BR112018074572B1 - Métodos de identificação de nucleotídeos e para calibrar um instrumento de sequenciamento, meio de armazenamento legível em computador não transitório, dispositivo e instrumento de sequenciamento - Google Patents
Métodos de identificação de nucleotídeos e para calibrar um instrumento de sequenciamento, meio de armazenamento legível em computador não transitório, dispositivo e instrumento de sequenciamento Download PDFInfo
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- BR112018074572B1 BR112018074572B1 BR112018074572-3A BR112018074572A BR112018074572B1 BR 112018074572 B1 BR112018074572 B1 BR 112018074572B1 BR 112018074572 A BR112018074572 A BR 112018074572A BR 112018074572 B1 BR112018074572 B1 BR 112018074572B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Data Mining & Analysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Burglar Alarm Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343997P | 2016-06-01 | 2016-06-01 | |
| US62/343,997 | 2016-06-01 | ||
| PCT/US2017/035420 WO2017210413A1 (en) | 2016-06-01 | 2017-06-01 | Pulse caller and base caller |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018074572A2 BR112018074572A2 (pt) | 2019-03-12 |
| BR112018074572B1 true BR112018074572B1 (pt) | 2024-02-27 |
Family
ID=59055317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018074572-3A BR112018074572B1 (pt) | 2016-06-01 | 2017-06-01 | Métodos de identificação de nucleotídeos e para calibrar um instrumento de sequenciamento, meio de armazenamento legível em computador não transitório, dispositivo e instrumento de sequenciamento |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10711299B2 (https=) |
| EP (2) | EP4009330A1 (https=) |
| JP (1) | JP6931665B2 (https=) |
| KR (1) | KR102425257B1 (https=) |
| CN (1) | CN109313925B (https=) |
| AU (1) | AU2017274412B2 (https=) |
| BR (1) | BR112018074572B1 (https=) |
| CA (1) | CA3026061A1 (https=) |
| MX (1) | MX2018014856A (https=) |
| TW (1) | TWI755400B (https=) |
| WO (1) | WO2017210413A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3471402B1 (en) | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| KR20180111999A (ko) | 2016-02-17 | 2018-10-11 | 테서렉트 헬스, 인코포레이티드 | 수명 촬상 및 검출 응용을 위한 센서 및 디바이스 |
| EP4113104A3 (en) | 2016-06-01 | 2023-02-22 | Quantum-si Incorporated | Integrated device for detecting and analyzing molecules |
| BR112019012414A2 (pt) | 2016-12-19 | 2020-02-27 | Quantum-Si Incorporated | Carregamento de moléculas em poços de amostra para análise |
| CA3047826A1 (en) | 2016-12-22 | 2018-06-28 | Quantum-Si Incorporated | Integrated photodetector with direct binning pixel |
| US11120104B2 (en) | 2017-03-01 | 2021-09-14 | Stmicroelectronics (Research & Development) Limited | Method and apparatus for processing a histogram output from a detector sensor |
| KR102709865B1 (ko) | 2017-05-05 | 2024-09-26 | 퀀텀-에스아이 인코포레이티드 | 생물학적 반응에 있어서 개질된 표면 반응성 및 오손방지 특성을 갖는 기재 |
| US11378544B2 (en) | 2018-01-08 | 2022-07-05 | Illumina, Inc. | High-throughput sequencing with semiconductor-based detection |
| NL2020621B1 (en) | 2018-01-08 | 2019-07-15 | Illumina Inc | Multiplexing of an active sensor detector using structured illumination |
| KR102239487B1 (ko) | 2018-01-08 | 2021-04-14 | 일루미나, 인코포레이티드 | 반도체-기반 검출을 사용한 고-처리율 서열분석 |
| WO2019147904A1 (en) * | 2018-01-26 | 2019-08-01 | Quantum-Si Incorporated | Machine learning enabled pulse and base calling for sequencing devices |
| CN119364214A (zh) | 2018-06-22 | 2025-01-24 | 宽腾矽公司 | 具有不同检测时间的电荷存储仓的集成光电检测器 |
| AU2019330042A1 (en) * | 2018-08-29 | 2021-03-11 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
