BR112019021828B1 - Anticorpo anti-pd-l1, molécula de ácido nucleico, célula hospedeira de levedura compreendendo a referida molécula de ácido nucleico, composição compreendendo o anticorpo anti-pdl1 e uso do referido anticorpo para tratar ou prevenir uma doença ou condição associada à modulação da atividade da pd-l1 humana - Google Patents

Anticorpo anti-pd-l1, molécula de ácido nucleico, célula hospedeira de levedura compreendendo a referida molécula de ácido nucleico, composição compreendendo o anticorpo anti-pdl1 e uso do referido anticorpo para tratar ou prevenir uma doença ou condição associada à modulação da atividade da pd-l1 humana Download PDF

Info

Publication number
BR112019021828B1
BR112019021828B1 BR112019021828-9A BR112019021828A BR112019021828B1 BR 112019021828 B1 BR112019021828 B1 BR 112019021828B1 BR 112019021828 A BR112019021828 A BR 112019021828A BR 112019021828 B1 BR112019021828 B1 BR 112019021828B1
Authority
BR
Brazil
Prior art keywords
antibody
seq
cancer
antibodies
cells
Prior art date
Application number
BR112019021828-9A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112019021828A2 (pt
Inventor
Yan Lavrovsky
Ting Xu
Sergei BARBASHOV
Alexey Repik
Mikhail Samsonov
Vasily Ignatiev
Shorena Archuadze
Original Assignee
R-Pharm Overseas, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R-Pharm Overseas, Inc filed Critical R-Pharm Overseas, Inc
Publication of BR112019021828A2 publication Critical patent/BR112019021828A2/pt
Publication of BR112019021828B1 publication Critical patent/BR112019021828B1/pt

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
BR112019021828-9A 2017-04-18 2018-04-18 Anticorpo anti-pd-l1, molécula de ácido nucleico, célula hospedeira de levedura compreendendo a referida molécula de ácido nucleico, composição compreendendo o anticorpo anti-pdl1 e uso do referido anticorpo para tratar ou prevenir uma doença ou condição associada à modulação da atividade da pd-l1 humana BR112019021828B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT/US2017/028206 2017-04-18
US2017028206 2017-04-18
PCT/US2018/028206 WO2018195226A1 (en) 2017-04-18 2018-04-18 Anti-pd-l1 antibody and use thereof

Publications (2)

Publication Number Publication Date
BR112019021828A2 BR112019021828A2 (pt) 2020-03-24
BR112019021828B1 true BR112019021828B1 (pt) 2022-09-20

Family

ID=63856823

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019021828-9A BR112019021828B1 (pt) 2017-04-18 2018-04-18 Anticorpo anti-pd-l1, molécula de ácido nucleico, célula hospedeira de levedura compreendendo a referida molécula de ácido nucleico, composição compreendendo o anticorpo anti-pdl1 e uso do referido anticorpo para tratar ou prevenir uma doença ou condição associada à modulação da atividade da pd-l1 humana

Country Status (17)

Country Link
US (1) US20210115143A1 (https=)
EP (1) EP3612565A4 (https=)
JP (2) JP2020517239A (https=)
KR (1) KR102323960B1 (https=)
CN (1) CN110856446A (https=)
AU (1) AU2018256392B2 (https=)
BR (1) BR112019021828B1 (https=)
CA (1) CA3059447A1 (https=)
CL (1) CL2019002953A1 (https=)
CO (1) CO2019012118A2 (https=)
EA (1) EA201900443A1 (https=)
MA (1) MA50038A (https=)
MX (1) MX2019012461A (https=)
MY (1) MY199319A (https=)
PH (1) PH12019502302A1 (https=)
SG (1) SG11201909041SA (https=)
WO (1) WO2018195226A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
US11046769B2 (en) 2018-11-13 2021-06-29 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof
CA3120096A1 (en) 2018-11-14 2020-05-22 Rubryc Therapeutics, Inc. Cd25 antibodies
EP3880698A4 (en) 2018-11-14 2022-11-30 RubrYc Therapeutics, Inc. MANIPULATED CD25 POLYPEPTIDES AND USES THEREOF
CN109929037B (zh) * 2019-04-01 2023-03-17 华博生物医药技术（上海）有限公司 针对程序性死亡配体的结合物及其应用
CN113677709B (zh) * 2019-04-11 2024-08-23 斯克里普斯抗体研究所 针对程序性细胞死亡蛋白配体-1(pd-l1)的抗体及其用途
EP3833691B1 (en) * 2019-04-26 2024-09-25 I-Mab Biopharma Co., Ltd. Human pd-l1 antibodies
WO2022006091A1 (en) * 2020-06-29 2022-01-06 Anovent Pharmaceutical (U.S.), Llc Biopharmaceutical formulation of anti-pd-1, anti-pd-l1, and anti-vegfr therapeutic monoclonal antibodies and method for treating nsclc by inhalation
CN116178545B (zh) * 2021-09-24 2025-09-12 广东菲鹏制药股份有限公司 一种抗人pd-l1人源化抗体或其抗原结合片段及其应用
WO2024160721A1 (en) 2023-01-30 2024-08-08 Kymab Limited Antibodies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2454587C (en) * 2001-07-25 2012-11-13 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
AU2009333580B2 (en) * 2008-12-09 2016-07-07 Genentech, Inc. Anti-PD-L1 antibodies and their use to enhance T-cell function
WO2015061668A1 (en) * 2013-10-25 2015-04-30 Dana-Farber Cancer Institute, Inc. Anti-pd-l1 monoclonal antibodies and fragments thereof
KR20220062143A (ko) * 2014-01-06 2022-05-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
CA2940242C (en) * 2014-02-20 2026-01-13 H. Lundbeck A/S Anti-acth antibodies and use thereof
CN105777906B (zh) * 2014-12-19 2019-04-23 苏州丁孚靶点生物技术有限公司 抗pd-l1全人抗体及其应用
CN108112254B (zh) * 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
CN117088979A (zh) * 2016-10-30 2023-11-21 上海复宏汉霖生物技术股份有限公司 抗-pd-l1抗体及变异体

