BR112018075176A2 - formas sólidas de venetoclax e processos para a preparação de venetoclax - Google Patents

formas sólidas de venetoclax e processos para a preparação de venetoclax

Info

Publication number
BR112018075176A2
BR112018075176A2 BR112018075176A BR112018075176A BR112018075176A2 BR 112018075176 A2 BR112018075176 A2 BR 112018075176A2 BR 112018075176 A BR112018075176 A BR 112018075176A BR 112018075176 A BR112018075176 A BR 112018075176A BR 112018075176 A2 BR112018075176 A2 BR 112018075176A2
Authority
BR
Brazil
Prior art keywords
venetoclax
processes
preparing
solid forms
aspects
Prior art date
Application number
BR112018075176A
Other languages
English (en)
Inventor
Azeezulla Baig Mohammed
Kumar Kottur Mohan
Rao Pallavi
Thipparaboina Rajesh
Chakka Ramesh
Jurupula Ramprasad
Oruganti Srinivas
Reddy Peddireddy Subba
Hareshwar Dahanukar Vilas
Peddy Vishweshwar
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of BR112018075176A2 publication Critical patent/BR112018075176A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

aspectos do presente pedido estão relacionados às formas sólidas de venetoclax e aos seus processos preparativos. aspectos específicos estão relacionados a uma forma amorfa de venetoclax, sua dispersão sólida e formas cristalinas de venetoclax ou sais deste. aspectos adicionais do presente pedido estão relacionados aos processos para a preparação de venetoclax.
BR112018075176A 2016-06-09 2017-06-08 formas sólidas de venetoclax e processos para a preparação de venetoclax BR112018075176A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN201641019846 2016-06-09
IN201641022742 2016-07-01
IN201641037731 2016-11-04
IN201741002081 2017-01-19
PCT/IB2017/053384 WO2017212431A1 (en) 2016-06-09 2017-06-08 Solid forms of venetoclax and processes for the preparation of venetoclax

Publications (1)

Publication Number Publication Date
BR112018075176A2 true BR112018075176A2 (pt) 2019-06-04

Family

ID=60578428

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018075176A BR112018075176A2 (pt) 2016-06-09 2017-06-08 formas sólidas de venetoclax e processos para a preparação de venetoclax

Country Status (7)

Country Link
US (1) US20190185471A1 (pt)
EP (1) EP3468973A4 (pt)
JP (1) JP2019521110A (pt)
CN (1) CN109563096A (pt)
BR (1) BR112018075176A2 (pt)
RU (1) RU2018146513A (pt)
WO (1) WO2017212431A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11001582B2 (en) 2016-03-10 2021-05-11 Assia Chemical Industries Ltd. Solid state forms of Venetoclax and processes for preparation of Venetoclax
WO2018069941A2 (en) * 2016-10-14 2018-04-19 Mylan Laboratories Limited Polymorphic forms of venetoclax
WO2018167652A1 (en) * 2017-03-13 2018-09-20 Laurus Labs Limited Process for preparation of amorphous form of venetoclax
WO2019135253A1 (en) 2018-01-02 2019-07-11 Mylan Laboratories Limited Polymorphic forms of venetoclax
WO2019150253A1 (en) 2018-01-30 2019-08-08 Alembic Pharmaceuticals Limited Solid state forms of venetoclax and its process for the preparation there of
IT201800003284A1 (it) * 2018-03-05 2019-09-05 Olon Spa Forme cristalline di venetoclax
WO2020023435A1 (en) 2018-07-24 2020-01-30 Albany Molecular Research, Inc. Venetoclax basic salts and processes for the purification of venetoclax
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療
WO2020225738A1 (en) * 2019-05-07 2020-11-12 Alembic Pharmaceuticals Limited Pharmaceutical composition comprising venetoclax
US20220251080A1 (en) * 2019-06-28 2022-08-11 Dr. Reddy's Laboratories Limited Substantially pure venetoclax and amorphous venetoclax in a free drug particulat e form
WO2021009770A1 (en) * 2019-07-12 2021-01-21 Natco Pharma Limited A process for the preparation of venetoclax and its polymorphs thereof
GB201911627D0 (en) * 2019-08-14 2019-09-25 Johnson Matthey Plc Polymorph of venetoclax and method for preparing the polymorph
CN110878098B (zh) * 2019-12-09 2022-04-12 南通常佑药业科技有限公司 一种bcl-2抑制剂-维特克拉的制备方法
WO2021207581A1 (en) * 2020-04-10 2021-10-14 Abbvie Inc. Crystalline forms of an apoptosis-inducing agent
KR102314558B1 (ko) 2020-05-14 2021-10-18 데루타-후라이 화마 가부시키가이샤 베네토클락스의 수용성 고분자 유도체
CN111848607B (zh) * 2020-07-22 2023-03-17 长沙创新药物工业技术研究院有限公司 一种新型bcl-2/bcl-xl抑制剂、药物组合物及用途
CN114057728A (zh) 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
WO2022043538A1 (en) 2020-08-29 2022-03-03 argenx BV Method of treatment of patients having reduced sensitivity to a bcl-2 inhibitor
CN113499344A (zh) * 2021-08-10 2021-10-15 深圳市泰力生物医药有限公司 一种维奈妥拉的盐组合物及其制备方法和用途
US20230181544A1 (en) * 2021-12-10 2023-06-15 Abbvie Inc. Dosing regimens for use in treating relapsed and refractory multiple myeloma with venetoclax
CN114042050A (zh) * 2021-12-23 2022-02-15 南京格亚医药科技有限公司 一种维奈妥拉片的制备方法
EP4421075A1 (en) 2023-02-27 2024-08-28 KRKA, d.d., Novo mesto Process for the preparation of venetoclax and intermediates used therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA113500C2 (xx) * 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
PT2643322T (pt) * 2010-11-23 2017-11-13 Abbvie Inc Sais e formas cristalinas de um agente indutor de apoptose
AR095265A1 (es) * 2013-03-13 2015-09-30 Abbvie Inc Procesos para la preparación de un agente inductor de la apoptosis

