BR112019000504A2 - métodos e composições poliméricas para o tratamento de descolamento de retina e outros distúrbios oculares - Google Patents

métodos e composições poliméricas para o tratamento de descolamento de retina e outros distúrbios oculares

Info

Publication number
BR112019000504A2
BR112019000504A2 BR112019000504-8A BR112019000504A BR112019000504A2 BR 112019000504 A2 BR112019000504 A2 BR 112019000504A2 BR 112019000504 A BR112019000504 A BR 112019000504A BR 112019000504 A2 BR112019000504 A2 BR 112019000504A2
Authority
BR
Brazil
Prior art keywords
polymer
retinal detachment
compositions
eye disorders
treatment
Prior art date
Application number
BR112019000504-8A
Other languages
English (en)
Other versions
BR112019000504B1 (pt
Inventor
James Anthony Stefater, Iii
Pawel Stryjewski Tomasz
Original Assignee
Massachusetts Eye And Ear Infirmary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye And Ear Infirmary filed Critical Massachusetts Eye And Ear Infirmary
Priority to BR122021015728-6A priority Critical patent/BR122021015728B1/pt
Publication of BR112019000504A2 publication Critical patent/BR112019000504A2/pt
Publication of BR112019000504B1 publication Critical patent/BR112019000504B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Abstract

a presente invenção refere-se a métodos e composições poliméricas para o tratamento do descolamento de retina e outros distúrbios oculares, onde os métodos empregam composições poliméricas que podem formar um hidrogel no olho de um indivíduo. o hidrogel é formado pela reação de (i) de um polímero núcleo-funcional, que é um polímero bio-compatível que contém uma pluralidade de grupos tio funcionais -r1-sh, em que r1 é um ligante que contém éster, tal como um polímero de álcool poli(vinílico) tiolado e (ii) um polímero eletro-funcional, que é um polímero bio-compatível que contém pelo menos um grupo de tiol reativo, tal como um polímero de poli(etileno glicol) que contém grupos de éster alfa-beta insaturado.
BR112019000504-8A 2016-07-13 2017-07-13 Método de suporte de tecido da retina, formulação ocular injetável e uso de um polímero núcleo-funcional e de um polímero eletro-funcional para o tratamento de descolamento de retina e outros distúrbios oculares BR112019000504B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122021015728-6A BR122021015728B1 (pt) 2016-07-13 2017-07-13 Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662361746P 2016-07-13 2016-07-13
US62/361,746 2016-07-13
PCT/US2017/041947 WO2018013819A1 (en) 2016-07-13 2017-07-13 Methods and polymer compositions for treating retinal detachment and other ocular disorders

Publications (2)

Publication Number Publication Date
BR112019000504A2 true BR112019000504A2 (pt) 2019-04-24
BR112019000504B1 BR112019000504B1 (pt) 2022-03-03

Family

ID=60952730

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122021015728-6A BR122021015728B1 (pt) 2016-07-13 2017-07-13 Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo
BR112019000504-8A BR112019000504B1 (pt) 2016-07-13 2017-07-13 Método de suporte de tecido da retina, formulação ocular injetável e uso de um polímero núcleo-funcional e de um polímero eletro-funcional para o tratamento de descolamento de retina e outros distúrbios oculares

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122021015728-6A BR122021015728B1 (pt) 2016-07-13 2017-07-13 Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo

Country Status (8)

Country Link
US (8) US20190224375A1 (pt)
EP (1) EP3484534A4 (pt)
JP (2) JP7038697B2 (pt)
CN (1) CN109641077A (pt)
AU (1) AU2017295715B2 (pt)
BR (2) BR122021015728B1 (pt)
CA (1) CA3030767C (pt)
WO (1) WO2018013819A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122021015728B1 (pt) 2016-07-13 2022-02-22 Massachusetts Eye And Ear Infirmary Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo
WO2019140212A1 (en) * 2018-01-12 2019-07-18 Pykus Therapeutics, Inc. Methods and polymer-containing formulations for treating retinal detachment and other ocular disorders
CN109692072B (zh) * 2019-01-09 2021-07-09 中南大学湘雅二医院 一种用于孔源性视网膜脱离的脉络膜上腔加压水凝胶球囊装置
WO2022150497A1 (en) * 2021-01-07 2022-07-14 Pykus Therapeutics, Inc. Extended-release hydrogel-drug formulations
US11883378B2 (en) * 2021-11-24 2024-01-30 Pykus Therapeutics, Inc. Hydrogel formulations and methods and devices for focal administration of the same
WO2024054997A1 (en) * 2022-09-09 2024-03-14 University Of Virginia Patent Foundation Inflammasome inhibition for neuroprotection

