BR112017024929A2 - conjugados de oligonucleotídeo-peptídeo - Google Patents

conjugados de oligonucleotídeo-peptídeo

Info

Publication number
BR112017024929A2
BR112017024929A2 BR112017024929-4A BR112017024929A BR112017024929A2 BR 112017024929 A2 BR112017024929 A2 BR 112017024929A2 BR 112017024929 A BR112017024929 A BR 112017024929A BR 112017024929 A2 BR112017024929 A2 BR 112017024929A2
Authority
BR
Brazil
Prior art keywords
oligonucleotide
peptide conjugates
peptide
peptides
oligonucleotides
Prior art date
Application number
BR112017024929-4A
Other languages
English (en)
Inventor
J. Hanson Gunnar
Zhou Ming
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of BR112017024929A2 publication Critical patent/BR112017024929A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

trata-se de oligonucleotídeos, peptídeos, e conjugados de peptídeo-oligonucletídeo. trata-se, também, de métodos para tratar uma doença muscular, uma infecção viral ou uma infecção bacteriana em um indivíduo em necessidade do mesmo, que compreende administrar ao indivíduo oligonucleotídeos, peptídeos e conjugados de peptídeo-oligonucletídeo descritos no presente documento.
BR112017024929-4A 2015-05-19 2016-05-19 conjugados de oligonucleotídeo-peptídeo BR112017024929A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562163960P 2015-05-19 2015-05-19
US62/163,960 2015-05-19
US201662337536P 2016-05-17 2016-05-17
US62/337,536 2016-05-17
PCT/US2016/033276 WO2016187425A1 (en) 2015-05-19 2016-05-19 Peptide oligonucleotide conjugates

Publications (1)

Publication Number Publication Date
BR112017024929A2 true BR112017024929A2 (pt) 2018-07-31

Family

ID=57320822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017024929-4A BR112017024929A2 (pt) 2015-05-19 2016-05-19 conjugados de oligonucleotídeo-peptídeo

Country Status (18)

Country Link
US (4) US10675356B2 (pt)
EP (2) EP3297649B1 (pt)
JP (2) JP6954843B2 (pt)
KR (2) KR20240035901A (pt)
CN (2) CN114681621A (pt)
AU (1) AU2016264471B2 (pt)
BR (1) BR112017024929A2 (pt)
CA (1) CA2986228A1 (pt)
DK (1) DK3297649T3 (pt)
ES (1) ES2964695T3 (pt)
FI (1) FI3297649T3 (pt)
HK (1) HK1252759A1 (pt)
HR (1) HRP20231431T1 (pt)
IL (1) IL255655B (pt)
MA (1) MA42134A (pt)
MX (1) MX2017014806A (pt)
NZ (1) NZ737757A (pt)
WO (1) WO2016187425A1 (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240035901A (ko) * 2015-05-19 2024-03-18 사렙타 쎄러퓨틱스 인코퍼레이티드 펩티드 올리고뉴클레오티드 콘주게이트
GB2545898B (en) 2015-12-21 2019-10-09 Sutura Therapeutics Ltd Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
CA3029772A1 (en) 2016-07-05 2018-01-11 Biomarin Technologies B.V. Pre-mrna splice switching or modulating oligonucleotides comprising bicyclic scaffold moieties, with improved characteristics for the treatment of genetic disorders
MX2019008199A (es) * 2017-01-06 2019-11-25 Avidity Biosciences Llc Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
KR102279333B1 (ko) 2017-03-07 2021-07-20 주식회사 만도 차량의 디스플레이 시스템 및 이의 구동 방법
GB2580569B (en) * 2017-06-28 2021-08-18 Sutura Therapeutics Ltd Improvements in drug delivery
GB2563875B (en) * 2017-06-28 2020-08-19 Sutura Therapeutics Ltd Improvements in drug delivery
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
EP3684376A4 (en) * 2017-09-22 2021-10-20 Avidity Biosciences, Inc. NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND EXON BREAK INDUCTION METHODS
CN111655268B (zh) 2017-10-04 2024-03-26 艾维迪提生物科学公司 核酸-多肽组合物及其用途
WO2019079367A1 (en) * 2017-10-17 2019-04-25 Sarepta Therapeutics, Inc. OLIGONUCLEOTIDE CONJUGATES-BICYCLIC PEPTIDES
MA51103A (fr) 2017-12-06 2020-10-14 Avidity Biosciences Inc Compositions et procédés de traitement de l'atrophie musculaire et de la dystrophie myotonique
TW202019442A (zh) * 2018-07-30 2020-06-01 美商薩羅塔治療公司 用於反義遞送之三聚合肽
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
MX2021001284A (es) 2018-08-02 2021-07-15 Dyne Therapeutics Inc Complejos dirigidos al musculo y sus usos para el tratamiento de distrofia muscular facioescapulohumeral.
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
GB201821269D0 (en) 2018-12-28 2019-02-13 Nippon Shinyaku Co Ltd Myostatin signal inhibitor
JP2022535588A (ja) 2019-06-06 2022-08-09 アビディティー バイオサイエンシーズ，インク． 核酸ポリペプチド組成物およびその使用
IL294271A (en) 2019-12-26 2022-08-01 Nippon Shinyaku Co Ltd Antisense nucleic acids that cause splicing on exon 50
EP4112083A1 (en) 2020-02-28 2023-01-04 Nippon Shinyaku Co., Ltd. Antisense nucleic acid inducing skipping of exon 51
CN115666589A (zh) 2020-03-19 2023-01-31 艾维迪提生物科学公司 治疗面肩肱型肌营养不良的组合物和方法
WO2022212886A1 (en) * 2021-04-02 2022-10-06 Avidity Biosciences, Inc. Antibody-oligonucleotide conjugate and antibody-peptide-oligonucleotide conjugate compositions and methods of inducing exon skipping
BR112023027298A2 (pt) 2021-06-23 2024-03-12 Nat Center Neurology & Psychiatry Combinação de oligômeros antissenso
IL310003A (en) 2021-07-08 2024-03-01 Nippon Shinyaku Co Ltd A substance that lowers nephrotoxicity
JPWO2023282346A1 (pt) 2021-07-08 2023-01-12
EP4368176A1 (en) 2021-07-08 2024-05-15 Nippon Shinyaku Co., Ltd. Nephrotoxicity reducing agent
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11648318B2 (en) 2021-07-09 2023-05-16 Dyne Therapeutics, Inc. Anti-transferrin receptor (TFR) antibody and uses thereof
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2023285700A1 (en) 2021-07-16 2023-01-19 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Oligonucleotide for inhibiting quaking activity
IL311452A (en) 2021-09-16 2024-05-01 Avidity Biosciences Inc Compositions and methods for the treatment of FSHD muscular dystrophy
US11931421B2 (en) 2022-04-15 2024-03-19 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating myotonic dystrophy
WO2023214373A2 (en) 2022-05-06 2023-11-09 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Oligonucleotide
WO2024069235A2 (en) 2022-09-30 2024-04-04 Sixfold Bioscience Ltd. Compositions containing oligonucleotides with theranostic applications

