BR112020004760A2 - métodos e composições para tratamento de doenças pulmonares crônicas - Google Patents
métodos e composições para tratamento de doenças pulmonares crônicas Download PDFInfo
- Publication number
- BR112020004760A2 BR112020004760A2 BR112020004760-0A BR112020004760A BR112020004760A2 BR 112020004760 A2 BR112020004760 A2 BR 112020004760A2 BR 112020004760 A BR112020004760 A BR 112020004760A BR 112020004760 A2 BR112020004760 A2 BR 112020004760A2
- Authority
- BR
- Brazil
- Prior art keywords
- igf
- agonist
- analog
- months
- weeks
- Prior art date
Links
- 230000001684 chronic effect Effects 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 27
- 208000019693 Lung disease Diseases 0.000 title claims abstract description 24
- 239000000203 mixture Substances 0.000 title abstract description 37
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims abstract description 87
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims abstract description 85
- 239000000556 agonist Substances 0.000 claims description 63
- 206010036590 Premature baby Diseases 0.000 claims description 39
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims description 35
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 claims description 34
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 claims description 34
- 230000000241 respiratory effect Effects 0.000 claims description 26
- 102000028416 insulin-like growth factor binding Human genes 0.000 claims description 21
- 108091022911 insulin-like growth factor binding Proteins 0.000 claims description 21
- 238000001990 intravenous administration Methods 0.000 claims description 18
- 210000002966 serum Anatomy 0.000 claims description 18
- 206010022840 Intraventricular haemorrhage Diseases 0.000 claims description 9
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 7
- 230000002028 premature Effects 0.000 claims description 6
- 238000007920 subcutaneous administration Methods 0.000 claims description 5
- 238000007918 intramuscular administration Methods 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims 13
- 101710186630 Insulin-1 Proteins 0.000 claims 10
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 25
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 22
- 230000001225 therapeutic effect Effects 0.000 description 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
- 229910052760 oxygen Inorganic materials 0.000 description 13
- 239000001301 oxygen Substances 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 239000003981 vehicle Substances 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 238000001802 infusion Methods 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 208000005107 Premature Birth Diseases 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 230000007774 longterm Effects 0.000 description 6
- 230000002175 menstrual effect Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 230000034994 death Effects 0.000 description 5
- 231100000517 death Toxicity 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 208000018773 low birth weight Diseases 0.000 description 5
- 231100000533 low birth weight Toxicity 0.000 description 5
- 230000035935 pregnancy Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000007717 exclusion Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 230000000306 recurrent effect Effects 0.000 description 4
- 102000014914 Carrier Proteins Human genes 0.000 description 3
- 206010012559 Developmental delay Diseases 0.000 description 3
- 101000840577 Homo sapiens Insulin-like growth factor-binding protein 7 Proteins 0.000 description 3
- 102100029228 Insulin-like growth factor-binding protein 7 Human genes 0.000 description 3
- 102000013275 Somatomedins Human genes 0.000 description 3
- 108091008324 binding proteins Proteins 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002483 medication Methods 0.000 description 3
- 239000005022 packaging material Substances 0.000 description 3
- 238000007911 parenteral administration Methods 0.000 description 3
- -1 peptides Chemical class 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 208000023504 respiratory system disease Diseases 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 2
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 2
- 208000004852 Lung Injury Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 206010069363 Traumatic lung injury Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229940124630 bronchodilator Drugs 0.000 description 2
