BR112019006227A2 - métodos de tratamento de leiomioma uterino e endometriose - Google Patents

métodos de tratamento de leiomioma uterino e endometriose

Info

Publication number
BR112019006227A2
BR112019006227A2 BR112019006227-0A BR112019006227A BR112019006227A2 BR 112019006227 A2 BR112019006227 A2 BR 112019006227A2 BR 112019006227 A BR112019006227 A BR 112019006227A BR 112019006227 A2 BR112019006227 A2 BR 112019006227A2
Authority
BR
Brazil
Prior art keywords
subject
methods
endometriosis
uterine leiomyoma
adenomyosis
Prior art date
Application number
BR112019006227-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Mark Johnson Brendan
Seely Lynn
N. Mudd Paul Jr.
Wollowitz Susan
Hibberd Mark
Tanimoto Masataka
Reddy Rajasekhar Vijaykumar
Vasant Sukhatme Mayukh
Original Assignee
Myovant Sciences Gmbh
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60915460&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112019006227(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Myovant Sciences Gmbh, Takeda Pharmaceutical Company Limited filed Critical Myovant Sciences Gmbh
Publication of BR112019006227A2 publication Critical patent/BR112019006227A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
BR112019006227-0A 2016-09-30 2017-09-29 métodos de tratamento de leiomioma uterino e endometriose BR112019006227A2 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662402034P 2016-09-30 2016-09-30
US201662402055P 2016-09-30 2016-09-30
US201662402150P 2016-09-30 2016-09-30
US62/402,034 2016-09-30
US62/402,150 2016-09-30
US62/402,055 2016-09-30
US201762492839P 2017-05-01 2017-05-01
US62/492,839 2017-05-01
US201762528409P 2017-07-03 2017-07-03
US62/528,409 2017-07-03
PCT/EP2017/074907 WO2018060501A2 (en) 2016-09-30 2017-09-29 Methods of treating uterine fibroids and endometriosis

Publications (1)

Publication Number Publication Date
BR112019006227A2 true BR112019006227A2 (pt) 2019-06-18

Family

ID=60915460

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019006227-0A BR112019006227A2 (pt) 2016-09-30 2017-09-29 métodos de tratamento de leiomioma uterino e endometriose

Country Status (24)

Country Link
US (4) US11033551B2 (https=)
EP (2) EP3518933B2 (https=)
JP (1) JP7043503B2 (https=)
CN (1) CN110312512B (https=)
AU (2) AU2017336363B2 (https=)
BR (1) BR112019006227A2 (https=)
CA (1) CA3038879A1 (https=)
CY (1) CY1125254T1 (https=)
DK (1) DK3518933T4 (https=)
ES (2) ES2912929T5 (https=)
FI (1) FI3518933T4 (https=)
HR (1) HRP20220708T4 (https=)
HU (2) HUE072130T2 (https=)
IL (2) IL300580B2 (https=)
LT (1) LT3518933T (https=)
MD (1) MD3518933T4 (https=)
MX (1) MX2019003726A (https=)
NZ (1) NZ752916A (https=)
PL (2) PL4094766T3 (https=)
PT (1) PT3518933T (https=)
RS (1) RS63300B2 (https=)
SI (1) SI3518933T2 (https=)
SM (1) SMT202200254T1 (https=)
WO (1) WO2018060501A2 (https=)

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ES2912929T5 (en) 2016-09-30 2025-05-09 Sumitomo Pharma Switzerland Gmbh Methods of treating uterine fibroids and endometriosis
MA46361A (fr) 2016-09-30 2021-03-31 Myovant Sciences Gmbh Traitement du cancer de la prostate
EA201992612A1 (ru) 2017-06-05 2020-05-20 Обсева С.А. Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза
KR102884301B1 (ko) 2017-06-05 2025-11-11 깃세이 야쿠힌 고교 가부시키가이샤 자궁 근종을 치료하고 월경혈량을 감소시키기 위한 고나도트로핀 방출 호르몬 길항제 투약 요법
CN112261942A (zh) * 2018-04-19 2021-01-22 艾伯维公司 治疗重度月经出血的方法
CA3117092A1 (en) 2018-10-29 2020-05-07 ObsEva S.A. Compositions and methods for the treatment of adenomyosis and rectovaginal endometriosis
RU2711658C1 (ru) * 2019-04-16 2020-01-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ лечения наружного генитального эндометриоза
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
CN114466665A (zh) * 2019-08-08 2022-05-10 奥布赛瓦股份公司 用于治疗雌激素依赖性病症的组合物和方法
WO2021069700A1 (en) * 2019-10-10 2021-04-15 Myovant Sciences Gmbh Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea
JP2022551316A (ja) 2019-10-10 2022-12-08 ミオバント サイエンシズ ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形
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CN113384581B (zh) * 2020-03-12 2023-11-14 成都倍特药业股份有限公司 一种包含促性腺激素释放激素拮抗剂的药物组合物
CA3185151A1 (en) 2020-05-29 2021-12-02 Myovant Sciences Gmbh Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists
WO2022101303A1 (en) 2020-11-11 2022-05-19 Myovant Sciences Gmbh Methods of administering relugolix
JP2024540922A (ja) 2021-10-18 2024-11-06 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素のエタノール溶媒和物の結晶形
CN117069735A (zh) * 2022-05-10 2023-11-17 北京海美源医药科技有限公司 一种高效合成瑞卢戈利的方法和其应用
WO2024015934A2 (en) * 2022-07-13 2024-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods of diagnostic screening and early detection of adenomyosis
TW202428262A (zh) * 2022-11-09 2024-07-16 美商坦帕斯醫療公司 三唑酮化合物及其用途
WO2025106820A1 (en) * 2023-11-16 2025-05-22 University Of South Florida Method of preventing progesterone contraceptive-induced abnormal uterine bleeding (aub)

