BR112019018495A2 - derivados de desmetilanetola tritiona para o tratamento de doenças relacionadas com a produção mitocondrial de espécies de oxigênio reativo (ero) - Google Patents

Info

Publication number

BR112019018495A2

BR112019018495A2 BR112019018495A BR112019018495A BR112019018495A2 BR 112019018495 A2 BR112019018495 A2 BR 112019018495A2 BR 112019018495 A BR112019018495 A BR 112019018495A BR 112019018495 A BR112019018495 A BR 112019018495A BR 112019018495 A2 BR112019018495 A2 BR 112019018495A2

Authority

BR

Brazil

Prior art keywords

day

inhibitor

production

petition

compound

Prior art date

2017-03-07

Links

• Espacenet
• Global Dossier
• Discuss

• 238000004519 manufacturing process Methods 0.000 title claims abstract description 386
• 239000003642 reactive oxygen metabolite Substances 0.000 title claims abstract description 344
• 230000002438 mitochondrial effect Effects 0.000 title claims abstract description 221
• 238000011282 treatment Methods 0.000 title claims abstract description 203
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 88
• 201000010099 disease Diseases 0.000 title claims abstract description 78
• VEDTXTNSFWUXGQ-UHFFFAOYSA-N Carbophenothion Chemical compound CCOP(=S)(OCC)SCSC1=CC=C(Cl)C=C1 VEDTXTNSFWUXGQ-UHFFFAOYSA-N 0.000 title 1
• 239000003112 inhibitor Substances 0.000 claims description 246
• 150000001875 compounds Chemical class 0.000 claims description 128
• 210000003470 mitochondria Anatomy 0.000 claims description 98
• 206010048610 Cardiotoxicity Diseases 0.000 claims description 95
• 231100000259 cardiotoxicity Toxicity 0.000 claims description 95
• 230000007681 cardiovascular toxicity Effects 0.000 claims description 95
• 238000000034 method Methods 0.000 claims description 85
• 229910052760 oxygen Inorganic materials 0.000 claims description 82
• 239000003814 drug Substances 0.000 claims description 79
• 239000001301 oxygen Substances 0.000 claims description 78
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 72
• -1 nitro, carboxy Chemical group 0.000 claims description 65
• 150000003839 salts Chemical class 0.000 claims description 54
• 239000012453 solvate Substances 0.000 claims description 46
• 239000008194 pharmaceutical composition Substances 0.000 claims description 39
• 239000001257 hydrogen Substances 0.000 claims description 27
• 229910052739 hydrogen Inorganic materials 0.000 claims description 27
• 230000032683 aging Effects 0.000 claims description 26
• 208000024172 Cardiovascular disease Diseases 0.000 claims description 24
• 208000010125 myocardial infarction Diseases 0.000 claims description 23
• 206010063837 Reperfusion injury Diseases 0.000 claims description 19
• 206010019280 Heart failures Diseases 0.000 claims description 18
• 125000003118 aryl group Chemical group 0.000 claims description 18
• 125000001188 haloalkyl group Chemical group 0.000 claims description 16
• 208000028867 ischemia Diseases 0.000 claims description 16
• 229910052717 sulfur Inorganic materials 0.000 claims description 16
• 125000003545 alkoxy group Chemical group 0.000 claims description 15
• 125000003282 alkyl amino group Chemical group 0.000 claims description 15
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 15
• 125000004103 aminoalkyl group Chemical group 0.000 claims description 15
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 15
• 230000006806 disease prevention Effects 0.000 claims description 15
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 15
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
• 230000008569 process Effects 0.000 claims description 15
• 208000006011 Stroke Diseases 0.000 claims description 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 13
• 125000004432 carbon atom Chemical group C* 0.000 claims description 13
• 125000004181 carboxyalkyl group Chemical group 0.000 claims description 13
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical group [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 12
• 239000011593 sulfur Substances 0.000 claims description 12
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 10
• 239000003153 chemical reaction reagent Substances 0.000 claims description 10
• 229910052757 nitrogen Inorganic materials 0.000 claims description 10
• 208000027089 Parkinsonian disease Diseases 0.000 claims description 9
• 229910052799 carbon Inorganic materials 0.000 claims description 9
• 208000023275 Autoimmune disease Diseases 0.000 claims description 8
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
• 230000000302 ischemic effect Effects 0.000 claims description 8
• 239000007800 oxidant agent Substances 0.000 claims description 8
• XXDYQIINMXOSSO-UHFFFAOYSA-N 5-(4-hydroxyphenyl)dithiol-3-one Chemical compound C1=CC(O)=CC=C1C1=CC(=O)SS1 XXDYQIINMXOSSO-UHFFFAOYSA-N 0.000 claims description 7
• 125000006163 5-membered heteroaryl group Chemical group 0.000 claims description 7
• 201000006306 Cor pulmonale Diseases 0.000 claims description 7
• 230000001590 oxidative effect Effects 0.000 claims description 7
• 208000018329 progeroid syndrome Diseases 0.000 claims description 7
• 239000001632 sodium acetate Substances 0.000 claims description 7
• 235000017281 sodium acetate Nutrition 0.000 claims description 7
• 208000019693 Lung disease Diseases 0.000 claims description 6
• 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 6
• IWBBKLMHAILHAR-UHFFFAOYSA-N chembl402341 Chemical compound C1=CC(O)=CC=C1C1=CC(=S)SS1 IWBBKLMHAILHAR-UHFFFAOYSA-N 0.000 claims description 6
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 5
• GEOXNKHTZAUVBM-UHFFFAOYSA-N 4-(5-hydroxyiminodithiol-3-yl)phenol Chemical compound OC1=CC=C(C=C1)C1=CC(SS1)=NO GEOXNKHTZAUVBM-UHFFFAOYSA-N 0.000 claims description 5
• 206010014523 Embolism and thrombosis Diseases 0.000 claims description 5
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 5
• 208000012902 Nervous system disease Diseases 0.000 claims description 5
• 208000025966 Neurological disease Diseases 0.000 claims description 5
• 208000037906 ischaemic injury Diseases 0.000 claims description 5
• 208000019423 liver disease Diseases 0.000 claims description 5
• 210000004072 lung Anatomy 0.000 claims description 5
• FZNSULGQTRGDDF-UHFFFAOYSA-N 4-(4-hydroxyphenyl)dithiole-3-thione Chemical compound C1=CC(O)=CC=C1C1=CSSC1=S FZNSULGQTRGDDF-UHFFFAOYSA-N 0.000 claims description 4
• MYTUEHUXUXSJCN-UHFFFAOYSA-N 5-(5-sulfanylidenedithiol-3-yl)-3H-1,3-benzoxazol-2-one Chemical compound OC=1OC2=C(N=1)C=C(C=C2)C1=CC(SS1)=S MYTUEHUXUXSJCN-UHFFFAOYSA-N 0.000 claims description 4
• 208000035473 Communicable disease Diseases 0.000 claims description 4
• 208000029578 Muscle disease Diseases 0.000 claims description 4
• KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 4
• 210000003734 kidney Anatomy 0.000 claims description 4
• TZVDSZGVPRAWHE-UHFFFAOYSA-N methyl 5-(5-sulfanylidenedithiol-3-yl)indole-1-carboxylate Chemical compound S=C1SSC(=C1)C=1C=C2C=CN(C2=CC=1)C(=O)OC TZVDSZGVPRAWHE-UHFFFAOYSA-N 0.000 claims description 4
• HLFFXEFJKQLPTQ-UHFFFAOYSA-N 5-(4-hydroxyphenyl)-1,2,4-dithiazole-3-thione Chemical compound OC1=CC=C(C=C1)C1=NC(SS1)=S HLFFXEFJKQLPTQ-UHFFFAOYSA-N 0.000 claims description 3
• 208000017169 kidney disease Diseases 0.000 claims description 3
• CMAFOEYOQDEIOR-UHFFFAOYSA-N 6-(5-sulfanylidenedithiol-3-yl)-3H-1,3-benzothiazol-2-one Chemical compound OC1=NC2=CC=C(C=C2S1)C1=CC(=S)SS1 CMAFOEYOQDEIOR-UHFFFAOYSA-N 0.000 claims description 2
• 125000004533 benzofuran-5-yl group Chemical group O1C=CC2=C1C=CC(=C2)* 0.000 claims description 2
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
• 125000001475 halogen functional group Chemical group 0.000 claims 4
• WRYNUJYAXVDTCB-UHFFFAOYSA-M acetyloxymercury Chemical group CC(=O)O[Hg] WRYNUJYAXVDTCB-UHFFFAOYSA-M 0.000 claims 1
• 230000002265 prevention Effects 0.000 abstract description 129
• 230000000694 effects Effects 0.000 abstract description 87
• 230000000977 initiatory effect Effects 0.000 abstract description 2
• 229940124639 Selective inhibitor Drugs 0.000 description 156
• 239000000203 mixture Substances 0.000 description 142
• 239000002537 cosmetic Substances 0.000 description 67
• 150000003254 radicals Chemical class 0.000 description 67
• 241000699670 Mus sp. Species 0.000 description 64
• 230000001086 cytosolic effect Effects 0.000 description 63
• 210000004027 cell Anatomy 0.000 description 60
• 230000002401 inhibitory effect Effects 0.000 description 57
• 229940079593 drug Drugs 0.000 description 53
• 235000002639 sodium chloride Nutrition 0.000 description 49
• 241001465754 Metazoa Species 0.000 description 46
• 235000006708 antioxidants Nutrition 0.000 description 45
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 37
• 229940045799 anthracyclines and related substance Drugs 0.000 description 34
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 33
• 210000002216 heart Anatomy 0.000 description 33
• 239000008103 glucose Substances 0.000 description 32
• 239000003981 vehicle Substances 0.000 description 32
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 30
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 30
• 210000001519 tissue Anatomy 0.000 description 30
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
• 238000005481 NMR spectroscopy Methods 0.000 description 26
• 238000006243 chemical reaction Methods 0.000 description 25
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 24
• 208000002815 pulmonary hypertension Diseases 0.000 description 24
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
• 239000000243 solution Substances 0.000 description 23
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 21
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 21
• 229940080817 rotenone Drugs 0.000 description 21
• JUVIOZPCNVVQFO-UHFFFAOYSA-N rotenone Natural products O1C2=C3CC(C(C)=C)OC3=CC=C2C(=O)C2C1COC1=C2C=C(OC)C(OC)=C1 JUVIOZPCNVVQFO-UHFFFAOYSA-N 0.000 description 21
• 239000000758 substrate Substances 0.000 description 21
• 230000003914 insulin secretion Effects 0.000 description 20
• 210000000056 organ Anatomy 0.000 description 20
• 238000012360 testing method Methods 0.000 description 20
• 230000002354 daily effect Effects 0.000 description 19
• 238000002474 experimental method Methods 0.000 description 19
• 239000007787 solid Substances 0.000 description 19
• 210000002569 neuron Anatomy 0.000 description 18
• 239000002904 solvent Substances 0.000 description 18
• 238000004458 analytical method Methods 0.000 description 17
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 17
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 16
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
• 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 description 16
• 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 description 16
• 239000003963 antioxidant agent Substances 0.000 description 16
• 239000003443 antiviral agent Substances 0.000 description 16
• 230000037396 body weight Effects 0.000 description 16
• 235000019271 petrolatum Nutrition 0.000 description 16
• 238000002054 transplantation Methods 0.000 description 16
• 102000004877 Insulin Human genes 0.000 description 15
• 108090001061 Insulin Proteins 0.000 description 15