- 239000000168 bronchodilator agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 229940000406 drug candidate Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 231100000515 lung injury Toxicity 0.000 description 2
- 238000005399 mechanical ventilation Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000153 supplemental effect Effects 0.000 description 2
- 230000036266 weeks of gestation Effects 0.000 description 2
- 206010003598 Atelectasis Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102100027827 Complexin-3 Human genes 0.000 description 1
- 101710137434 Complexin-3 Proteins 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 102100021860 Endothelial cell-specific molecule 1 Human genes 0.000 description 1
- 101710153170 Endothelial cell-specific molecule 1 Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 description 1
- 102000004372 Insulin-like growth factor binding protein 2 Human genes 0.000 description 1
- 108090000964 Insulin-like growth factor binding protein 2 Proteins 0.000 description 1
- 102000004371 Insulin-like growth factor binding protein 5 Human genes 0.000 description 1
- 108090000961 Insulin-like growth factor binding protein 5 Proteins 0.000 description 1
- 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 1
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 description 1
- 102000004369 Insulin-like growth factor-binding protein 4 Human genes 0.000 description 1
- 108090000969 Insulin-like growth factor-binding protein 4 Proteins 0.000 description 1
- 102000004883 Insulin-like growth factor-binding protein 6 Human genes 0.000 description 1
- 108090001014 Insulin-like growth factor-binding protein 6 Proteins 0.000 description 1
- 208000035752 Live birth Diseases 0.000 description 1
- 208000036626 Mental retardation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010051606 Necrotising colitis Diseases 0.000 description 1
- 208000020241 Neonatal disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000037129 Newborn Diseases Infant Diseases 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 241000183024 Populus tremula Species 0.000 description 1
- 208000007123 Pulmonary Atelectasis Diseases 0.000 description 1
- 208000030934 Restrictive pulmonary disease Diseases 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000030303 breathing problems Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000035611 feeding Effects 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 210000004276 hyalin Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 229960003613 mecasermin rinfabate Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 230000004766 neurogenesis Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000009596 postnatal growth Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 201000009621 pulmonary immaturity Diseases 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000007939 sustained release tablet Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000028016 temperature homeostasis Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1754—Insulin-like growth factor binding proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Marine Sciences & Fisheries (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762557113P | 2017-09-11 | 2017-09-11 | |
| US62/557,113 | 2017-09-11 | ||
| PCT/US2018/050427 WO2019051474A1 (en) | 2017-09-11 | 2018-09-11 | METHODS AND COMPOSITIONS FOR TREATING CHRONIC PULMONARY DISEASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020004760A2 true BR112020004760A2 (pt) | 2020-09-15 |
Family
ID=63794620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020004760-0A BR112020004760A2 (pt) | 2017-09-11 | 2018-09-11 | métodos e composições para tratamento de doenças pulmonares crônicas |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20190151411A1 (enExample) |
| EP (2) | EP4663184A3 (enExample) |
| JP (3) | JP7819893B2 (enExample) |
| KR (1) | KR20200097679A (enExample) |
| CN (1) | CN111432881A (enExample) |
| AU (2) | AU2018328827B2 (enExample) |
| BR (1) | BR112020004760A2 (enExample) |
| CA (1) | CA3075482A1 (enExample) |
| CL (1) | CL2020000597A1 (enExample) |
| CO (1) | CO2020004244A2 (enExample) |
| EA (1) | EA202090705A1 (enExample) |
| EC (1) | ECSP20055797A (enExample) |
| IL (1) | IL273174B2 (enExample) |
| MX (1) | MX421623B (enExample) |
| MY (1) | MY204825A (enExample) |
| PE (1) | PE20201166A1 (enExample) |
| PH (1) | PH12020500489A1 (enExample) |
| SG (1) | SG11202002088TA (enExample) |
