BR112021021809A2 - Terapias de combinação compreendendo os inibidores de apremilast e tyk2 - Google Patents
Terapias de combinação compreendendo os inibidores de apremilast e tyk2Info
- Publication number
- BR112021021809A2 BR112021021809A2 BR112021021809A BR112021021809A BR112021021809A2 BR 112021021809 A2 BR112021021809 A2 BR 112021021809A2 BR 112021021809 A BR112021021809 A BR 112021021809A BR 112021021809 A BR112021021809 A BR 112021021809A BR 112021021809 A2 BR112021021809 A2 BR 112021021809A2
- Authority
- BR
- Brazil
- Prior art keywords
- apremilast
- combination therapies
- tyk2
- tyk2 inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2019/029772 WO2020222773A1 (en) | 2019-04-30 | 2019-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021021809A2 true BR112021021809A2 (pt) | 2022-01-04 |
Family
ID=66476870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021021809A BR112021021809A2 (pt) | 2019-04-30 | 2019-04-30 | Terapias de combinação compreendendo os inibidores de apremilast e tyk2 |
| BR112021021826A BR112021021826A8 (pt) | 2019-04-30 | 2020-04-30 | Uso de apremilaste e um inibidor da tirosina quinase 2 no tratamento de uma doença ou um transtorno responsivo à inibição da fosfodiesterase tipo 4 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021021826A BR112021021826A8 (pt) | 2019-04-30 | 2020-04-30 | Uso de apremilaste e um inibidor da tirosina quinase 2 no tratamento de uma doença ou um transtorno responsivo à inibição da fosfodiesterase tipo 4 |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP3962475A1 (es) |
| JP (2) | JP2022537877A (es) |
| KR (2) | KR20220002488A (es) |
| CN (2) | CN114269336A (es) |
| AU (2) | AU2019443366A1 (es) |
| BR (2) | BR112021021809A2 (es) |
| CA (2) | CA3138473A1 (es) |
| CL (1) | CL2021002847A1 (es) |
| CO (2) | CO2021015622A2 (es) |
| IL (2) | IL287665A (es) |
| MA (1) | MA55799A (es) |
| MX (2) | MX2021013317A (es) |
| SG (2) | SG11202112043PA (es) |
| WO (2) | WO2020222773A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202112043PA (en) | 2019-04-30 | 2021-11-29 | Celgene Corp | Combination therapies comprising apremilast and tyk2 inhibitors |
| TW202246232A (zh) | 2021-02-19 | 2022-12-01 | 英商蘇多生物科學有限公司 | Ｔｙｋ２抑制劑及其用途 |
| AU2022350509A1 (en) * | 2021-09-23 | 2024-04-04 | Bristol-Myers Squibb Company | Methods of treating hair-loss disorders with tyk2 inhibitors |
| CA3236262A1 (en) | 2021-10-25 | 2023-05-04 | Isaac Marx | Tyk2 degraders and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962940B2 (en) * | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| US8367689B2 (en) * | 2009-05-06 | 2013-02-05 | Portola Pharmaceuticals, Inc. | Inhibitors of JAK |
| AU2011328237A1 (en) | 2010-11-09 | 2013-05-23 | Cellzome Limited | Pyridine compounds and aza analogues thereof as TYK2 inhibitors |
| WO2012149251A1 (en) * | 2011-04-28 | 2012-11-01 | Celgene Corporation | Methods and compositions using pde4 inhibitors for the treatment and management of autoimmune and inflammatory diseases |
| UA113750C2 (xx) | 2011-12-27 | 2017-03-10 | Склад (+)-2-$1-(3-етокси-4-метоксифеніл)-2-метансульфонілетил]-4-ацетиламіноізоіндолін-1,3-діону | |
| RU2627661C2 (ru) | 2012-01-10 | 2017-08-09 | Ф. Хоффманн-Ля Рош Аг | Соединения пиридазинамида и их применение в качестве ингибиторов тирозинкиназы селезенки (syk) |
| EP2832734A4 (en) | 2012-03-28 | 2015-08-26 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| US9296725B2 (en) | 2012-05-24 | 2016-03-29 | Cellzome Limited | Heterocyclyl pyrimidine analogues as TYK2 inhibitors |
| UY35126A (es) | 2012-11-08 | 2014-05-30 | Bristol Myers Squibb Co | Ojo es alfa |
| EA028052B1 (ru) * | 2012-11-08 | 2017-10-31 | Бристол-Майерс Сквибб Компани | АЛКИЛАМИДЗАМЕЩЁННЫЕ ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ, ПРИГОДНЫЕ ДЛЯ МОДУЛЯЦИИ IL-12, IL-23 И/ИЛИ IFNα |
| WO2014151180A1 (en) * | 2013-03-14 | 2014-09-25 | Celgene Corporation | Treatment of psoriatic arthritis using apremilast |
| EP3029031A4 (en) | 2013-07-30 | 2017-01-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2015032423A1 (en) | 2013-09-03 | 2015-03-12 | Sareum Limited | Pharmaceutical compounds |
| AR094537A1 (es) | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
| CN105992768B (zh) | 2013-12-10 | 2018-04-20 | 百时美施贵宝公司 | 用作IL‑12、IL‑23和/或IFNα响应的调节剂的咪唑并哒嗪化合物 |
| WO2015091584A1 (en) | 2013-12-18 | 2015-06-25 | F. Hoffmann-La Roche Ag | Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors |
| WO2015123453A1 (en) | 2014-02-14 | 2015-08-20 | Portola Pharmaceuticals, Inc. | Pyridazine compounds as jak inhibitors |