• 239000002246 antineoplastic agent Substances 0.000 description 15
• 230000015572 biosynthetic process Effects 0.000 description 15
• 229940125396 insulin Drugs 0.000 description 15
• 210000003523 substantia nigra Anatomy 0.000 description 15
• 229920000858 Cyclodextrin Polymers 0.000 description 14
• 206010012289 Dementia Diseases 0.000 description 14
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
• 238000003556 assay Methods 0.000 description 14
• 230000007423 decrease Effects 0.000 description 14
• 150000002431 hydrogen Chemical class 0.000 description 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 14
• 239000000543 intermediate Substances 0.000 description 14
• 238000000746 purification Methods 0.000 description 14
• 229940041181 antineoplastic drug Drugs 0.000 description 13
• 230000001965 increasing effect Effects 0.000 description 13
• 239000002674 ointment Substances 0.000 description 13
• 230000010410 reperfusion Effects 0.000 description 13
• 208000018737 Parkinson disease Diseases 0.000 description 12
• 210000004369 blood Anatomy 0.000 description 12
• 239000008280 blood Substances 0.000 description 12
• 230000000747 cardiac effect Effects 0.000 description 12
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
• 125000004122 cyclic group Chemical group 0.000 description 12
• 230000006378 damage Effects 0.000 description 12
• 238000005259 measurement Methods 0.000 description 12
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 12
• 230000002685 pulmonary effect Effects 0.000 description 12
• 150000007660 quinolones Chemical class 0.000 description 12
• 230000002829 reductive effect Effects 0.000 description 12
• 125000001424 substituent group Chemical group 0.000 description 12
• 238000003786 synthesis reaction Methods 0.000 description 12
• 238000000540 analysis of variance Methods 0.000 description 11
• 239000000872 buffer Substances 0.000 description 11
• 230000001684 chronic effect Effects 0.000 description 11
• 125000005843 halogen group Chemical group 0.000 description 11
• 239000011159 matrix material Substances 0.000 description 11
• 230000035806 respiratory chain Effects 0.000 description 11
• 210000001525 retina Anatomy 0.000 description 11
• 239000000126 substance Substances 0.000 description 11
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 11
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 10
• 102000004722 NADPH Oxidases Human genes 0.000 description 10
• 108010002998 NADPH Oxidases Proteins 0.000 description 10
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
• 239000003795 chemical substances by application Substances 0.000 description 10
• 206010012601 diabetes mellitus Diseases 0.000 description 10
• 208000035475 disorder Diseases 0.000 description 10
• 230000037406 food intake Effects 0.000 description 10
• 235000012631 food intake Nutrition 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 208000012947 ischemia reperfusion injury Diseases 0.000 description 10
• 239000007788 liquid Substances 0.000 description 10
• 229940049920 malate Drugs 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• 230000008811 mitochondrial respiratory chain Effects 0.000 description 10
• 239000003921 oil Substances 0.000 description 10
• 235000019198 oils Nutrition 0.000 description 10
• 230000003647 oxidation Effects 0.000 description 10
• 238000007254 oxidation reaction Methods 0.000 description 10
• 230000026731 phosphorylation Effects 0.000 description 10
• 238000006366 phosphorylation reaction Methods 0.000 description 10
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 9
• QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 9
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 9
• 239000002253 acid Substances 0.000 description 9
• 239000000853 adhesive Substances 0.000 description 9
• 230000001070 adhesive effect Effects 0.000 description 9
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 9
• 239000003925 fat Substances 0.000 description 9
• 229930195712 glutamate Natural products 0.000 description 9
• 238000007912 intraperitoneal administration Methods 0.000 description 9
• BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 9
• 210000001700 mitochondrial membrane Anatomy 0.000 description 9
• 230000010627 oxidative phosphorylation Effects 0.000 description 9
• 239000002953 phosphate buffered saline Substances 0.000 description 9
• 229920001223 polyethylene glycol Polymers 0.000 description 9
• 230000009467 reduction Effects 0.000 description 9
• 239000000741 silica gel Substances 0.000 description 9
• 229910002027 silica gel Inorganic materials 0.000 description 9
• 230000001988 toxicity Effects 0.000 description 9
• 231100000419 toxicity Toxicity 0.000 description 9
• XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 description 8
• UIFFUZWRFRDZJC-UHFFFAOYSA-N Antimycin A1 Natural products CC1OC(=O)C(CCCCCC)C(OC(=O)CC(C)C)C(C)OC(=O)C1NC(=O)C1=CC=CC(NC=O)=C1O UIFFUZWRFRDZJC-UHFFFAOYSA-N 0.000 description 8
• NQWZLRAORXLWDN-UHFFFAOYSA-N Antimycin-A Natural products CCCCCCC(=O)OC1C(C)OC(=O)C(NC(=O)c2ccc(NC=O)cc2O)C(C)OC(=O)C1CCCC NQWZLRAORXLWDN-UHFFFAOYSA-N 0.000 description 8
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 8
• 206010021143 Hypoxia Diseases 0.000 description 8
• 206010027476 Metastases Diseases 0.000 description 8
• 206010028980 Neoplasm Diseases 0.000 description 8
• OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 8
• 230000009471 action Effects 0.000 description 8
• UIFFUZWRFRDZJC-SBOOETFBSA-N antimycin A Chemical compound C[C@H]1OC(=O)[C@H](CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@H]1NC(=O)C1=CC=CC(NC=O)=C1O UIFFUZWRFRDZJC-SBOOETFBSA-N 0.000 description 8
• PVEVXUMVNWSNIG-UHFFFAOYSA-N antimycin A3 Natural products CC1OC(=O)C(CCCC)C(OC(=O)CC(C)C)C(C)OC(=O)C1NC(=O)C1=CC=CC(NC=O)=C1O PVEVXUMVNWSNIG-UHFFFAOYSA-N 0.000 description 8
• 230000008499 blood brain barrier function Effects 0.000 description 8
• 210000001218 blood-brain barrier Anatomy 0.000 description 8
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 8
• UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical group C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 230000005764 inhibitory process Effects 0.000 description 8
• 239000010410 layer Substances 0.000 description 8
• 230000009401 metastasis Effects 0.000 description 8
• 238000012545 processing Methods 0.000 description 8
• 238000007634 remodeling Methods 0.000 description 8
• 239000011780 sodium chloride Substances 0.000 description 8
• PKYCWFICOKSIHZ-UHFFFAOYSA-N 1-(3,7-dihydroxyphenoxazin-10-yl)ethanone Chemical compound OC1=CC=C2N(C(=O)C)C3=CC=C(O)C=C3OC2=C1 PKYCWFICOKSIHZ-UHFFFAOYSA-N 0.000 description 7
• PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 7
• XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 description 7
• 102000015782 Electron Transport Complex III Human genes 0.000 description 7
• 108010024882 Electron Transport Complex III Proteins 0.000 description 7
• 241000282414 Homo sapiens Species 0.000 description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 7
• 239000002202 Polyethylene glycol Substances 0.000 description 7
• 210000003169 central nervous system Anatomy 0.000 description 7
• 235000011187 glycerol Nutrition 0.000 description 7
• 238000011534 incubation Methods 0.000 description 7
• 208000002780 macular degeneration Diseases 0.000 description 7
• 230000036542 oxidative stress Effects 0.000 description 7
• 239000012071 phase Substances 0.000 description 7
• CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical group S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 description 7
• 239000003755 preservative agent Substances 0.000 description 7
• 230000004224 protection Effects 0.000 description 7
• 210000001147 pulmonary artery Anatomy 0.000 description 7
• 230000000241 respiratory effect Effects 0.000 description 7
• 210000005241 right ventricle Anatomy 0.000 description 7
• 229910000104 sodium hydride Inorganic materials 0.000 description 7
• 238000007619 statistical method Methods 0.000 description 7
• 239000001993 wax Substances 0.000 description 7
• 208000024827 Alzheimer disease Diseases 0.000 description 6
• ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 6
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
• 206010061216 Infarction Diseases 0.000 description 6
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
• 240000001970 Raphanus sativus var. sativus Species 0.000 description 6
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 6
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
• 229930006000 Sucrose Natural products 0.000 description 6
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
• 230000004872 arterial blood pressure Effects 0.000 description 6
• 208000006673 asthma Diseases 0.000 description 6
• 201000011510 cancer Diseases 0.000 description 6
• 235000017471 coenzyme Q10 Nutrition 0.000 description 6
• 239000006071 cream Substances 0.000 description 6
• IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 6
• 210000001508 eye Anatomy 0.000 description 6
• 235000013305 food Nutrition 0.000 description 6
• 238000007446 glucose tolerance test Methods 0.000 description 6
• 235000009200 high fat diet Nutrition 0.000 description 6
• 230000007574 infarction Effects 0.000 description 6
• 238000002955 isolation Methods 0.000 description 6
• 239000006210 lotion Substances 0.000 description 6
• 239000002609 medium Substances 0.000 description 6
• 230000004065 mitochondrial dysfunction Effects 0.000 description 6
• 230000003287 optical effect Effects 0.000 description 6
• 238000004321 preservation Methods 0.000 description 6
• 239000011541 reaction mixture Substances 0.000 description 6
• NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 6
• 229940083542 sodium Drugs 0.000 description 6
• 235000015424 sodium Nutrition 0.000 description 6
• 239000012312 sodium hydride Substances 0.000 description 6
• 239000005720 sucrose Substances 0.000 description 6
• 230000001225 therapeutic effect Effects 0.000 description 6
• 238000012546 transfer Methods 0.000 description 6
• 229940035936 ubiquinone Drugs 0.000 description 6
• 239000003643 water by type Substances 0.000 description 6
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
• CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 5
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
• 230000003915 cell function Effects 0.000 description 5
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 5
• 238000004440 column chromatography Methods 0.000 description 5
• 238000002425 crystallisation Methods 0.000 description 5
• 230000008025 crystallization Effects 0.000 description 5
• 239000004744 fabric Substances 0.000 description 5
• 239000012894 fetal calf serum Substances 0.000 description 5
• 239000000499 gel Substances 0.000 description 5
• 230000006872 improvement Effects 0.000 description 5
• 230000007246 mechanism Effects 0.000 description 5
• 239000012528 membrane Substances 0.000 description 5
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 5
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 5
• AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 5
• 239000012188 paraffin wax Substances 0.000 description 5
