BR112019000323A2 - arcabouços de biomatriz para uso no diagnóstico e modelagem de câncer - Google Patents
arcabouços de biomatriz para uso no diagnóstico e modelagem de câncerInfo
- Publication number
- BR112019000323A2 BR112019000323A2 BR112019000323-1A BR112019000323A BR112019000323A2 BR 112019000323 A2 BR112019000323 A2 BR 112019000323A2 BR 112019000323 A BR112019000323 A BR 112019000323A BR 112019000323 A2 BR112019000323 A2 BR 112019000323A2
- Authority
- BR
- Brazil
- Prior art keywords
- frameworks
- biomatrix
- organ
- modeling
- cancer diagnosis
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 208000015634 Rectal Neoplasms Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 206010038038 rectal cancer Diseases 0.000 abstract 1
- 201000001275 rectum cancer Diseases 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
Abstract
são descritos nesse relatório descritivo modelos de metástase de câncer in vitro que recapitulam facetas biológicas de especificidade de órgão, como indicado pelo comportamento de células de câncer cólon-retal humano quando em substratos de arcabouços de biomatriz de fígado e pulmão, extratos de matriz órgão-específica gerados por novel estratégias de descelularização. células tumorais formaram espontaneamente colônias que simulavam lesões metastáticas in vivo em termos de histologia, biologia e genética e outros traços fenotípicos. sem se prender a uma teoria em particular, é postulado que respostas de tumores à radiação ou agentes quimioterápicos provaram serem dependentes do substrato de matriz usado; dessa forma, acredita-se que os arcabouços forneçam uma ferramenta poderosa para pesquisa e diagnóstico de câncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662361306P | 2016-07-12 | 2016-07-12 | |
US62/361,306 | 2016-07-12 | ||
US201762460056P | 2017-02-16 | 2017-02-16 | |
US62/460,056 | 2017-02-16 | ||
PCT/US2017/041500 WO2018013542A1 (en) | 2016-07-12 | 2017-07-11 | Biomatrix scaffolds for use in diagnosing and modeling cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019000323A2 true BR112019000323A2 (pt) | 2019-04-16 |
Family
ID=60953359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000323-1A BR112019000323A2 (pt) | 2016-07-12 | 2017-07-11 | arcabouços de biomatriz para uso no diagnóstico e modelagem de câncer |
Country Status (13)
Country | Link |
---|---|
US (1) | US20190234937A1 (pt) |
EP (1) | EP3484487A4 (pt) |
JP (1) | JP2019528682A (pt) |
KR (1) | KR20190028726A (pt) |
CN (1) | CN109843328A (pt) |
AU (1) | AU2017296208A1 (pt) |
BR (1) | BR112019000323A2 (pt) |
CA (1) | CA3030166A1 (pt) |
IL (1) | IL264117A (pt) |
MX (1) | MX2019000353A (pt) |
RU (1) | RU2019103382A (pt) |
SG (1) | SG11201900057WA (pt) |
WO (1) | WO2018013542A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020092220A1 (en) * | 2018-10-29 | 2020-05-07 | The Jackson Laboratory | Three dimensional human brain tumor models |
EP3973005A4 (en) * | 2019-05-23 | 2023-06-14 | Micro Vention, Inc. | PARTICLES |
EP4146789A4 (en) * | 2020-05-05 | 2024-05-29 | Xylyx Bio Inc | DEVICES AND METHODS FOR IN VITRO MODELING OF METASTATIC CANCER |
US20230407267A1 (en) * | 2020-11-03 | 2023-12-21 | Iscaff Pharma Ab | Uses of patient-derived scaffolds |
CN113029728B (zh) * | 2021-05-24 | 2021-09-10 | 北京恩泽康泰生物科技有限公司 | 一种使用冰冻切片机提高组织外泌体产量的方法 |
KR20240049553A (ko) * | 2021-07-15 | 2024-04-16 | 사이프레, 인코포레이티드 | 암 치료의 개선을 위한 조성물 및 방법(compositions and methods for improving treatment of cancer) |
WO2023151683A1 (en) * | 2022-02-11 | 2023-08-17 | Shanghaitech University | Individualized patient-derived tumor organoids |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080255066A1 (en) * | 1997-09-23 | 2008-10-16 | Sarissa Inc. | Antisense oligonucleotide strategies for the enhancement of cancer therapies |
WO2007138098A2 (en) * | 2006-05-31 | 2007-12-06 | Projech Science To Technology, S.L. | Animal models of tumour metastasis and toxicity |
JP2013539960A (ja) * | 2010-07-02 | 2013-10-31 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 工業規模の散布のためのバイオマトリックス足場 |
US20130196349A1 (en) * | 2011-08-02 | 2013-08-01 | Realbio Technology, Inc. | In Vitro Tumor Metastasis Model |
US20130344490A1 (en) * | 2012-04-27 | 2013-12-26 | Min Peter Kim | Neoplastic cells grown on decellularized biomatrix |
AU2014229505B2 (en) * | 2013-03-15 | 2020-02-27 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
-
2017
- 2017-07-11 SG SG11201900057WA patent/SG11201900057WA/en unknown
- 2017-07-11 WO PCT/US2017/041500 patent/WO2018013542A1/en unknown
- 2017-07-11 CN CN201780053256.0A patent/CN109843328A/zh active Pending
- 2017-07-11 EP EP17828288.5A patent/EP3484487A4/en active Pending
- 2017-07-11 KR KR1020197003665A patent/KR20190028726A/ko unknown
- 2017-07-11 CA CA3030166A patent/CA3030166A1/en active Pending
- 2017-07-11 BR BR112019000323-1A patent/BR112019000323A2/pt not_active IP Right Cessation
- 2017-07-11 AU AU2017296208A patent/AU2017296208A1/en not_active Abandoned
- 2017-07-11 RU RU2019103382A patent/RU2019103382A/ru not_active Application Discontinuation
- 2017-07-11 US US16/317,323 patent/US20190234937A1/en active Pending
- 2017-07-11 JP JP2019500616A patent/JP2019528682A/ja active Pending
- 2017-07-11 MX MX2019000353A patent/MX2019000353A/es unknown
-
2019
- 2019-01-07 IL IL264117A patent/IL264117A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3484487A4 (en) | 2020-06-17 |
CN109843328A (zh) | 2019-06-04 |
SG11201900057WA (en) | 2019-02-27 |
JP2019528682A (ja) | 2019-10-17 |
CA3030166A1 (en) | 2018-01-18 |
WO2018013542A1 (en) | 2018-01-18 |
MX2019000353A (es) | 2019-06-13 |
KR20190028726A (ko) | 2019-03-19 |
US20190234937A1 (en) | 2019-08-01 |
EP3484487A1 (en) | 2019-05-22 |
AU2017296208A1 (en) | 2019-02-21 |
RU2019103382A (ru) | 2020-08-11 |
IL264117A (en) | 2019-02-28 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2594 DE 24-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |