BR112021021683A2 - Compostos multivalentes de ligação a pd-l1 para tratar câncer - Google Patents

Compostos multivalentes de ligação a pd-l1 para tratar câncer

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Publication number
BR112021021683A2
BR112021021683A2 BR112021021683A BR112021021683A BR112021021683A2 BR 112021021683 A2 BR112021021683 A2 BR 112021021683A2 BR 112021021683 A BR112021021683 A BR 112021021683A BR 112021021683 A BR112021021683 A BR 112021021683A BR 112021021683 A2 BR112021021683 A2 BR 112021021683A2
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Brazil
Prior art keywords
multivalent
binding compounds
materials
binding
compounds
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BR112021021683A
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English (en)
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BR112021021683B1 (pt
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A Barry Michael
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Mayo Found Medical Education & Res
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Publication date
Application filed by Mayo Found Medical Education & Res filed Critical Mayo Found Medical Education & Res
Publication of BR112021021683A2 publication Critical patent/BR112021021683A2/pt
Publication of BR112021021683B1 publication Critical patent/BR112021021683B1/pt

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

compostos multivalentes de ligação a pd-l1 para tratar câncer. esta invenção provê métodos e materiais para tratar câncer. a invenção engloba métodos e materiais para direcionar compostos de ligação ao ligante 1 de morte programada (pd-l1) e/ou composições contendo um ou mais compostos monovalentes ou multivalentes de ligação ao ligante 1 de morte programada (pd-l1) que são administrados a um mamífero tendo câncer para tratar o mamífero. em alguns casos, um composto multivalente de ligação a pd-l1 pode incluir dois ou mais polipeptídeos de proteína 1 de morte celular programada (pd-1) (e/ou fragmentos dos mesmos tendo a capacidade de se ligar a pd-l1). esta invenção também provê métodos e materiais para produzir compostos multivalentes de ligação a pd-l1 e métodos e materiais para produzir moléculas de ácido nucleico que codificam compostos de ligação a pd-l1.
BR112021021683-9A 2019-04-29 2020-04-28 Compostos multivalentes de ligação a pd-l1 para tratar câncer, composição farmacêutica e uso relacionados BR112021021683B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962839916P 2019-04-29 2019-04-29
US62/839,916 2019-04-29
PCT/US2020/030240 WO2020223217A1 (en) 2019-04-29 2020-04-28 Multivalent pd-l1 binding compounds for treating cancer

Publications (2)

Publication Number Publication Date
BR112021021683A2 true BR112021021683A2 (pt) 2021-12-21
BR112021021683B1 BR112021021683B1 (pt) 2024-05-28

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Also Published As

Publication number Publication date
IL292788B1 (en) 2023-08-01
WO2020223217A1 (en) 2020-11-05
CA3138527A1 (en) 2020-11-05
IL292788A (en) 2022-07-01
EP3911671A1 (en) 2021-11-24
IL287593A (en) 2021-12-01
JP2022530892A (ja) 2022-07-04
US20200339654A1 (en) 2020-10-29
ZA202105885B (en) 2022-08-31
IL292788B2 (en) 2023-12-01
KR20210144818A (ko) 2021-11-30
IL287593B (en) 2022-06-01
SG11202109196XA (en) 2021-09-29
US11485767B2 (en) 2022-11-01
MX2021010577A (es) 2021-10-13
AU2020266125A1 (en) 2021-09-30
JP7381604B2 (ja) 2023-11-15
AU2020266125B2 (en) 2023-04-13
CA3138527C (en) 2024-03-12
CN113710694A (zh) 2021-11-26

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