022015116A2
- Authority
- BR
- Brazil
- Prior art keywords
- same
- methods
- disorders
- monoacylglycerol lipase
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
MODULADORES DA LIPASE DE MONOACILGLICEROL. A presente invenção refere-se aos compostos 3.1.0 e 4.1.0 azabiciclo da fórmula (I), às composições farmacêuticas contendo os mesmos, aos métodos de preparo dos mesmos e métodos de uso dos mesmos, incluindo métodos para tratamento de estados, distúrbios e condições de doença associados à modulação da MGL, como aqueles associados à dor, aos distúrbios psiquiátricos, aos distúrbios neurológicos (incluindo, mas sem se limitar, ao distúrbio depressivo maior, depressão resistente a tratamento, depressão por ansiedade, distúrbio bipolar), cânceres e condições oculares. Em que X, Y, R1, R2a e R2b são definidos aqui.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062972484P | 2020-02-10 | 2020-02-10 | |
PCT/EP2021/053062 WO2021160602A1 (en) | 2020-02-10 | 2021-02-09 | Monoacylglycerol lipase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022015116A2 true BR112022015116A2 (pt) | 2022-09-27 |
Family
ID=74595268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022015116A BR112022015116A2 (pt) | 2020-02-10 | 2021-02-09 | Moduladores de monoacilglicerol lipase |
Country Status (21)
Country | Link |
---|---|
US (2) | US11708359B2 (pt) |
EP (1) | EP4103557A1 (pt) |
JP (1) | JP2023512729A (pt) |
KR (1) | KR20220140581A (pt) |
CN (1) | CN115066422A (pt) |
AR (1) | AR121296A1 (pt) |
AU (1) | AU2021220539A1 (pt) |
BR (1) | BR112022015116A2 (pt) |
CA (1) | CA3169988A1 (pt) |
CL (1) | CL2022002136A1 (pt) |
CO (1) | CO2022011275A2 (pt) |
CR (1) | CR20220376A (pt) |
DO (1) | DOP2022000162A (pt) |
EC (1) | ECSP22062460A (pt) |
IL (1) | IL295447A (pt) |
JO (1) | JOP20220180A1 (pt) |
MX (1) | MX2022009804A (pt) |
PE (1) | PE20221576A1 (pt) |
TW (1) | TW202140465A (pt) |
UY (1) | UY39066A (pt) |
WO (1) | WO2021160602A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3169988A1 (en) | 2020-02-10 | 2021-08-19 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
WO2021191390A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Azaspirocycles as monoacylglycerol lipase modulators |
CA3176113A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Aminocyclobutanes as monoacylglycerol lipase modulators |
CN115362151A (zh) | 2020-03-26 | 2022-11-18 | 詹森药业有限公司 | 作为单酰基甘油脂肪酶调节剂的芳基哌啶 |
AU2022328310A1 (en) | 2021-08-09 | 2024-03-28 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators for use in autism spectrum disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2493637A1 (en) | 2002-07-25 | 2004-02-12 | Manuela Villa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
EP2090576A1 (en) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
EP2760450A1 (en) * | 2011-09-30 | 2014-08-06 | Janssen Pharmaceutica, N.V. | Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders |
EP3438109B1 (en) | 2016-03-31 | 2021-08-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
AR108012A1 (es) | 2016-03-31 | 2018-07-04 | Takeda Pharmaceuticals Co | Derivados de azaespiro[3,4]octan-6-ona como inhibidores de magl |
CN111148746B (zh) * | 2017-09-29 | 2022-08-05 | 武田药品工业株式会社 | 杂环化合物 |
WO2020211798A1 (zh) | 2019-04-16 | 2020-10-22 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
CA3169988A1 (en) | 2020-02-10 | 2021-08-19 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
WO2021191390A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Azaspirocycles as monoacylglycerol lipase modulators |
CA3176113A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Aminocyclobutanes as monoacylglycerol lipase modulators |
CN115362151A (zh) | 2020-03-26 | 2022-11-18 | 詹森药业有限公司 | 作为单酰基甘油脂肪酶调节剂的芳基哌啶 |
-
2021
- 2021-02-09 CA CA3169988A patent/CA3169988A1/en active Pending
- 2021-02-09 KR KR1020227031216A patent/KR20220140581A/ko unknown
- 2021-02-09 JO JOP/2022/0180A patent/JOP20220180A1/ar unknown
- 2021-02-09 CN CN202180013762.3A patent/CN115066422A/zh active Pending
- 2021-02-09 US US17/171,559 patent/US11708359B2/en active Active
- 2021-02-09 WO PCT/EP2021/053062 patent/WO2021160602A1/en active Application Filing
- 2021-02-09 BR BR112022015116A patent/BR112022015116A2/pt unknown
- 2021-02-09 AU AU2021220539A patent/AU2021220539A1/en active Pending
