BR112019003197A2 - compostos contendo espirocíclicos e seus usos farmacêuticos - Google Patents

compostos contendo espirocíclicos e seus usos farmacêuticos

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Publication number
BR112019003197A2
BR112019003197A2 BR112019003197A BR112019003197A BR112019003197A2 BR 112019003197 A2 BR112019003197 A2 BR 112019003197A2 BR 112019003197 A BR112019003197 A BR 112019003197A BR 112019003197 A BR112019003197 A BR 112019003197A BR 112019003197 A2 BR112019003197 A2 BR 112019003197A2
Authority
BR
Brazil
Prior art keywords
spirocyclic
containing compounds
tec
present
pharmaceutical uses
Prior art date
Application number
BR112019003197A
Other languages
English (en)
Inventor
Laurent Alain
J Morris Stephen
Original Assignee
Gb005 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA2965813A external-priority patent/CA2965813A1/en
Application filed by Gb005 Inc filed Critical Gb005 Inc
Publication of BR112019003197A2 publication Critical patent/BR112019003197A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

a presente invenção diz respeito a uma nova família de inibidores de quinases covalentes. compostos dessa classe têm demonstrado possuir atividade inibidora contra membros da família tec quinase, particularmente itk e/ou txk, btk, tec e/ou combinações das mesmas. a presente invenção é direcionada a um composto da fórmula i ou sal farmaceuticamente aceitável, solvato, solvatos de sal, estereoisômero, tautômero, isótopo, pró-fármaco, complexo ou metabólito biologicamente ativo do mesmo, para uso em terapia.
BR112019003197A 2016-08-17 2017-08-16 compostos contendo espirocíclicos e seus usos farmacêuticos BR112019003197A2 (pt)

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CA2939286A CA2939286A1 (en) 2016-08-17 2016-08-17 Spirocyclic containing compounds and pharmaceutical uses thereof
CA2959055A CA2959055A1 (en) 2016-08-17 2017-02-27 Spirocyclic containing compounds and pharmaceutical uses thereof
CA2965813A CA2965813A1 (en) 2016-08-17 2017-05-02 Spirocyclic containing compounds and pharmaceutical uses thereof
PCT/CA2017/050970 WO2018032104A1 (en) 2016-08-17 2017-08-16 Spirocyclic containing compounds and pharmaceutical uses thereof

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CA2976819A1 (en) * 2017-08-21 2019-02-21 Pharmascience Inc. Benzimidazole compounds as kinase inhibitors
CN117281803A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
EP3842431B1 (en) * 2018-08-23 2023-12-27 Zhuhai United Laboratories Co., Ltd. [1,2,4]triazolo[1,5-a]pyridine compound as jak inhibitor and application thereof
CN112661773B (zh) * 2018-08-29 2022-03-11 杭州阿诺生物医药科技有限公司 Sting蛋白激动剂偶联化合物
TWI767148B (zh) * 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
WO2021080980A1 (en) * 2019-10-22 2021-04-29 Alphala Co., Ltd. Pyrimidine amide compounds and use thereof
EP4105214A4 (en) * 2020-02-13 2023-11-08 Zhuhai United Laboratories Co., Ltd. USE OF JAK INHIBITORS IN THE MANUFACTURING OF DRUGS FOR TREATING JAK KINASE RELATED DISEASES

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WO2013024427A1 (en) * 2011-08-16 2013-02-21 Glenmark Pharmaceuticals S.A. Novel urea derivatives as tec kinase inhibitors and uses thereof
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JP6486954B2 (ja) * 2014-01-29 2019-03-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂｔｋ阻害剤としてのピラゾール化合物
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CA2906137A1 (en) * 2015-09-25 2017-03-25 Pharmascience Inc. Novel protein kinase inhibitors

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JP2019527727A (ja) 2019-10-03
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CA2959055A1 (en) 2018-02-17
EP3500566A4 (en) 2020-01-01
CA3033156A1 (en) 2018-02-22
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