| US11210554B2 (en) | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| US11783917B2 (en) | 2019-03-21 | 2023-10-10 | Illumina, Inc. | Artificial intelligence-based base calling |
| US11423306B2 (en) | 2019-05-16 | 2022-08-23 | Illumina, Inc. | Systems and devices for characterization and performance analysis of pixel-based sequencing |
| US11593649B2 (en) | 2019-05-16 | 2023-02-28 | Illumina, Inc. | Base calling using convolutions |
| US11712715B2 (en) | 2019-10-11 | 2023-08-01 | Quantum-Si Incorporated | Surface modification in the vapor phase |
| AU2021208557A1 (en) | 2020-01-14 | 2022-09-01 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
| WO2021146473A1 (en) | 2020-01-14 | 2021-07-22 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| US12591780B2 (en) | 2020-02-20 | 2026-03-31 | Illumina, Inc. | Data compression for artificial intelligence-based base calling |
| US12592298B2 (en) | 2020-02-20 | 2026-03-31 | Illumina, Inc. | Hardware execution and acceleration of artificial intelligence-based base caller |
| CN121034400A (zh) | 2020-02-20 | 2025-11-28 | 因美纳有限公司 | 基于人工智能的多对多碱基判读 |
| US12354008B2 (en) | 2020-02-20 | 2025-07-08 | Illumina, Inc. | Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller |
| TW202147591A (zh) * | 2020-03-02 | 2021-12-16 | 美商寬騰矽公司 | 用於多維信號分析之整合感應器 |
| KR20220165754A (ko) | 2020-04-08 | 2022-12-15 | 퀀텀-에스아이 인코포레이티드 | 스큐가 감소된 통합 센서 |
| US20220065785A1 (en) * | 2020-07-23 | 2022-03-03 | Quantum-Si Incorporated | System and method for detecting change points |
| CA3199745A1 (en) * | 2020-10-27 | 2022-05-05 | Quantum-Si Incorporated | Calibration of single-molecule detection system |
| US12525320B2 (en) | 2021-03-16 | 2026-01-13 | Illumina, Inc. | Neural network parameter quantization for base calling |
| US12217829B2 (en) | 2021-04-15 | 2025-02-04 | Illumina, Inc. | Artificial intelligence-based analysis of protein three-dimensional (3D) structures |
| US12444482B2 (en) | 2021-04-15 | 2025-10-14 | Illumina, Inc. | Multi-channel protein voxelization to predict variant pathogenicity using deep convolutional neural networks |
| US12530882B2 (en) | 2021-07-01 | 2026-01-20 | Illumina, Inc. | Efficient artificial intelligence-based base calling of index sequences |
| WO2023137051A2 (en) | 2022-01-12 | 2023-07-20 | Quantum-Si Incorporated | Integrated sensor |
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| CA2155186A1 (en) * | 1993-02-01 | 1994-08-18 | Kevin M. Ulmer | Methods and apparatus for dna sequencing |
| DE19744490A1 (de) * | 1997-10-08 | 1999-04-15 | Temp Rite International Gmbh | Trinkwasseraufbereitungsanlage |
| JP4566299B2 (ja) * | 1998-04-09 | 2010-10-20 | シスメックス株式会社 | 赤芽球の分類計数方法 |
| WO2000009753A1 (en) * | 1998-08-11 | 2000-02-24 | Caliper Technologies Corp. | Methods and systems for sequencing dna by distinguishing the decay times of fluorescent probes |
| DE19844931C1 (de) * | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
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| CA2689626C (en) * | 2007-06-06 | 2016-10-25 | Pacific Biosciences Of California, Inc. | Methods and processes for calling bases in sequence by incorporation methods |
| JP5643650B2 (ja) | 2007-11-21 | 2014-12-17 | コスモシド・インコーポレーテッド | ゲノム同定システム |
| US20110165652A1 (en) * | 2008-01-14 | 2011-07-07 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
| CA2767521A1 (en) * | 2009-07-10 | 2011-01-13 | Perkinelmer Health Sciences, Inc. | Detecting multinucleotide repeats |