• 238000002360 preparation method Methods 0.000 description 5
• 239000000047 product Substances 0.000 description 5
• 230000029058 respiratory gaseous exchange Effects 0.000 description 5
• 239000011734 sodium Substances 0.000 description 5
• 229910052708 sodium Inorganic materials 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 230000032258 transport Effects 0.000 description 5
• 239000008096 xylene Substances 0.000 description 5
• XKTFQMCPGMTBMD-ZDBABOMLSA-N (2z,4r,5s,6e)-3,5-dimethoxy-4-methyl-7-[2-[2-[(2s,3e,5e)-7-methylocta-3,5-dien-2-yl]-1,3-thiazol-4-yl]-1,3-thiazol-4-yl]hepta-2,6-dienamide Chemical compound NC(=O)/C=C(\OC)[C@H](C)[C@@H](OC)\C=C\C1=CSC(C=2N=C(SC=2)[C@@H](C)\C=C\C=C\C(C)C)=N1 XKTFQMCPGMTBMD-ZDBABOMLSA-N 0.000 description 4
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
• ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
• ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 4
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
• 208000024412 Friedreich ataxia Diseases 0.000 description 4
• 201000011240 Frontotemporal dementia Diseases 0.000 description 4
• 108010010803 Gelatin Proteins 0.000 description 4
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 4
• 208000021642 Muscular disease Diseases 0.000 description 4
• 201000009623 Myopathy Diseases 0.000 description 4
• 102000003992 Peroxidases Human genes 0.000 description 4
• 239000004264 Petrolatum Substances 0.000 description 4
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
• 206010039710 Scleroderma Diseases 0.000 description 4
• 230000035508 accumulation Effects 0.000 description 4
• 238000009825 accumulation Methods 0.000 description 4
• 206010064930 age-related macular degeneration Diseases 0.000 description 4
• 230000029936 alkylation Effects 0.000 description 4
• 238000005804 alkylation reaction Methods 0.000 description 4
• 229910052782 aluminium Inorganic materials 0.000 description 4
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
• 238000010171 animal model Methods 0.000 description 4
• 230000003078 antioxidant effect Effects 0.000 description 4
• 235000011089 carbon dioxide Nutrition 0.000 description 4
• 230000005754 cellular signaling Effects 0.000 description 4
• 229940082500 cetostearyl alcohol Drugs 0.000 description 4
• 229960000541 cetyl alcohol Drugs 0.000 description 4
• 235000015165 citric acid Nutrition 0.000 description 4
• QPNKYNYIKKVVQB-UHFFFAOYSA-N crotaleschenine Natural products O1C(=O)C(C)C(C)C(C)(O)C(=O)OCC2=CCN3C2C1CC3 QPNKYNYIKKVVQB-UHFFFAOYSA-N 0.000 description 4
• 229940097362 cyclodextrins Drugs 0.000 description 4
• 238000001514 detection method Methods 0.000 description 4
• 235000005911 diet Nutrition 0.000 description 4
• 238000009472 formulation Methods 0.000 description 4
• 239000008273 gelatin Substances 0.000 description 4
• 229920000159 gelatin Polymers 0.000 description 4
• 229940014259 gelatin Drugs 0.000 description 4
• 235000019322 gelatine Nutrition 0.000 description 4
• 235000011852 gelatine desserts Nutrition 0.000 description 4
• 230000036541 health Effects 0.000 description 4
• 230000007954 hypoxia Effects 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 210000004153 islets of langerhan Anatomy 0.000 description 4
• 210000004185 liver Anatomy 0.000 description 4
• BRMYZIKAHFEUFJ-UHFFFAOYSA-L mercury diacetate Chemical group CC(=O)O[Hg]OC(C)=O BRMYZIKAHFEUFJ-UHFFFAOYSA-L 0.000 description 4
• 239000002480 mineral oil Substances 0.000 description 4
• 235000010446 mineral oil Nutrition 0.000 description 4
• 230000006705 mitochondrial oxidative phosphorylation Effects 0.000 description 4
• QVCMHGGNRFRMAD-XFGHUUIASA-N monocrotaline Chemical compound C1OC(=O)[C@](C)(O)[C@@](O)(C)[C@@H](C)C(=O)O[C@@H]2CCN3[C@@H]2C1=CC3 QVCMHGGNRFRMAD-XFGHUUIASA-N 0.000 description 4
• QVCMHGGNRFRMAD-UHFFFAOYSA-N monocrotaline Natural products C1OC(=O)C(C)(O)C(O)(C)C(C)C(=O)OC2CCN3C2C1=CC3 QVCMHGGNRFRMAD-UHFFFAOYSA-N 0.000 description 4
• GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 4
• 230000004770 neurodegeneration Effects 0.000 description 4
• 210000001328 optic nerve Anatomy 0.000 description 4
• 230000001575 pathological effect Effects 0.000 description 4
• 230000010412 perfusion Effects 0.000 description 4
• 229940066842 petrolatum Drugs 0.000 description 4
• 108091008695 photoreceptors Proteins 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 230000000750 progressive effect Effects 0.000 description 4
• AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 description 4
• LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 4
• 230000006950 reactive oxygen species formation Effects 0.000 description 4
• HSSLDCABUXLXKM-UHFFFAOYSA-N resorufin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3N=C21 HSSLDCABUXLXKM-UHFFFAOYSA-N 0.000 description 4
• 230000002441 reversible effect Effects 0.000 description 4
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 4
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
• 210000003491 skin Anatomy 0.000 description 4
• 239000003381 stabilizer Substances 0.000 description 4
• 238000010186 staining Methods 0.000 description 4
• XIUROWKZWPIAIB-UHFFFAOYSA-N sulfotep Chemical compound CCOP(=S)(OCC)OP(=S)(OCC)OCC XIUROWKZWPIAIB-UHFFFAOYSA-N 0.000 description 4
• 208000024891 symptom Diseases 0.000 description 4
• 208000011580 syndromic disease Diseases 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 4
• 239000008158 vegetable oil Substances 0.000 description 4
• 235000013311 vegetables Nutrition 0.000 description 4
• HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 description 3
• CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
• 201000009030 Carcinoma Diseases 0.000 description 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 3
• 230000005778 DNA damage Effects 0.000 description 3
• 231100000277 DNA damage Toxicity 0.000 description 3
• 239000001116 FEMA 4028 Substances 0.000 description 3
• 239000004471 Glycine Substances 0.000 description 3
• 241000282412 Homo Species 0.000 description 3
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 3
• 208000025500 Hutchinson-Gilford progeria syndrome Diseases 0.000 description 3
• 206010020772 Hypertension Diseases 0.000 description 3
• 206010022489 Insulin Resistance Diseases 0.000 description 3
• 229930195725 Mannitol Natural products 0.000 description 3
• 244000062730 Melissa officinalis Species 0.000 description 3
• 235000010654 Melissa officinalis Nutrition 0.000 description 3
• 241000699666 Mus <mouse, genus> Species 0.000 description 3
• 239000005662 Paraffin oil Substances 0.000 description 3
• 206010034010 Parkinsonism Diseases 0.000 description 3
• 229920001213 Polysorbate 20 Polymers 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 208000007932 Progeria Diseases 0.000 description 3
• 229920002125 Sokalan® Polymers 0.000 description 3
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
• 208000027418 Wounds and injury Diseases 0.000 description 3
• 238000013019 agitation Methods 0.000 description 3
• 230000000172 allergic effect Effects 0.000 description 3
• 230000001093 anti-cancer Effects 0.000 description 3
• 210000001367 artery Anatomy 0.000 description 3
• 206010003246 arthritis Diseases 0.000 description 3
• 208000010668 atopic eczema Diseases 0.000 description 3
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
• 235000019445 benzyl alcohol Nutrition 0.000 description 3
• 229960004853 betadex Drugs 0.000 description 3
• 239000006172 buffering agent Substances 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 239000004359 castor oil Substances 0.000 description 3
• 235000019438 castor oil Nutrition 0.000 description 3
• 210000003986 cell retinal photoreceptor Anatomy 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 235000010980 cellulose Nutrition 0.000 description 3
• 210000004087 cornea Anatomy 0.000 description 3
• 210000000805 cytoplasm Anatomy 0.000 description 3
• 230000037213 diet Effects 0.000 description 3
• 230000029087 digestion Effects 0.000 description 3
• 238000009826 distribution Methods 0.000 description 3
• 210000005064 dopaminergic neuron Anatomy 0.000 description 3
• 230000004064 dysfunction Effects 0.000 description 3
• 238000002571 electroretinography Methods 0.000 description 3
• 239000003995 emulsifying agent Substances 0.000 description 3
• 239000003623 enhancer Substances 0.000 description 3
• 239000003889 eye drop Substances 0.000 description 3
• 229940012356 eye drops Drugs 0.000 description 3
• 238000003818 flash chromatography Methods 0.000 description 3
• 229940050410 gluconate Drugs 0.000 description 3
• 230000004153 glucose metabolism Effects 0.000 description 3
• 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 3
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
• 229960002449 glycine Drugs 0.000 description 3
• 238000011194 good manufacturing practice Methods 0.000 description 3
• 230000009931 harmful effect Effects 0.000 description 3
• 238000004128 high performance liquid chromatography Methods 0.000 description 3
• 230000001146 hypoxic effect Effects 0.000 description 3
• 238000000099 in vitro assay Methods 0.000 description 3
• 208000030603 inherited susceptibility to asthma Diseases 0.000 description 3
• 229940090044 injection Drugs 0.000 description 3
• 208000014674 injury Diseases 0.000 description 3
• 230000003834 intracellular effect Effects 0.000 description 3
• 239000007928 intraperitoneal injection Substances 0.000 description 3
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 3
• CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 description 3
• 210000005240 left ventricle Anatomy 0.000 description 3
• 239000000865 liniment Substances 0.000 description 3
• 229940057995 liquid paraffin Drugs 0.000 description 3
• 230000007774 longterm Effects 0.000 description 3
• 239000000594 mannitol Substances 0.000 description 3
• 235000010355 mannitol Nutrition 0.000 description 3
• 230000001394 metastastic effect Effects 0.000 description 3
• VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 3
• LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
• 201000006417 multiple sclerosis Diseases 0.000 description 3
• 230000000324 neuroprotective effect Effects 0.000 description 3
• 239000012044 organic layer Substances 0.000 description 3
• 230000004792 oxidative damage Effects 0.000 description 3
• WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 3
• 230000035699 permeability Effects 0.000 description 3
• 108040007629 peroxidase activity proteins Proteins 0.000 description 3
• 230000035479 physiological effects, processes and functions Effects 0.000 description 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
• 230000002633 protecting effect Effects 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 206010039073 rheumatoid arthritis Diseases 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 230000009759 skin aging Effects 0.000 description 3
• UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 3
• 239000000600 sorbitol Substances 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 229940012831 stearyl alcohol Drugs 0.000 description 3
• 150000003431 steroids Chemical class 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 239000004094 surface-active agent Substances 0.000 description 3
