BR112019003579A2 - Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos - Google Patents

Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos

Info

Publication number
BR112019003579A2
BR112019003579A2 BR112019003579-6A BR112019003579A BR112019003579A2 BR 112019003579 A2 BR112019003579 A2 BR 112019003579A2 BR 112019003579 A BR112019003579 A BR 112019003579A BR 112019003579 A2 BR112019003579 A2 BR 112019003579A2
Authority
BR
Brazil
Prior art keywords
nicotinamide
compositions
neurodegenerative disorders
methods
riboside
Prior art date
Application number
BR112019003579-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Alexander Marcotulli Eric
Antonio Alminana Daniel
Original Assignee
Elysium Health, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elysium Health, Inc. filed Critical Elysium Health, Inc.
Publication of BR112019003579A2 publication Critical patent/BR112019003579A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
BR112019003579-6A 2016-08-22 2017-08-22 Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos BR112019003579A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378053P 2016-08-22 2016-08-22
US62/378,053 2016-08-22
PCT/US2017/047979 WO2018039207A1 (en) 2016-08-22 2017-08-22 Nicotinamide riboside and pterostilbene compositions and methods for treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
BR112019003579A2 true BR112019003579A2 (pt) 2019-05-21

Family

ID=61246253

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019003579-6A BR112019003579A2 (pt) 2016-08-22 2017-08-22 Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos

Country Status (12)

Country Link
US (2) US11260069B2 (enExample)
EP (1) EP3500267A4 (enExample)
JP (1) JP7132907B2 (enExample)
KR (1) KR20190046895A (enExample)
CN (2) CN109982706A (enExample)
AU (1) AU2017316614B2 (enExample)
BR (1) BR112019003579A2 (enExample)
CA (1) CA3034673A1 (enExample)
MX (1) MX2019002211A (enExample)
RU (1) RU2019108100A (enExample)
WO (1) WO2018039207A1 (enExample)
ZA (1) ZA201901536B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109982706A (zh) 2016-08-22 2019-07-05 益力舒健康公司 用于治疗神经退行性病症的烟酰胺核苷和紫檀芪的组合物和方法
WO2018213715A1 (en) * 2017-05-18 2018-11-22 Elysium Health, Inc. Methods and compositions for improving sleep
US11286274B2 (en) 2017-06-19 2022-03-29 Mitopower Llc Nicotinamide riboside derivatives and their uses
CN111542312A (zh) * 2017-07-28 2020-08-14 老龄化控制中心股份公司 预防和逆转衰老方面的组合物和方法
JP7273954B2 (ja) * 2018-10-19 2023-05-15 ディスアーム セラピューティクス， インコーポレイテッド Ｎａｄ＋またはｎａｄ＋前駆体と組み合わせたｓａｒｍ１の阻害
WO2020102326A1 (en) * 2018-11-13 2020-05-22 Elysium Health, Inc Methods for determining and increasing nad levels
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
WO2020176445A1 (en) * 2019-02-26 2020-09-03 Universitat De Valencia-Estudi General Methods and compositions for treating motor neuron diseases
CN110812365A (zh) * 2019-11-07 2020-02-21 明特奇点医疗科技（北京）有限公司 一种组合物及其制备方法与制剂
CN111838669B (zh) * 2020-08-07 2022-11-29 四川大学华西医院 治疗改善易损脏器的纳米组合物、制剂及制备方法和用途
EP4079311B1 (en) * 2021-04-20 2025-10-01 Nuvamid SA Nmn and derivatives for use in the treatment of depression and/or anxiety in patients having a form of parkinsonism
WO2022269064A1 (en) * 2021-06-24 2022-12-29 Vestlandets Innovasjonsselskap As (Vis) Nad-augmentation therapy for parkinson's disease
PL4284387T3 (pl) * 2021-06-24 2024-11-25 Vestlandets Innovasjonsselskap As (Vis) Terapia podnosząca poziom NAD w chorobie Parkinsona
EP4422644A4 (en) * 2021-10-27 2025-08-27 Elysium Health Inc METHODS OF TREATING MENOPAUSAL SYNDROMES
CN116807985A (zh) * 2023-06-20 2023-09-29 风火轮(上海)生物科技有限公司 一种烟酰胺核糖组合物及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3006040B1 (en) * 2004-06-04 2017-11-22 Washington University Methods and compositions for treating neuropathies
US20060229265A1 (en) 2005-03-30 2006-10-12 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
US20090069444A1 (en) * 2007-09-07 2009-03-12 The United States Of America, As Represented By Th E Secretary Of Agriculture Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration
WO2009082459A2 (en) * 2007-12-24 2009-07-02 Natrol, Inc. Anti-aging composition containing resveratrol and method of administration
WO2010095926A1 (en) * 2009-02-20 2010-08-26 N.V. Nutricia Use of reveratrol for preserving cognitive functioning
EP2445488B1 (en) 2009-06-22 2020-03-18 Indus Biotech Private Limited Process for obtaining purified pterostilbene and methods of use thereof
MY159856A (en) 2009-07-24 2017-02-15 Amazentis Sa Compounds, compositions and methods for protecting brain health in neurodegenerative disorders
US9439875B2 (en) * 2011-05-11 2016-09-13 The United States Of America, As Represented By The Secretary Of Agriculture Anxiolytic effect of pterostilbene
EP2574339A1 (de) * 2011-09-27 2013-04-03 Johannes Huber Pharmazeutisches Präparat zur Behandlung von NADH-bedingten Erkrankungen
US20130149277A1 (en) 2011-12-13 2013-06-13 Cliffstar Llc Pterostilbene and pvp grape juice extract combination for treatment of metabolic, vascular, and neurodegenerative disorders
US20130296440A1 (en) * 2012-05-01 2013-11-07 ChromaDex Inc. Pterostilbene and curcumin combination for treatment of oxidative stress and inflammation
CA2928656C (en) * 2013-10-30 2020-07-28 ChromaDex Inc. Nicotinamide riboside compositions for topical use in treating skin conditions
MX2016015997A (es) 2014-06-02 2017-04-05 Glaxosmithkline Intellectual Property (No 2) Ltd Preparacion y uso de beta-d-nicotinamida ribosido cristalina.
WO2016122832A1 (en) * 2015-01-30 2016-08-04 Natural Formulations Compositions, therapeutic and prophylactic methods for treatment of neurodegenerative diseases and brain injuries
US20180071273A1 (en) * 2015-03-17 2018-03-15 Speccialty Nutrition Group, Inc. Nutritional compositions to enhance mitochondrial energy production
CN109982706A (zh) 2016-08-22 2019-07-05 益力舒健康公司 用于治疗神经退行性病症的烟酰胺核苷和紫檀芪的组合物和方法

