BR112020007442A2 - inibidor de mek para o tratamento de infecções virais e bacterianas - Google Patents
inibidor de mek para o tratamento de infecções virais e bacterianas Download PDFInfo
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- BR112020007442A2 BR112020007442A2 BR112020007442-0A BR112020007442A BR112020007442A2 BR 112020007442 A2 BR112020007442 A2 BR 112020007442A2 BR 112020007442 A BR112020007442 A BR 112020007442A BR 112020007442 A2 BR112020007442 A2 BR 112020007442A2
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- Prior art keywords
- infection
- pharmaceutically acceptable
- virus
- acceptable salt
- bacterial
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- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU100487 | 2017-10-17 | ||
| LULU100487 | 2017-10-17 | ||
| PCT/EP2018/078335 WO2019076947A1 (en) | 2017-10-17 | 2018-10-17 | NEW MEK INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS |
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| BR112020007442A2 true BR112020007442A2 (pt) | 2020-10-27 |
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| BR112020007442-0A BR112020007442A2 (pt) | 2017-10-17 | 2018-10-17 | inibidor de mek para o tratamento de infecções virais e bacterianas |
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| US (2) | US11903917B2 (ko) |
| EP (2) | EP3697405B1 (ko) |
| JP (2) | JP7227967B2 (ko) |
| KR (1) | KR20200072499A (ko) |
| CN (2) | CN118141795A (ko) |
| AU (2) | AU2018351475A1 (ko) |
| BR (1) | BR112020007442A2 (ko) |
| CA (1) | CA3078424A1 (ko) |
| CY (1) | CY1124507T1 (ko) |
| DK (1) | DK3697405T3 (ko) |
| EA (1) | EA202090693A1 (ko) |
| ES (1) | ES2883639T3 (ko) |
| HR (1) | HRP20211252T1 (ko) |
| HU (1) | HUE055738T2 (ko) |
| LT (1) | LT3697405T (ko) |
| MX (2) | MX2020003473A (ko) |
| PL (1) | PL3697405T3 (ko) |
| PT (1) | PT3697405T (ko) |
| SI (1) | SI3697405T1 (ko) |
| WO (1) | WO2019076947A1 (ko) |
| ZA (1) | ZA202002069B (ko) |
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| LU101183B1 (en) * | 2019-04-16 | 2020-10-16 | Atriva Therapeutics Gmbh | Novel mek-inhibitor for the treatment of viral and bacterial infections |
| WO2021037956A1 (en) | 2019-08-27 | 2021-03-04 | Atriva Therapeutics Gmbh | Combinations of mek inhibitors with cap-dependent endonuclease inhibitors |
| US20220378730A1 (en) | 2019-10-08 | 2022-12-01 | Atriva Therapeutics Gmbh | Mek inhibitors for the treatment of hantavirus infections |
| CN112957361B (zh) * | 2021-03-24 | 2022-07-29 | 中国科学院武汉病毒研究所 | 曲美替尼在制备抗沙粒病毒的抗病毒制剂中的应用 |
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| US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| JP2002534381A (ja) * | 1999-01-07 | 2002-10-15 | ワーナー−ランバート・カンパニー | Ｍｅｋ阻害剤を用いた抗ウィルス法 |
| TR200200082T2 (tr) | 1999-07-16 | 2002-04-22 | Warner-Lambert Company | MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi. |
| DE10017480A1 (de) * | 2000-04-07 | 2001-10-11 | Transmit Technologietransfer | Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren |
| WO2003062191A1 (en) | 2002-01-23 | 2003-07-31 | Warner-Lambert Company Llc | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters |
| DE10300222A1 (de) * | 2003-01-03 | 2004-07-15 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen |
| JP2007055983A (ja) * | 2005-08-26 | 2007-03-08 | Tokyo Univ Of Science | 細胞内に侵入した病原性細菌に起因する疾患の予防・改善剤 |
| WO2012019113A2 (en) | 2010-08-05 | 2012-02-09 | Case Western Reserve University | Inhibitors of erk for developmental disorders of neuronal connectivity |
| EA028605B1 (ru) * | 2012-10-08 | 2017-12-29 | Атрива Терапьютикс Гмбх | Комбинация озельтамивира и ингибитора mek для лечения вирусных заболеваний |
| EP3142658B1 (en) | 2014-05-16 | 2020-01-15 | Atriva Therapeutics GmbH | Novel anti-infective strategy against influenza virus and s. aureus coinfections |
| US20220378730A1 (en) | 2019-10-08 | 2022-12-01 | Atriva Therapeutics Gmbh | Mek inhibitors for the treatment of hantavirus infections |
| EP3912623B1 (en) | 2020-05-20 | 2024-07-31 | Atriva Therapeutics GmbH | Pd-0184264 for the treatment of coronavirus infections and/or covid-19 cytokine storm |
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2018
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- 2018-10-17 EA EA202090693A patent/EA202090693A1/ru unknown
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- 2018-10-17 CN CN201880081184.5A patent/CN111479566B/zh active Active
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- 2018-10-17 HU HUE18800045A patent/HUE055738T2/hu unknown
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- 2018-10-17 JP JP2020521541A patent/JP7227967B2/ja active Active
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2020
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2021
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2023
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3697405A1 (en) | 2020-08-26 |
| JP2020537659A (ja) | 2020-12-24 |
| ES2883639T3 (es) | 2021-12-09 |
| CY1124507T1 (el) | 2022-07-22 |
| CN118141795A (zh) | 2024-06-07 |
| HRP20211252T1 (hr) | 2021-11-12 |
| CN111479566A (zh) | 2020-07-31 |
| CA3078424A1 (en) | 2019-04-25 |
| US11903917B2 (en) | 2024-02-20 |
| JP7227967B2 (ja) | 2023-02-22 |
| SI3697405T1 (sl) | 2021-11-30 |
| ZA202002069B (en) | 2021-10-27 |
| DK3697405T3 (da) | 2021-08-23 |
| HUE055738T2 (hu) | 2021-12-28 |
| US20240245637A1 (en) | 2024-07-25 |
| AU2024205853A1 (en) | 2024-09-05 |
| AU2018351475A1 (en) | 2020-04-30 |
| MX2022016066A (es) | 2023-02-02 |
| CN111479566B (zh) | 2024-05-07 |
| PT3697405T (pt) | 2021-08-27 |
| PL3697405T3 (pl) | 2021-12-13 |
| US20200289445A1 (en) | 2020-09-17 |
| MX2020003473A (es) | 2020-10-01 |
| LT3697405T (lt) | 2021-10-25 |
| EP3697405B1 (en) | 2021-07-14 |
| EA202090693A1 (ru) | 2020-10-19 |
| EP3973960A1 (en) | 2022-03-30 |
| WO2019076947A1 (en) | 2019-04-25 |
| JP2023058631A (ja) | 2023-04-25 |
| KR20200072499A (ko) | 2020-06-22 |
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