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
AU5698186A (en) 1985-03-15 1986-10-13 Summerton, J. Polynucleotide assay reagent and method
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5521063A (en) 1985-03-15 1996-05-28 Antivirals Inc. Polynucleotide reagent containing chiral subunits and methods of use
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US6559279B1 (en) * 2000-09-08 2003-05-06 Isis Pharmaceuticals, Inc. Process for preparing peptide derivatized oligomeric compounds
MX2010004955A (es) 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
AU2009308236B2 (en) * 2008-10-23 2016-06-30 Lumen Bioscience, Inc. Modified photosynthetic microorganisms for producing triglycerides
EP3428278A1 (en) * 2008-10-24 2019-01-16 Sarepta Therapeutics, Inc. Multiple exon skipping compositions for dmd
US20110269665A1 (en) 2009-06-26 2011-11-03 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
EP2623507B1 (en) 2010-09-30 2016-11-02 Nippon Shinyaku Co., Ltd. Morpholino nucleic acid derivative
AU2012246822B2 (en) * 2011-04-22 2017-05-25 Biomarin Technologies B.V. New compounds for treating, delaying and/or preventing a human genetic disorder such as myotonic dystrophy type 1 (DM1)
JP6478632B2 (ja) * 2011-05-05 2019-03-06 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチドコンジュゲート
ES2832531T3 (es) * 2011-11-30 2021-06-10 Sarepta Therapeutics Inc Oligonucleótidos para el tratamiento de enfermedades por expansión de repeticiones
LT2788487T (lt) * 2011-12-08 2018-09-10 Sarepta Therapeutics, Inc. Oligonukleotido analogai, nukreipti į žmogaus lmna
WO2013142087A1 (en) * 2012-03-20 2013-09-26 Sarepta Therapeutics, Inc. Boronic acid conjugates of oligonucleotide analogues
EP2870246B1 (en) * 2012-07-03 2019-09-11 BioMarin Technologies B.V. Oligonucleotide for the treatment of muscular dystrophy patients
TWI677350B (zh) * 2012-09-25 2019-11-21 美商健臻公司 治療強直性肌失養症之經胜肽連結之嗎啉基反義寡核苷酸
NZ631289A (en) 2013-03-15 2017-08-25 Sarepta Therapeutics Inc Improved compositions for treating muscular dystrophy
BR112017018383B1 (pt) 2015-02-27 2023-04-25 Murdoch University Compostos anti-sentido que induzem a inclusão de éxon2, composições farmacêuticas que compreendem ditos compostos e usos dos mesmos para tratar doença de armazenamento de glicogênio tipo ii
KR20240035901A (ko) * 2015-05-19 2024-03-18 사렙타 쎄러퓨틱스 인코퍼레이티드 펩티드 올리고뉴클레오티드 콘주게이트

