BR112020023252A2 - composição do agente terapêutico e método de uso para tratamento de deficiência cognitiva leve, depressão e distúrbios psicológicos. - Google Patents
composição do agente terapêutico e método de uso para tratamento de deficiência cognitiva leve, depressão e distúrbios psicológicos. Download PDFInfo
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- 229960001600 xylazine Drugs 0.000 description 1
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- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671485P | 2018-05-15 | 2018-05-15 | |
| US201862671466P | 2018-05-15 | 2018-05-15 | |
| US62/671,466 | 2018-05-15 | ||
| US62/671,485 | 2018-05-15 | ||
| US201862674855P | 2018-05-22 | 2018-05-22 | |
| US62/674,855 | 2018-05-22 | ||
| PCT/US2019/032403 WO2019222339A1 (en) | 2018-05-15 | 2019-05-15 | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
Publications (1)
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| BR112020023252A2 true BR112020023252A2 (pt) | 2021-02-23 |
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Country Status (9)
| Country | Link |
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| US (3) | US11090303B2 (https=) |
| EP (1) | EP3843768A4 (https=) |
| JP (2) | JP7699378B2 (https=) |
| CN (1) | CN112423774A (https=) |
| AU (1) | AU2019271189A1 (https=) |
| BR (1) | BR112020023252A2 (https=) |
| GB (1) | GB202015788D0 (https=) |
| MA (1) | MA53500A (https=) |
| WO (1) | WO2019222339A1 (https=) |
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| US20240398792A1 (en) * | 2018-05-15 | 2024-12-05 | Lloyd Hung Loi Tran | Therapeutic agent composition and method of use, for treating, relieving, or alleviating alzheimer's disease |
| EP3843768A4 (en) * | 2018-05-15 | 2022-11-23 | Tran, Lloyd Hung Loi | THERAPEUTIC COMPOSITION AND METHODS OF USE IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT, DEPRESSION AND MENTAL DISORDERS |
| GB2613460B (en) * | 2020-04-20 | 2025-07-23 | Lloyd Hung Loi Tran | Pharmaceutical Compositions for use in methods for the prophylaxis or treatment of COVID such as COVID-19; and compound for use in the treatment of a |
| WO2022051631A1 (en) * | 2020-09-03 | 2022-03-10 | University Of Notre Dame Du Lac | Therapy to stimulate hippocampal neural progenitors and adult neurogenesis |
| TW202245773A (zh) * | 2021-02-12 | 2022-12-01 | 紐西蘭商紐藍製藥公司 | 普威二氏症候群之治療 |
| CN114582507A (zh) * | 2022-03-04 | 2022-06-03 | 青海省畜牧兽医科学院 | 基于地理探测器的泡型包虫病环境风险因子分析方法 |
| KR20260049797A (ko) * | 2023-07-12 | 2026-04-14 | 로이드 트란 | 경도 인지 장애 치료를 위한 병용 요법의 치료제 조성물 및 사용 방법 |
| WO2025088052A1 (en) * | 2023-10-26 | 2025-05-01 | Rousselot Bv | Cyclic analogue of glycine-proline for use in the prevention and/or treatment of medical implant-related fibrosis |
| WO2025160184A1 (en) * | 2024-01-23 | 2025-07-31 | Lloyd Tran | Methods for the prophylaxis and treatment of obesity and related conditions and disorders |
| WO2025179250A1 (en) * | 2024-02-25 | 2025-08-28 | Lloyd Tran | Methods for the prophylaxis and treatment of autism related disorders |
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| CN119770491B (zh) * | 2024-12-20 | 2025-10-17 | 北京大学 | 环甘氨酸-脯氨酸在制备治疗暴食症的药物中的应用 |
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| JP2670563B2 (ja) | 1988-10-12 | 1997-10-29 | 富士通株式会社 | 半導体装置の製造方法 |
| JP2757960B2 (ja) | 1988-10-17 | 1998-05-25 | サントリー株式会社 | (2R,3S,4S)−α−(カルボキシシクロプロピル)グリシン |
| SE8803847A0 (sv) | 1988-10-27 | 1990-04-28 | Kabigen Ab | Neuromodulerande peptid |
