BR112022013573A2 - Vacinas universais contra imunógenos de organismos patogênicos que conferem proteção específica para organismo e entre grupos - Google Patents

Vacinas universais contra imunógenos de organismos patogênicos que conferem proteção específica para organismo e entre grupos

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Publication number
BR112022013573A2
BR112022013573A2 BR112022013573A BR112022013573A BR112022013573A2 BR 112022013573 A2 BR112022013573 A2 BR 112022013573A2 BR 112022013573 A BR112022013573 A BR 112022013573A BR 112022013573 A BR112022013573 A BR 112022013573A BR 112022013573 A2 BR112022013573 A2 BR 112022013573A2
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Prior art keywords
organisms
vaccines against
immugens
groups
provide specific
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BR112022013573A
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English (en)
Inventor
Qing Xu Jian
Yan Zhang Xiao
Wang Jing
Yan Zhu Ling
W Lubit Beverly
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Cn Usa Biotech Holdings Inc
Qing Xu Jian
Yan Zhang Xiao
Wang Jing
Yan Zhu Ling
W Lubit Beverly
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Application filed by Cn Usa Biotech Holdings Inc, Qing Xu Jian, Yan Zhang Xiao, Wang Jing, Yan Zhu Ling, W Lubit Beverly filed Critical Cn Usa Biotech Holdings Inc
Publication of BR112022013573A2 publication Critical patent/BR112022013573A2/pt

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • C12N2760/00011—Details
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS. A presente invenção refere-se, em parte, a uma plataforma com base em vetor de estimulação e reforço para desenvolver vacinas contra patógenos que são adaptadas para provocar uma ampla resposta de células T que têm como alvo epítopos virais conservados. As vacinas universais são preparadas contra um imunógeno de um organismo patogênico infeccioso selecionado a partir de um vírus, uma bactéria, um fungo ou um protozoário que compreende pelo menos um polinucleotídeo de ácido ribonucleico (RNA) que compreende um quadro de leitura aberta que codifica pelo menos um antígeno polipeptídico ou um fragmento imunogênico do mesmo, em que o antígeno polipeptídico, ou fragmento imunogênico do mesmo, compreende uma proteína interna conservada que é enriquecida em antígenos de reconhecimento de células T CD8(mais elevado). A eficácia da plataforma de estimulação e reforço é testada em um modelo de camundongo humanizado que compreende um sistema imune humano totalmente funcional.
BR112022013573A 2018-09-11 2020-12-18 Vacinas universais contra imunógenos de organismos patogênicos que conferem proteção específica para organismo e entre grupos BR112022013573A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2018/105020 WO2020051766A1 (zh) 2018-09-11 2018-09-11 一种广谱抗流感疫苗免疫原及其应用
US16/737,546 US11471523B2 (en) 2018-09-11 2020-01-08 Universal vaccines against immunogens of pathogenic organisms that provide organism-specific and cross-group protection
PCT/US2020/066059 WO2021141758A1 (en) 2018-09-11 2020-12-18 Universal vaccines against immunogens of pathogenic organisms that provide organism-specific and cross-group protection

Publications (1)

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BR112022013573A2 true BR112022013573A2 (pt) 2022-09-13

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Country Status (7)

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US (3) US20220118077A1 (pt)
EP (2) EP3851120A4 (pt)
JP (3) JP7320601B2 (pt)
CN (2) CN111315407B (pt)
AU (1) AU2020421142A1 (pt)
BR (1) BR112022013573A2 (pt)
WO (2) WO2020051766A1 (pt)

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