| UA (1) | UA128690C2 (enExample) |
| WO (1) | WO2019051474A1 (enExample) |
| ZA (1) | ZA202001568B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3005966T3 (en) * | 2020-10-19 | 2025-03-17 | Oak Hill Bio Ltd | Compositions suitable for use in neonates |
| IL316413A (en) * | 2022-05-04 | 2024-12-01 | Oak Hill Bio Ltd | Combination therapy for preterm infants |
| WO2023242440A1 (en) * | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Treament of lungs in infants |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| AU627423B2 (en) | 1987-04-06 | 1992-08-27 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them |
| DK131988A (da) | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
| US5258287A (en) | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| DE3854842T2 (de) | 1988-04-12 | 1996-06-13 | Amgen Boulder Inc | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
| GB8826451D0 (en) | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
| IL92816A0 (en) | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
| AU4238493A (en) | 1992-05-08 | 1993-12-13 | Thomas Jefferson University | IGF-1 analogs |
| US5563046A (en) | 1993-08-02 | 1996-10-08 | Celtrix Pharmaceuticals, Inc. | Fusion polypeptides and proteins |
| US5789547A (en) | 1995-06-07 | 1998-08-04 | Celtrix Pharmaceuticals, Inc. | Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| AU2002239560B2 (en) * | 2000-11-28 | 2006-03-02 | Premacure Ab | Determination of risk and treatment of complications of prematurity |
| US8518877B2 (en) * | 2007-04-18 | 2013-08-27 | Premacure Ab | Method and product for treatment and/or prevention of complications of prematurity |
-
2018
- 2018-09-11 KR KR1020207009049A patent/KR20200097679A/ko not_active Ceased
- 2018-09-11 BR BR112020004760-0A patent/BR112020004760A2/pt unknown
- 2018-09-11 EP EP25211426.9A patent/EP4663184A3/en active Pending
- 2018-09-11 MX MX2020002744A patent/MX421623B/es unknown
- 2018-09-11 PE PE2020000320A patent/PE20201166A1/es unknown
- 2018-09-11 EP EP18783187.0A patent/EP3681602B1/en active Active
- 2018-09-11 US US16/127,988 patent/US20190151411A1/en not_active Abandoned
- 2018-09-11 UA UAA202002323A patent/UA128690C2/uk unknown
- 2018-09-11 MY MYPI2020001266A patent/MY204825A/en unknown
- 2018-09-11 WO PCT/US2018/050427 patent/WO2019051474A1/en not_active Ceased
- 2018-09-11 EA EA202090705A patent/EA202090705A1/ru unknown
- 2018-09-11 IL IL273174A patent/IL273174B2/en unknown
- 2018-09-11 CA CA3075482A patent/CA3075482A1/en active Pending
- 2018-09-11 CN CN201880058512.XA patent/CN111432881A/zh active Pending
- 2018-09-11 SG SG11202002088TA patent/SG11202002088TA/en unknown
- 2018-09-11 JP JP2020514518A patent/JP7819893B2/ja active Active
- 2018-09-11 AU AU2018328827A patent/AU2018328827B2/en active Active
-
2020
- 2020-03-09 CL CL2020000597A patent/CL2020000597A1/es unknown
- 2020-03-11 PH PH12020500489A patent/PH12020500489A1/en unknown
- 2020-03-12 ZA ZA2020/01568A patent/ZA202001568B/en unknown
- 2020-04-07 CO CONC2020/0004244A patent/CO2020004244A2/es unknown
- 2020-09-08 EC ECSENADI202055797A patent/ECSP20055797A/es unknown
-
2021
- 2021-05-11 US US17/317,152 patent/US20220088132A1/en active Pending
-
2023
- 2023-08-01 JP JP2023125304A patent/JP2023145646A/ja active Pending
-
2024
- 2024-08-30 US US18/821,397 patent/US20240415927A1/en active Pending
- 2024-10-24 AU AU2024227601A patent/AU2024227601B2/en active Active
-
2025
- 2025-05-23 JP JP2025086115A patent/JP2025114869A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9463222B2 (en) | Methods for treatment of complications of prematurity comprising administration of IGF-I and IGFBP-3 | |
| AU2024227601B2 (en) | Methods and compositions for treating chronic lung diseases | |
| TWI912393B (zh) | 適用於新生兒的組成物 | |
| EP1402266B1 (en) | Reducing RISK OF COMPLICATIONS OF PREMATURITY | |
| EA044079B1 (ru) | Способы и композиции, предназначенные для лечения хронических заболеваний легких | |
| HK40033881A (en) | Methods and compositions for treating chronic lung diseases | |
| EA049095B1 (ru) | Композиции, подходящие для применения у новорожденных | |
| HK40099225B (en) | Compositions suitable for use in neonates | |
| HK40099225A (en) | Compositions suitable for use in neonates | |
| PT1402266E (pt) | Redução do risco de complicações da prematuridade |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) |
|
| B25A | Requested transfer of rights approved |
Owner name: OAK HILL BIO LIMITED (GB) |