BR112020024088B1 - Formulação farmacêutica líquida de nicotina, cartucho para uso com cigarro eletrônico compreendendo a mesma, método para distribuir nicotina e cigarro eletrônico - Google Patents
Formulação farmacêutica líquida de nicotina, cartucho para uso com cigarro eletrônico compreendendo a mesma, método para distribuir nicotina e cigarro eletrônico Download PDFInfo
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- BR112020024088B1 BR112020024088B1 BR112020024088-5A BR112020024088A BR112020024088B1 BR 112020024088 B1 BR112020024088 B1 BR 112020024088B1 BR 112020024088 A BR112020024088 A BR 112020024088A BR 112020024088 B1 BR112020024088 B1 BR 112020024088B1
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- Prior art keywords
- acid
- formulation
- nicotine
- fact
- weight
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 79
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 71
- 229960002715 nicotine Drugs 0.000 title claims abstract description 71
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000003571 electronic cigarette Substances 0.000 title claims description 20
- 239000007788 liquid Substances 0.000 title claims description 14
- 239000000203 mixture Substances 0.000 claims abstract description 126
- 238000009472 formulation Methods 0.000 claims abstract description 111
- 239000006199 nebulizer Substances 0.000 claims abstract description 18
- 239000002253 acid Substances 0.000 claims description 48
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- -1 acetylsalicylic acid, alginic acid Chemical class 0.000 claims description 27
- 239000000796 flavoring agent Substances 0.000 claims description 22
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 22
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 21
- 229930195729 fatty acid Natural products 0.000 claims description 21
- 239000000194 fatty acid Substances 0.000 claims description 21
- 239000002904 solvent Substances 0.000 claims description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 20
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 18
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 16
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 16
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 16
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 16
- 244000060011 Cocos nucifera Species 0.000 claims description 16
- 239000005642 Oleic acid Substances 0.000 claims description 16
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 16
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 16
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 16
- 235000013355 food flavoring agent Nutrition 0.000 claims description 15
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 14
- 239000000443 aerosol Substances 0.000 claims description 14
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 14
- 239000012669 liquid formulation Substances 0.000 claims description 13
- 229920002582 Polyethylene Glycol 600 Polymers 0.000 claims description 12
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 12
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 12
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 12
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 12
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 12
- ISYWECDDZWTKFF-UHFFFAOYSA-N nonadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCCC(O)=O ISYWECDDZWTKFF-UHFFFAOYSA-N 0.000 claims description 12
- 239000004359 castor oil Substances 0.000 claims description 10
- 235000019438 castor oil Nutrition 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 10
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims description 10
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 10
- SZHOJFHSIKHZHA-UHFFFAOYSA-N tridecanoic acid Chemical compound CCCCCCCCCCCCC(O)=O SZHOJFHSIKHZHA-UHFFFAOYSA-N 0.000 claims description 10
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 claims description 10
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 10
- TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 239000004310 lactic acid Substances 0.000 claims description 9
- 235000014655 lactic acid Nutrition 0.000 claims description 9
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 8
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- GJWSUKYXUMVMGX-UHFFFAOYSA-N citronellic acid Chemical compound OC(=O)CC(C)CCC=C(C)C GJWSUKYXUMVMGX-UHFFFAOYSA-N 0.000 claims description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 8
- 235000003599 food sweetener Nutrition 0.000 claims description 8
- KEMQGTRYUADPNZ-UHFFFAOYSA-N heptadecanoic acid Chemical compound CCCCCCCCCCCCCCCCC(O)=O KEMQGTRYUADPNZ-UHFFFAOYSA-N 0.000 claims description 8
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 8
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 8
- 229960002446 octanoic acid Drugs 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 239000003765 sweetening agent Substances 0.000 claims description 8
- 229960003080 taurine Drugs 0.000 claims description 8
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 8
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 8
- LDQYRCPDQDZUOY-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)propan-1-ol Chemical compound CCCCCCCCCCCCOCCOC(C)CO LDQYRCPDQDZUOY-UHFFFAOYSA-N 0.000 claims description 7
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 7
- 244000061176 Nicotiana tabacum Species 0.000 claims description 7
- 235000011054 acetic acid Nutrition 0.000 claims description 7
- 229960000583 acetic acid Drugs 0.000 claims description 7
- 235000019634 flavors Nutrition 0.000 claims description 7
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 7
- 229940037640 ppg-1-peg-9 lauryl glycol ether Drugs 0.000 claims description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 6
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- 235000019253 formic acid Nutrition 0.000 claims description 6
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims description 6
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims description 6
- 229920002675 Polyoxyl Polymers 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- YAQXGBBDJYBXKL-UHFFFAOYSA-N iron(2+);1,10-phenanthroline;dicyanide Chemical compound [Fe+2].N#[C-].N#[C-].C1=CN=C2C3=NC=CC=C3C=CC2=C1.C1=CN=C2C3=NC=CC=C3C=CC2=C1 YAQXGBBDJYBXKL-UHFFFAOYSA-N 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
- 235000019260 propionic acid Nutrition 0.000 claims description 5
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims description 4
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 4
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims description 4
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 4
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 4
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims description 4
- FYEHYMARPSSOBO-UHFFFAOYSA-N Aurin Chemical compound C1=CC(O)=CC=C1C(C=1C=CC(O)=CC=1)=C1C=CC(=O)C=C1 FYEHYMARPSSOBO-UHFFFAOYSA-N 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 4
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- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 4
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- 239000011668 ascorbic acid Substances 0.000 claims description 4
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- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacture Of Tobacco Products (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18175640.4A EP3574902A1 (en) | 2018-06-01 | 2018-06-01 | Nicotine formulation and mode of delivery |
| EP18175640.4 | 2018-06-01 | ||
| PCT/EP2019/064212 WO2019229249A1 (en) | 2018-06-01 | 2019-05-31 | Nicotine formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112020024088A2 BR112020024088A2 (pt) | 2021-02-17 |
| BR112020024088B1 true BR112020024088B1 (pt) | 2022-10-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020024088-5A BR112020024088B1 (pt) | 2018-06-01 | 2019-05-31 | Formulação farmacêutica líquida de nicotina, cartucho para uso com cigarro eletrônico compreendendo a mesma, método para distribuir nicotina e cigarro eletrônico |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11833145B2 (https=) |
