BR112022001710A2 - Moléculas mhc de classe ii e métodos de uso das mesmas - Google Patents
Moléculas mhc de classe ii e métodos de uso das mesmasInfo
- Publication number
- BR112022001710A2 BR112022001710A2 BR112022001710A BR112022001710A BR112022001710A2 BR 112022001710 A2 BR112022001710 A2 BR 112022001710A2 BR 112022001710 A BR112022001710 A BR 112022001710A BR 112022001710 A BR112022001710 A BR 112022001710A BR 112022001710 A2 BR112022001710 A2 BR 112022001710A2
- Authority
- BR
- Brazil
- Prior art keywords
- class
- amino acid
- methods
- molecules
- hla
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70539—MHC-molecules, e.g. HLA-molecules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
moléculas mhc classe ii e métodos de uso das mesmas. a presente invenção refere-se a moléculas hla de classe ii tendo uma afinidade maior para cd4 do que as moléculas hla de classe ii que ocorrem naturalmente. em certos aspectos, a molécula hla de classe ii compreende uma cadeia dq beta tendo (i) um aminoácido que não leucina em uma posição correspondente ao resíduo de aminoácido 114 da seq id no: 1, (ii) um aminoácido que não a valina em uma posição correspondente ao resíduo de aminoácido 143 da seq id no: 1, (iii) ou ambos (i) e (ii). certos aspectos da presente invenção referem-se a moléculas de ácido nucleico que codificam as moléculas hla de classe ii, vetores compreendendo a molécula de ácido nucleico, células que compreendem as mesmas, e métodos de uso das mesmas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962880501P | 2019-07-30 | 2019-07-30 | |
US202063029114P | 2020-05-22 | 2020-05-22 | |
PCT/IB2020/057173 WO2021019473A1 (en) | 2019-07-30 | 2020-07-29 | Mhc class ii molecules and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022001710A2 true BR112022001710A2 (pt) | 2022-06-21 |
Family
ID=74228599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022001710A BR112022001710A2 (pt) | 2019-07-30 | 2020-07-29 | Moléculas mhc de classe ii e métodos de uso das mesmas |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220275051A1 (pt) |
EP (1) | EP4004034A4 (pt) |
JP (1) | JP2022542447A (pt) |
KR (1) | KR20220052943A (pt) |
CN (1) | CN114450302A (pt) |
AU (1) | AU2020322246A1 (pt) |
BR (1) | BR112022001710A2 (pt) |
CA (1) | CA3146292A1 (pt) |
IL (1) | IL290223A (pt) |
MX (1) | MX2022001210A (pt) |
TW (1) | TW202116797A (pt) |
WO (1) | WO2021019473A1 (pt) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100364611C (zh) * | 1996-11-13 | 2008-01-30 | 明治乳业株式会社 | 肽基免疫治疗剂 |
AU2002240057A1 (en) * | 2001-01-24 | 2002-08-06 | President And Fellows Of Harvard College | Therapeutic peptides for demyelinating conditions |
GB0107628D0 (en) * | 2001-03-27 | 2001-05-16 | Avidex Ltd | Substances |
EP1403283A4 (en) * | 2001-06-12 | 2006-05-10 | Greenpeptide Co Ltd | TUMOR ANTIGENS |
EP1696027A4 (en) * | 2003-11-05 | 2008-05-14 | Int Inst Cancer Immunology Inc | ANTIGEN PEPTIDE BINDING TO ORIGINAL HLA-DR WT1 |
CN101001868A (zh) * | 2004-06-17 | 2007-07-18 | 曼康公司 | 表位类似物 |
US20060084116A1 (en) * | 2004-09-13 | 2006-04-20 | Xencor, Inc. | Analysis of MHC-peptide binding interactions |
US20060228758A1 (en) * | 2004-09-13 | 2006-10-12 | Xencor, Inc. | Analysis of MHC-peptide binding interactions |
WO2008109075A2 (en) * | 2007-03-05 | 2008-09-12 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to ctla-4 antagonists |
WO2016135363A1 (es) * | 2015-02-23 | 2016-09-01 | Servicio Andaluz De Salud | Método de obtención de datos útiles para predecir o pronosticar la transmisión vertical, la cronificación y/o el aclaramiento del virus de la hepatitis c |
US11396536B2 (en) * | 2016-04-27 | 2022-07-26 | University Health Network | Peptide-HLA complexes and methods of producing same |
CN111712254A (zh) * | 2017-12-23 | 2020-09-25 | 鲁比厄斯治疗法股份有限公司 | 人工抗原呈递细胞和使用方法 |
-
2020
- 2020-07-29 BR BR112022001710A patent/BR112022001710A2/pt unknown
