CN111655295A - 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 - Google Patents
抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 Download PDFInfo
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Abstract
本发明涉及抗HER2抗体药物偶联物(ADC)在制备用于治疗尿路上皮癌的药物中的用途。本发明所述的药物对于尿路上皮癌特别是局部晚期或转移性尿路上皮癌患者安全有效,能有效延长患者生存期。
Description
PCT国内申请,说明书已公开。
Claims (18)
- PCT国内申请,权利要求书已公开。
Priority Applications (1)
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CN202410581446.1A CN118557749A (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
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CN2018109980554 | 2018-08-29 | ||
CN201810998055 | 2018-08-29 | ||
PCT/CN2019/101283 WO2020042941A1 (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
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CN202410581446.1A Division CN118557749A (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
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CN111655295A true CN111655295A (zh) | 2020-09-11 |
CN111655295B CN111655295B (zh) | 2024-05-28 |
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CN202410581446.1A Pending CN118557749A (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
CN201980002467.0A Active CN111655295B (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
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CN202410581446.1A Pending CN118557749A (zh) | 2018-08-29 | 2019-08-19 | 抗her2抗体药物偶联物在治疗尿路上皮癌中的用途 |
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US (1) | US20200289663A1 (zh) |
EP (1) | EP3845252A4 (zh) |
JP (3) | JP7105304B2 (zh) |
KR (2) | KR20230051318A (zh) |
CN (2) | CN118557749A (zh) |
AU (2) | AU2019330680A1 (zh) |
BR (1) | BR112020010856A8 (zh) |
CA (1) | CA3077260C (zh) |
RU (1) | RU2750817C1 (zh) |
SG (1) | SG11202009130XA (zh) |
TW (2) | TWI767139B (zh) |
WO (1) | WO2020042941A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115925954A (zh) * | 2022-12-28 | 2023-04-07 | 广州誉衡生物科技有限公司 | 抗-pd-1抗体及其在制备治疗尿路上皮癌患者的药物中的用途 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3077260C (en) * | 2018-08-29 | 2023-03-07 | Remegen, Ltd. | Use of anti-her2 antibody-drug conjugate in treating urothelial carcinoma |
BR112023023398A2 (pt) * | 2021-05-21 | 2024-01-23 | Remegen Co Ltd | Usos de um conjugado anticorpo-droga em combinação com um inibidor de checkpoint imune e de uma quantidade eficaz de conjugado anticorpo-droga e um inibidor de checkpoint imune, método para tratar um paciente com câncer urotelial, e, composição farmacêutica |
EP4346908A1 (en) * | 2021-05-24 | 2024-04-10 | RemeGen Co., Ltd. | Use of her2-targeting antibody-drug conjugate in treatment of her2-low expressing breast cancer |
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CN105008398A (zh) * | 2013-11-19 | 2015-10-28 | 烟台荣昌生物工程有限公司 | 抗her2抗体及其缀合物 |
CN106456794A (zh) * | 2014-05-22 | 2017-02-22 | 斯索恩生物制药有限公司 | 接头药物与抗体的位点特异性缀合以及所得adc |
US20170209594A1 (en) * | 2015-06-25 | 2017-07-27 | Immunomedics, Inc. | Synergistic effect of anti-trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or parp inhibitors |
CN107532217A (zh) * | 2015-05-29 | 2018-01-02 | 豪夫迈·罗氏有限公司 | 用于癌症的治疗和诊断方法 |
CN107789631A (zh) * | 2017-11-03 | 2018-03-13 | 合肥瀚科迈博生物技术有限公司 | 抗人ErbB2双表位抗体‑药物偶联物及其应用 |
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EP3170821B1 (en) * | 2011-05-27 | 2021-09-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
CN103319599B (zh) * | 2013-05-27 | 2015-02-18 | 上海交联药物研发有限公司 | 一种抗人ErbB2抗体—美登木素偶联物及其应用 |
TW201625304A (zh) | 2014-10-24 | 2016-07-16 | 美國禮來大藥廠 | 泌尿上皮癌之療法 |
CN107029244B (zh) * | 2016-02-04 | 2021-04-27 | 浙江昭华生物医药有限公司 | 抗her2抗体-药物偶联物及其应用 |
TW201825118A (zh) * | 2016-11-30 | 2018-07-16 | 美商艾堤爾製藥公司 | 抗-hrs抗體及用於治療癌症之組合療法 |
CA3077260C (en) | 2018-08-29 | 2023-03-07 | Remegen, Ltd. | Use of anti-her2 antibody-drug conjugate in treating urothelial carcinoma |
-
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CN105008398A (zh) * | 2013-11-19 | 2015-10-28 | 烟台荣昌生物工程有限公司 | 抗her2抗体及其缀合物 |
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TW202310877A (zh) | 2023-03-16 |
KR102520974B1 (ko) | 2023-04-17 |
BR112020010856A8 (pt) | 2023-03-07 |
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BR112020010856A2 (pt) | 2021-03-09 |
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US20200289663A1 (en) | 2020-09-17 |
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