JOP20220180A1 - مُعدلات ليباز أُحادِيُّ الجلِيسِريد - Google Patents

مُعدلات ليباز أُحادِيُّ الجلِيسِريد

Info

Publication number
JOP20220180A1
JOP20220180A1 JOP/2022/0180A JOP20220180A JOP20220180A1 JO P20220180 A1 JOP20220180 A1 JO P20220180A1 JO P20220180 A JOP20220180 A JO P20220180A JO P20220180 A1 JOP20220180 A1 JO P20220180A1
Authority
JO
Jordan
Prior art keywords
methods
disorders
monoacylglycerol lipase
modulators
depression
Prior art date
Application number
JOP/2022/0180A
Other languages
English (en)
Inventor
Michael K Ameriks
Brian Ngo Laforteza
Cynthia B Berry
Pablo Garcia-Reynaga
Jimmy T Liang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of JOP20220180A1 publication Critical patent/JOP20220180A1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

مركبات آزا ثنائي الحلقات 3.1.0 و4.1.0 بالصيغة (I) وتركيبات صيدلانية تحتوي عليها وطرق صنعها، وأساليب استخدامها بما في ذلك وسائل علاج الحالات المرضية والاضطرابات والظروف المرتبطة بتعديل ليباز أحادي الجلِيسِريد (MGL)، مثل تلك المرتبطة بالألم، الاضطرابات النفسية، الاضطرابات العصبية (بما في ذلك، على سبيل المثال لا الحصر، الاضطراب الاكتئابي الرئيسي، والاكتئاب المقاوم للعلاج، والاكتئاب الناتج عن القلق، والاضطراب ثنائي القطب)، والسرطانات وأمراض العيون. ؛ حيث يتم تعريف X، وY، وR1، وR2a، وR2b بهذا الاختراع.
JOP/2022/0180A 2020-02-10 2021-02-09 مُعدلات ليباز أُحادِيُّ الجلِيسِريد JOP20220180A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062972484P 2020-02-10 2020-02-10
PCT/EP2021/053062 WO2021160602A1 (en) 2020-02-10 2021-02-09 Monoacylglycerol lipase modulators

Publications (1)

Publication Number Publication Date
JOP20220180A1 true JOP20220180A1 (ar) 2023-01-30

Family

ID=74595268

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2022/0180A JOP20220180A1 (ar) 2020-02-10 2021-02-09 مُعدلات ليباز أُحادِيُّ الجلِيسِريد

Country Status (21)

Country Link
US (2) US11708359B2 (ar)
EP (1) EP4103557A1 (ar)
JP (1) JP2023512729A (ar)
KR (1) KR20220140581A (ar)
CN (1) CN115066422A (ar)
AR (1) AR121296A1 (ar)
AU (1) AU2021220539A1 (ar)
BR (1) BR112022015116A2 (ar)
CA (1) CA3169988A1 (ar)
CL (1) CL2022002136A1 (ar)
CO (1) CO2022011275A2 (ar)
CR (1) CR20220376A (ar)
DO (1) DOP2022000162A (ar)
EC (1) ECSP22062460A (ar)
IL (1) IL295447A (ar)
JO (1) JOP20220180A1 (ar)
MX (1) MX2022009804A (ar)
PE (1) PE20221576A1 (ar)
TW (1) TW202140465A (ar)
UY (1) UY39066A (ar)
WO (1) WO2021160602A1 (ar)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3169988A1 (en) 2020-02-10 2021-08-19 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
KR20220158060A (ko) 2020-03-26 2022-11-29 얀센 파마슈티카 엔.브이. 모노아실글리세롤 리파아제 조절제로서의 아릴 피페리딘
WO2021191390A1 (en) 2020-03-26 2021-09-30 Janssen Pharmaceutica Nv Azaspirocycles as monoacylglycerol lipase modulators
BR112022019178A2 (pt) 2020-03-26 2022-11-01 Janssen Pharmaceutica Nv Aminociclobutanos como moduladores da monoacilglicerol lipase
CN118076351A (zh) 2021-08-09 2024-05-24 詹森药业有限公司 用于自闭症谱系障碍的单酰基甘油脂肪酶调节剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005537290A (ja) 2002-07-25 2005-12-08 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
EP2090576A1 (en) 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
MX2014003879A (es) * 2011-09-30 2014-09-01 Janssen Pharmaceutica Nv Inhibidores de monoacilglicerol lipasa para el tratamiento de enfermedades metabolicas y trastornos relacionados.
WO2017170830A1 (ja) 2016-03-31 2017-10-05 武田薬品工業株式会社 複素環化合物
TWI738753B (zh) 2016-03-31 2021-09-11 日商武田藥品工業股份有限公司 雜環化合物
CN111148746B (zh) 2017-09-29 2022-08-05 武田药品工业株式会社 杂环化合物
WO2020211798A1 (zh) 2019-04-16 2020-10-22 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
CA3169988A1 (en) 2020-02-10 2021-08-19 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
KR20220158060A (ko) 2020-03-26 2022-11-29 얀센 파마슈티카 엔.브이. 모노아실글리세롤 리파아제 조절제로서의 아릴 피페리딘
WO2021191390A1 (en) 2020-03-26 2021-09-30 Janssen Pharmaceutica Nv Azaspirocycles as monoacylglycerol lipase modulators
BR112022019178A2 (pt) 2020-03-26 2022-11-01 Janssen Pharmaceutica Nv Aminociclobutanos como moduladores da monoacilglicerol lipase

Also Published As

Publication number Publication date
AR121296A1 (es) 2022-05-04
IL295447A (en) 2022-10-01
CA3169988A1 (en) 2021-08-19
ECSP22062460A (es) 2022-11-30
US11708359B2 (en) 2023-07-25
CL2022002136A1 (es) 2023-02-03
KR20220140581A (ko) 2022-10-18
CO2022011275A2 (es) 2022-08-30
MX2022009804A (es) 2022-09-02
CR20220376A (es) 2022-09-16
AU2021220539A1 (en) 2022-10-06
PE20221576A1 (es) 2022-10-06
EP4103557A1 (en) 2022-12-21
UY39066A (es) 2021-08-31
US20230382902A1 (en) 2023-11-30
DOP2022000162A (es) 2022-10-31
WO2021160602A1 (en) 2021-08-19
TW202140465A (zh) 2021-11-01
BR112022015116A2 (pt) 2022-09-27
US20210253565A1 (en) 2021-08-19
CN115066422A (zh) 2022-09-16
JP2023512729A (ja) 2023-03-28

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