| US9670243B2 (en) * | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| US20140235474A1 (en) * | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
| US9145623B2 (en) | 2011-07-20 | 2015-09-29 | Thermo Fisher Scientific Oy | Transposon nucleic acids comprising a calibration sequence for DNA sequencing |
| JP5790242B2 (ja) * | 2011-07-25 | 2015-10-07 | 富士ゼロックス株式会社 | 故障予測装置及びプログラム |
| CA2867489A1 (en) * | 2012-03-30 | 2013-10-03 | Pacific Biosciences Of California, Inc. | Methods and composition for sequencing modified nucleic acids |
| CA2877094A1 (en) | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| HK1221053A1 (zh) * | 2013-05-23 | 2017-05-19 | 艾弗诺泰普有限责任公司 | 用於保持或改善健康的方法和系统 |
| WO2015074001A1 (en) * | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| EP3084002A4 (en) | 2013-12-16 | 2017-08-23 | Complete Genomics, Inc. | Basecaller for dna sequencing using machine learning |
| CN106462670B (zh) | 2014-05-12 | 2020-04-10 | 豪夫迈·罗氏有限公司 | 超深度测序中的罕见变体召集 |
| CA2957543A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| EP3471402B1 (en) | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| EP4421188A3 (en) | 2014-08-08 | 2024-10-23 | Quantum-Si Incorporated | Integrated device with external light source for probing, detecting, and analyzing molecules |
| US10185803B2 (en) | 2015-06-15 | 2019-01-22 | Deep Genomics Incorporated | Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network |
| US9922285B1 (en) | 2017-07-13 | 2018-03-20 | HumanCode, Inc. | Predictive assignments that relate to genetic information and leverage machine learning models |
-
2017
- 2017-06-01 TW TW106118155A patent/TWI755400B/zh not_active IP Right Cessation
- 2017-06-01 CN CN201780034484.3A patent/CN109313925B/zh active Active
- 2017-06-01 WO PCT/US2017/035420 patent/WO2017210413A1/en not_active Ceased
- 2017-06-01 MX MX2018014856A patent/MX2018014856A/es unknown
- 2017-06-01 JP JP2018562554A patent/JP6931665B2/ja active Active
- 2017-06-01 BR BR112018074572-3A patent/BR112018074572B1/pt not_active IP Right Cessation
- 2017-06-01 EP EP21199556.8A patent/EP4009330A1/en not_active Withdrawn
- 2017-06-01 US US15/611,573 patent/US10711299B2/en active Active
- 2017-06-01 AU AU2017274412A patent/AU2017274412B2/en not_active Ceased
- 2017-06-01 CA CA3026061A patent/CA3026061A1/en active Pending
- 2017-06-01 EP EP17730003.5A patent/EP3465503B1/en active Active
- 2017-06-01 KR KR1020187037813A patent/KR102425257B1/ko not_active Expired - Fee Related
-
2020
- 2020-06-02 US US16/889,917 patent/US20200291467A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170349944A1 (en) | 2017-12-07 |
| TW201800739A (zh) | 2018-01-01 |
| CN109313925A (zh) | 2019-02-05 |
| EP4009330A1 (en) | 2022-06-08 |
| JP2019529865A (ja) | 2019-10-17 |
| CN109313925B (zh) | 2022-09-02 |
| MX2018014856A (es) | 2019-03-07 |
| KR20190015371A (ko) | 2019-02-13 |
| AU2017274412B2 (en) | 2022-07-21 |
| KR102425257B1 (ko) | 2022-07-27 |
| BR112018074572A2 (pt) | 2019-03-12 |
| EP3465503B1 (en) | 2021-09-29 |
| AU2017274412A1 (en) | 2018-12-06 |
| WO2017210413A1 (en) | 2017-12-07 |
| JP6931665B2 (ja) | 2021-09-08 |
| US10711299B2 (en) | 2020-07-14 |
| US20200291467A1 (en) | 2020-09-17 |
| CA3026061A1 (en) | 2017-12-07 |
| EP3465503A1 (en) | 2019-04-10 |
| TWI755400B (zh) | 2022-02-21 |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: G06F 19/22 Ipc: C12Q 1/68 (2018.01), G01N 21/64 (2006.01), G16B 30 |
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| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/06/2017, OBSERVADAS AS CONDICOES LEGAIS |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 9A ANUIDADE. |