BR112019027479A2 - l-asparaginase modificada - Google Patents
l-asparaginase modificada Download PDFInfo
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- BR112019027479A2 BR112019027479A2 BR112019027479-0A BR112019027479A BR112019027479A2 BR 112019027479 A2 BR112019027479 A2 BR 112019027479A2 BR 112019027479 A BR112019027479 A BR 112019027479A BR 112019027479 A2 BR112019027479 A2 BR 112019027479A2
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- Brazil
- Prior art keywords
- asparaginase
- amino acid
- modified protein
- protein
- modified
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/82—Asparaginase (3.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01001—Asparaginase (3.5.1.1)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762523061P | 2017-06-21 | 2017-06-21 | |
| EP17177237.9A EP3418383A1 (en) | 2017-06-21 | 2017-06-21 | Modified l-asparaginase |
| EP17177237.9 | 2017-06-21 | ||
| US62/523,061 | 2017-06-21 | ||
| US15/671,086 | 2017-08-07 | ||
| US15/671,086 US10174302B1 (en) | 2017-06-21 | 2017-08-07 | Modified L-asparaginase |
| PCT/EP2018/066647 WO2018234492A1 (en) | 2017-06-21 | 2018-06-21 | L-ASPARAGINASE MODIFIED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019027479A2 true BR112019027479A2 (pt) | 2020-09-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019027479-0A BR112019027479A2 (pt) | 2017-06-21 | 2018-06-21 | l-asparaginase modificada |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP3642340B1 (https=) |
| JP (2) | JP7808424B2 (https=) |
| KR (1) | KR102727396B1 (https=) |
| CN (1) | CN111315878B (https=) |
| AU (1) | AU2018287145B2 (https=) |
| BR (1) | BR112019027479A2 (https=) |
| CA (1) | CA3068100A1 (https=) |
| DK (1) | DK3642340T3 (https=) |
| ES (1) | ES2979314T3 (https=) |
| FI (1) | FI3642340T3 (https=) |
| IL (1) | IL271504B2 (https=) |
| MX (2) | MX2019015502A (https=) |
| SA (2) | SA519410870B1 (https=) |
| SG (1) | SG11201912625QA (https=) |
| WO (1) | WO2018234492A1 (https=) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11839597B2 (en) | 2016-07-22 | 2023-12-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
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| ES2877539T3 (es) | 2015-12-22 | 2021-11-17 | Xl Protein Gmbh | Acidos nucleicos que codifican secuencias repetitivas de aminoácidos ricos en residuos de prolina y alanina que tienen bajas secuencias de nucleótidos repetitivas |
| IL271504B2 (en) * | 2017-06-21 | 2024-05-01 | Jazz Pharmaceuticals Ireland Ltd | Modified l-asparaginase |
| WO2019101308A1 (en) * | 2017-11-22 | 2019-05-31 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant botulinum toxin with increased duration of effect |
| JP2022553399A (ja) * | 2019-10-25 | 2022-12-22 | ジャズ ファーマシューティカルズ アイルランド リミテッド | 組換えｌ－アスパラギナーゼ |
| US20220227805A1 (en) * | 2020-12-23 | 2022-07-21 | Jazz Pharmaceuticals Ireland Ltd. | Methods of purifying charge-shielded fusion proteins |
| WO2022211829A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
| WO2024015529A2 (en) | 2022-07-14 | 2024-01-18 | Jazz Pharmaceuticals Ireland Ltd. | Combination therapies involving l-asparaginase |
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| GB8519753D0 (en) * | 1985-08-06 | 1985-09-11 | Health Lab Service Board | Production of 1-asparaginase |
| GB9017002D0 (en) * | 1990-08-02 | 1990-09-19 | Health Lab Service Board | Improved method for the purification of erwina l-asparaginase |
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| US7666652B2 (en) * | 2007-03-09 | 2010-02-23 | Novozymes A/S | Asparaginases |
| ATE502114T1 (de) | 2007-06-21 | 2011-04-15 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| WO2011003633A1 (en) * | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| WO2011144756A1 (en) | 2010-05-21 | 2011-11-24 | Xl-Protein Gmbh | Biosynthetic proline/alanine random coil polypeptides and their uses |
| CN117462693A (zh) | 2012-02-27 | 2024-01-30 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| IL271504B2 (en) | 2017-06-21 | 2024-05-01 | Jazz Pharmaceuticals Ireland Ltd | Modified l-asparaginase |
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| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12295926B1 (en) | 2022-02-07 | 2025-05-13 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US12551457B1 (en) | 2022-02-07 | 2026-02-17 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111315878A (zh) | 2020-06-19 |
| EP4180525A1 (en) | 2023-05-17 |
| SA522433360B1 (ar) | 2024-06-23 |
| ES2979314T3 (es) | 2024-09-25 |
| JP7808424B2 (ja) | 2026-01-29 |
| RU2020101972A (ru) | 2021-07-21 |
| AU2018287145B2 (en) | 2024-04-18 |
| JP2020528743A (ja) | 2020-10-01 |
| RU2020101972A3 (https=) | 2021-11-09 |
| WO2018234492A1 (en) | 2018-12-27 |
| EP3642340B1 (en) | 2024-03-20 |
| JP7770352B2 (ja) | 2025-11-14 |
| KR20200030065A (ko) | 2020-03-19 |
| SG11201912625QA (en) | 2020-01-30 |
| IL271504B1 (en) | 2024-01-01 |
| KR102727396B1 (ko) | 2024-11-08 |
| MX2019015502A (es) | 2020-07-28 |
| CA3068100A1 (en) | 2018-12-27 |
| SA519410870B1 (ar) | 2023-03-06 |
| AU2018287145A1 (en) | 2020-02-06 |
| FI3642340T3 (fi) | 2024-06-18 |
| DK3642340T3 (da) | 2024-06-03 |
| IL271504B2 (en) | 2024-05-01 |
| CN111315878B (zh) | 2024-04-26 |
| JP2023081915A (ja) | 2023-06-13 |
| EP3642340A1 (en) | 2020-04-29 |
| IL271504A (en) | 2020-02-27 |
| MX2024015050A (es) | 2025-01-09 |
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