Also Published As

Publication number Publication date
EP3468973A4 (en) 2020-02-26
CN109563096A (zh) 2019-04-02
WO2017212431A1 (en) 2017-12-14
RU2018146513A (ru) 2020-07-09
US20190185471A1 (en) 2019-06-20
JP2019521110A (ja) 2019-07-25
EP3468973A1 (en) 2019-04-17

Similar Documents

Publication Publication Date Title
BR112018075176A2 (pt) formas sólidas de venetoclax e processos para a preparação de venetoclax
EP3548352A4 (en) APPARATUS FOR USING MASS ESTIMATES FOR VEHICLES
ME03463B (me) Kompozicije koje sadrže bakterijske sojeve
EP3552083A4 (en) MAGNETIC SPRING CONTROL
EP3452423A4 (en) SYNTHETIC POUZZOLANES
EP3119311A4 (en) Constant force spring with active bias
BR112018017091A2 (pt) profármacos de pth
BR112016019871A2 (pt) anticorpos anti-cd38 para o tratamento de leucemia linfoblástica aguda
BR112017012141A2 (pt) composições inibidoras de nitrificação e métodos para preparação das mesmas
EP3646219A4 (en) DETECTION OF SYNTHETIC ONLINE ENTITIES BY PRIMARY ENTITIES
BR112016028045A2 (pt) Biopolímeros modificados, e seus métodos de produção
BR112019008958A2 (pt) métodos e equipamentos para configurar parâmetros relacionados a csi da sub-banda
DK3134410T3 (da) Hæmning af ionkanalen af overgangsreceptorpotentialet A1
EA201691367A1 (ru) Кристаллические формы дималеата афатиниба
BR112017001391A2 (pt) componentes para o fusionamento de corpos vertebrais
BR112017003051A2 (pt) composto, método para produção de material magnético
BR112017013498A2 (pt) composições de inibidor de nitrificação e métodos para a preparação das mesmas
BR112017009471A2 (pt) síntese de copanlisib e seu sal de di-hidrocloreto.
DK3653599T3 (da) Krystallinsk tapentadolphosphat
BR112017002662A2 (pt) processo para preparar furfural e/ou derivados de furfural.
EP3551596A4 (en) GRAPHENE FOR FERTILIZER APPLICATIONS
CO2019005528A2 (es) Material compuesto transparente
BR112017008854A2 (pt) partículas de cadotrila
EP3592392A4 (en) FASL-MODIFIED BIOMATERIALS WITH IMMUNOMODULATOR FUNCTION
CO2017010143A2 (es) Procesos para preparar fluorocetólidos

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]