- 2021-02-09 AR ARP210100333A patent/AR121296A1/es unknown
- 2021-02-09 UY UY0001039066A patent/UY39066A/es unknown
- 2021-02-09 IL IL295447A patent/IL295447A/en unknown
- 2021-02-09 TW TW110104960A patent/TW202140465A/zh unknown
- 2021-02-09 JP JP2022548400A patent/JP2023512729A/ja active Pending
- 2021-02-09 MX MX2022009804A patent/MX2022009804A/es unknown
- 2021-02-09 PE PE2022001698A patent/PE20221576A1/es unknown
- 2021-02-09 CR CR20220376A patent/CR20220376A/es unknown
- 2021-02-09 EP EP21705124.2A patent/EP4103557A1/en active Pending
-
2022
- 2022-08-08 CL CL2022002136A patent/CL2022002136A1/es unknown
- 2022-08-09 EC ECSENADI202262460A patent/ECSP22062460A/es unknown
- 2022-08-10 CO CONC2022/0011275A patent/CO2022011275A2/es unknown
- 2022-08-10 DO DO2022000162A patent/DOP2022000162A/es unknown
-
2023
- 2023-06-02 US US18/328,242 patent/US20230382902A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210253565A1 (en) | 2021-08-19 |
JP2023512729A (ja) | 2023-03-28 |
AR121296A1 (es) | 2022-05-04 |
DOP2022000162A (es) | 2022-10-31 |
JOP20220180A1 (ar) | 2023-01-30 |
TW202140465A (zh) | 2021-11-01 |
UY39066A (es) | 2021-08-31 |
AU2021220539A1 (en) | 2022-10-06 |
PE20221576A1 (es) | 2022-10-06 |
US11708359B2 (en) | 2023-07-25 |
US20230382902A1 (en) | 2023-11-30 |
MX2022009804A (es) | 2022-09-02 |
IL295447A (en) | 2022-10-01 |
CO2022011275A2 (es) | 2022-08-30 |
CR20220376A (es) | 2022-09-16 |
EP4103557A1 (en) | 2022-12-21 |
ECSP22062460A (es) | 2022-11-30 |
CN115066422A (zh) | 2022-09-16 |
KR20220140581A (ko) | 2022-10-18 |
WO2021160602A1 (en) | 2021-08-19 |
CL2022002136A1 (es) | 2023-02-03 |
CA3169988A1 (en) | 2021-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022015116A2 (pt) | Moduladores de monoacilglicerol lipase | |
CR20210153A (es) | Moduladores de monoacilglicerol lipasa | |
BR112022019155A2 (pt) | Aril piperidinas como moduladores da monoacilglicerol lipase | |
BR112022019178A2 (pt) | Aminociclobutanos como moduladores da monoacilglicerol lipase | |
BR112022019077A2 (pt) | Moduladores da monoacilglicerol lipase | |
BR112022019211A2 (pt) | Azaspirociclos como moduladores de lipase de monoacilglicerol | |
MX2021003661A (es) | Moduladores de la monoacilglicerol lipasa. | |
Gelain et al. | Transplantation of nanostructured composite scaffolds results in the regeneration of chronically injured spinal cords | |
EA201100461A1 (ru) | Спиро-трициклические соединения как модуляторы бета-секретазы и способы их использования | |
MX366855B (es) | Compuestos perfluorados de 5,6-dihidro-4h-1,3-oxazin-2-amina como inhibidores de beta-secretasa y metodos de uso. | |
CR10062A (es) | Composiciones y metodos de tratamiento para trastornos del sistema nervioso central | |
BRPI0608032A2 (pt) | composição para o cuidado do cabelo e/ou do couro cabeludo, método para tratar e/ou prevenir as afecções inflamatórias da pele, uso de um composto de amino-oxo-indol-ilideno e uso de uma composição | |
EA201992127A1 (ru) | ФАРМАКОЛОГИЧЕСКИ АКТИВНЫЕ АЛИЦИКЛИЧЕСКИ ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА | |
UY38304A (es) | Dinucleótidos cíclicos como agonistas de sting y composiciones farmacéuticas que los contienen | |
MX2023003240A (es) | Moduladores de monoacilglicerol lipasa de ciclobutilamida. | |
BR112021019055A2 (pt) | Compostos e composições farmacêuticas dos mesmos para o tratamento de distúrbios inflamatórios | |
MX2023003165A (es) | Moduladores de la caseína cinasa 1 delta. | |
Neville et al. | Neural precursor cell lines promote neurite branching | |
BR112023022524A2 (pt) | Moduladores de molécula pequena de atividade de glicocerebrosidase e usos dos mesmos | |
BR112022021203A2 (pt) | Modulação de enzima e via com compostos sulfidrila e seus derivados | |
BR112023022567A2 (pt) | Moduladores de molécula pequena de atividade de glicocerebrosidase e usos dos mesmos | |
WO2024081961A3 (en) | Ester analogs of psilocin, processes for the preparation thereof, and methods of use | |
Takei et al. | Ecto-Phosphorylation and Regeneration of the Adult Central Nervous System | |
EP4189069A1 (en) | Combination treatment of induced pluripotent stem cells using interleukins | |
BR112023005216A2 (pt) | Composto para aumentar a eficácia de terapia de reposição do fator viii |