| EP (3) | EP3574902A1 (https=) |
| JP (1) | JP7224375B2 (https=) |
| CN (1) | CN112218637A (https=) |
| AU (2) | AU2019276357B2 (https=) |
| BR (1) | BR112020024088B1 (https=) |
| ES (1) | ES2883799T3 (https=) |
| MA (2) | MA50205B1 (https=) |
| MX (1) | MX390509B (https=) |
| PL (1) | PL3684362T3 (https=) |
| SG (1) | SG11202011761XA (https=) |
| WO (1) | WO2019229249A1 (https=) |
| ZA (1) | ZA202007717B (https=) |
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|---|---|---|---|---|
| EP3574902A1 (en) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Nicotine formulation and mode of delivery |
| GB201817865D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817868D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| GB201817867D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817863D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB201817860D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| BR112021010222A2 (pt) * | 2018-12-31 | 2021-08-24 | Philip Morris Products S.A. | Formulação de nicotina líquida compreendendo solventes imiscíveis em água |
| PL3905908T3 (pl) | 2019-06-20 | 2025-03-24 | Shaheen Innovations Holding Limited | Ultradźwiękowe urządzenie rozpylające do użytku osobistego |
| FR3102041B1 (fr) * | 2019-10-22 | 2025-02-14 | Aroma Sens | Edulcorant pour liquides de cigarette électronique |
| US12233207B2 (en) | 2019-12-15 | 2025-02-25 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| US11730193B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| ES3014051T3 (en) | 2019-12-15 | 2025-04-16 | Shaheen Innovations Holding Ltd | Mist inhaler devices |
| US11666713B2 (en) | 2019-12-15 | 2023-06-06 | Shaheen Innovations Holding Limited | Mist inhaler devices |
| JP7583061B2 (ja) | 2019-12-15 | 2024-11-13 | シャヒーン イノベーションズ ホールディング リミテッド | 超音波ミスト吸入器 |
| US12213516B2 (en) | 2019-12-15 | 2025-02-04 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
| US12121056B2 (en) | 2019-12-15 | 2024-10-22 | Shaheen Innovations Holding Limited | Hookah device |
| PL4292632T3 (pl) | 2019-12-15 | 2025-11-24 | Shaheen Innovations Holding Limited | Ultradźwiękowy inhalator mgiełki |
| US11589610B2 (en) | 2019-12-15 | 2023-02-28 | Shaheen Innovations Holding Limited | Nicotine delivery device having a mist generator device and a driver device |
| US11911559B2 (en) | 2019-12-15 | 2024-02-27 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler |
| US11944120B2 (en) | 2019-12-15 | 2024-04-02 | Shaheen Innovations Holding Limited | Ultrasonic mist inhaler with capillary retainer |
| US12201144B2 (en) | 2019-12-15 | 2025-01-21 | Shaheen Innovations Holding Limited | Hookah device |
| US11730191B2 (en) | 2019-12-15 | 2023-08-22 | Shaheen Innovations Holding Limited | Hookah device |
| US12538944B2 (en) | 2019-12-15 | 2026-02-03 | Shaheen Innovations Holding Limited | Nicotine delivery device with identification arrangement |
| BR112022011449A2 (pt) * | 2019-12-18 | 2022-08-30 | Philip Morris Products Sa | Formulação para uso em um sistema gerador de aerossol |
| JP7609561B2 (ja) * | 2020-02-05 | 2025-01-07 | 日本たばこ産業株式会社 | 液体加熱式の加熱型香味吸引器用の液体組成物 |
| IL296737A (en) | 2020-03-27 | 2022-11-01 | Mcneil Ab | A cartridge with nicotine |
| MA57567B1 (fr) * | 2020-04-06 | 2022-09-30 | Shaheen Innovations Holding Ltd | Dispositifs d'inhalateur de brouillard |
| CN111802686A (zh) * | 2020-07-27 | 2020-10-23 | 湖北中烟工业有限责任公司 | 含脂肪酸、植物油的雾化剂以及加热不燃烧卷烟 |
| CN111855866A (zh) * | 2020-08-25 | 2020-10-30 | 甘肃烟草工业有限责任公司 | 一种快速测定烟用添加剂中甲醛的方法 |
| IL303786B2 (en) * | 2020-12-15 | 2024-07-01 | Shaheen Innovations Holding Ltd | Mist inhaler devices |
| CN114947174A (zh) * | 2021-02-25 | 2022-08-30 | 深圳市合元科技有限公司 | 气溶胶形成基质以及气溶胶生成系统 |
| CN113197330A (zh) * | 2021-04-28 | 2021-08-03 | 深圳市博睿生物科技有限公司 | 一种电子烟新型甜味剂及制备方法及应用 |
| IL283002A (en) * | 2021-05-06 | 2022-12-01 | Nicogen Ltd | Nicotine formulations and aerosols |
