JP7699378B2 - 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 - Google Patents
軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 Download PDFInfo
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- JP7699378B2 JP7699378B2 JP2021514303A JP2021514303A JP7699378B2 JP 7699378 B2 JP7699378 B2 JP 7699378B2 JP 2021514303 A JP2021514303 A JP 2021514303A JP 2021514303 A JP2021514303 A JP 2021514303A JP 7699378 B2 JP7699378 B2 JP 7699378B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025014460A JP2025084741A (ja) | 2018-05-15 | 2025-01-31 | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671485P | 2018-05-15 | 2018-05-15 | |
| US201862671466P | 2018-05-15 | 2018-05-15 | |
| US62/671,466 | 2018-05-15 | ||
| US62/671,485 | 2018-05-15 | ||
| US201862674855P | 2018-05-22 | 2018-05-22 | |
| US62/674,855 | 2018-05-22 | ||
| PCT/US2019/032403 WO2019222339A1 (en) | 2018-05-15 | 2019-05-15 | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025014460A Division JP2025084741A (ja) | 2018-05-15 | 2025-01-31 | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021524864A JP2021524864A (ja) | 2021-09-16 |
| JP2021524864A5 JP2021524864A5 (https=) | 2022-11-02 |
| JP7699378B2 true JP7699378B2 (ja) | 2025-06-27 |
Family
ID=68541027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021514303A Active JP7699378B2 (ja) | 2018-05-15 | 2019-05-15 | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
| JP2025014460A Pending JP2025084741A (ja) | 2018-05-15 | 2025-01-31 | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025014460A Pending JP2025084741A (ja) | 2018-05-15 | 2025-01-31 | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11090303B2 (https=) |
| EP (1) | EP3843768A4 (https=) |
| JP (2) | JP7699378B2 (https=) |
| CN (1) | CN112423774A (https=) |
| AU (1) | AU2019271189A1 (https=) |
| BR (1) | BR112020023252A2 (https=) |
| GB (1) | GB202015788D0 (https=) |
| MA (1) | MA53500A (https=) |
| WO (1) | WO2019222339A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240398792A1 (en) * | 2018-05-15 | 2024-12-05 | Lloyd Hung Loi Tran | Therapeutic agent composition and method of use, for treating, relieving, or alleviating alzheimer's disease |
| EP3843768A4 (en) * | 2018-05-15 | 2022-11-23 | Tran, Lloyd Hung Loi | THERAPEUTIC COMPOSITION AND METHODS OF USE IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT, DEPRESSION AND MENTAL DISORDERS |
| GB2613460B (en) * | 2020-04-20 | 2025-07-23 | Lloyd Hung Loi Tran | Pharmaceutical Compositions for use in methods for the prophylaxis or treatment of COVID such as COVID-19; and compound for use in the treatment of a |
| WO2022051631A1 (en) * | 2020-09-03 | 2022-03-10 | University Of Notre Dame Du Lac | Therapy to stimulate hippocampal neural progenitors and adult neurogenesis |
| TW202245773A (zh) * | 2021-02-12 | 2022-12-01 | 紐西蘭商紐藍製藥公司 | 普威二氏症候群之治療 |
| CN114582507A (zh) * | 2022-03-04 | 2022-06-03 | 青海省畜牧兽医科学院 | 基于地理探测器的泡型包虫病环境风险因子分析方法 |
| KR20260049797A (ko) * | 2023-07-12 | 2026-04-14 | 로이드 트란 | 경도 인지 장애 치료를 위한 병용 요법의 치료제 조성물 및 사용 방법 |
| WO2025088052A1 (en) * | 2023-10-26 | 2025-05-01 | Rousselot Bv | Cyclic analogue of glycine-proline for use in the prevention and/or treatment of medical implant-related fibrosis |
| WO2025160184A1 (en) * | 2024-01-23 | 2025-07-31 | Lloyd Tran | Methods for the prophylaxis and treatment of obesity and related conditions and disorders |
| WO2025179250A1 (en) * | 2024-02-25 | 2025-08-28 | Lloyd Tran | Methods for the prophylaxis and treatment of autism related disorders |
| WO2025198995A1 (en) * | 2024-03-18 | 2025-09-25 | Lloyd Tran | Methods for the prophylaxis and treatment of stroke related disorders |
| CN119770491B (zh) * | 2024-12-20 | 2025-10-17 | 北京大学 | 环甘氨酸-脯氨酸在制备治疗暴食症的药物中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060258663A1 (en) | 2003-09-03 | 2006-11-16 | Neuren Pharmaceuticals Limited | Cyclic G-2AllylProline in treatment of Parkinson's disease |
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| US20150306171A1 (en) | 2001-11-13 | 2015-10-29 | Lloyd Hung Loi Tran | Therapeutic agent composition and method of use |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2670563B2 (ja) | 1988-10-12 | 1997-10-29 | 富士通株式会社 | 半導体装置の製造方法 |
| JP2757960B2 (ja) | 1988-10-17 | 1998-05-25 | サントリー株式会社 | (2R,3S,4S)−α−(カルボキシシクロプロピル)グリシン |
| SE8803847A0 (sv) | 1988-10-27 | 1990-04-28 | Kabigen Ab | Neuromodulerande peptid |
| EP0597033B1 (en) | 1991-08-01 | 1997-04-09 | Genentech, Inc. | Igf-1 to improve the neural condition |