Also Published As

Publication number Publication date
ES2964695T3 (es) 2024-04-09
CN107921092A (zh) 2018-04-17
EP3297649A4 (en) 2018-11-21
EP4306538A2 (en) 2024-01-17
DK3297649T3 (da) 2023-12-18
JP6954843B2 (ja) 2021-10-27
IL255655A (en) 2019-08-29
JP2018521970A (ja) 2018-08-09
HRP20231431T1 (hr) 2024-03-01
MX2017014806A (es) 2018-05-11
KR20240035901A (ko) 2024-03-18
EP3297649A1 (en) 2018-03-28
US20220072143A1 (en) 2022-03-10
US10675356B2 (en) 2020-06-09
KR20180008591A (ko) 2018-01-24
HK1252759A1 (zh) 2019-05-31
EP4306538A3 (en) 2024-05-01
US20230310625A1 (en) 2023-10-05
CN107921092B (zh) 2022-04-08
US11672871B2 (en) 2023-06-13
US20200254109A1 (en) 2020-08-13
US20180214567A1 (en) 2018-08-02
AU2016264471B2 (en) 2022-01-27
AU2016264471A1 (en) 2017-12-14
KR102644053B1 (ko) 2024-03-06
IL255655B (en) 2022-06-01
NZ737757A (en) 2023-07-28
CA2986228A1 (en) 2016-11-24
US11097011B2 (en) 2021-08-24
EP3297649B1 (en) 2023-10-11
JP2021011505A (ja) 2021-02-04
CN114681621A (zh) 2022-07-01
WO2016187425A1 (en) 2016-11-24
FI3297649T3 (fi) 2023-11-30
MA42134A (fr) 2018-03-28

Similar Documents

Publication Publication Date Title
BR112017024929A2 (pt) conjugados de oligonucleotídeo-peptídeo
NZ746680A (en) Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same
MX2021015329A (es) Composiciones a base de nanoparticulas.
BR112014021498A2 (pt) composto, composição e método para tratar uma doença associada com formação de dna circular covalentemente fechado
BR112014024159A2 (pt) Formulações de vacina oral específicas do local gastrintestinal , ativas no íleo e apêndice.
BR112014016810A8 (pt) composições e métodos para tratamento de distúrbios metabólicos
MX356210B (es) Formulaciones de polimero acrilico.
MX2023000796A (es) Composicion farmaceutica, metodos para tratamiento y sus usos.
CL2015003343A1 (es) Composición farmacéutica que comprende un agente terapéutico modificado en base a hemoglobina, para el tratamiento para tratar el cáncer, e imágenes de diagnóstico.
PH12017502216A1 (en) Nucleic acid-cationic polymer compositions and methods of making and using the same
MX2021012894A (es) Compuestos ciclicos de fosfato.
BR112017014361A2 (pt) métodos para aperfeiçoamento de terapia celular
CY1114757T1 (el) Παραγωγα οξαζινης και η χρηση τους στη θεραπεια νευρολογικων διαταραχων
BR112018012237A2 (pt) conjugados oligonucleotídeos-peptídeos
WO2015054678A3 (en) Human papilloma virus therapeutic vaccine
PH12016502243A1 (en) Pharmaceutical compositions for treating infectious diseases
BR112019007928A2 (pt) conjugados de bacitracina-oligômero de alginato
MX2018014129A (es) Composiciones farmaceuticas de oligomero de morfolino fosforodiamidato.
EP3357996A4 (en) DEVICE FOR THE PRODUCTION OF BIOLOGICAL TISSUE, SYSTEM FOR THE PRODUCTION OF BIOLOGICAL TISSUE AND MEDICAL COST CALCULATION SYSTEM
WO2015159155A3 (en) Novel ademetionine formulations
UA117563C2 (uk) Композиція для лікування або профілактики хвороби, асоційованої з інфекцією впл
WO2017079403A3 (en) Polymeric nanoparticles
BR112016028402A2 (pt) toxina botulínica para uso no tratamento da paratonia
EA201792539A1 (ru) Пептид-олигонуклеотидные конъюгаты
TH158862A (th) สารประกอบสำหรับการบำบัดการฝ่อของกล้ามเนื้อกระดูกสันหลัง

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]