KR102727396B1 - 변형된 l-아스파라기나아제 - Google Patents

변형된 l-아스파라기나아제 Download PDF

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Publication number
KR102727396B1
KR102727396B1 KR1020207002029A KR20207002029A KR102727396B1 KR 102727396 B1 KR102727396 B1 KR 102727396B1 KR 1020207002029 A KR1020207002029 A KR 1020207002029A KR 20207002029 A KR20207002029 A KR 20207002029A KR 102727396 B1 KR102727396 B1 KR 102727396B1
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KR
South Korea
Prior art keywords
asparaginase
modified protein
ala pro
pro ala
amino acid
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KR1020207002029A
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English (en)
Korean (ko)
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KR20200030065A (ko
Inventor
라스 프리드리히
앤 오도넬
Original Assignee
재즈 파마슈티칼즈 아일랜드 리미티드
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Priority claimed from EP17177237.9A external-priority patent/EP3418383A1/en
Priority claimed from US15/671,086 external-priority patent/US10174302B1/en
Application filed by 재즈 파마슈티칼즈 아일랜드 리미티드 filed Critical 재즈 파마슈티칼즈 아일랜드 리미티드
Publication of KR20200030065A publication Critical patent/KR20200030065A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01001—Asparaginase (3.5.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020207002029A 2017-06-21 2018-06-21 변형된 l-아스파라기나아제 Active KR102727396B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762523061P 2017-06-21 2017-06-21
EP17177237.9A EP3418383A1 (en) 2017-06-21 2017-06-21 Modified l-asparaginase
EP17177237.9 2017-06-21
US62/523,061 2017-06-21
US15/671,086 2017-08-07
US15/671,086 US10174302B1 (en) 2017-06-21 2017-08-07 Modified L-asparaginase
PCT/EP2018/066647 WO2018234492A1 (en) 2017-06-21 2018-06-21 L-ASPARAGINASE MODIFIED

Publications (2)

Publication Number Publication Date
KR20200030065A KR20200030065A (ko) 2020-03-19
KR102727396B1 true KR102727396B1 (ko) 2024-11-08

Family

ID=64737515

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207002029A Active KR102727396B1 (ko) 2017-06-21 2018-06-21 변형된 l-아스파라기나아제

Country Status (15)

Country Link
EP (2) EP3642340B1 (https=)
JP (2) JP7808424B2 (https=)
KR (1) KR102727396B1 (https=)
CN (1) CN111315878B (https=)
AU (1) AU2018287145B2 (https=)
BR (1) BR112019027479A2 (https=)
CA (1) CA3068100A1 (https=)
DK (1) DK3642340T3 (https=)
ES (1) ES2979314T3 (https=)
FI (1) FI3642340T3 (https=)
IL (1) IL271504B2 (https=)
MX (2) MX2019015502A (https=)
SA (2) SA519410870B1 (https=)
SG (1) SG11201912625QA (https=)
WO (1) WO2018234492A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2877539T3 (es) 2015-12-22 2021-11-17 Xl Protein Gmbh Acidos nucleicos que codifican secuencias repetitivas de aminoácidos ricos en residuos de prolina y alanina que tienen bajas secuencias de nucleótidos repetitivas
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
IL271504B2 (en) * 2017-06-21 2024-05-01 Jazz Pharmaceuticals Ireland Ltd Modified l-asparaginase
WO2019101308A1 (en) * 2017-11-22 2019-05-31 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
CN113473980A (zh) 2019-03-01 2021-10-01 弗拉梅尔爱尔兰有限公司 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物
JP2022553399A (ja) * 2019-10-25 2022-12-22 ジャズ ファーマシューティカルズ アイルランド リミテッド 組換えｌ－アスパラギナーゼ
US20220227805A1 (en) * 2020-12-23 2022-07-21 Jazz Pharmaceuticals Ireland Ltd. Methods of purifying charge-shielded fusion proteins
WO2022211829A1 (en) 2021-03-30 2022-10-06 Jazz Pharmaceuticals Ireland Ltd. Dosing of recombinant l-asparaginase
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
WO2024015529A2 (en) 2022-07-14 2024-01-18 Jazz Pharmaceuticals Ireland Ltd. Combination therapies involving l-asparaginase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003633A1 (en) 2009-07-06 2011-01-13 Alize Pharma Ii Pegylated l-asparaginase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
GB8519753D0 (en) * 1985-08-06 1985-09-11 Health Lab Service Board Production of 1-asparaginase
GB9017002D0 (en) * 1990-08-02 1990-09-19 Health Lab Service Board Improved method for the purification of erwina l-asparaginase
US7985548B2 (en) 2006-03-03 2011-07-26 The United States Of America As Represented By The Department Of Health And Human Services Materials and methods directed to asparagine synthetase and asparaginase therapies
US7666652B2 (en) * 2007-03-09 2010-02-23 Novozymes A/S Asparaginases
ATE502114T1 (de) 2007-06-21 2011-04-15 Univ Muenchen Tech Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität
WO2011144756A1 (en) 2010-05-21 2011-11-24 Xl-Protein Gmbh Biosynthetic proline/alanine random coil polypeptides and their uses
CN117462693A (zh) 2012-02-27 2024-01-30 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
IL271504B2 (en) 2017-06-21 2024-05-01 Jazz Pharmaceuticals Ireland Ltd Modified l-asparaginase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011003633A1 (en) 2009-07-06 2011-01-13 Alize Pharma Ii Pegylated l-asparaginase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Enzyme Microb Technol.,79-80:49-54(2015.7.17)
Protein Expr Purif.,34(2):296-301(2004.4.)

Also Published As

Publication number Publication date
CN111315878A (zh) 2020-06-19
EP4180525A1 (en) 2023-05-17
SA522433360B1 (ar) 2024-06-23
ES2979314T3 (es) 2024-09-25
JP7808424B2 (ja) 2026-01-29
RU2020101972A (ru) 2021-07-21
AU2018287145B2 (en) 2024-04-18
JP2020528743A (ja) 2020-10-01
RU2020101972A3 (https=) 2021-11-09
WO2018234492A1 (en) 2018-12-27
EP3642340B1 (en) 2024-03-20
JP7770352B2 (ja) 2025-11-14
KR20200030065A (ko) 2020-03-19
SG11201912625QA (en) 2020-01-30
IL271504B1 (en) 2024-01-01
MX2019015502A (es) 2020-07-28
CA3068100A1 (en) 2018-12-27
SA519410870B1 (ar) 2023-03-06
AU2018287145A1 (en) 2020-02-06
FI3642340T3 (fi) 2024-06-18
DK3642340T3 (da) 2024-06-03
IL271504B2 (en) 2024-05-01
CN111315878B (zh) 2024-04-26
JP2023081915A (ja) 2023-06-13
EP3642340A1 (en) 2020-04-29
IL271504A (en) 2020-02-27
MX2024015050A (es) 2025-01-09
BR112019027479A2 (pt) 2020-09-15

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