BR112021014881A2 - Composto de poliol anti-hipertensivo e derivados do mesmo - Google Patents

Composto de poliol anti-hipertensivo e derivados do mesmo

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Publication number
BR112021014881A2
BR112021014881A2 BR112021014881A BR112021014881A BR112021014881A2 BR 112021014881 A2 BR112021014881 A2 BR 112021014881A2 BR 112021014881 A BR112021014881 A BR 112021014881A BR 112021014881 A BR112021014881 A BR 112021014881A BR 112021014881 A2 BR112021014881 A2 BR 112021014881A2
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BR
Brazil
Prior art keywords
hypertension
antihypertensive
derivatives
present
compound
Prior art date
Application number
BR112021014881A
Other languages
English (en)
Inventor
Honglin Li
Jianjun Fu
Qian Jiao
Rui Wang
Shiliang Li
Xuhong Qian
Yinchu Shen
Yufang Xu
Zhenjiang Zhao
Original Assignee
Univ East China Science & Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Univ East China Science & Tech filed Critical Univ East China Science & Tech
Publication of BR112021014881A2 publication Critical patent/BR112021014881A2/pt

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    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
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    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
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    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Abstract

composto de poliol anti-hipertensivo e derivados do mesmo. a presente invenção fornece um composto conforme representado pela fórmula i, ou um sal ou éster farmaceuticamente aceitável, um pró-fármaco, um isômero óptico, um estereoisômero ou um solvato do mesmo. o composto fornecido pela presente invenção pode ser usado para preparar fármacos para prevenir ou tratar hipertensão, ou doenças relacionadas à hipertensão, ou hipertensão pulmonar, ou doenças relacionadas à hipertensão pulmonar. o composto fornecido pela presente invenção tem um mecanismo diferente dos fármacos existentes para o tratamento de hipertensão e de hipertensão pulmonar, estabelecendo assim uma nova base material para o desenvolvimento de fármacos para o tratamento de hipertensão e de hipertensão pulmonar.
BR112021014881A 2019-06-12 2020-06-12 Composto de poliol anti-hipertensivo e derivados do mesmo BR112021014881A2 (pt)

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JP2006522109A (ja) * 2003-03-31 2006-09-28 大正製薬株式会社 新規なキナゾリン誘導体及びそれらの使用に関連する治療方法
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