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ES2912929T5 (en) 2016-09-30 2025-05-09 Sumitomo Pharma Switzerland Gmbh Methods of treating uterine fibroids and endometriosis
MA46361A (fr) 2016-09-30 2021-03-31 Myovant Sciences Gmbh Traitement du cancer de la prostate
EA201992612A1 (ru) 2017-06-05 2020-05-20 Обсева С.А. Схемы применения антагониста гонадотропин-высвобождающего гормона для лечения эндометриоза
JP2022551316A (ja) 2019-10-10 2022-12-08 ミオバント サイエンシズ ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形
WO2021069700A1 (en) 2019-10-10 2021-04-15 Myovant Sciences Gmbh Crystalline solvated forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4- tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea
CA3185151A1 (en) 2020-05-29 2021-12-02 Myovant Sciences Gmbh Combination solid oral dosage forms of gonadotropin-releasing hormone antagonists
WO2022101303A1 (en) 2020-11-11 2022-05-19 Myovant Sciences Gmbh Methods of administering relugolix
JP2024540922A (ja) 2021-10-18 2024-11-06 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素のエタノール溶媒和物の結晶形

Also Published As

Publication number Publication date
JP2019529575A (ja) 2019-10-17
US20190262346A1 (en) 2019-08-29
HRP20220708T1 (hr) 2022-07-22
HUE072130T2 (hu) 2025-10-28
IL265700A (en) 2019-05-30
IL265700B2 (en) 2023-07-01
WO2018060501A2 (en) 2018-04-05
NZ752916A (en) 2022-09-30
EP3518933A2 (en) 2019-08-07
HUE059101T2 (hu) 2022-10-28
IL265700B1 (en) 2023-03-01
DK3518933T4 (da) 2025-04-22
PL3518933T3 (pl) 2022-06-20
IL300580A (en) 2023-04-01
US20210401841A1 (en) 2021-12-30
ES3018413T3 (es) 2025-05-16
PT3518933T (pt) 2022-05-10
SI3518933T2 (sl) 2025-05-30
CN110312512B (zh) 2023-05-09
LT3518933T (lt) 2022-06-10
CN110312512A (zh) 2019-10-08
AU2022241582B2 (en) 2024-06-13
JP7043503B2 (ja) 2022-03-29
IL300580B1 (en) 2025-07-01
AU2022241582C1 (en) 2024-11-28
EP3518933B1 (en) 2022-03-16
ES2912929T3 (es) 2022-05-30
MX2019003726A (es) 2019-09-26
ES2912929T5 (en) 2025-05-09
AU2017336363B2 (en) 2022-08-04
CA3038879A1 (en) 2018-04-05
SMT202200254T1 (it) 2022-07-21
EP4094766A1 (en) 2022-11-30
CY1125254T1 (el) 2024-02-16
RS63300B2 (sr) 2025-05-30
FI3518933T4 (fi) 2025-05-14
US11033551B2 (en) 2021-06-15
US11957684B2 (en) 2024-04-16
US11793812B2 (en) 2023-10-24
EP4094766B1 (en) 2025-04-02
IL300580B2 (en) 2025-11-01
US20220370462A1 (en) 2022-11-24
MD3518933T4 (ro) 2025-10-31
WO2018060501A3 (en) 2018-05-11
DK3518933T3 (da) 2022-05-30
RS63300B1 (sr) 2022-07-29
US20240165118A1 (en) 2024-05-23
AU2017336363A1 (en) 2019-05-16
AU2022241582A1 (en) 2022-10-27
MD3518933T2 (ro) 2022-07-31
PL4094766T3 (pl) 2025-07-28
SI3518933T1 (sl) 2022-06-30
PL3518933T5 (pl) 2025-05-05
HRP20220708T4 (hr) 2025-04-25
EP3518933B2 (en) 2025-02-26

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