BR112012024232A2 - aptâmero para ngf e uso do mesmo. - Google Patents

aptâmero para ngf e uso do mesmo.

Info

Publication number
BR112012024232A2
BR112012024232A2 BR112012024232A BR112012024232A BR112012024232A2 BR 112012024232 A2 BR112012024232 A2 BR 112012024232A2 BR 112012024232 A BR112012024232 A BR 112012024232A BR 112012024232 A BR112012024232 A BR 112012024232A BR 112012024232 A2 BR112012024232 A2 BR 112012024232A2
Authority
BR
Brazil
Prior art keywords
ngf
aptitude
aptamer
ugaaaraaacc
cgaamraaacu
Prior art date
Application number
BR112012024232A
Other languages
English (en)
Other versions
BR112012024232A8 (pt
Inventor
Hisanao Hiramatsu
Ling Jin
Yoshikazu Nakamura
Original Assignee
Ribomic Inc
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribomic Inc, Shionogi & Co filed Critical Ribomic Inc
Publication of BR112012024232A2 publication Critical patent/BR112012024232A2/pt
Publication of BR112012024232A8 publication Critical patent/BR112012024232A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

aptâmero para ngf e uso do mesmo. a presente invenção refere-se a um aptâmero de maior qualidade tendo uma atividade de ligação ao ngf. um aptâmero que se liga ao ngf, o qual satisfaz (1) e (2) a seguir: (1) contém a sequência representada por ugaaaraaacc (seq id no:64) ou cgaamraaacu (seg id no:65) e (2) tem um comprimento de base de não mais do que 73.
BR112012024232A 2010-03-24 2011-03-24 "aptâmero de 73 nucleotídeos ou menos, complexo, composição farmacêutica e medicamento anti-dor" BR112012024232A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010068546 2010-03-24
PCT/JP2011/057105 WO2011118682A1 (ja) 2010-03-24 2011-03-24 Ｎｇｆに対するアプタマー及びその使用

Publications (2)

Publication Number Publication Date
BR112012024232A2 true BR112012024232A2 (pt) 2016-11-29
BR112012024232A8 BR112012024232A8 (pt) 2018-02-06

Family

ID=44673231

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012024232A BR112012024232A8 (pt) 2010-03-24 2011-03-24 "aptâmero de 73 nucleotídeos ou menos, complexo, composição farmacêutica e medicamento anti-dor"

Country Status (17)

Country Link
US (1) US9175292B2 (pt)
EP (1) EP2551346B1 (pt)
JP (1) JP5027956B2 (pt)
KR (1) KR101806429B1 (pt)
CN (1) CN102844436B (pt)
AU (1) AU2011230388B2 (pt)
BR (1) BR112012024232A8 (pt)
CA (1) CA2794199C (pt)
DK (1) DK2551346T3 (pt)
ES (1) ES2567270T3 (pt)
HR (1) HRP20160378T1 (pt)
HU (1) HUE028939T2 (pt)
IN (1) IN2012KN03036A (pt)
PL (1) PL2551346T3 (pt)
SI (1) SI2551346T1 (pt)
TW (1) TWI500425B (pt)
WO (1) WO2011118682A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020003168A (es) 2010-04-12 2022-05-31 Somalogic Inc Pirimidinas modificadas en la posicion 5 y su uso.
CA2850346C (en) * 2011-09-28 2020-02-18 Ribomic Inc. Ngf aptamer and application thereof
KR20160138215A (ko) * 2014-03-27 2016-12-02 가부시키가이샤 리보믹 오토탁신에 결합하여 오토탁신의 생리 활성을 저해하는 압타머 및 그의 이용
CN105301262B (zh) * 2015-11-29 2016-12-21 内蒙古华大金浦生物科技有限公司 一种用于人脑疾病检测的试剂盒
CN108368509B (zh) * 2015-12-04 2022-03-22 全药工业株式会社 改善了血中滞留性的抗il－17适体
WO2019210194A1 (en) * 2018-04-26 2019-10-31 Vitrisa Therapeutics, Inc. Pegylated compositions for ocular use, and methods thereof
CN114540349A (zh) * 2020-11-27 2022-05-27 中国科学院分子细胞科学卓越创新中心 结合yb-1蛋白的核酸分子

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
JP2763958B2 (ja) 1990-06-11 1998-06-11 ネクスター ファーマスーティカルズ，インコーポレイテッド 核酸リガンド
WO1994008050A1 (en) 1992-09-29 1994-04-14 Nexagen, Inc. Nucleic acid ligands and methods for producing the same
JPH09502354A (ja) 1993-09-08 1997-03-11 ネクスター ファーマスーティカルズ，インコーポレイテッド 核酸リガンドと、同リガンドを製造するための改良された方法
US20030054360A1 (en) 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
AU2003217379A1 (en) 2002-02-15 2003-09-09 Somalogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
DE60335957D1 (de) 2002-10-08 2011-03-17 Rinat Neuroscience Corp Verfahren zur behandlung von postoperativen schmerzen durch verabreichung eines antikörpers gegen nervenwachstumsfaktor und diesen enthaltende zusammensetzungen
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7255860B2 (en) 2002-10-08 2007-08-14 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
EP1594441B1 (en) 2003-02-19 2010-12-15 Rinat Neuroscience Corp. Method for treating pain by administering a nerve growth factor antagonist and an nsaid and composition containing the same
KR20060135060A (ko) 2004-04-07 2006-12-28 리나트 뉴로사이언스 코퍼레이션 신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법
KR101516024B1 (ko) 2006-11-14 2015-04-29 가부시키가이샤 리보믹 미드카인에 대한 압타머 및 그 사용
CA2730796C (en) * 2008-07-14 2015-11-03 The University Of Tokyo Aptamer against il-17 and use thereof
ES2543222T3 (es) * 2008-09-24 2015-08-17 Ribomic Inc. Aptámero para NGF y uso del mismo

Also Published As

Publication number Publication date
AU2011230388A2 (en) 2012-11-15
DK2551346T3 (en) 2016-04-11
CA2794199C (en) 2017-11-14
WO2011118682A1 (ja) 2011-09-29
CN102844436A (zh) 2012-12-26
AU2011230388B2 (en) 2016-09-08
CA2794199A1 (en) 2011-09-29
CN102844436B (zh) 2015-11-25
ES2567270T3 (es) 2016-04-21
JP5027956B2 (ja) 2012-09-19
IN2012KN03036A (pt) 2015-04-10
EP2551346B1 (en) 2016-01-27
SI2551346T1 (sl) 2016-05-31
JPWO2011118682A1 (ja) 2013-07-04
HRP20160378T1 (hr) 2016-05-20
HUE028939T2 (en) 2017-01-30
US9175292B2 (en) 2015-11-03
US20130052176A1 (en) 2013-02-28
AU2011230388A1 (en) 2012-11-01
TW201201817A (en) 2012-01-16
EP2551346A4 (en) 2014-04-30
KR20130028917A (ko) 2013-03-20
BR112012024232A8 (pt) 2018-02-06
KR101806429B1 (ko) 2017-12-07
PL2551346T3 (pl) 2016-07-29
TWI500425B (zh) 2015-09-21
EP2551346A1 (en) 2013-01-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: RIBOMIC INC. (JP)

B25A Requested transfer of rights approved

Owner name: RIBOMIC INC. (JP) , FUJIMOTO PHARMACEUTICAL CORPOR

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time