• 230000009885 systemic effect Effects 0.000 description 3
• 238000007280 thionation reaction Methods 0.000 description 3
• 238000011200 topical administration Methods 0.000 description 3
• 231100000331 toxic Toxicity 0.000 description 3
• 230000002588 toxic effect Effects 0.000 description 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
• 210000005166 vasculature Anatomy 0.000 description 3
• 235000015112 vegetable and seed oil Nutrition 0.000 description 3
• 230000035899 viability Effects 0.000 description 3
• 239000003871 white petrolatum Substances 0.000 description 3
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
• FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 2
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 2
• KDJVJTMHWXZZJJ-UHFFFAOYSA-N 5-(1-benzofuran-5-yl)dithiole-3-thione Chemical compound O1C=CC2=C1C=CC(=C2)C1=CC(SS1)=S KDJVJTMHWXZZJJ-UHFFFAOYSA-N 0.000 description 2
• 208000006888 Agnosia Diseases 0.000 description 2
• 208000000044 Amnesia Diseases 0.000 description 2
• KYLIZBIRMBGUOP-UHFFFAOYSA-N Anetholtrithion Chemical compound C1=CC(OC)=CC=C1C1=CC(=S)SS1 KYLIZBIRMBGUOP-UHFFFAOYSA-N 0.000 description 2
• 229930182536 Antimycin Natural products 0.000 description 2
• 208000003343 Antiphospholipid Syndrome Diseases 0.000 description 2
• 239000004475 Arginine Substances 0.000 description 2
• 201000001320 Atherosclerosis Diseases 0.000 description 2
• 208000005692 Bloom Syndrome Diseases 0.000 description 2
• 239000004255 Butylated hydroxyanisole Substances 0.000 description 2
• QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
• 239000004215 Carbon black (E152) Substances 0.000 description 2
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
• 208000031229 Cardiomyopathies Diseases 0.000 description 2
• 208000002177 Cataract Diseases 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
• 208000010200 Cockayne syndrome Diseases 0.000 description 2
• 102000008186 Collagen Human genes 0.000 description 2
• 108010035532 Collagen Proteins 0.000 description 2
• 102000029816 Collagenase Human genes 0.000 description 2
• 108060005980 Collagenase Proteins 0.000 description 2
• 206010062759 Congenital dyskeratosis Diseases 0.000 description 2
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
• 206010011878 Deafness Diseases 0.000 description 2
• OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• 201000010374 Down Syndrome Diseases 0.000 description 2
• 238000002965 ELISA Methods 0.000 description 2
• 108091006149 Electron carriers Proteins 0.000 description 2
• 102000002045 Endothelin Human genes 0.000 description 2
• 108050009340 Endothelin Proteins 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
• 208000005176 Hepatitis C Diseases 0.000 description 2
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
• 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 description 2
• 101000605835 Homo sapiens Serine/threonine-protein kinase PINK1, mitochondrial Proteins 0.000 description 2
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
• 208000023105 Huntington disease Diseases 0.000 description 2
• WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
• 206010020880 Hypertrophy Diseases 0.000 description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
• 239000007836 KH2PO4 Substances 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• 239000004166 Lanolin Substances 0.000 description 2
• 239000002841 Lewis acid Substances 0.000 description 2
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
• 208000026139 Memory disease Diseases 0.000 description 2
• 208000026072 Motor neurone disease Diseases 0.000 description 2
• 208000016285 Movement disease Diseases 0.000 description 2
• 239000007832 Na2SO4 Substances 0.000 description 2
• 101710138657 Neurotoxin Proteins 0.000 description 2
• 208000008589 Obesity Diseases 0.000 description 2
• 102000004316 Oxidoreductases Human genes 0.000 description 2
• 108090000854 Oxidoreductases Proteins 0.000 description 2
• 229910019142 PO4 Inorganic materials 0.000 description 2
• 208000037273 Pathologic Processes Diseases 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 206010036631 Presenile dementia Diseases 0.000 description 2
• 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 description 2
• 208000010378 Pulmonary Embolism Diseases 0.000 description 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
• 208000000924 Right ventricular hypertrophy Diseases 0.000 description 2
• 241000283984 Rodentia Species 0.000 description 2
• 108010074686 Selenoproteins Proteins 0.000 description 2
• 102000008114 Selenoproteins Human genes 0.000 description 2
• 102100038376 Serine/threonine-protein kinase PINK1, mitochondrial Human genes 0.000 description 2
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
• 229920002472 Starch Polymers 0.000 description 2
• 102000019259 Succinate Dehydrogenase Human genes 0.000 description 2
• 108010012901 Succinate Dehydrogenase Proteins 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
• HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 2
• 239000007983 Tris buffer Substances 0.000 description 2
• 201000004810 Vascular dementia Diseases 0.000 description 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
• XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
• PFYWPQMAWCYNGW-UHFFFAOYSA-M [6-(dimethylamino)-9-(2-methoxycarbonylphenyl)xanthen-3-ylidene]-dimethylazanium;perchlorate Chemical compound [O-]Cl(=O)(=O)=O.COC(=O)C1=CC=CC=C1C1=C2C=CC(=[N+](C)C)C=C2OC2=CC(N(C)C)=CC=C21 PFYWPQMAWCYNGW-UHFFFAOYSA-M 0.000 description 2
• 238000010521 absorption reaction Methods 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
• 230000002411 adverse Effects 0.000 description 2
• 239000000556 agonist Substances 0.000 description 2
• 150000001408 amides Chemical class 0.000 description 2
• 229940126575 aminoglycoside Drugs 0.000 description 2
• 206010002022 amyloidosis Diseases 0.000 description 2
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
• 239000010775 animal oil Substances 0.000 description 2
• 230000000118 anti-neoplastic effect Effects 0.000 description 2
• CQIUKKVOEOPUDV-IYSWYEEDSA-N antimycin Chemical compound OC1=C(C(O)=O)C(=O)C(C)=C2[C@H](C)[C@@H](C)OC=C21 CQIUKKVOEOPUDV-IYSWYEEDSA-N 0.000 description 2
• 229940034982 antineoplastic agent Drugs 0.000 description 2
• 201000007201 aphasia Diseases 0.000 description 2
• 230000006907 apoptotic process Effects 0.000 description 2
• 239000008346 aqueous phase Substances 0.000 description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
• 125000004429 atom Chemical group 0.000 description 2
• 230000004888 barrier function Effects 0.000 description 2
• 235000013871 bee wax Nutrition 0.000 description 2
• 239000012166 beeswax Substances 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• 230000002457 bidirectional effect Effects 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 210000004204 blood vessel Anatomy 0.000 description 2
• ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 description 2
• 210000004556 brain Anatomy 0.000 description 2
• 201000009267 bronchiectasis Diseases 0.000 description 2
• 235000019282 butylated hydroxyanisole Nutrition 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 description 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
• 206010061592 cardiac fibrillation Diseases 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 230000002490 cerebral effect Effects 0.000 description 2
• 206010008118 cerebral infarction Diseases 0.000 description 2
• 230000008859 change Effects 0.000 description 2
• OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
• 229960004106 citric acid Drugs 0.000 description 2
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
• 208000010877 cognitive disease Diseases 0.000 description 2
• 229920001436 collagen Polymers 0.000 description 2
• 229960002424 collagenase Drugs 0.000 description 2
• 230000000052 comparative effect Effects 0.000 description 2
• 239000013058 crude material Substances 0.000 description 2
• 231100000895 deafness Toxicity 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 230000007850 degeneration Effects 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 229940119744 dextran 40 Drugs 0.000 description 2
• 229940119743 dextran 70 Drugs 0.000 description 2
• 235000014113 dietary fatty acids Nutrition 0.000 description 2
• 239000002612 dispersion medium Substances 0.000 description 2
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
• 239000008298 dragée Substances 0.000 description 2
• 239000000975 dye Substances 0.000 description 2
• 239000003974 emollient agent Substances 0.000 description 2
• 239000008387 emulsifying waxe Substances 0.000 description 2
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 2
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
• 230000001037 epileptic effect Effects 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 238000000105 evaporative light scattering detection Methods 0.000 description 2
• 208000015402 facioscapulohumeral muscular dystrophy 1 Diseases 0.000 description 2
• 229930195729 fatty acid Natural products 0.000 description 2
• 239000000194 fatty acid Substances 0.000 description 2
• 239000010408 film Substances 0.000 description 2
• 239000000706 filtrate Substances 0.000 description 2
• 239000007903 gelatin capsule Substances 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 229960005150 glycerol Drugs 0.000 description 2
• 238000001631 haemodialysis Methods 0.000 description 2
• 229910052736 halogen Inorganic materials 0.000 description 2
• 150000002367 halogens Chemical class 0.000 description 2
• 208000016354 hearing loss disease Diseases 0.000 description 2
• 230000000322 hemodialysis Effects 0.000 description 2
• 125000001072 heteroaryl group Chemical group 0.000 description 2
• 239000003906 humectant Substances 0.000 description 2
• 229930195733 hydrocarbon Natural products 0.000 description 2
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
• QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 2
• 239000003018 immunosuppressive agent Substances 0.000 description 2
• 229940125721 immunosuppressive agent Drugs 0.000 description 2
• 238000000338 in vitro Methods 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• 230000004968 inflammatory condition Effects 0.000 description 2
• 208000027866 inflammatory disease Diseases 0.000 description 2
• 230000015788 innate immune response Effects 0.000 description 2
• 230000035987 intoxication Effects 0.000 description 2
• 231100000566 intoxication Toxicity 0.000 description 2
• 229910052740 iodine Inorganic materials 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
• 239000007951 isotonicity adjuster Substances 0.000 description 2
• 206010023497 kuru Diseases 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 235000019388 lanolin Nutrition 0.000 description 2
• 229940039717 lanolin Drugs 0.000 description 2
• 235000010445 lecithin Nutrition 0.000 description 2
• 239000000787 lecithin Substances 0.000 description 2
• 229940067606 lecithin Drugs 0.000 description 2
• 150000007517 lewis acids Chemical class 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 229960003511 macrogol Drugs 0.000 description 2