| EP0597033B1 (en) | 1991-08-01 | 1997-04-09 | Genentech, Inc. | Igf-1 to improve the neural condition |
| US5439930A (en) | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
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| US5840736A (en) | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5942422A (en) | 1996-11-14 | 1999-08-24 | The Trustees Of Columbia University In The City Of New York | Method for generating a directed, recombinant fusion nucleic acid |
| US6015786A (en) | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6187906B1 (en) | 1997-08-11 | 2001-02-13 | Aukland Uniservices Limited | Methods to improve neural outcome |
| US6124361A (en) | 1997-12-31 | 2000-09-26 | Pfizer Inc | Bicyclo[3.1.0]hexanes and related compounds |
| PT1064256E (pt) | 1998-03-17 | 2004-10-29 | Pfizer Prod Inc | Biciclo[2.2.1] heptanos e compostos relacionados |
| US6258582B1 (en) | 1998-09-30 | 2001-07-10 | Millennium Pharmaceuticals, Inc. | CSAPTP nucleic acid molecules and uses therefor |
| US6303576B1 (en) | 1999-04-21 | 2001-10-16 | Adherex Technologies Inc. | Compounds and methods for modulating β-catenin mediated gene expression |
| AU781044B2 (en) | 1999-11-05 | 2005-05-05 | Axonyx, Inc. | Peptide analogs and mimetics suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid-like deposits or beta-sheet rich pathological precursor thereof |
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| WO2003039487A2 (en) * | 2001-11-09 | 2003-05-15 | Neuronz Limited | Cyclo(prolyl-glycine) and methods of use to treat neural disorders |
| CA2466701C (en) * | 2001-11-13 | 2013-11-12 | Loi Tran | Neuroprotective use of cyclic prolyl glycine |
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
| US20050209142A1 (en) * | 2002-11-20 | 2005-09-22 | Goran Bertilsson | Compounds and methods for increasing neurogenesis |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| JP4842817B2 (ja) * | 2003-09-03 | 2011-12-21 | ニューレン ファーマシューティカルズ リミテッド | 神経保護二環式化合物およびその使用方法 |
| US8791117B2 (en) * | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| EP1870097A1 (en) * | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
| WO2009154697A2 (en) | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| CN102348723A (zh) | 2008-12-05 | 2012-02-08 | 安吉奥开米公司 | 肽治疗剂轭合物及其应用 |
| WO2015013397A2 (en) * | 2013-07-25 | 2015-01-29 | Neuren Pharmaceuticals Limited | Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders |
| JP2021514303A (ja) * | 2018-02-19 | 2021-06-10 | ザ マテリアル ワークス,リミテッド | 金属薄板デスケーラのための幅及び速度コントロールならびにそれを使用する方法 |
| EP3843768A4 (en) | 2018-05-15 | 2022-11-23 | Tran, Lloyd Hung Loi | THERAPEUTIC COMPOSITION AND METHODS OF USE IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT, DEPRESSION AND MENTAL DISORDERS |
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Also Published As
| Publication number | Publication date |
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| JP7699378B2 (ja) | 2025-06-27 |
| WO2019222339A1 (en) | 2019-11-21 |
| EP3843768A4 (en) | 2022-11-23 |
| US12070458B2 (en) | 2024-08-27 |
| JP2021524864A (ja) | 2021-09-16 |
| EP3843768A1 (en) | 2021-07-07 |
| GB202015788D0 (en) | 2020-11-18 |
| CN112423774A (zh) | 2021-02-26 |
| US20200054629A1 (en) | 2020-02-20 |
| AU2019271189A1 (en) | 2021-01-07 |
| US11090303B2 (en) | 2021-08-17 |
| MA53500A (fr) | 2021-08-18 |
| US20220000866A1 (en) | 2022-01-06 |
| US20230381175A1 (en) | 2023-11-30 |
| JP2025084741A (ja) | 2025-06-03 |
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