BR112019007928A2 - conjugados de bacitracina-oligômero de alginato - Google Patents

conjugados de bacitracina-oligômero de alginato

Info

Publication number
BR112019007928A2
BR112019007928A2 BR112019007928A BR112019007928A BR112019007928A2 BR 112019007928 A2 BR112019007928 A2 BR 112019007928A2 BR 112019007928 A BR112019007928 A BR 112019007928A BR 112019007928 A BR112019007928 A BR 112019007928A BR 112019007928 A2 BR112019007928 A2 BR 112019007928A2
Authority
BR
Brazil
Prior art keywords
bacitracin
alginate oligomer
conjugate
oligomer conjugates
bacterial
Prior art date
Application number
BR112019007928A
Other languages
English (en)
Inventor
Dessen Arne
William Thomas David
Ferguson Elaine
Rye Philip
Original Assignee
Algipharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algipharma As filed Critical Algipharma As
Publication of BR112019007928A2 publication Critical patent/BR112019007928A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C07K7/58—Bacitracins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

a invenção fornece um conjugado bacitracina-oligômero de alginato constituído por um antibiótico da classe das bacitracinas ligado covalentemente a pelo menos um oligômero de alginato por meio de uma ligação direta covalente ou de um ligador molecular covalente, ou um sal, solvato, hidrato, diastereoisômero, tautômero, enantiômero ou metabolito ativo farmaceuticamente aceitável do dito conjugado. são igualmente fornecidos métodos para a preparação do referido conjugado, as composições farmacêuticas que o incluem e a sua utilização em um método para o tratamento ou prevenção de uma infecção bacteriana em um indivíduo com, suspeito de ter, ou em risco de ter, uma infecção bacteriana.
BR112019007928A 2016-10-21 2017-10-20 conjugados de bacitracina-oligômero de alginato BR112019007928A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1617862.6A GB2555391B (en) 2016-10-21 2016-10-21 Bacitracin-alginate oligomer conjugates
PCT/EP2017/076926 WO2018073448A1 (en) 2016-10-21 2017-10-20 Bacitracin-alginate oligomer conjugates

Publications (1)

Publication Number Publication Date
BR112019007928A2 true BR112019007928A2 (pt) 2019-07-02

Family

ID=57738026

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019007928A BR112019007928A2 (pt) 2016-10-21 2017-10-20 conjugados de bacitracina-oligômero de alginato

Country Status (16)

Country Link
US (1) US20230139922A1 (pt)
EP (1) EP3528829B1 (pt)
JP (1) JP7191014B2 (pt)
KR (1) KR20190070946A (pt)
CN (1) CN109862904A (pt)
AU (1) AU2017345294A1 (pt)
BR (1) BR112019007928A2 (pt)
CA (1) CA3040796A1 (pt)
DK (1) DK3528829T3 (pt)
ES (1) ES2914784T3 (pt)
GB (1) GB2555391B (pt)
PL (1) PL3528829T3 (pt)
PT (1) PT3528829T (pt)
RU (1) RU2766345C2 (pt)
SI (1) SI3528829T1 (pt)
WO (1) WO2018073448A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110484473B (zh) * 2019-08-31 2022-08-19 暨南大学 一种促进鹤羽田戴尔福特菌在植物根际定殖的方法
CN111057131A (zh) * 2019-12-13 2020-04-24 上海市食品药品检验所 一种杆菌肽及其组分的分析方法
CN111420024B (zh) * 2020-04-07 2023-10-03 中国科学院深圳先进技术研究院 杆菌酞a在制备预防和治疗冠状病毒的药物中的应用
CN112812150A (zh) * 2021-01-29 2021-05-18 深圳海创生物科技有限公司 一种活性环肽、活性环肽组合物及其在制备具有抗氧化或抗炎作用的产品中的应用
CN113413490B (zh) * 2021-05-14 2022-05-27 哈尔滨医科大学 一种超声响应性复合水凝胶及其制备方法和应用
CN117679350B (zh) * 2023-12-13 2024-06-07 诺德溯源(广州)生物科技有限公司 一种淡化痘印和抚平痘坑的愈创木组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1433593A (en) * 1972-06-09 1976-04-28 Royal College Of Surgeons Conjugates
GB2270920B (en) * 1992-09-25 1997-04-02 Univ Keele Alginate-bioactive agent conjugates
US6248360B1 (en) * 2000-06-21 2001-06-19 International Health Management Associates, Inc. Complexes to improve oral absorption of poorly absorbable antibiotics
JP5639475B2 (ja) 2007-11-27 2014-12-10 アルギファルマ アイピーアール エーエス バイオフィルムと闘う際のアルギネートオリゴマーの使用
EP2161020A1 (en) * 2008-09-09 2010-03-10 Koninklijke Philips Electronics N.V. Chelating amphiphilic polymers
CA2764195C (en) * 2009-06-03 2017-09-26 Algipharma As Treatment of acinetobacter with alginate oligomers and antibiotics
JP6336902B2 (ja) 2011-06-22 2018-06-06 ビョーメ バイオサイエンシズ ピーブイティー．リミテッド コンジュゲートベースの抗真菌性および抗菌性プロドラッグ
US10195282B2 (en) * 2014-11-20 2019-02-05 University Of Southern California Use of alginate formulation for intraincisional drug delivery

Also Published As

Publication number Publication date
CA3040796A1 (en) 2018-04-26
PL3528829T3 (pl) 2022-09-19
KR20190070946A (ko) 2019-06-21
DK3528829T3 (da) 2022-05-30
GB2555391A (en) 2018-05-02
RU2019109728A3 (pt) 2021-02-16
US20230139922A1 (en) 2023-05-04
RU2766345C2 (ru) 2022-03-15
EP3528829A1 (en) 2019-08-28
AU2017345294A1 (en) 2019-05-02
PT3528829T (pt) 2022-06-02
SI3528829T1 (sl) 2022-07-29
GB2555391B (en) 2019-06-26
JP2019535669A (ja) 2019-12-12
JP7191014B2 (ja) 2022-12-16
EP3528829B1 (en) 2022-03-02
ES2914784T3 (es) 2022-06-16
GB201617862D0 (en) 2016-12-07
WO2018073448A1 (en) 2018-04-26
CN109862904A (zh) 2019-06-07
RU2019109728A (ru) 2020-11-23

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements