BR112019014652A2 - anticorpos monovalentes antiproperdina e fragmentos de anticorpo - Google Patents
anticorpos monovalentes antiproperdina e fragmentos de anticorpo Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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Landscapes
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- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
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| US201762452187P | 2017-01-30 | 2017-01-30 | |
| US62/452,187 | 2017-01-30 | ||
| PCT/US2018/015985 WO2018140956A1 (en) | 2017-01-30 | 2018-01-30 | Monovalent anti-properdin antibodies and antibody fragments |
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| BR112019014652A2 true BR112019014652A2 (pt) | 2020-08-18 |
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| WO (1) | WO2018140956A1 (OSRAM) |
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| CN117327188A (zh) | 2017-07-11 | 2024-01-02 | 亚力兄制药公司 | 结合补体成分c5或血清白蛋白的多肽及其融合蛋白 |
| US20220053741A1 (en) * | 2018-09-13 | 2022-02-24 | Regeneron Pharmaceuticals, Inc. | Complement Factor H Gene Knockout Rat as a Model of C3 Glomerulopathy |
| WO2021140475A1 (en) * | 2020-01-08 | 2021-07-15 | Cadila Healthcare Limited | Anti-properdin antibodies and preparation thereof |
| JP7787164B2 (ja) | 2020-09-23 | 2025-12-16 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体媒介性障害の治療のための医薬化合物 |
| CN118593708A (zh) * | 2020-10-30 | 2024-09-06 | 广州市妇女儿童医疗中心 | 诊断胆道闭锁的方法 |
| WO2023023227A1 (en) | 2021-08-20 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods for treating sickle cell disease or beta thalassemia using complement alternative pathway inhibitors |
| US11981727B2 (en) | 2021-08-31 | 2024-05-14 | Novelmed Therapeutics, Inc | Monospecific and bispecific antibodies and antigen binding fragments thereof |
| WO2024108529A1 (en) * | 2022-11-25 | 2024-05-30 | Linno Pharmaceuticals Inc. | Properdin binding protein and use thereof |
| EP4565608A2 (en) * | 2022-08-05 | 2025-06-11 | Alexion Pharmaceuticals, Inc. | Pharmaceutical compositions of fusion proteins and methods of use thereof |
| TW202417490A (zh) * | 2022-08-31 | 2024-05-01 | 美商艾力克森製藥公司 | 用於治療鐮狀細胞病的融合多肽之劑量及投與 |
| CN118401253A (zh) * | 2022-11-25 | 2024-07-26 | 领诺(上海)医药科技有限公司 | 备解素结合蛋白及其用途 |
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| US7423128B2 (en) * | 2004-11-03 | 2008-09-09 | Amgen Fremont Inc. | Anti-properdin antibodies, and methods for making and using same |
| JP5735194B2 (ja) | 2005-01-25 | 2015-06-17 | セル セラピューティクス インコーポレーテッド | 改善された生体内半減期を有する生物学的に活性なタンパク質 |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| SI2500030T2 (sl) * | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uporaba inhibitorjev komplementarnih procesov za zdravljenje očesnih bolezni |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| ES2538114T3 (es) * | 2008-03-03 | 2015-06-17 | Novelmed Therapeutics, Inc. | Anticuerpos anti-properdina |
| US20110002931A1 (en) | 2009-06-23 | 2011-01-06 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
| UY32920A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
| CA2811221C (en) | 2010-03-10 | 2018-01-09 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-properdin antibodies |
| PT2621519T (pt) | 2010-09-28 | 2017-10-04 | Aegerion Pharmaceuticals Inc | Polipéptido de fusão de leptina-abd com duração de ação melhorada |
| WO2012062713A1 (en) | 2010-11-08 | 2012-05-18 | Novartis Ag | Cxcr2 binding polypeptides |
| US9701742B2 (en) | 2011-07-01 | 2017-07-11 | The Trustees Of The University Of Pennsylvania | Anti-properdin antibodies and uses thereof |
| JP6006309B2 (ja) | 2011-07-08 | 2016-10-12 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
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| AU2012362217A1 (en) | 2011-12-28 | 2014-07-24 | Novelmed Therapeutics, Inc. | Aglycosylated human antibody and fusion protein and uses thereof |
| JP2015532303A (ja) | 2012-10-04 | 2015-11-09 | ノベルメド セラピューティクス，インコーポレーテッド | 溶血性疾患を治療するための補体第２経路特異的抗体 |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
| CN110003335B (zh) * | 2019-04-12 | 2023-07-04 | 深圳普瑞金生物药业股份有限公司 | Cd47单域抗体、核酸及试剂盒 |
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- 2018-01-30 CN CN201880008892.6A patent/CN110831626B/zh active Active
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- 2018-01-30 EP EP18744926.9A patent/EP3573661A4/en active Pending
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| WO2018140956A1 (en) | 2018-08-02 |
| RU2019124873A3 (OSRAM) | 2021-03-01 |
| JP2024116321A (ja) | 2024-08-27 |
| IL267898B2 (en) | 2024-06-01 |
| KR20190111946A (ko) | 2019-10-02 |
| EP3573661A4 (en) | 2020-08-12 |
| CN118184777A (zh) | 2024-06-14 |
| CA3049806A1 (en) | 2018-08-02 |
| IL267898A (en) | 2019-09-26 |
| AU2018212012B2 (en) | 2025-02-13 |
| US20220162292A1 (en) | 2022-05-26 |
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| MX2023007840A (es) | 2023-07-07 |
| CO2019007686A2 (es) | 2019-07-31 |
| RU2019124873A (ru) | 2021-03-01 |
| KR102613874B1 (ko) | 2023-12-15 |
| IL309890A (en) | 2024-03-01 |
| US20190352381A1 (en) | 2019-11-21 |
| CN110831626B (zh) | 2024-04-19 |
| EP3573661A1 (en) | 2019-12-04 |
| KR20230173731A (ko) | 2023-12-27 |
| IL267898B1 (en) | 2024-02-01 |
| US12497445B2 (en) | 2025-12-16 |
| JP2022153405A (ja) | 2022-10-12 |
| CN110831626A (zh) | 2020-02-21 |
| MX2019008827A (es) | 2019-09-26 |
| AU2025200709A1 (en) | 2025-02-20 |
| JP2020507561A (ja) | 2020-03-12 |
| AU2018212012A1 (en) | 2019-07-25 |
| US11198725B2 (en) | 2021-12-14 |
| JP7101684B2 (ja) | 2022-07-15 |
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