• 229910001629 magnesium chloride Inorganic materials 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 238000004949 mass spectrometry Methods 0.000 description 2
• 230000008018 melting Effects 0.000 description 2
• 238000002844 melting Methods 0.000 description 2
• 230000006984 memory degeneration Effects 0.000 description 2
• 208000023060 memory loss Diseases 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• 206010061289 metastatic neoplasm Diseases 0.000 description 2
• 150000005009 methylarylethers Chemical class 0.000 description 2
• 230000005012 migration Effects 0.000 description 2
• 238000013508 migration Methods 0.000 description 2
• 230000004898 mitochondrial function Effects 0.000 description 2
• 230000006540 mitochondrial respiration Effects 0.000 description 2
• GVZFUVXPTPGOQT-UHFFFAOYSA-M mitoq Chemical compound CS([O-])(=O)=O.O=C1C(OC)=C(OC)C(=O)C(CCCCCCCCCC[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1C GVZFUVXPTPGOQT-UHFFFAOYSA-M 0.000 description 2
• 230000003020 moisturizing effect Effects 0.000 description 2
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
• 235000019796 monopotassium phosphate Nutrition 0.000 description 2
• 208000005264 motor neuron disease Diseases 0.000 description 2
• 238000010172 mouse model Methods 0.000 description 2
• 201000006938 muscular dystrophy Diseases 0.000 description 2
• 125000001624 naphthyl group Chemical group 0.000 description 2
• 230000017074 necrotic cell death Effects 0.000 description 2
• 239000002581 neurotoxin Substances 0.000 description 2
• 231100000618 neurotoxin Toxicity 0.000 description 2
• 231100000252 nontoxic Toxicity 0.000 description 2
• 230000003000 nontoxic effect Effects 0.000 description 2
• 235000020824 obesity Nutrition 0.000 description 2
• CKNAQFVBEHDJQV-UHFFFAOYSA-N oltipraz Chemical compound S1SC(=S)C(C)=C1C1=CN=CC=N1 CKNAQFVBEHDJQV-UHFFFAOYSA-N 0.000 description 2
• 229950008687 oltipraz Drugs 0.000 description 2
• 238000001543 one-way ANOVA Methods 0.000 description 2
• 229940054534 ophthalmic solution Drugs 0.000 description 2
• 239000002997 ophthalmic solution Substances 0.000 description 2
• 238000012261 overproduction Methods 0.000 description 2
• 230000036284 oxygen consumption Effects 0.000 description 2
• 210000000496 pancreas Anatomy 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 239000006072 paste Substances 0.000 description 2
• 230000008506 pathogenesis Effects 0.000 description 2
• 230000009054 pathological process Effects 0.000 description 2
• 239000008188 pellet Substances 0.000 description 2
• 229960001412 pentobarbital Drugs 0.000 description 2
• 239000003208 petroleum Substances 0.000 description 2
• 230000000144 pharmacologic effect Effects 0.000 description 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
• 235000021317 phosphate Nutrition 0.000 description 2
• 230000000865 phosphorylative effect Effects 0.000 description 2
• 239000006187 pill Substances 0.000 description 2
• 230000036470 plasma concentration Effects 0.000 description 2
• 206010035653 pneumoconiosis Diseases 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 208000005987 polymyositis Diseases 0.000 description 2
• 229920005862 polyol Polymers 0.000 description 2
• 150000003077 polyols Chemical class 0.000 description 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
• 229940068977 polysorbate 20 Drugs 0.000 description 2
• 229940068968 polysorbate 80 Drugs 0.000 description 2
• 229920000053 polysorbate 80 Polymers 0.000 description 2
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
• 238000013105 post hoc analysis Methods 0.000 description 2
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
• 239000001103 potassium chloride Substances 0.000 description 2
• 235000011164 potassium chloride Nutrition 0.000 description 2
• GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
• 230000002335 preservative effect Effects 0.000 description 2
• 230000003449 preventive effect Effects 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
• 230000001012 protector Effects 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 238000010992 reflux Methods 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 230000027756 respiratory electron transport chain Effects 0.000 description 2
• 239000006254 rheological additive Substances 0.000 description 2
• 238000005070 sampling Methods 0.000 description 2
• 208000008864 scrapie Diseases 0.000 description 2
• 229940076279 serotonin Drugs 0.000 description 2
• 239000000377 silicon dioxide Substances 0.000 description 2
• 210000002027 skeletal muscle Anatomy 0.000 description 2
• 235000017557 sodium bicarbonate Nutrition 0.000 description 2
• 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
• 229910052938 sodium sulfate Inorganic materials 0.000 description 2
• 235000011152 sodium sulphate Nutrition 0.000 description 2
• 230000006641 stabilisation Effects 0.000 description 2
• 238000011105 stabilization Methods 0.000 description 2
• 239000008107 starch Substances 0.000 description 2
• 235000019698 starch Nutrition 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• 208000023516 stroke disease Diseases 0.000 description 2
• 239000007940 sugar coated tablet Substances 0.000 description 2
• 230000004083 survival effect Effects 0.000 description 2
• 239000012730 sustained-release form Substances 0.000 description 2
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
• 238000002560 therapeutic procedure Methods 0.000 description 2
• AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 2
• 239000002562 thickening agent Substances 0.000 description 2
• UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 229910001428 transition metal ion Inorganic materials 0.000 description 2
• 208000018726 traumatic encephalopathy Diseases 0.000 description 2
• 230000004102 tricarboxylic acid cycle Effects 0.000 description 2
• 230000001960 triggered effect Effects 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
• TWQVZFCNOMQQQV-UHFFFAOYSA-N 1,2,4-dithiazole-3-thione Chemical compound S=C1N=CSS1 TWQVZFCNOMQQQV-UHFFFAOYSA-N 0.000 description 1
• UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 description 1
• LMGBDZJLZIPJPZ-UHFFFAOYSA-M 1-methyl-4-phenylpyridin-1-ium;chloride Chemical compound [Cl-].C1=C[N+](C)=CC=C1C1=CC=CC=C1 LMGBDZJLZIPJPZ-UHFFFAOYSA-M 0.000 description 1
• 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
• 238000005160 1H NMR spectroscopy Methods 0.000 description 1
• CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
• PXEZTIWVRVSYOK-UHFFFAOYSA-N 2-(3,6-diacetyloxy-2,7-dichloro-9h-xanthen-9-yl)benzoic acid Chemical compound C1=2C=C(Cl)C(OC(=O)C)=CC=2OC2=CC(OC(C)=O)=C(Cl)C=C2C1C1=CC=CC=C1C(O)=O PXEZTIWVRVSYOK-UHFFFAOYSA-N 0.000 description 1
• YGTUPRIZNBMOFV-UHFFFAOYSA-N 2-(4-hydroxybenzoyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C(=O)C1=CC=C(O)C=C1 YGTUPRIZNBMOFV-UHFFFAOYSA-N 0.000 description 1
• BARVGPTVPZLMIU-UHFFFAOYSA-N 2-(diethylamino)ethanol Chemical compound [CH2]CN(CC)CCO BARVGPTVPZLMIU-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• IKCLCGXPQILATA-UHFFFAOYSA-N 2-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1Cl IKCLCGXPQILATA-UHFFFAOYSA-N 0.000 description 1
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
• HSTOKWSFWGCZMH-UHFFFAOYSA-N 3,3'-diaminobenzidine Chemical compound C1=C(N)C(N)=CC=C1C1=CC=C(N)C(N)=C1 HSTOKWSFWGCZMH-UHFFFAOYSA-N 0.000 description 1
• PBVZQAXFSQKDKK-UHFFFAOYSA-N 3-Methoxy-3-oxopropanoic acid Chemical compound COC(=O)CC(O)=O PBVZQAXFSQKDKK-UHFFFAOYSA-N 0.000 description 1
• FQJXITFHANYMET-UHFFFAOYSA-N 3-pentoxypropane-1,2-diol Chemical compound CCCCCOCC(O)CO FQJXITFHANYMET-UHFFFAOYSA-N 0.000 description 1
• DIYMIIYCRMJNIN-UHFFFAOYSA-N 4-(4-methoxyphenyl)dithiole-3-thione Chemical compound C1=CC(OC)=CC=C1C1=CSSC1=S DIYMIIYCRMJNIN-UHFFFAOYSA-N 0.000 description 1
• NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 description 1
• ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• 230000002407 ATP formation Effects 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 208000019253 Acrogeria Diseases 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 241001047040 Agnosia Species 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 206010068783 Alstroem syndrome Diseases 0.000 description 1
• 201000005932 Alstrom Syndrome Diseases 0.000 description 1
• 102100039160 Amiloride-sensitive amine oxidase [copper-containing] Human genes 0.000 description 1
• 108010028700 Amine Oxidase (Copper-Containing) Proteins 0.000 description 1
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
• 208000026828 Aorta coarctation Diseases 0.000 description 1
• 208000006179 Aortic Coarctation Diseases 0.000 description 1
• 206010002915 Aortic valve incompetence Diseases 0.000 description 1
• 206010003062 Apraxia Diseases 0.000 description 1
• 208000036487 Arthropathies Diseases 0.000 description 1
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
• 206010050245 Autoimmune thrombocytopenia Diseases 0.000 description 1
• 201000005943 Barth syndrome Diseases 0.000 description 1
• 208000009137 Behcet syndrome Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 1
• 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 208000019838 Blood disease Diseases 0.000 description 1
• 238000010152 Bonferroni least significant difference Methods 0.000 description 1
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
• 208000013165 Bowen disease Diseases 0.000 description 1
• 208000019337 Bowen disease of the skin Diseases 0.000 description 1
• 238000009010 Bradford assay Methods 0.000 description 1
• 101800004538 Bradykinin Proteins 0.000 description 1
• 201000006474 Brain Ischemia Diseases 0.000 description 1
• 206010063292 Brain stem syndrome Diseases 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
• 101100191768 Caenorhabditis elegans pbs-4 gene Proteins 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 201000002927 Cardiofaciocutaneous syndrome Diseases 0.000 description 1
• 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
• 206010008120 Cerebral ischaemia Diseases 0.000 description 1
• 206010008138 Cerebral venous thrombosis Diseases 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 208000017667 Chronic Disease Diseases 0.000 description 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
• 206010009807 Coarctation of the aorta Diseases 0.000 description 1
• 206010009900 Colitis ulcerative Diseases 0.000 description 1
• 208000006992 Color Vision Defects Diseases 0.000 description 1
• 206010052465 Congenital poikiloderma Diseases 0.000 description 1
• 208000011990 Corticobasal Degeneration Diseases 0.000 description 1
• 206010067380 Costello Syndrome Diseases 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
• 201000003883 Cystic fibrosis Diseases 0.000 description 1
• 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 1
• 102100030497 Cytochrome c Human genes 0.000 description 1
• 108010052832 Cytochromes Proteins 0.000 description 1
• 102000018832 Cytochromes Human genes 0.000 description 1
• 108010075031 Cytochromes c Proteins 0.000 description 1
• DSLZVSRJTYRBFB-LLEIAEIESA-N D-glucaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 description 1
• IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 1
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
• 208000001708 Dupuytren contracture Diseases 0.000 description 1
• 206010013976 Dyspraxia Diseases 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 206010048554 Endothelial dysfunction Diseases 0.000 description 1
• 102000004190 Enzymes Human genes 0.000 description 1
• 108090000790 Enzymes Proteins 0.000 description 1
• 206010066919 Epidemic polyarthritis Diseases 0.000 description 1
• 240000001624 Espostoa lanata Species 0.000 description 1
• 235000009161 Espostoa lanata Nutrition 0.000 description 1
• 108090000371 Esterases Proteins 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 208000023281 Fallot tetralogy Diseases 0.000 description 1
• 208000034846 Familial Amyloid Neuropathies Diseases 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 description 1
• 102100036250 GPI mannosyltransferase 4 Human genes 0.000 description 1
• 208000007223 Gerstmann syndrome Diseases 0.000 description 1
• 208000007465 Giant cell arteritis Diseases 0.000 description 1
• 208000002705 Glucose Intolerance Diseases 0.000 description 1
• 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 102000000587 Glycerolphosphate Dehydrogenase Human genes 0.000 description 1
• 108010041921 Glycerolphosphate Dehydrogenase Proteins 0.000 description 1
• 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
• 208000003807 Graves Disease Diseases 0.000 description 1
• 208000015023 Graves' disease Diseases 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 206010018985 Haemorrhage intracranial Diseases 0.000 description 1
• 102100025255 Haptoglobin Human genes 0.000 description 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
• 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 description 1
• 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 description 1
• 101001074618 Homo sapiens GPI mannosyltransferase 4 Proteins 0.000 description 1
• 101100402621 Homo sapiens MSANTD4 gene Proteins 0.000 description 1
• 102000013266 Human Regular Insulin Human genes 0.000 description 1
• 108010090613 Human Regular Insulin Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
• 206010021118 Hypotonia Diseases 0.000 description 1
• 241000143229 Idaea consanguinaria Species 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 208000008574 Intracranial Hemorrhages Diseases 0.000 description 1
• PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
• 206010048804 Kearns-Sayre syndrome Diseases 0.000 description 1
• 208000034607 Kindler epidermolysis bullosa Diseases 0.000 description 1
• 201000004290 Kindler syndrome Diseases 0.000 description 1
• 102100035792 Kininogen-1 Human genes 0.000 description 1
• 239000012839 Krebs-Henseleit buffer Substances 0.000 description 1
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 1
• 208000005101 LEOPARD Syndrome Diseases 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 208000004552 Lacunar Stroke Diseases 0.000 description 1
• 201000000639 Leber hereditary optic neuropathy Diseases 0.000 description 1
• 208000006136 Leigh Disease Diseases 0.000 description 1
• 208000017507 Leigh syndrome Diseases 0.000 description 1
• 208000009829 Lewy Body Disease Diseases 0.000 description 1
• 201000002832 Lewy body dementia Diseases 0.000 description 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
• 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 description 1
• 201000002169 Mitochondrial myopathy Diseases 0.000 description 1
• 208000020128 Mitral stenosis Diseases 0.000 description 1
• 206010027727 Mitral valve incompetence Diseases 0.000 description 1
• 208000019022 Mood disease Diseases 0.000 description 1
• 206010062901 Multiple lentigines syndrome Diseases 0.000 description 1
• 208000001089 Multiple system atrophy Diseases 0.000 description 1
• 206010028289 Muscle atrophy Diseases 0.000 description 1
• 102100031642 Myb/SANT-like DNA-binding domain-containing protein 4 Human genes 0.000 description 1
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
• 108010007843 NADH oxidase Proteins 0.000 description 1
• 108010045510 NADPH-Ferrihemoprotein Reductase Proteins 0.000 description 1
• 229910002651 NO3 Inorganic materials 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
• SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
• 239000000006 Nitroglycerin Substances 0.000 description 1
• 206010029748 Noonan syndrome Diseases 0.000 description 1
• 208000010708 Noonan syndrome with multiple lentigines Diseases 0.000 description 1
• 229910004679 ONO2 Inorganic materials 0.000 description 1
• 208000011623 Obstructive Lung disease Diseases 0.000 description 1
• NPGIHFRTRXVWOY-UHFFFAOYSA-N Oil red O Chemical compound Cc1ccc(C)c(c1)N=Nc1cc(C)c(cc1C)N=Nc1c(O)ccc2ccccc12 NPGIHFRTRXVWOY-UHFFFAOYSA-N 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
• 229930040373 Paraformaldehyde Natural products 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 208000031845 Pernicious anaemia Diseases 0.000 description 1
• 108700020962 Peroxidase Proteins 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical class OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 description 1
• 208000000609 Pick Disease of the Brain Diseases 0.000 description 1
• 206010057041 Poikiloderma Diseases 0.000 description 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
• 229920000148 Polycarbophil calcium Polymers 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
• 206010036105 Polyneuropathy Diseases 0.000 description 1
• 239000004372 Polyvinyl alcohol Substances 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 208000010291 Primary Progressive Nonfluent Aphasia Diseases 0.000 description 1
• 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
• HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
• 206010061924 Pulmonary toxicity Diseases 0.000 description 1
• 239000012980 RPMI-1640 medium Substances 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 206010061481 Renal injury Diseases 0.000 description 1
• 201000007737 Retinal degeneration Diseases 0.000 description 1
• 206010039163 Right ventricular failure Diseases 0.000 description 1
• 208000000791 Rothmund-Thomson syndrome Diseases 0.000 description 1
• 206010039796 Seborrhoeic keratosis Diseases 0.000 description 1
• 208000018642 Semantic dementia Diseases 0.000 description 1
• 206010039966 Senile dementia Diseases 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 206010040070 Septic Shock Diseases 0.000 description 1
• 208000021386 Sjogren Syndrome Diseases 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• 206010040925 Skin striae Diseases 0.000 description 1
• 108010052164 Sodium Channels Proteins 0.000 description 1
• 102000018674 Sodium Channels Human genes 0.000 description 1
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
• 208000006045 Spondylarthropathies Diseases 0.000 description 1
• 208000031439 Striae Distensae Diseases 0.000 description 1
• 102000019197 Superoxide Dismutase Human genes 0.000 description 1
• 108010012715 Superoxide dismutase Proteins 0.000 description 1
• 229920002253 Tannate Polymers 0.000 description 1
• 206010043118 Tardive Dyskinesia Diseases 0.000 description 1
• 208000034799 Tauopathies Diseases 0.000 description 1
• 239000004809 Teflon Substances 0.000 description 1
• 229920006362 Teflon® Polymers 0.000 description 1
• SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• 201000003005 Tetralogy of Fallot Diseases 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• 241001061127 Thione Species 0.000 description 1
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
• 102000000591 Tight Junction Proteins Human genes 0.000 description 1
• 108010002321 Tight Junction Proteins Proteins 0.000 description 1
• 208000026062 Tissue disease Diseases 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 208000032109 Transient ischaemic attack Diseases 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 239000013504 Triton X-100 Substances 0.000 description 1
• 229920004890 Triton X-100 Polymers 0.000 description 1
• 238000010162 Tukey test Methods 0.000 description 1
• 201000006704 Ulcerative Colitis Diseases 0.000 description 1
• 208000032594 Vascular Remodeling Diseases 0.000 description 1
• 206010047115 Vasculitis Diseases 0.000 description 1
• 208000033457 Weary type hereditary sclerosing poikiloderma Diseases 0.000 description 1
• 208000013058 Weber syndrome Diseases 0.000 description 1
• 208000031037 Wiedemann-Rautenstrauch syndrome Diseases 0.000 description 1
• 208000018839 Wilson disease Diseases 0.000 description 1
• 206010048218 Xeroderma Diseases 0.000 description 1
• 201000006083 Xeroderma Pigmentosum Diseases 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• ZHAFUINZIZIXFC-UHFFFAOYSA-N [9-(dimethylamino)-10-methylbenzo[a]phenoxazin-5-ylidene]azanium;chloride Chemical compound [Cl-].O1C2=CC(=[NH2+])C3=CC=CC=C3C2=NC2=C1C=C(N(C)C)C(C)=C2 ZHAFUINZIZIXFC-UHFFFAOYSA-N 0.000 description 1
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• 239000003070 absorption delaying agent Substances 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• 229960004308 acetylcysteine Drugs 0.000 description 1
• 201000000761 achromatopsia Diseases 0.000 description 1
• 208000009621 actinic keratosis Diseases 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
• 210000000577 adipose tissue Anatomy 0.000 description 1
• 208000026594 alcoholic fatty liver disease Diseases 0.000 description 1
• 150000001298 alcohols Chemical class 0.000 description 1
• 150000001447 alkali salts Chemical class 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
• 229940063655 aluminum stearate Drugs 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 229940024606 amino acid Drugs 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 239000002280 amphoteric surfactant Substances 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 229960005238 anethole trithione Drugs 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 125000000129 anionic group Chemical group 0.000 description 1
• 239000003945 anionic surfactant Substances 0.000 description 1
• 208000005028 anomia Diseases 0.000 description 1
• 206010068346 anosognosia Diseases 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000001772 anti-angiogenic effect Effects 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 230000000845 anti-microbial effect Effects 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 230000000890 antigenic effect Effects 0.000 description 1
• 239000004599 antimicrobial Substances 0.000 description 1
• 206010002906 aortic stenosis Diseases 0.000 description 1
• 201000002064 aortic valve insufficiency Diseases 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• 238000013475 authorization Methods 0.000 description 1
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
• 201000000889 autosomal recessive cutis laxa type III Diseases 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 238000003287 bathing Methods 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 235000012216 bentonite Nutrition 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
• UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