| US5439930A (en) | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
| WO1995017204A1 (en) | 1993-12-23 | 1995-06-29 | Auckland Uniservices Limited | Composition and methods to improve neural outcome |
| US5840736A (en) | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5942422A (en) | 1996-11-14 | 1999-08-24 | The Trustees Of Columbia University In The City Of New York | Method for generating a directed, recombinant fusion nucleic acid |
| US6015786A (en) | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6187906B1 (en) | 1997-08-11 | 2001-02-13 | Aukland Uniservices Limited | Methods to improve neural outcome |
| US6124361A (en) | 1997-12-31 | 2000-09-26 | Pfizer Inc | Bicyclo[3.1.0]hexanes and related compounds |
| PT1064256E (pt) | 1998-03-17 | 2004-10-29 | Pfizer Prod Inc | Biciclo[2.2.1] heptanos e compostos relacionados |
| US6258582B1 (en) | 1998-09-30 | 2001-07-10 | Millennium Pharmaceuticals, Inc. | CSAPTP nucleic acid molecules and uses therefor |
| US6303576B1 (en) | 1999-04-21 | 2001-10-16 | Adherex Technologies Inc. | Compounds and methods for modulating β-catenin mediated gene expression |
| AU781044B2 (en) | 1999-11-05 | 2005-05-05 | Axonyx, Inc. | Peptide analogs and mimetics suitable for in vivo use in the treatment of diseases associated with abnormal protein folding into amyloid, amyloid-like deposits or beta-sheet rich pathological precursor thereof |
| US6689904B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine |
| WO2003039487A2 (en) * | 2001-11-09 | 2003-05-15 | Neuronz Limited | Cyclo(prolyl-glycine) and methods of use to treat neural disorders |
| CA2466701C (en) * | 2001-11-13 | 2013-11-12 | Loi Tran | Neuroprotective use of cyclic prolyl glycine |
| US20050209142A1 (en) * | 2002-11-20 | 2005-09-22 | Goran Bertilsson | Compounds and methods for increasing neurogenesis |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US8791117B2 (en) * | 2003-09-03 | 2014-07-29 | Neuren Pharmaceuticals Limited | Cyclic glycyl-2-allyl proline improves cognitive performance in impaired animals |
| EP1870097A1 (en) * | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
| WO2009154697A2 (en) | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| CN102348723A (zh) | 2008-12-05 | 2012-02-08 | 安吉奥开米公司 | 肽治疗剂轭合物及其应用 |
| WO2015013397A2 (en) * | 2013-07-25 | 2015-01-29 | Neuren Pharmaceuticals Limited | Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders |
| JP2021514303A (ja) * | 2018-02-19 | 2021-06-10 | ザ マテリアル ワークス,リミテッド | 金属薄板デスケーラのための幅及び速度コントロールならびにそれを使用する方法 |
| EP3843768A4 (en) | 2018-05-15 | 2022-11-23 | Tran, Lloyd Hung Loi | THERAPEUTIC COMPOSITION AND METHODS OF USE IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT, DEPRESSION AND MENTAL DISORDERS |
-
2019
- 2019-05-15 EP EP19804060.2A patent/EP3843768A4/en active Pending
- 2019-05-15 BR BR112020023252-1A patent/BR112020023252A2/pt not_active IP Right Cessation
- 2019-05-15 CN CN201980047677.1A patent/CN112423774A/zh active Pending
- 2019-05-15 JP JP2021514303A patent/JP7699378B2/ja active Active
- 2019-05-15 GB GBGB2015788.9A patent/GB202015788D0/en not_active Ceased
- 2019-05-15 WO PCT/US2019/032403 patent/WO2019222339A1/en not_active Ceased
- 2019-05-15 US US16/412,759 patent/US11090303B2/en active Active
- 2019-05-15 AU AU2019271189A patent/AU2019271189A1/en not_active Abandoned
- 2019-05-15 MA MA053500A patent/MA53500A/fr unknown
-
2021
- 2021-06-26 US US17/359,515 patent/US20220000866A1/en not_active Abandoned
-
2023
- 2023-05-11 US US18/315,910 patent/US12070458B2/en active Active
-
2025
- 2025-01-31 JP JP2025014460A patent/JP2025084741A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| US20150306171A1 (en) | 2001-11-13 | 2015-10-29 | Lloyd Hung Loi Tran | Therapeutic agent composition and method of use |
| US20060258663A1 (en) | 2003-09-03 | 2006-11-16 | Neuren Pharmaceuticals Limited | Cyclic G-2AllylProline in treatment of Parkinson's disease |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019222339A1 (en) | 2019-11-21 |
| EP3843768A4 (en) | 2022-11-23 |
| US12070458B2 (en) | 2024-08-27 |
| BR112020023252A2 (pt) | 2021-02-23 |
| JP2021524864A (ja) | 2021-09-16 |
| EP3843768A1 (en) | 2021-07-07 |
| GB202015788D0 (en) | 2020-11-18 |
| CN112423774A (zh) | 2021-02-26 |
| US20200054629A1 (en) | 2020-02-20 |
| AU2019271189A1 (en) | 2021-01-07 |
| US11090303B2 (en) | 2021-08-17 |
| MA53500A (fr) | 2021-08-18 |
| US20220000866A1 (en) | 2022-01-06 |
| US20230381175A1 (en) | 2023-11-30 |
| JP2025084741A (ja) | 2025-06-03 |
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