BR112021022431A2 - Moduladores de molécula pequena de metabolismo bacteriano intestinal do ácido biliar - Google Patents
Moduladores de molécula pequena de metabolismo bacteriano intestinal do ácido biliarInfo
- Publication number
- BR112021022431A2 BR112021022431A2 BR112021022431A BR112021022431A BR112021022431A2 BR 112021022431 A2 BR112021022431 A2 BR 112021022431A2 BR 112021022431 A BR112021022431 A BR 112021022431A BR 112021022431 A BR112021022431 A BR 112021022431A BR 112021022431 A2 BR112021022431 A2 BR 112021022431A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- hepatitis
- cancer
- liver
- small molecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962846457P | 2019-05-10 | 2019-05-10 | |
| US202062962048P | 2020-01-16 | 2020-01-16 | |
| PCT/US2020/032016 WO2020231776A1 (en) | 2019-05-10 | 2020-05-08 | Small molecule modulators of gut bacterial bile acid metabolism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021022431A2 true BR112021022431A2 (pt) | 2022-05-24 |
Family
ID=73289482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021022431A BR112021022431A2 (pt) | 2019-05-10 | 2020-05-08 | Moduladores de molécula pequena de metabolismo bacteriano intestinal do ácido biliar |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12577273B2 (enExample) |
| EP (1) | EP3965748A4 (enExample) |
| JP (2) | JP7769176B2 (enExample) |
| KR (2) | KR102893599B1 (enExample) |
| CN (2) | CN120757601A (enExample) |
| AU (2) | AU2020274319B2 (enExample) |
| BR (1) | BR112021022431A2 (enExample) |
| WO (1) | WO2020231776A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| WO2020117945A1 (en) | 2018-12-04 | 2020-06-11 | President And Fellows Of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| IT202200008861A1 (it) * | 2022-05-03 | 2023-11-03 | Chemelectiva S R L | Processo per la preparazione di derivati dell’acido colico. |
| CN115337312B (zh) * | 2022-08-19 | 2025-06-03 | 金熊药业(珠海横琴)有限公司 | 胆酸复合物及其制备方法和应用 |
| CN117801047B (zh) * | 2023-01-19 | 2024-12-20 | 北京华睿鼎信科技有限公司 | 神经甾体衍生物及其用途 |
| CN118021751A (zh) * | 2024-01-15 | 2024-05-14 | 中国人民解放军总医院第五医学中心 | 一种免疫调节的口服微球、制备方法及应用 |
| US20250299939A1 (en) * | 2024-03-25 | 2025-09-25 | Thermo Finnigan Llc | Calibration of an Image Current-based Mass Analyzer Included in a Mass Spectrometer |
| WO2025235593A1 (en) * | 2024-05-09 | 2025-11-13 | The Regents Of The University Of California | Treatment for obstructive sleep apnea-associated atherosclerosis |
| CN119565571B (zh) * | 2024-10-17 | 2025-11-21 | 湖北省食品质量安全监督检验研究院(湖北食品、保健食品、化妆品质量安全检测中心) | 一种不溶性吸附除氟复合材料颗粒及其制备方法、应用和除氟包 |
| CN119950519B (zh) * | 2025-01-07 | 2025-11-21 | 山东省海洋科学研究院(青岛国家海洋科学研究中心) | 奥贝胆酸在对虾急性肝胰腺坏死病防治中的应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1360354A (en) | 1972-01-20 | 1974-07-17 | Union International Co Ltd | Chenodeoxycholic acid |
| JPS5826360B2 (ja) | 1974-08-23 | 1983-06-02 | エ−ザイ カブシキガイシヤ | グリコケノデオキシコ−ルサンノ セイホウ |
| IT1221734B (it) | 1983-02-24 | 1990-07-12 | Schiena Michele Giuseppe Di | Ursodesossicolico solfato acido sale sodico |
| US5210272A (en) | 1990-02-16 | 1993-05-11 | Prototek, Inc. | Process for forming a fluoromethyl ketone |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| NZ245504A (en) | 1991-12-20 | 1995-08-28 | Hoechst Ag | Bile acid derivatives containing an ethylenically unsaturated grouping |