• 229960001950 benzethonium chloride Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
• 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
• 230000002715 bioenergetic effect Effects 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
• 239000004327 boric acid Substances 0.000 description 1
• 229960002645 boric acid Drugs 0.000 description 1
• 235000010338 boric acid Nutrition 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 1
• 230000003925 brain function Effects 0.000 description 1
• 208000029028 brain injury Diseases 0.000 description 1
• 201000007293 brain stem infarction Diseases 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 239000007853 buffer solution Substances 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 210000005252 bulbus oculi Anatomy 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
• CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
• 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
• 229940067596 butylparaben Drugs 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 235000011148 calcium chloride Nutrition 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 229940096529 carboxypolymethylene Drugs 0.000 description 1
• 210000004413 cardiac myocyte Anatomy 0.000 description 1
• 238000013172 carotid endarterectomy Methods 0.000 description 1
• 229960001777 castor oil Drugs 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 239000003093 cationic surfactant Substances 0.000 description 1
• 230000020411 cell activation Effects 0.000 description 1
• 230000030833 cell death Effects 0.000 description 1
• 210000000170 cell membrane Anatomy 0.000 description 1
• 230000004656 cell transport Effects 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
• 208000026106 cerebrovascular disease Diseases 0.000 description 1
• 239000007806 chemical reaction intermediate Substances 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 229960004926 chlorobutanol Drugs 0.000 description 1
• 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 210000003161 choroid Anatomy 0.000 description 1
• 230000007882 cirrhosis Effects 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 229960003920 cocaine Drugs 0.000 description 1
• 230000019771 cognition Effects 0.000 description 1
• 239000008119 colloidal silica Substances 0.000 description 1
• 201000007254 color blindness Diseases 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 210000000795 conjunctiva Anatomy 0.000 description 1
• 230000037020 contractile activity Effects 0.000 description 1
• 230000008602 contraction Effects 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000003431 cross linking reagent Substances 0.000 description 1
• 239000002577 cryoprotective agent Substances 0.000 description 1
• 230000001186 cumulative effect Effects 0.000 description 1
• 229940109275 cyclamate Drugs 0.000 description 1
• JLQNHALFVCURHW-UHFFFAOYSA-N cyclooctasulfur Chemical group S1SSSSSSS1 JLQNHALFVCURHW-UHFFFAOYSA-N 0.000 description 1
• 230000003436 cytoskeletal effect Effects 0.000 description 1
• 210000000172 cytosol Anatomy 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 208000003023 de Barsy syndrome Diseases 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 230000002939 deleterious effect Effects 0.000 description 1
• 230000002951 depilatory effect Effects 0.000 description 1
• 201000001981 dermatomyositis Diseases 0.000 description 1
• 230000006866 deterioration Effects 0.000 description 1
• 239000011903 deuterated solvents‎ Substances 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000013229 diet-induced obese mouse Methods 0.000 description 1
• 230000000378 dietary effect Effects 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
• UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
• 229940008099 dimethicone Drugs 0.000 description 1
• AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
• 239000004205 dimethyl polysiloxane Substances 0.000 description 1
• 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
• 229950010286 diolamine Drugs 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• LNGNZSMIUVQZOX-UHFFFAOYSA-L disodium;dioxido(sulfanylidene)-$l^{4}-sulfane Chemical compound [Na+].[Na+].[O-]S([O-])=S LNGNZSMIUVQZOX-UHFFFAOYSA-L 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
• 229960003638 dopamine Drugs 0.000 description 1
• 239000012636 effector Substances 0.000 description 1
• 239000007938 effervescent tablet Substances 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 230000027721 electron transport chain Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 238000001839 endoscopy Methods 0.000 description 1
• 230000008694 endothelial dysfunction Effects 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000006353 environmental stress Effects 0.000 description 1
• 229940088598 enzyme Drugs 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• 229950007655 esilate Drugs 0.000 description 1
• 235000020774 essential nutrients Nutrition 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
• 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
• DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
• NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 150000002194 fatty esters Chemical class 0.000 description 1
• 208000010706 fatty liver disease Diseases 0.000 description 1
• JFSPBVWPKOEZCB-UHFFFAOYSA-N fenfuram Chemical compound O1C=CC(C(=O)NC=2C=CC=CC=2)=C1C JFSPBVWPKOEZCB-UHFFFAOYSA-N 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 208000017561 flaccidity Diseases 0.000 description 1
• FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
• 229940013640 flavin mononucleotide Drugs 0.000 description 1
• FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 description 1
• 239000011768 flavin mononucleotide Substances 0.000 description 1
• 238000007667 floating Methods 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 239000003269 fluorescent indicator Substances 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
• 235000021588 free fatty acids Nutrition 0.000 description 1
• 230000008014 freezing Effects 0.000 description 1
• 238000007710 freezing Methods 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 1
• 230000005021 gait Effects 0.000 description 1
• 229960001731 gluceptate Drugs 0.000 description 1
• KWMLJOLKUYYJFJ-VFUOTHLCSA-N glucoheptonic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C(O)=O KWMLJOLKUYYJFJ-VFUOTHLCSA-N 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• 150000002314 glycerols Chemical class 0.000 description 1
• 229960003711 glyceryl trinitrate Drugs 0.000 description 1
• 210000004209 hair Anatomy 0.000 description 1
• 210000002837 heart atrium Anatomy 0.000 description 1
• 208000019622 heart disease Diseases 0.000 description 1
• 210000005003 heart tissue Anatomy 0.000 description 1
• 208000014951 hematologic disease Diseases 0.000 description 1
• 208000018706 hematopoietic system disease Diseases 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000005842 heteroatom Chemical group 0.000 description 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
• LJXICGDBVCTCOC-UHFFFAOYSA-H hexasodium;diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LJXICGDBVCTCOC-UHFFFAOYSA-H 0.000 description 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 229950000177 hibenzate Drugs 0.000 description 1
• 238000012203 high throughput assay Methods 0.000 description 1
• 229960001340 histamine Drugs 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 230000013632 homeostatic process Effects 0.000 description 1
• 238000000265 homogenisation Methods 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229940103471 humulin Drugs 0.000 description 1
• 150000004678 hydrides Chemical group 0.000 description 1
• 150000002430 hydrocarbons Chemical class 0.000 description 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
• 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
• TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
• 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 230000002102 hyperpolarization Effects 0.000 description 1
• 208000018875 hypoxemia Diseases 0.000 description 1
• 206010021198 ichthyosis Diseases 0.000 description 1
• 125000002883 imidazolyl group Chemical group 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000002055 immunohistochemical effect Effects 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 230000002458 infectious effect Effects 0.000 description 1
• 230000036512 infertility Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 238000009434 installation Methods 0.000 description 1
• PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 230000004068 intracellular signaling Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 230000009545 invasion Effects 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 229960002725 isoflurane Drugs 0.000 description 1
• XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
• YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
• 150000002540 isothiocyanates Chemical class 0.000 description 1
• 210000004731 jugular vein Anatomy 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• 208000037806 kidney injury Diseases 0.000 description 1
• TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 208000004343 lateral medullary syndrome Diseases 0.000 description 1
• 231100000518 lethal Toxicity 0.000 description 1
• 230000001665 lethal effect Effects 0.000 description 1
• 150000002617 leukotrienes Chemical class 0.000 description 1
• 238000004811 liquid chromatography Methods 0.000 description 1
• 239000006193 liquid solution Substances 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 208000018191 liver inflammation Diseases 0.000 description 1
• 238000011068 loading method Methods 0.000 description 1
• 238000000464 low-speed centrifugation Methods 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 201000005202 lung cancer Diseases 0.000 description 1
• 208000020816 lung neoplasm Diseases 0.000 description 1
• 229960003646 lysine Drugs 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
• 239000000391 magnesium silicate Substances 0.000 description 1
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
• 235000019341 magnesium sulphate Nutrition 0.000 description 1
• 229940091250 magnesium supplement Drugs 0.000 description 1
• 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
• 235000019793 magnesium trisilicate Nutrition 0.000 description 1
• 229940099273 magnesium trisilicate Drugs 0.000 description 1
• HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 230000010534 mechanism of action Effects 0.000 description 1
• 229960003194 meglumine Drugs 0.000 description 1
• 210000001259 mesencephalon Anatomy 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
• ASUWPSZNKIBZQX-UHFFFAOYSA-N methyl 2-(4-methoxyphenyl)-3-oxopropanoate Chemical compound COC(=O)C(C=O)c1ccc(OC)cc1 ASUWPSZNKIBZQX-UHFFFAOYSA-N 0.000 description 1
• IUFUNQCWHNVYGG-UHFFFAOYSA-N methyl 3-(1-benzofuran-5-yl)-3-oxopropanoate Chemical compound COC(=O)CC(=O)C1=CC=C2OC=CC2=C1 IUFUNQCWHNVYGG-UHFFFAOYSA-N 0.000 description 1
• AGADEVQOWQDDFX-UHFFFAOYSA-N methyl 3-oxopropanoate Chemical compound COC(=O)CC=O AGADEVQOWQDDFX-UHFFFAOYSA-N 0.000 description 1