| CN113912585B (zh) * | 2021-11-09 | 2023-02-24 | 深圳萨特瓦生物科技有限公司 | 复合尼古丁盐及其制备方法与应用、电子烟油及电子烟 |
| US20230188901A1 (en) | 2021-12-15 | 2023-06-15 | Shaheen Innovations Holding Limited | Apparatus for transmitting ultrasonic waves |
| CN116326810B (zh) * | 2021-12-22 | 2026-03-17 | 深圳市富淼生物科技有限公司 | 水基雾化剂、指定用途水基雾化物、雾化弹以及雾化装置 |
| CN114886145A (zh) * | 2022-06-10 | 2022-08-12 | 广州市维城生物科技有限公司 | 一种水基烟碱电子烟雾化液及其制备方法 |
| KR20240012197A (ko) * | 2022-07-20 | 2024-01-29 | 주식회사 케이티앤지 | 표면파 아토마이저에 사용하기 위한 액상형 흡입제형, 이를 포함하는 카트리지 및 에어로졸 생성장치 |
| KR102872477B1 (ko) * | 2022-08-10 | 2025-10-20 | 주식회사 케이티앤지 | 니코틴 흡입성 조성물 및 이를 포함하는 에어로졸 발생 장치 및 시스템 |
| CN116019250B (zh) * | 2022-12-22 | 2025-02-14 | 东莞市吉纯生物技术有限公司 | 基于酸性电解水的雾化液、制备方法和酸性电解水制备方法 |
| WO2024138377A1 (zh) * | 2022-12-27 | 2024-07-04 | 思摩尔国际控股有限公司 | 一种雾化液、雾化器及电子雾化装置 |
| WO2024161313A1 (en) * | 2023-01-31 | 2024-08-08 | Rai Strategic Holdings, Inc. | Stabilized aerosol precursor formulations |
| CN118787123A (zh) * | 2023-04-14 | 2024-10-18 | 思摩尔国际控股有限公司 | 一种水基电子烟雾化制剂及其制备方法和应用 |
| PL446676A1 (pl) * | 2023-11-08 | 2025-05-12 | Dmitrii Shesternenko | Kompozycja liquidu do e-papierosa oraz e-papieros zawierający taką kompozycję |
| FR3159394A1 (fr) * | 2024-02-19 | 2025-08-22 | Swm Holdco Luxembourg | Feuille de papier comprenant un extrait de plante et de la nicotine stabilisée |
| CN117898466B (zh) * | 2024-02-29 | 2024-09-24 | 深圳市艾斯摩迪斯科技有限公司 | 一种复合尼古丁盐的制备方法及其应用 |
| CN120923467A (zh) * | 2025-07-31 | 2025-11-11 | 深圳曼华生物科技有限公司 | 尼古丁盐的制备方法、检测方法、制备的尼古丁盐及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| GB2133691B (en) * | 1983-01-21 | 1986-05-21 | Leo Ab | Smoking substitutes for nasal administration |
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| SE0201669D0 (sv) | 2002-06-03 | 2002-06-03 | Pharmacia Ab | New formulation and use thereof |
| GB0712308D0 (en) * | 2007-06-25 | 2007-08-01 | Kind Group Ltd | An inhalable composition |
| WO2014182736A1 (en) * | 2013-05-06 | 2014-11-13 | Ploom, Inc. | Nicotine salt formulations for aerosol devices and methods thereof |
| CN110367592B (zh) * | 2013-07-19 | 2022-12-02 | 奥驰亚客户服务有限责任公司 | 电子吸烟器具的液体气溶胶制剂 |
| DE102015117811A1 (de) * | 2015-10-20 | 2017-04-20 | Chv Pharma Gmbh & Co. Kg | Inhalator sowie wirkstoffhaltige Zubereitung für einen Inhalator |
| EP3574902A1 (en) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Nicotine formulation and mode of delivery |
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2018
- 2018-06-01 EP EP18175640.4A patent/EP3574902A1/en not_active Withdrawn
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2019
- 2019-05-31 WO PCT/EP2019/064212 patent/WO2019229249A1/en not_active Ceased
- 2019-05-31 BR BR112020024088-5A patent/BR112020024088B1/pt active IP Right Grant
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- 2019-05-31 ES ES19727687T patent/ES2883799T3/es active Active
- 2019-05-31 MA MA054714A patent/MA54714A/fr unknown
- 2019-05-31 JP JP2020567039A patent/JP7224375B2/ja active Active
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| BR112020024088A2 (pt) | 2021-02-17 |
| US20210196700A1 (en) | 2021-07-01 |
| AU2019276357A1 (en) | 2020-11-26 |
| JP2021526147A (ja) | 2021-09-30 |
| US11833145B2 (en) | 2023-12-05 |
| EP3909581A1 (en) | 2021-11-17 |
| ZA202007717B (en) | 2026-03-25 |
| MX390509B (es) | 2025-03-11 |
| CN112218637A (zh) | 2021-01-12 |
| EP3684362B1 (en) | 2021-06-23 |
| MA50205A (fr) | 2020-07-29 |
| CA3099940A1 (en) | 2019-12-05 |
| MA50205B1 (fr) | 2021-09-30 |
| AU2023202855B2 (en) | 2024-08-22 |
| PL3684362T3 (pl) | 2021-12-20 |
| EP3684362A1 (en) | 2020-07-29 |
| SG11202011761XA (en) | 2020-12-30 |
| US20240050424A1 (en) | 2024-02-15 |
| MA54714A (fr) | 2021-11-17 |
| AU2023202855A1 (en) | 2023-05-25 |
| ES2883799T3 (es) | 2021-12-09 |
| JP7224375B2 (ja) | 2023-02-17 |
| WO2019229249A1 (en) | 2019-12-05 |
| AU2019276357B2 (en) | 2023-04-20 |
| NZ769793A (en) | 2024-05-31 |
| EP3574902A1 (en) | 2019-12-04 |
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