BR112019022483A2 - Métodos e composições para tratamento de apneia do sono - Google Patents

Métodos e composições para tratamento de apneia do sono Download PDF

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Publication number
BR112019022483A2
BR112019022483A2 BR112019022483-1A BR112019022483A BR112019022483A2 BR 112019022483 A2 BR112019022483 A2 BR 112019022483A2 BR 112019022483 A BR112019022483 A BR 112019022483A BR 112019022483 A2 BR112019022483 A2 BR 112019022483A2
Authority
BR
Brazil
Prior art keywords
fact
receptor antagonist
muscarinic receptor
nri
atomoxetine
Prior art date
Application number
BR112019022483-1A
Other languages
English (en)
Portuguese (pt)
Inventor
Andrew Wellman D.
Taranto-Montemurro Luigi
Original Assignee
The Brigham And Women´S Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63918622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112019022483(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Brigham And Women´S Hospital, Inc. filed Critical The Brigham And Women´S Hospital, Inc.
Publication of BR112019022483A2 publication Critical patent/BR112019022483A2/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112019022483-1A 2017-04-28 2018-04-26 Métodos e composições para tratamento de apneia do sono BR112019022483A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762491504P 2017-04-28 2017-04-28
US62/491,504 2017-04-28
US201762558814P 2017-09-14 2017-09-14
US62/558,814 2017-09-14
PCT/US2018/029518 WO2018200775A1 (en) 2017-04-28 2018-04-26 Methods and compositions for treating sleep apnea

Publications (1)

Publication Number Publication Date
BR112019022483A2 true BR112019022483A2 (pt) 2020-05-12

Family

ID=63918622

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019022483-1A BR112019022483A2 (pt) 2017-04-28 2018-04-26 Métodos e composições para tratamento de apneia do sono

Country Status (22)