• MTTCUMSOYHYXOI-UHFFFAOYSA-N methyl 5-(3-methoxy-3-oxopropanoyl)indole-1-carboxylate Chemical compound COC(=O)CC(=O)C1=CC=C2N(C=CC2=C1)C(=O)OC MTTCUMSOYHYXOI-UHFFFAOYSA-N 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 229960002900 methylcellulose Drugs 0.000 description 1
• 235000010981 methylcellulose Nutrition 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• 239000004200 microcrystalline wax Substances 0.000 description 1
• 235000019808 microcrystalline wax Nutrition 0.000 description 1
• 210000001589 microsome Anatomy 0.000 description 1
• 230000006676 mitochondrial damage Effects 0.000 description 1
• 208000006887 mitral valve stenosis Diseases 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000020763 muscle atrophy Effects 0.000 description 1
• 230000004118 muscle contraction Effects 0.000 description 1
• 201000000585 muscular atrophy Diseases 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 125000005487 naphthalate group Chemical group 0.000 description 1
• 229920005615 natural polymer Polymers 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 230000027405 negative regulation of phosphorylation Effects 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 210000002682 neurofibrillary tangle Anatomy 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 239000012299 nitrogen atmosphere Substances 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 201000009583 nominal aphasia Diseases 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 238000013116 obese mouse model Methods 0.000 description 1
• 230000000414 obstructive effect Effects 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 229950004864 olamine Drugs 0.000 description 1
• 239000000082 organ preservation Substances 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 1
• 125000002971 oxazolyl group Chemical group 0.000 description 1
• 238000002734 oxidative phosphorylation assay Methods 0.000 description 1
• 230000008557 oxygen metabolism Effects 0.000 description 1
• 239000012186 ozocerite Substances 0.000 description 1
• 150000002942 palmitic acid derivatives Chemical class 0.000 description 1
• 229920002866 paraformaldehyde Polymers 0.000 description 1
• 230000001991 pathophysiological effect Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 235000019371 penicillin G benzathine Nutrition 0.000 description 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
• 208000008494 pericarditis Diseases 0.000 description 1
• 210000001428 peripheral nervous system Anatomy 0.000 description 1
• 150000002978 peroxides Chemical class 0.000 description 1
• 210000002824 peroxisome Anatomy 0.000 description 1
• 239000000575 pesticide Substances 0.000 description 1
• 239000002831 pharmacologic agent Substances 0.000 description 1
• 238000011458 pharmacological treatment Methods 0.000 description 1
• 150000007965 phenolic acids Chemical class 0.000 description 1
• WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• 201000008124 phonagnosia Diseases 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
• 230000008832 photodamage Effects 0.000 description 1
• 230000000704 physical effect Effects 0.000 description 1
• 231100000374 pneumotoxicity Toxicity 0.000 description 1
• 229960000502 poloxamer Drugs 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 229950005134 polycarbophil Drugs 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
• 230000007824 polyneuropathy Effects 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
• 235000007686 potassium Nutrition 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 229960003975 potassium Drugs 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 239000011736 potassium bicarbonate Substances 0.000 description 1
• 235000015497 potassium bicarbonate Nutrition 0.000 description 1
• 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
• 229940094025 potassium bicarbonate Drugs 0.000 description 1
• 229910000027 potassium carbonate Inorganic materials 0.000 description 1
• 229940093956 potassium carbonate Drugs 0.000 description 1
• 235000011181 potassium carbonates Nutrition 0.000 description 1
• TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
• 235000010241 potassium sorbate Nutrition 0.000 description 1
• 239000004302 potassium sorbate Substances 0.000 description 1
• 229940069338 potassium sorbate Drugs 0.000 description 1
• DKGFIVSGQRBSOG-UHFFFAOYSA-M potassium;4-hydroxybenzoate Chemical class [K+].OC1=CC=C(C([O-])=O)C=C1 DKGFIVSGQRBSOG-UHFFFAOYSA-M 0.000 description 1
• TUMYXYVXTFDMTJ-UHFFFAOYSA-M potassium;4-propoxycarbonylphenolate Chemical compound [K+].CCCOC(=O)C1=CC=C([O-])C=C1 TUMYXYVXTFDMTJ-UHFFFAOYSA-M 0.000 description 1
• 230000003334 potential effect Effects 0.000 description 1
• 238000005381 potential energy Methods 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 201000002212 progressive supranuclear palsy Diseases 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
• 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• 235000013772 propylene glycol Nutrition 0.000 description 1
• 229960003415 propylparaben Drugs 0.000 description 1
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
• 229950008679 protamine sulfate Drugs 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 235000019419 proteases Nutrition 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 230000036593 pulmonary vascular resistance Effects 0.000 description 1
• 238000005086 pumping Methods 0.000 description 1
• 239000008213 purified water Substances 0.000 description 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
• 239000002510 pyrogen Substances 0.000 description 1
• 229940043131 pyroglutamate Drugs 0.000 description 1
• 125000000168 pyrrolyl group Chemical group 0.000 description 1
• 150000004053 quinones Chemical class 0.000 description 1
• 125000004151 quinonyl group Chemical group 0.000 description 1
• 239000002516 radical scavenger Substances 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 239000013557 residual solvent Substances 0.000 description 1
• 208000034979 restrictive dermopathy Diseases 0.000 description 1
• 230000004258 retinal degeneration Effects 0.000 description 1
• 239000000790 retinal pigment Substances 0.000 description 1
• 210000003583 retinal pigment epithelium Anatomy 0.000 description 1
• 201000003068 rheumatic fever Diseases 0.000 description 1
• 235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 238000007363 ring formation reaction Methods 0.000 description 1
• MNOALXGAYUJNKX-UHFFFAOYSA-N s-chloro chloromethanethioate Chemical compound ClSC(Cl)=O MNOALXGAYUJNKX-UHFFFAOYSA-N 0.000 description 1
• YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
• 210000002235 sarcomere Anatomy 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 201000000980 schizophrenia Diseases 0.000 description 1
• 201000003385 seborrheic keratosis Diseases 0.000 description 1
• 239000011669 selenium Substances 0.000 description 1
• 230000035945 sensitivity Effects 0.000 description 1
• 230000036303 septic shock Effects 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 230000008054 signal transmission Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
• 235000012239 silicon dioxide Nutrition 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 210000002460 smooth muscle Anatomy 0.000 description 1
• 229960004249 sodium acetate Drugs 0.000 description 1
• 229940001607 sodium bisulfite Drugs 0.000 description 1
• CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
• 229910000029 sodium carbonate Inorganic materials 0.000 description 1
• HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
• 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
• 229940001584 sodium metabisulfite Drugs 0.000 description 1
• 235000010262 sodium metabisulphite Nutrition 0.000 description 1
• IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
• 230000007928 solubilization Effects 0.000 description 1
• 238000005063 solubilization Methods 0.000 description 1
• 229940075554 sorbate Drugs 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 238000001228 spectrum Methods 0.000 description 1
• 201000005671 spondyloarthropathy Diseases 0.000 description 1
• 230000002269 spontaneous effect Effects 0.000 description 1
• 230000007480 spreading Effects 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• 230000003068 static effect Effects 0.000 description 1
• 238000010245 stereological analysis Methods 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 150000005846 sugar alcohols Chemical class 0.000 description 1
• 150000008163 sugars Chemical class 0.000 description 1
• 125000004434 sulfur atom Chemical group 0.000 description 1
• 230000000475 sunscreen effect Effects 0.000 description 1
• 239000000516 sunscreening agent Substances 0.000 description 1
• 239000006228 supernatant Substances 0.000 description 1
• 230000007755 survival signaling Effects 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 238000010408 sweeping Methods 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 230000009897 systematic effect Effects 0.000 description 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 239000003760 tallow Substances 0.000 description 1
• 238000004885 tandem mass spectrometry Methods 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 238000003419 tautomerization reaction Methods 0.000 description 1
• 206010043207 temporal arteritis Diseases 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
• 125000000335 thiazolyl group Chemical group 0.000 description 1
• RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
• 229940033663 thimerosal Drugs 0.000 description 1
• 150000003573 thiols Chemical class 0.000 description 1
• 210000001578 tight junction Anatomy 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
• 210000002105 tongue Anatomy 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 201000010875 transient cerebral ischemia Diseases 0.000 description 1
• 201000007905 transthyretin amyloidosis Diseases 0.000 description 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
• RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 description 1
• WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical class [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
• 229960000281 trometamol Drugs 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• 238000001946 ultra-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
• 229940099259 vaseline Drugs 0.000 description 1
• 230000003639 vasoconstrictive effect Effects 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 230000000007 visual effect Effects 0.000 description 1
• 210000004127 vitreous body Anatomy 0.000 description 1
• 230000001755 vocal effect Effects 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 230000004584 weight gain Effects 0.000 description 1
• 235000019786 weight gain Nutrition 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 210000002268 wool Anatomy 0.000 description 1
• 230000037303 wrinkles Effects 0.000 description 1
• 229920001285 xanthan gum Polymers 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 239000011787 zinc oxide Substances 0.000 description 1
• 235000014692 zinc oxide Nutrition 0.000 description 1
• 108010027843 zonulin Proteins 0.000 description 1