Also Published As

Publication number Publication date
EP3612565A4 (en) 2021-06-16
EA201900443A1 (ru) 2020-03-06
MA50038A (fr) 2020-07-08
MX2019012461A (es) 2019-12-11
PH12019502302A1 (en) 2020-09-21
JP2020517239A (ja) 2020-06-18
KR20190141169A (ko) 2019-12-23
JP2023025003A (ja) 2023-02-21
SG11201909041SA (en) 2019-11-28
MY199319A (en) 2023-10-24
KR102323960B1 (ko) 2021-11-10
AU2018256392B2 (en) 2024-05-16
CO2019012118A2 (es) 2020-04-01
BR112019021828A2 (pt) 2020-03-24
WO2018195226A1 (en) 2018-10-25
CA3059447A1 (en) 2018-10-25
CN110856446A (zh) 2020-02-28
AU2018256392A1 (en) 2019-10-17
CL2019002953A1 (es) 2020-01-10
US20210115143A1 (en) 2021-04-22
EP3612565A1 (en) 2020-02-26

Similar Documents

Publication Publication Date Title
BR112019021828B1 (pt) Anticorpo anti-pd-l1, molécula de ácido nucleico, célula hospedeira de levedura compreendendo a referida molécula de ácido nucleico, composição compreendendo o anticorpo anti-pdl1 e uso do referido anticorpo para tratar ou prevenir uma doença ou condição associada à modulação da atividade da pd-l1 humana
JP6873445B2 (ja) 抗ガレクチン−９抗体及びその使用
TWI818308B (zh) 標靶ｒｏｒ１的抗體或其抗原結合片段及製備方法和應用
US12509520B2 (en) Anti-CD3 and anti-CD123 bispecific antibody and use thereof
ES2737307T3 (es) Anticuerpos no antagonistas dirigidos contra la cadena alfa del dominio extracelular del receptor de IL7 y uso del mismo en el tratamiento del cáncer
BR112021009835A2 (pt) anticorpo anti-cd40, fragmento de ligação ao antígeno e uso farmacêutico dos mesmos
TW202334215A (zh) 靶向cldn18.2之抗體、雙特異性抗體及其應用
JP2024534795A (ja) 二重特異性抗体およびその使用
TW202438528A (zh) 特異性結合Ｃｌａｕｄｉｎ １８．２的抗體及其製法和應用
TW202602921A (zh) 多功能ｎｋ細胞接合器
BR112019016513A2 (pt) anticorpo anticâncer conversível de célula t reguladora induzível por ifn-gama (irtca) e usos do mesmo
US20240309115A1 (en) Novel multispecific antibodies
JP2024542879A (ja) Ｐｄ－１およびｔｇｆ－ｂｒｉｉ結合ドメインを含む多重特異性結合部位
KR20230158058A (ko) 시알산-결합 ig-유사 렉틴 15에 특이적인 항체 및 이의 용도
EA044327B1 (ru) Антитело к pd-l1 и его применение
WO2025241703A1 (zh) 高亲和力b7h7抗体或其抗原结合片段及其用途
JP2026507507A (ja) Ｃｃｒ９陽性癌を治療するｃｃｒ９標的化部分
HK40082759B (zh) 抗半乳凝素-9抗体及其用途
HK40105152A (zh) 对muc18特异性的抗体
WO2023025306A1 (zh) 靶向pd-l1和cldn18.2的双特异性抗体及其制备方法和应用
BR112023019749B1 (pt) Conjugados de exatecano anti-nectina-4, composição farmacêutica que os compreende e seus usos
WO2023019505A1 (zh) 抗TGFβ抗体及其制备方法和应用
HK40066347B (zh) 靶向 cldn18.2 的抗体及其制备方法和应用
BR122023027661A2 (pt) Proteínas de ligação de tgf-beta-rii
HK40060753B (zh) 对muc18特异性的抗体

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/04/2018, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 8A ANUIDADE.