| IT1255450B (it) | 1992-06-30 | 1995-10-31 | Montefarmaco Spa | Uso di acidi biliari come agenti antivirali |
| EP0624593A3 (de) | 1993-05-08 | 1995-06-07 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel. |
| IT1270853B (it) * | 1993-05-20 | 1997-05-13 | Sanofi Elf | Procedimento per la preparazione di derivati taurocolanici |
| CN1132586C (zh) | 1993-09-09 | 2003-12-31 | 罗拉斯医疗公司 | 来自胆汁的免疫调节组合物、其制备方法及其用途 |
| US5695738A (en) | 1995-06-15 | 1997-12-09 | Glycomed Incorporated | Steroidal C-glycosides |
| US5763435A (en) | 1995-11-21 | 1998-06-09 | Children's Hospital Medical Center | Sulfate conjugates of ursodeoxycholic acid, and their beneficial use in inflammatory disorders |
| CA2206047A1 (en) | 1997-05-23 | 1998-11-23 | Romeo Rang (Deceased) | Immunomodulating compositions for the treatment of viral disorders |
| DE19849722A1 (de) | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| JP2002543216A (ja) | 1999-04-30 | 2002-12-17 | アーチ ディベロップメント コーポレイション | ステロイド誘導体 |
| DE19941764A1 (de) | 1999-09-02 | 2001-03-15 | Aventis Pharma Gmbh | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
| WO2001021642A1 (de) | 1999-09-22 | 2001-03-29 | Aventis Pharma Deutschland Gmbh | 4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung |
| US6451355B1 (en) | 2000-07-17 | 2002-09-17 | Howard M. Reisner | Composition to treat diabetes |
| ITTO20020102A1 (it) | 2002-02-06 | 2003-08-06 | Abc Ist Biolog Chem Spa | Procedimento per la preparazione dell'acido ursodesossicolico disolfato e suoi sali farmaceuticamente accettabili. |
| ITMI20030822A1 (it) | 2003-04-18 | 2004-10-19 | Erregierre Spa | Processo per la preparazione dell'acido ursodesossicolico |
| US20070032464A1 (en) | 2004-10-08 | 2007-02-08 | Shutsung Liao | Methods of treating cancers |
| UA90718C2 (ru) | 2005-05-10 | 2010-05-25 | Лаборатуар Фурнье С.А. | Новое применение агонистов печеночного рецептора х |
| US9295677B2 (en) | 2008-02-26 | 2016-03-29 | Qing Bile Therapeutics Inc. | Polyhydroxylated bile acids for treatment of biliary disorders |
| US8771668B2 (en) | 2008-04-09 | 2014-07-08 | Cornell University | Commensal bacteria as signal mediators within a mammalian host |
| US8318663B2 (en) | 2008-11-26 | 2012-11-27 | Satiogen Pharmaceuticals, Inc. | Methods of treating diabetes and/or obesity using an enteroendocrine peptide secretion enhancing agent |
| IT1393095B1 (it) | 2009-02-19 | 2012-04-11 | Prodotti Chimici Alimentari | Processo per la sintesi del sale disodico dell'acido ursodesossicolico 3,7-disolfato. |
| JP2013500986A (ja) | 2009-07-29 | 2013-01-10 | ザ・ユニバーシティ・オブ・シカゴ | 肝臓ｘ受容体アゴニスト |
| CN102712672B (zh) | 2009-08-25 | 2016-09-14 | 胆清医药有限公司 | 用于治疗胆疾病的多羟基化胆汁酸 |
| KR20140030171A (ko) | 2011-05-02 | 2014-03-11 | 바이오키어 인코포레이티드 | 당뇨병 치료를 위한 조성물 및 치료법 |
| JP2015506349A (ja) | 2011-12-21 | 2015-03-02 | アルデリックス， インコーポレイテッド | 非全身性ｔｇｒ５アゴニスト |
| WO2013113680A1 (en) | 2012-02-03 | 2013-08-08 | Aarhus Universitet | Radiolabeled bile acids and bile acid derivatives |
| US20140206657A1 (en) * | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
| US9580459B2 (en) | 2013-04-26 | 2017-02-28 | Metselex, Inc. | Water-soluble ursodeoxycholic acid prodrugs |
| ES2748692T3 (es) | 2014-11-19 | 2020-03-17 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides |
| WO2016100619A2 (en) | 2014-12-17 | 2016-06-23 | Rgenix, Inc. | Treatment and diagnosis of cancer |
| PE20171138A1 (es) | 2014-12-23 | 2017-08-09 | 4D Pharma Res Ltd | Modulacion inmunitaria |
| TW201704251A (zh) * | 2015-04-29 | 2017-02-01 | 正大天晴藥業集團股份有限公司 | 鵝去氧膽酸衍生物 |
| TW201700447A (zh) | 2015-06-19 | 2017-01-01 | 英特賽普醫藥品公司 | Tgr5調控劑及其用法 |
| TWI618714B (zh) | 2015-08-27 | 2018-03-21 | 中央研究院 | 涎酸轉移酶抑制劑及其用途 |
| CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| US20200262865A1 (en) * | 2016-02-15 | 2020-08-20 | Alexander Khoruts | Compositions and methods for treating clostridium associated diseases |
| US20170233431A1 (en) * | 2016-02-17 | 2017-08-17 | City Of Hope | Bile acid derivatives and methods for synthesis and use |
| RU2665685C1 (ru) | 2017-09-18 | 2018-09-04 | Общество с ограниченной ответственностью "МДК Медика" | Способ получения алкиламмонийных солей алкилсерных кислот |
| WO2019075365A1 (en) | 2017-10-13 | 2019-04-18 | Battelle Memorial Institute | PROBE FOR BSH (BILE SALT HYDROLASE), ITS PREPARATION AND USE METHOD |
| WO2019191637A1 (en) | 2018-03-29 | 2019-10-03 | Metselex, Inc. | Compositions for the prevention and treatment of parkinson's disease |
| US12186329B2 (en) | 2018-08-23 | 2025-01-07 | President And Fellows Of Harvard College | Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes |
| WO2020117945A1 (en) | 2018-12-04 | 2020-06-11 | President And Fellows Of Harvard College | Synthetic derivatives of cholic acid 7-sulfate and uses thereof |
| WO2021226447A1 (en) | 2020-05-08 | 2021-11-11 | President And Fellows Of Harvard College | Methods for inducing bile acid sulfotransferase sult2a for treating metabolic disorders |
-
2020
- 2020-05-08 CN CN202510563299.XA patent/CN120757601A/zh active Pending
- 2020-05-08 KR KR1020217040058A patent/KR102893599B1/ko active Active
- 2020-05-08 JP JP2021567062A patent/JP7769176B2/ja active Active
- 2020-05-08 AU AU2020274319A patent/AU2020274319B2/en active Active
- 2020-05-08 US US17/610,037 patent/US12577273B2/en active Active
- 2020-05-08 BR BR112021022431A patent/BR112021022431A2/pt unknown
- 2020-05-08 KR KR1020257039741A patent/KR20250171471A/ko active Pending
- 2020-05-08 WO PCT/US2020/032016 patent/WO2020231776A1/en not_active Ceased
- 2020-05-08 CN CN202080050183.1A patent/CN114641280B/zh active Active
- 2020-05-08 EP EP20805532.7A patent/EP3965748A4/en active Pending
-
2025
- 2025-08-28 JP JP2025141993A patent/JP2026000925A/ja active Pending
-
2026
- 2026-05-09 AU AU2026203554A patent/AU2026203554A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN120757601A (zh) | 2025-10-10 |
| KR20250171471A (ko) | 2025-12-08 |
| AU2020274319B2 (en) | 2026-02-12 |
| EP3965748A1 (en) | 2022-03-16 |
| JP2026000925A (ja) | 2026-01-06 |
| CN114641280A (zh) | 2022-06-17 |
| JP7769176B2 (ja) | 2025-11-13 |
| CA3137308A1 (en) | 2020-11-19 |
| EP3965748A4 (en) | 2023-02-01 |
| CN114641280B (zh) | 2025-05-27 |
| KR20220007112A (ko) | 2022-01-18 |
| KR102893599B1 (ko) | 2025-12-01 |
| AU2020274319A1 (en) | 2021-12-02 |
| WO2020231776A8 (en) | 2021-05-14 |
| WO2020231776A1 (en) | 2020-11-19 |
| US12577273B2 (en) | 2026-03-17 |
| AU2026203554A1 (en) | 2026-05-28 |
| US20220204548A1 (en) | 2022-06-30 |
| JP2022533069A (ja) | 2022-07-21 |
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