- 2020-07-29 WO PCT/IB2020/057173 patent/WO2021019473A1/en active Application Filing
- 2020-07-29 CA CA3146292A patent/CA3146292A1/en active Pending
- 2020-07-29 US US17/631,821 patent/US20220275051A1/en active Pending
- 2020-07-29 EP EP20848105.1A patent/EP4004034A4/en active Pending
- 2020-07-29 CN CN202080067823.XA patent/CN114450302A/zh active Pending
- 2020-07-29 JP JP2022506467A patent/JP2022542447A/ja active Pending
- 2020-07-29 AU AU2020322246A patent/AU2020322246A1/en active Pending
- 2020-07-29 TW TW109125665A patent/TW202116797A/zh unknown
- 2020-07-29 MX MX2022001210A patent/MX2022001210A/es unknown
- 2020-07-29 KR KR1020227006943A patent/KR20220052943A/ko unknown
-
2022
- 2022-01-30 IL IL290223A patent/IL290223A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP4004034A1 (en) | 2022-06-01 |
IL290223A (en) | 2022-03-01 |
MX2022001210A (es) | 2022-05-03 |
KR20220052943A (ko) | 2022-04-28 |
US20220275051A1 (en) | 2022-09-01 |
TW202116797A (zh) | 2021-05-01 |
CA3146292A1 (en) | 2021-02-04 |
AU2020322246A1 (en) | 2022-03-03 |
WO2021019473A1 (en) | 2021-02-04 |
CN114450302A (zh) | 2022-05-06 |
JP2022542447A (ja) | 2022-10-03 |
EP4004034A4 (en) | 2023-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018000477A2 (pt) | proteína de ligação de imunoglobulina não natural, composição, uso da proteína de ligação de ig não natural, método de purificação de afinidade de imunoglobulinas, método de geração de uma proteína de ligação de imunoglobulina não natural, molécula de ácido nucleico, vetor, célula hospedeira ou um hospedeiro não humano, e método para a produção de uma proteína de ligação de imunoglobulina não natural | |
CY1122576T1 (el) | Ανθρωπινα αντισωματα που δεσμευουν το γονιδιο-3 ενεργοποιησης λεμφοκυτταρων (leg-3), και χρησεις εξ' αυτων | |
WO2022109339A8 (en) | Use of dextramer in single cell analysis | |
AR060583A1 (es) | Anticuerpo de c- kit humanizado | |
BRPI0620946A8 (pt) | anticorpo il-23p19 isolado, composição, método in vitro, artigo de fabricação, molécula e vetor de ácido nucleico, célula hospedeira procariótica | |
BR112012017124B8 (pt) | método para produzir e para purificar um multímero polipeptídico | |
BRPI0515649B8 (pt) | Processo para preparação de composições de anticorpo monoclonal altamente concentradas | |
BRPI0612273C1 (pt) | anticorpo de ligação a il-1 beta ou fragmento de ligação a il-1 beta do mesmo, ácido nucleico, vetor, e, composição | |
AR083295A1 (es) | Metodo para activar celulas t auxiliares | |
WO2020123425A3 (en) | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses | |
BR112021018734A2 (pt) | Receptores de células t e métodos de uso destes | |
BR112012011598A2 (pt) | polipeptídeos de haemophilus parasuis e métodos de uso | |
ECSP23024373A (es) | Composición para inmunoterapia | |
BR112012024232A2 (pt) | aptâmero para ngf e uso do mesmo. | |
BR112023002724A2 (pt) | Neoantígenos ras e seus usos | |
AR051928A1 (es) | Peptidos y derivados tipo apl de la hsp60 y composiciones farmaceuticas | |
BR112022001710A2 (pt) | Moléculas mhc de classe ii e métodos de uso das mesmas | |
BR112022001704A2 (pt) | Moléculas mhc de classe ii e métodos de uso das mesmas | |
BR112022001702A2 (pt) | Moléculas mhc classe ii e métodos de uso das mesmas | |
MX2021010837A (es) | Receptores en linfocitos t de la proteina 1 de tumor de wilms (wt1) de alta avidez. | |
BR112021012240A2 (pt) | Terapia de gene-célula-tronco hematopoiética para síndrome wiskott-aldrich | |
BR0313083A (pt) | moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas | |
BR112022012057A2 (pt) | Novos métodos de entrega celular | |
MX2022001204A (es) | Métodos de identificación de receptores de linfocitos t. | |
BR112013013158B1 (pt) | composições farmacêutica para uso no tratamento de câncer, métodos in vitro para induzir célula apresentadora de antígeno, bem como vetor, e uso |