SG11202112018YA - Combination therapies comprising apremilast and tyk2 inhibitors - Google Patents
Combination therapies comprising apremilast and tyk2 inhibitorsInfo
- Publication number
- SG11202112018YA SG11202112018YA SG11202112018YA SG11202112018YA SG11202112018YA SG 11202112018Y A SG11202112018Y A SG 11202112018YA SG 11202112018Y A SG11202112018Y A SG 11202112018YA SG 11202112018Y A SG11202112018Y A SG 11202112018YA SG 11202112018Y A SG11202112018Y A SG 11202112018YA
- Authority
- SG
- Singapore
- Prior art keywords
- apremilast
- combination therapies
- tyk2 inhibitors
- tyk2
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2019/029772 WO2020222773A1 (en) | 2019-04-30 | 2019-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
| PCT/US2020/030608 WO2020223431A1 (en) | 2019-04-30 | 2020-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202112018YA true SG11202112018YA (en) | 2021-11-29 |
Family
ID=66476870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202112043PA SG11202112043PA (en) | 2019-04-30 | 2019-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
| SG11202112018YA SG11202112018YA (en) | 2019-04-30 | 2020-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202112043PA SG11202112043PA (en) | 2019-04-30 | 2019-04-30 | Combination therapies comprising apremilast and tyk2 inhibitors |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP3962475A1 (en) |
| JP (2) | JP2022537877A (en) |
| KR (2) | KR20220002488A (en) |
| CN (2) | CN114269336A (en) |
| AU (2) | AU2019443366A1 (en) |
| BR (2) | BR112021021809A2 (en) |
| CA (2) | CA3138473A1 (en) |
| CL (1) | CL2021002847A1 (en) |
| CO (2) | CO2021015614A2 (en) |
| IL (2) | IL287665A (en) |
| MA (1) | MA55799A (en) |
| MX (2) | MX2021013317A (en) |
| SG (2) | SG11202112043PA (en) |
| WO (2) | WO2020222773A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019443366A1 (en) | 2019-04-30 | 2021-12-02 | Celgene Corporation | Combination therapies comprising apremilast and Tyk2 inhibitors |
| KR20230159421A (en) | 2021-02-19 | 2023-11-21 | 수도 바이오사이언시즈 리미티드 | TYK2 inhibitors and uses thereof |
| AU2022350509A1 (en) * | 2021-09-23 | 2024-04-04 | Bristol-Myers Squibb Company | Methods of treating hair-loss disorders with tyk2 inhibitors |
| WO2023076161A1 (en) | 2021-10-25 | 2023-05-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| WO2010129802A1 (en) * | 2009-05-06 | 2010-11-11 | Portola Pharmaceuticals, Inc. | Inhibitors of jak |
| CN103298794A (en) | 2010-11-09 | 2013-09-11 | 塞尔卓姆有限公司 | Pyridine compounds and aza analogues thereof as TYK2 inhibitors |
| JP6022548B2 (en) * | 2011-04-28 | 2016-11-09 | セルジーン コーポレイション | Methods and compositions for using PDE4 inhibitors in the treatment and management of autoimmune and inflammatory diseases |
| EP2797581B1 (en) * | 2011-12-27 | 2020-05-06 | Amgen (Europe) GmbH | Formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione |
| CA2860547A1 (en) | 2012-01-10 | 2013-07-18 | Johannes Cornelius Hermann | Pyridazine amide compounds and their use as syk inhibitors |
| WO2013146963A1 (en) | 2012-03-28 | 2013-10-03 | 武田薬品工業株式会社 | Heterocyclic compound |
| EP2855451B1 (en) | 2012-05-24 | 2017-10-04 | Cellzome Limited | Heterocyclyl pyrimidine analogues as tyk2 inhibitors |
| HRP20220766T1 (en) * | 2012-11-08 | 2022-09-16 | Bristol-Myers Squibb Company | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| WO2014074670A1 (en) | 2012-11-08 | 2014-05-15 | Bristol-Myers Squibb Company | ALKYL AMIDE-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL IN THE MODULATION OF IL-12, IL-23 AND/OR IFNα |
| CN105050624A (en) * | 2013-03-14 | 2015-11-11 | 细胞基因公司 | Treatment of psoriatic arthritis using apremilast |
| JPWO2015016206A1 (en) | 2013-07-30 | 2017-03-02 | 武田薬品工業株式会社 | Heterocyclic compounds |
| JP6239118B2 (en) | 2013-09-03 | 2017-11-29 | サリウム リミテッド | Pharmaceutical compounds |
| AR094537A1 (en) | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | PIRIDIL COMPOUNDS REPLACED WITH USEFUL ALQUILAMIDE AS MODULATORS OF THE ANSWERS OF IL-12, IL-23 AND / OR IFNa |
| JP6458038B2 (en) | 2013-12-10 | 2019-01-23 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and / or IFNα responses |
| WO2015091584A1 (en) | 2013-12-18 | 2015-06-25 | F. Hoffmann-La Roche Ag | Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors |
| US9834548B2 (en) * | 2014-02-14 | 2017-12-05 | Portola Pharmaceuticals, Inc. | Pyridazine compounds as JAK inhibitors |
| AU2015222865B2 (en) | 2014-02-28 | 2019-06-20 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