Also Published As

Publication number Publication date
WO2018039207A1 (en) 2018-03-01
AU2017316614A1 (en) 2019-03-21
EP3500267A4 (en) 2020-03-18
CA3034673A1 (en) 2018-03-01
KR20190046895A (ko) 2019-05-07
MX2019002211A (es) 2019-10-30
US20190201426A1 (en) 2019-07-04
US11260069B2 (en) 2022-03-01
CN109982706A (zh) 2019-07-05
CN115645432A (zh) 2023-01-31
AU2017316614B2 (en) 2023-06-15
JP7132907B2 (ja) 2022-09-07
US11998561B2 (en) 2024-06-04
RU2019108100A3 (enExample) 2020-11-27
JP2019524856A (ja) 2019-09-05
US20220143055A1 (en) 2022-05-12
RU2019108100A (ru) 2020-09-22
ZA201901536B (en) 2024-06-26
EP3500267A1 (en) 2019-06-26

Similar Documents

Publication Publication Date Title
BR112019003579A2 (pt) Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos
PH12019500521A1 (en) Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
EP4272834A3 (en) Therapeutic use of mitochondria and combined mitochondrial agents
CO2019013707A2 (es) Polinucleótidos de aadc para el tratamiento de la enfermedad de parkinson
PH12019501443A1 (en) Benzooxazole derivatives as immunomodulators
ZA201800056B (en) Nicotinamide riboside and pterostilbene compositions and methods for treatment of skin disorders
BR112017009497A2 (pt) polinucleotídeos de aadc para o tratamento da doença de parkinson
BR112017007063A2 (pt) ?composições e métodos para o tratamento de insônia?
EP4289820A3 (en) Compounds for use in treating alzheimer's disease in apoe4+/+ patients
MX2019004859A (es) Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.
CY1125113T1 (el) Συνθεσεις και μεθοδοι για χρηση στην αγωγη της ομοκυστινουριας
MX379359B (es) Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano.
PH12016501371A1 (en) Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
PT3302454T (pt) Composições para utilização no tratamento da doença de parkinson e distúrbios associados
BR112017002260A2 (pt) derivados de piperazina como moduladores do receptor x do fígado
MX380290B (es) Composiciones y métodos para el tratamiento y la prevención de trastornos neurodegenerativos.
MX2022013283A (es) Composiciones para limpieza de colon y tratamiento de trastornos gastrointestinales.
WO2018013951A9 (en) Targeting adenosine a2a receptors for the treatment of levodopa-induced dyskinesias
EP3554496A4 (en) METHODS AND COMPOSITIONS FOR TREATING PARKINSON'S DISEASE
IL265911A (en) Epilimod preparations and methods of using them in the treatment of Alzheimer's disease
EP3634979A4 (en) COMPOSITIONS AND METHODS OF TREATING ALZHEIMER'S MORBUS
EP3518914A4 (en) COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE AND PARKINSON'S DISEASE
BR112017009599A2 (pt) composições contendo apoaequorina e métodos de uso das mesmas para tratar inflamação neuronal
ZA201806103B (en) Compositions and methods for the treatment of sinus disease and disorders
HK40013419A (en) Apilimod compositions and methods for using same in the treatment of alzheimer's disease

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]