| ES2921874T3 (es) | 2014-02-28 | 2022-09-01 | Nimbus Lakshmi Inc | Inhibidores de TYK2 y usos de los mismos |
| EP3157520B1 (en) | 2014-06-23 | 2019-09-04 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
| US10092541B2 (en) * | 2014-08-15 | 2018-10-09 | Celgene Corporation | Methods for the treatment of diseases ameliorated by PDE4 inhibition using dosage titration of apremilast |
| NO2721710T3 (es) | 2014-08-21 | 2018-03-31 | ||
| WO2016047678A1 (ja) | 2014-09-25 | 2016-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| TWI788655B (zh) | 2015-02-27 | 2023-01-01 | 美商林伯士拉克許米公司 | 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途 |
| EP4327809A3 (en) | 2015-09-02 | 2024-04-17 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
| DK3419978T3 (da) | 2016-02-24 | 2020-06-02 | Pfizer | Pyrazolo[1,5-A]pyrazin-4-yl-derivater som JAK-hæmmere |
| ES2902995T3 (es) | 2016-10-07 | 2022-03-30 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| US10323036B2 (en) | 2016-10-14 | 2019-06-18 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| WO2018075937A1 (en) | 2016-10-21 | 2018-04-26 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| WO2018081488A1 (en) | 2016-10-28 | 2018-05-03 | Bristol-Myers Squibb Company | Heterobicyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| CN110191887B (zh) | 2016-11-17 | 2022-02-18 | 百时美施贵宝公司 | IL-12、IL-23和/或IFN-α的咪唑并哒嗪调节剂 |
| GB2562702B (en) | 2017-03-06 | 2022-05-18 | Linear Shaped Ltd | Frame and linear shaped charge |
| TW202321243A (zh) * | 2017-03-08 | 2023-06-01 | 美商林伯士拉克許米公司 | Ｔｙｋ２抑制劑之生產方法 |
| SG11202112043PA (en) | 2019-04-30 | 2021-11-29 | Celgene Corp | Combination therapies comprising apremilast and tyk2 inhibitors |
-
2019
- 2019-04-30 SG SG11202112043PA patent/SG11202112043PA/en unknown
- 2019-04-30 EP EP19723291.1A patent/EP3962475A1/en active Pending
- 2019-04-30 MX MX2021013317A patent/MX2021013317A/es unknown
- 2019-04-30 WO PCT/US2019/029772 patent/WO2020222773A1/en unknown
- 2019-04-30 KR KR1020217038511A patent/KR20220002488A/ko unknown
- 2019-04-30 CN CN201980097711.6A patent/CN114269336A/zh active Pending
- 2019-04-30 CA CA3138473A patent/CA3138473A1/en active Pending
- 2019-04-30 BR BR112021021809A patent/BR112021021809A2/pt unknown
- 2019-04-30 AU AU2019443366A patent/AU2019443366A1/en not_active Abandoned
- 2019-04-30 IL IL287665A patent/IL287665A/en unknown
- 2019-04-30 JP JP2021564469A patent/JP2022537877A/ja not_active Abandoned
-
2020
- 2020-04-30 WO PCT/US2020/030608 patent/WO2020223431A1/en unknown
- 2020-04-30 CA CA3138686A patent/CA3138686A1/en active Pending
- 2020-04-30 SG SG11202112018YA patent/SG11202112018YA/en unknown
- 2020-04-30 BR BR112021021826A patent/BR112021021826A8/pt unknown
- 2020-04-30 JP JP2021564471A patent/JP7453251B2/ja active Active
- 2020-04-30 CN CN202080046457.XA patent/CN114206333A/zh active Pending
- 2020-04-30 MA MA055799A patent/MA55799A/fr unknown
- 2020-04-30 EP EP20725978.9A patent/EP3962476A1/en active Pending
- 2020-04-30 MX MX2021013318A patent/MX2021013318A/es unknown
- 2020-04-30 AU AU2020266143A patent/AU2020266143A1/en active Pending
- 2020-04-30 KR KR1020217038512A patent/KR20220002489A/ko unknown
-
2021
- 2021-10-28 IL IL287670A patent/IL287670A/en unknown
- 2021-10-29 CL CL2021002847A patent/CL2021002847A1/es unknown
- 2021-11-22 CO CONC2021/0015622A patent/CO2021015622A2/es unknown
- 2021-11-22 CO CONC2021/0015614A patent/CO2021015614A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220002489A (ko) | 2022-01-06 |
| CL2021002847A1 (es) | 2022-07-22 |
| CA3138473A1 (en) | 2020-11-05 |
| JP7453251B2 (ja) | 2024-03-19 |
| IL287670A (en) | 2021-12-01 |
| EP3962476A1 (en) | 2022-03-09 |
| IL287665A (en) | 2022-07-01 |
| MA55799A (fr) | 2022-03-09 |
| AU2020266143A1 (en) | 2021-12-02 |
| CN114206333A (zh) | 2022-03-18 |
| JP2022537877A (ja) | 2022-08-31 |
| MX2021013317A (es) | 2022-01-18 |
| CA3138686A1 (en) | 2020-11-05 |
| MX2021013318A (es) | 2022-01-31 |
| SG11202112018YA (en) | 2021-11-29 |
| EP3962475A1 (en) | 2022-03-09 |
| AU2019443366A1 (en) | 2021-12-02 |
| WO2020222773A1 (en) | 2020-11-05 |
| KR20220002488A (ko) | 2022-01-06 |
| BR112021021826A2 (pt) | 2022-01-04 |
| CN114269336A (zh) | 2022-04-01 |
| BR112021021826A8 (pt) | 2022-06-21 |
| WO2020223431A1 (en) | 2020-11-05 |
| CO2021015614A2 (es) | 2021-12-10 |
| SG11202112043PA (en) | 2021-11-29 |
| JP2022537878A (ja) | 2022-08-31 |
| CO2021015622A2 (es) | 2022-02-28 |
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