| EP3157520B1 (en) * | 2014-06-23 | 2019-09-04 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
| WO2016025686A1 (en) * | 2014-08-15 | 2016-02-18 | Celgene Corporation | Dosage titration of apremilast for the treatment of diseases ameliorated by pde4 inhibition |
| NO2721710T3 (en) | 2014-08-21 | 2018-03-31 | ||
| WO2016047678A1 (en) | 2014-09-25 | 2016-03-31 | 武田薬品工業株式会社 | Heterocyclic compound |
| TWI744225B (en) | 2015-02-27 | 2021-11-01 | 美商林伯士拉克許米公司 | Tyk2 inhibitors and uses thereof |
| TWI707852B (en) | 2015-09-02 | 2020-10-21 | 美商林伯士拉克許米公司 | Tyk2 inhibitors and uses thereof |
| AU2017222417B2 (en) | 2016-02-24 | 2020-07-09 | Pfizer Inc. | Pyrazolo[1,5-a]pyrazin-4-yl derivatives as JAK-inhibitors |
| CN110036015B (en) | 2016-10-07 | 2022-07-19 | 百时美施贵宝公司 | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha response |
| CA3039202A1 (en) | 2016-10-14 | 2018-04-19 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| AU2017345736B2 (en) | 2016-10-21 | 2022-04-07 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
| MA46620A (en) | 2016-10-28 | 2021-05-26 | Bristol Myers Squibb Co | USEFUL HETEROBICYCLIC COMPOUNDS AS MODULATORS OF RESPONSES TO IL-12, IL-23 AND / OR IFN ALPHA |
| JP7012082B2 (en) | 2016-11-17 | 2022-01-27 | ブリストル－マイヤーズ スクイブ カンパニー | Imidazopyridazine regulator of IL-12, IL-23 and / or IFN-alpha |
| GB2562702B (en) | 2017-03-06 | 2022-05-18 | Linear Shaped Ltd | Frame and linear shaped charge |
| AU2018230737B2 (en) * | 2017-03-08 | 2022-09-22 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors, uses, and methods for production thereof |
| AU2019443366A1 (en) | 2019-04-30 | 2021-12-02 | Celgene Corporation | Combination therapies comprising apremilast and Tyk2 inhibitors |
-
2019
- 2019-04-30 AU AU2019443366A patent/AU2019443366A1/en not_active Abandoned
- 2019-04-30 CN CN201980097711.6A patent/CN114269336A/en active Pending
- 2019-04-30 KR KR1020217038511A patent/KR20220002488A/en unknown
- 2019-04-30 SG SG11202112043PA patent/SG11202112043PA/en unknown
- 2019-04-30 JP JP2021564469A patent/JP2022537877A/en not_active Abandoned
- 2019-04-30 MX MX2021013317A patent/MX2021013317A/en unknown
- 2019-04-30 EP EP19723291.1A patent/EP3962475A1/en active Pending
- 2019-04-30 WO PCT/US2019/029772 patent/WO2020222773A1/en unknown
- 2019-04-30 CA CA3138473A patent/CA3138473A1/en active Pending
- 2019-04-30 BR BR112021021809A patent/BR112021021809A2/en unknown
- 2019-04-30 IL IL287665A patent/IL287665A/en unknown
-
2020
- 2020-04-30 MA MA055799A patent/MA55799A/en unknown
- 2020-04-30 CN CN202080046457.XA patent/CN114206333A/en active Pending
- 2020-04-30 JP JP2021564471A patent/JP7453251B2/en active Active
- 2020-04-30 AU AU2020266143A patent/AU2020266143A1/en active Pending
- 2020-04-30 CA CA3138686A patent/CA3138686A1/en active Pending
- 2020-04-30 WO PCT/US2020/030608 patent/WO2020223431A1/en unknown
- 2020-04-30 KR KR1020217038512A patent/KR20220002489A/en unknown
- 2020-04-30 BR BR112021021826A patent/BR112021021826A8/en unknown
- 2020-04-30 SG SG11202112018YA patent/SG11202112018YA/en unknown
- 2020-04-30 MX MX2021013318A patent/MX2021013318A/en unknown
- 2020-04-30 EP EP20725978.9A patent/EP3962476A1/en active Pending
-
2021
- 2021-10-28 IL IL287670A patent/IL287670A/en unknown
- 2021-10-29 CL CL2021002847A patent/CL2021002847A1/en unknown
- 2021-11-22 CO CONC2021/0015614A patent/CO2021015614A2/en unknown
- 2021-11-22 CO CONC2021/0015622A patent/CO2021015622A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220002488A (en) | 2022-01-06 |
| CO2021015622A2 (en) | 2022-02-28 |
| EP3962475A1 (en) | 2022-03-09 |
| EP3962476A1 (en) | 2022-03-09 |
| BR112021021809A2 (en) | 2022-01-04 |
| AU2020266143A1 (en) | 2021-12-02 |
| IL287670A (en) | 2021-12-01 |
| AU2019443366A1 (en) | 2021-12-02 |
| CN114206333A (en) | 2022-03-18 |
| CA3138686A1 (en) | 2020-11-05 |
| MX2021013317A (en) | 2022-01-18 |
| IL287665A (en) | 2022-07-01 |
| BR112021021826A8 (en) | 2022-06-21 |
| MX2021013318A (en) | 2022-01-31 |
| KR20220002489A (en) | 2022-01-06 |
| MA55799A (en) | 2022-03-09 |
| JP2022537878A (en) | 2022-08-31 |
| CO2021015614A2 (en) | 2021-12-10 |
| BR112021021826A2 (en) | 2022-01-04 |
| WO2020222773A1 (en) | 2020-11-05 |
| CL2021002847A1 (en) | 2022-07-22 |
| JP2022537877A (en) | 2022-08-31 |
| CN114269336A (en) | 2022-04-01 |
| WO2020223431A1 (en) | 2020-11-05 |
| CA3138473A1 (en) | 2020-11-05 |
| JP7453251B2 (en) | 2024-03-19 |
| SG11202112043PA (en) | 2021-11-29 |
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