BR112022014849A2 - Métodos de tratamento de um tumor sólido, métodos para induzir a proliferação de células t, para induzir a proliferação de células nk e para induzir a produção de ifny - Google Patents

Métodos de tratamento de um tumor sólido, métodos para induzir a proliferação de células t, para induzir a proliferação de células nk e para induzir a produção de ifny

Info

Publication number
BR112022014849A2
BR112022014849A2 BR112022014849A BR112022014849A BR112022014849A2 BR 112022014849 A2 BR112022014849 A2 BR 112022014849A2 BR 112022014849 A BR112022014849 A BR 112022014849A BR 112022014849 A BR112022014849 A BR 112022014849A BR 112022014849 A2 BR112022014849 A2 BR 112022014849A2
Authority
BR
Brazil
Prior art keywords
induce
methods
cell proliferation
treatment
solid tumor
Prior art date
Application number
BR112022014849A
Other languages
English (en)
Portuguese (pt)
Inventor
Joachim Paul Ungewickell Alexander
Shivva Vittal
Yadav Rajbharan
Original Assignee
Genentech Inc
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Xencor Inc filed Critical Genentech Inc
Publication of BR112022014849A2 publication Critical patent/BR112022014849A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
BR112022014849A 2020-01-28 2021-01-28 Métodos de tratamento de um tumor sólido, métodos para induzir a proliferação de células t, para induzir a proliferação de células nk e para induzir a produção de ifny BR112022014849A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062966976P 2020-01-28 2020-01-28
PCT/US2021/015552 WO2021155042A1 (en) 2020-01-28 2021-01-28 Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of cancer

Publications (1)

Publication Number Publication Date
BR112022014849A2 true BR112022014849A2 (pt) 2022-10-11

Family

ID=74672461

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022014849A BR112022014849A2 (pt) 2020-01-28 2021-01-28 Métodos de tratamento de um tumor sólido, métodos para induzir a proliferação de células t, para induzir a proliferação de células nk e para induzir a produção de ifny

Country Status (12)

Country Link
US (1) US20230149509A1 (https=)
EP (1) EP4096698A1 (https=)
JP (2) JP2023511439A (https=)
KR (1) KR20220132598A (https=)
CN (1) CN115397456A (https=)
AU (1) AU2021213767A1 (https=)
BR (1) BR112022014849A2 (https=)
CA (1) CA3165460A1 (https=)
IL (1) IL294944A (https=)
MX (1) MX2022009100A (https=)
TW (1) TW202136318A (https=)
WO (1) WO2021155042A1 (https=)

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WO2019204646A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
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TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
EP4376869A1 (en) * 2021-07-28 2024-06-05 Genentech, Inc. Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers
EP4380596A1 (en) * 2021-08-04 2024-06-12 Genentech, Inc. Il15/il15r alpha heterodimeric fc-fusion proteins for the expansion of nk cells in the treatment of solid tumours
CN119923274A (zh) 2022-07-07 2025-05-02 基因泰克公司 IL15/IL15Rα异二聚体Fc融合蛋白与FcRH5xCD3双特异性抗体的组合用于治疗血癌
CN119790066A (zh) * 2022-08-05 2025-04-08 舒泰神(加州)生物科技有限公司 一种新型IL-15R alpha Fc融合蛋白及其使用
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WO2025233861A1 (en) * 2024-05-08 2025-11-13 Suzhou Forlong Biotechnology Co., Ltd. Long-acting il-15 agonist for treating tumor
WO2025252840A1 (en) 2024-06-04 2025-12-11 Technische Universitaet Muenchen, In Vertretung Des Freistaates Bayern Half-life modulation by a tag comprising at least one constant domain of an immunoglobulin light chain

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Also Published As

Publication number Publication date
EP4096698A1 (en) 2022-12-07
AU2021213767A1 (en) 2022-07-28
MX2022009100A (es) 2022-08-18
WO2021155042A1 (en) 2021-08-05
JP2026062701A (ja) 2026-04-10
CA3165460A1 (en) 2021-08-05
IL294944A (en) 2022-09-01
CN115397456A (zh) 2022-11-25
JP2023511439A (ja) 2023-03-17
US20230149509A1 (en) 2023-05-18
TW202136318A (zh) 2021-10-01
KR20220132598A (ko) 2022-09-30

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