BR112020010856A8 - Uso de conjugado de anticorpo anti-her2-fármaco no tratamento de carcinoma urotelial - Google Patents

Uso de conjugado de anticorpo anti-her2-fármaco no tratamento de carcinoma urotelial

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Publication number
BR112020010856A8
BR112020010856A8 BR112020010856A BR112020010856A BR112020010856A8 BR 112020010856 A8 BR112020010856 A8 BR 112020010856A8 BR 112020010856 A BR112020010856 A BR 112020010856A BR 112020010856 A BR112020010856 A BR 112020010856A BR 112020010856 A8 BR112020010856 A8 BR 112020010856A8
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BR
Brazil
Prior art keywords
carcinoma
her2
urotelial
treatment
drug
Prior art date
Application number
BR112020010856A
Other languages
English (en)
Other versions
BR112020010856A2 (pt
Inventor
Fang Jianmin
Original Assignee
Remegen Co Ltd
Remegen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Remegen Co Ltd, Remegen Ltd filed Critical Remegen Co Ltd
Publication of BR112020010856A2 publication Critical patent/BR112020010856A2/pt
Publication of BR112020010856A8 publication Critical patent/BR112020010856A8/pt

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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  • Health & Medical Sciences (AREA)
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  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

USO DE CONJUGADO DE ANTICORPO ANTI-HER2-FÁRMACO NO TRATAMENTO DE CARCINOMA UROTELIAL. A presente invenção se refere ao uso de um conjugado de fármaco e anticorpo anti-HER2 (ADC) na preparação de um fármaco para tratar carcinoma urotelial. O fármaco é seguro e eficaz para pacientes com carcinoma urotelial, especialmente carcinoma urotelial metastático ou localmente avançado, e pode prolongar de modo eficaz o tempo de sobrevida dos pacientes.
BR112020010856A 2018-08-29 2019-08-19 Uso de conjugado de anticorpo anti-her2-fármaco no tratamento de carcinoma urotelial BR112020010856A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810998055 2018-08-29
CN201810998055.4 2018-08-29
PCT/CN2019/101283 WO2020042941A1 (zh) 2018-08-29 2019-08-19 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途

Publications (2)

Publication Number Publication Date
BR112020010856A2 BR112020010856A2 (pt) 2021-03-09
BR112020010856A8 true BR112020010856A8 (pt) 2023-03-07

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BR112020010856A BR112020010856A8 (pt) 2018-08-29 2019-08-19 Uso de conjugado de anticorpo anti-her2-fármaco no tratamento de carcinoma urotelial

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US (1) US20200289663A1 (pt)
EP (1) EP3845252A4 (pt)
JP (3) JP7105304B2 (pt)
KR (2) KR20230051318A (pt)
CN (2) CN118557749A (pt)
AU (2) AU2019330680A1 (pt)
BR (1) BR112020010856A8 (pt)
CA (1) CA3077260C (pt)
RU (1) RU2750817C1 (pt)
SG (1) SG11202009130XA (pt)
TW (2) TWI767139B (pt)
WO (1) WO2020042941A1 (pt)

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CA3077260C (en) * 2018-08-29 2023-03-07 Remegen, Ltd. Use of anti-her2 antibody-drug conjugate in treating urothelial carcinoma
BR112023023398A2 (pt) * 2021-05-21 2024-01-23 Remegen Co Ltd Usos de um conjugado anticorpo-droga em combinação com um inibidor de checkpoint imune e de uma quantidade eficaz de conjugado anticorpo-droga e um inibidor de checkpoint imune, método para tratar um paciente com câncer urotelial, e, composição farmacêutica
EP4346908A1 (en) * 2021-05-24 2024-04-10 RemeGen Co., Ltd. Use of her2-targeting antibody-drug conjugate in treatment of her2-low expressing breast cancer
CN115925954A (zh) * 2022-12-28 2023-04-07 广州誉衡生物科技有限公司 抗-pd-1抗体及其在制备治疗尿路上皮癌患者的药物中的用途

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CA3077260C (en) 2018-08-29 2023-03-07 Remegen, Ltd. Use of anti-her2 antibody-drug conjugate in treating urothelial carcinoma

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WO2020042941A1 (zh) 2020-03-05
JP7105304B2 (ja) 2022-07-22
KR20240033092A (ko) 2024-03-12
JP7470154B2 (ja) 2024-04-17
KR20200134268A (ko) 2020-12-01
JP2024086799A (ja) 2024-06-28
AU2019330680A1 (en) 2020-04-23
TWI767139B (zh) 2022-06-11
TW202023626A (zh) 2020-07-01
TW202310877A (zh) 2023-03-16
KR102520974B1 (ko) 2023-04-17
CN111655295B (zh) 2024-05-28
BR112020010856A2 (pt) 2021-03-09
KR20230051318A (ko) 2023-04-17
US20200289663A1 (en) 2020-09-17
SG11202009130XA (en) 2020-10-29
CA3077260C (en) 2023-03-07
CN118557749A (zh) 2024-08-30
CN111655295A (zh) 2020-09-11
RU2750817C1 (ru) 2021-07-05
AU2022252734A1 (en) 2022-11-03
TWI843105B (zh) 2024-05-21
CA3077260A1 (en) 2020-03-05
JP2021504427A (ja) 2021-02-15
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JP2022130744A (ja) 2022-09-06
EP3845252A1 (en) 2021-07-07

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