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654349A (en) 1994-07-22 1997-08-05 Staar Surgical Company, Inc. Biocompatible optically transparent polymeric material based upon collagen and method of making
US7115417B1 (en) * 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US7589107B2 (en) * 2003-05-19 2009-09-15 Othera Holding, Inc. Amelioration of vitrectomy-induced cataracts
US20060141049A1 (en) 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
EP1719521A1 (en) * 2004-01-30 2006-11-08 Mitsubishi Pharma Corporation Preventive and/or remedy for retinopathy
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US7659260B2 (en) 2005-01-14 2010-02-09 Eddie Francis Kadrmas Tamponade compositions and methods for retinal repair
EP2038309A2 (en) 2006-07-11 2009-03-25 University of Utah Research Foundation Macromolecules modified with electrophilic groups and methods of making and using thereof
US8282959B2 (en) 2006-11-27 2012-10-09 Actamax Surgical Materials, Llc Branched end reactants and polymeric hydrogel tissue adhesives therefrom
CN101338036B (zh) 2007-07-06 2010-11-03 常州百瑞吉生物医药有限公司 生物相容快速凝胶化水凝胶及其喷雾剂的制备方法
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US7833206B1 (en) * 2010-02-02 2010-11-16 Peregrine Surgical, Ltd. Method and apparatus for disposable aspirator cassette
WO2011135400A1 (en) * 2010-04-30 2011-11-03 Indian Institute Of Technology Bombay Nanoparticulate in-situ gels as vitreous humor substitutes for ocular diseases
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
CN101934089B (zh) * 2010-09-01 2013-05-01 北京大学人民医院 一种可眼内注射的原位交联水凝胶在制备人工玻璃体中的应用
US9205150B2 (en) * 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
JP6206987B2 (ja) 2012-05-11 2017-10-04 メディカス バイオサイエンシーズ，エルエルシー 網膜剥離の処置のための生体適合性ヒドロゲル製剤
CN102911493A (zh) * 2012-09-28 2013-02-06 山东赛克赛斯药业科技有限公司 可生物降解的医用水凝胶及其制备方法与应用
DE102013203289A1 (de) 2013-02-27 2014-08-28 Franz Baur Verbindungsmittel
US9873769B2 (en) 2014-07-10 2018-01-23 Cambridge Polymer Group, Inc. Thiolated PEG-PVA hydrogels
WO2016049791A1 (zh) * 2014-09-29 2016-04-07 清华大学 一种用于玻璃体替代材料的原位凝胶及其制备方法与应用
US20180161291A1 (en) * 2015-06-05 2018-06-14 Kato Pharmaceuticals, Inc. Extended release urea compositions
BR122021015728B1 (pt) 2016-07-13 2022-02-22 Massachusetts Eye And Ear Infirmary Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo
WO2019140212A1 (en) 2018-01-12 2019-07-18 Pykus Therapeutics, Inc. Methods and polymer-containing formulations for treating retinal detachment and other ocular disorders
WO2022150497A1 (en) 2021-01-07 2022-07-14 Pykus Therapeutics, Inc. Extended-release hydrogel-drug formulations

Also Published As

Publication number Publication date
US10973955B2 (en) 2021-04-13
US20210187168A1 (en) 2021-06-24
CN109641077A (zh) 2019-04-16
BR122021015728B1 (pt) 2022-02-22
JP7038697B2 (ja) 2022-03-18
JP2019522006A (ja) 2019-08-08
AU2017295715B2 (en) 2022-03-17
EP3484534A1 (en) 2019-05-22
US10973954B2 (en) 2021-04-13
US20210077664A1 (en) 2021-03-18
WO2018013819A1 (en) 2018-01-18
US20210077663A1 (en) 2021-03-18
CA3030767A1 (en) 2018-01-18
EP3484534A4 (en) 2020-03-18
US20190224375A1 (en) 2019-07-25
US20220133956A1 (en) 2022-05-05
US20210077662A1 (en) 2021-03-18
US11547779B2 (en) 2023-01-10
AU2017295715A1 (en) 2019-01-24
JP2022040410A (ja) 2022-03-10
US10874767B2 (en) 2020-12-29
BR112019000504B1 (pt) 2022-03-03
US11077232B2 (en) 2021-08-03
US20230414838A1 (en) 2023-12-28
US20190175791A1 (en) 2019-06-13
CA3030767C (en) 2023-08-22

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Legal Events

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/07/2017, OBSERVADAS AS CONDICOES LEGAIS.