Country Link
US (4) US11123313B2 (enIt.pdf)
EP (1) EP3615016A4 (enIt.pdf)
JP (2) JP7373997B2 (enIt.pdf)
KR (2) KR20240042261A (enIt.pdf)
CN (1) CN110799181A (enIt.pdf)
AU (2) AU2018260666B2 (enIt.pdf)
BR (1) BR112019022483A2 (enIt.pdf)
CA (1) CA3061468A1 (enIt.pdf)
CO (1) CO2019013180A2 (enIt.pdf)
CR (1) CR20190546A (enIt.pdf)
DO (1) DOP2019000274A (enIt.pdf)
EC (1) ECSP19084058A (enIt.pdf)
GE (2) GEP20227387B (enIt.pdf)
MA (1) MA49069A (enIt.pdf)
MX (2) MX2019012729A (enIt.pdf)
MY (1) MY200172A (enIt.pdf)
NI (1) NI201900110A (enIt.pdf)
PH (1) PH12019502427A1 (enIt.pdf)
SG (2) SG11201909973UA (enIt.pdf)
UA (1) UA127759C2 (enIt.pdf)
WO (1) WO2018200775A1 (enIt.pdf)
ZA (1) ZA201907158B (enIt.pdf)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012729A (es) * 2017-04-28 2019-12-19 Brigham & Womens Hospital Inc Metodos y composiciones para el tratamiento de apnea del sue?o.
SG11202007226UA (en) 2018-01-30 2020-08-28 Apnimed Inc Delaware Methods and compositions for treating sleep apnea
CN108309261B (zh) * 2018-02-11 2020-05-22 西安交通大学 一种猝死预警方法及装置和系统
US20190381056A1 (en) 2018-06-17 2019-12-19 Axsome Therapeutics, Inc. Compositions for delivery of reboxetine
US11020402B2 (en) 2018-10-15 2021-06-01 Axsome Therapeutics, Inc. Use of reboxetine to treat narcolepsy
MX2021004883A (es) * 2018-10-31 2021-08-05 Apnimed Inc Delaware Metodos y composiciones para tratar apnea del sue?o.
EA202192202A1 (ru) * 2019-02-08 2021-11-03 Дзе Брихэм Энд Уимен'З Хоспитал, Инк. Способы и композиции для лечения синдрома обструктивного апноэ, возникающего во сне
WO2021091902A1 (en) * 2019-11-04 2021-05-14 Apnimed, Inc. (Delaware) Combination pharmacological interventions for multiple mechanisms of obstructive sleep apnea
RU2757470C1 (ru) * 2020-11-19 2021-10-18 Ренат Рашитович Ахмеров Способ лечения храпа с помощью введения тромбоцитарной аутологичной плазмы
WO2022155162A1 (en) * 2021-01-14 2022-07-21 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
AU2022231133A1 (en) * 2021-03-04 2023-09-21 Apnimed, Inc. (Delaware) Combination of reboxetine and a muscarinic receptor antagonist (mra) for use in treating sleep apnea
AU2022259671A1 (en) * 2021-04-16 2023-11-09 Apnimed, Inc. (Delaware) Combination of a norepinephrine reuptake inhibitor and a cannabinoid for use in treating sleep apnea
MX2023014709A (es) * 2021-06-17 2024-01-15 Apnimed Inc Delaware Inhibidores de la recaptacion de norepinefrina para tratamiento de la apnea del sue?o.
WO2023034265A1 (en) * 2021-08-31 2023-03-09 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
MX2024007768A (es) 2021-12-22 2024-07-01 Bayer Ag Combinacion de un antagonista de adrenoreceptor a2 subtipo c (alfa-2c) con un inhibidor de recaptacion de norepinefrina para el tratamiento de apnea del sue?o.
WO2023118098A1 (en) 2021-12-22 2023-06-29 Bayer Aktiengesellschaft COMBINATION OF AN α2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS WITH A MUSCARINIC RECEPTOR ANTAGONIST FOR THE TREATMENT OF SLEEP APNEA
MX2024007764A (es) * 2021-12-22 2024-07-04 Bayer Ag Combinacion de un bloqueante de canales task1/3 con un inhibidor de la recaptacion de norepinefrina para el tratamiento de la apnea del sue?o.
WO2023219991A1 (en) * 2022-05-13 2023-11-16 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU767877B2 (en) 1999-05-20 2003-11-27 Sepracor, Inc. Methods for treatment of asthma using S-oxybutynin
JP2003523382A (ja) 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
WO2006023703A2 (en) 2004-08-20 2006-03-02 Cypress Bioscience, Inc. Method for treating sleep related breathing disorders
US8512751B2 (en) * 2004-12-20 2013-08-20 Collegium Pharmaceutical, Inc. Pharmaceutical compositions for sleep disorders
US8753327B2 (en) * 2011-01-28 2014-06-17 Pfantastic Medical Research Institute, Llc Methods for treating obstructive sleep apnea
MX2019012729A (es) * 2017-04-28 2019-12-19 Brigham & Womens Hospital Inc Metodos y composiciones para el tratamiento de apnea del sue?o.
SG11202007226UA (en) * 2018-01-30 2020-08-28 Apnimed Inc Delaware Methods and compositions for treating sleep apnea

Also Published As

Publication number Publication date
KR20240042261A (ko) 2024-04-01
ECSP19084058A (es) 2020-01-31
WO2018200775A1 (en) 2018-11-01
KR102682159B1 (ko) 2024-07-08
NZ758564A (en) 2023-12-22
US20200054583A1 (en) 2020-02-20
PH12019502427A1 (en) 2020-10-05
CA3061468A1 (en) 2018-11-01
EP3615016A1 (en) 2020-03-04
US20210401777A1 (en) 2021-12-30
SG11201909973UA (en) 2019-11-28
MY200172A (en) 2023-12-12
ZA201907158B (en) 2021-09-29
UA127759C2 (uk) 2023-12-27
SG10202111623TA (en) 2021-12-30
JP2023139000A (ja) 2023-10-03
US20240189261A1 (en) 2024-06-13
KR20190140019A (ko) 2019-12-18
CO2019013180A2 (es) 2020-02-07
EP3615016A4 (en) 2021-02-24
AU2018260666A1 (en) 2019-11-14
CN110799181A (zh) 2020-02-14
JP7373997B2 (ja) 2023-11-06
CR20190546A (es) 2020-04-08
JP2020517719A (ja) 2020-06-18
GEP20227387B (en) 2022-06-10
AU2018260666B2 (en) 2022-07-21
NI201900110A (es) 2020-03-18
US20240261239A1 (en) 2024-08-08
AU2022241471A1 (en) 2022-10-27
MX2022010349A (es) 2022-09-19
MX2019012729A (es) 2019-12-19
GEP20247617B (en) 2024-04-25
MA49069A (fr) 2020-03-04
US11123313B2 (en) 2021-09-21
DOP2019000274A (es) 2019-12-30

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